UniProtKB - Q86VH5 (LRRT3_HUMAN)
Protein
Leucine-rich repeat transmembrane neuronal protein 3
Gene
LRRTM3
Organism
Homo sapiens (Human)
Status
Functioni
Exhibits a limited synaptogenic activity in vitro, restricted to excitatory presynaptic differentiation (By similarity). May play a role in the development and maintenance of the vertebrate nervous system.By similarity
GO - Biological processi
- positive regulation of amyloid-beta formation Source: MGI
- positive regulation of synapse assembly Source: Ensembl
- presynapse assembly Source: SynGO
Enzyme and pathway databases
PathwayCommonsi | Q86VH5 |
Reactomei | R-HSA-6794361, Neurexins and neuroligins |
Names & Taxonomyi
Protein namesi | Recommended name: Leucine-rich repeat transmembrane neuronal protein 3 |
Gene namesi | Name:LRRTM3 ORF Names:UNQ803/PRO1693 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19410, LRRTM3 |
MIMi | 610869, gene |
neXtProti | NX_Q86VH5 |
VEuPathDBi | HostDB:ENSG00000198739.10 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
- postsynaptic cell membrane By similarity; Single-pass type I membrane protein By similarity
Extracellular region or secreted
- extracellular matrix Source: GO_Central
- extracellular space Source: GO_Central
Plasma Membrane
- integral component of postsynaptic density membrane Source: Ensembl
Other locations
- glutamatergic synapse Source: SynGO
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 31 – 419 | ExtracellularSequence analysisAdd BLAST | 389 | |
Transmembranei | 420 – 440 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 441 – 581 | CytoplasmicSequence analysisAdd BLAST | 141 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, SynapsePathology & Biotechi
Organism-specific databases
DisGeNETi | 347731 |
OpenTargetsi | ENSG00000198739 |
PharmGKBi | PA134962991 |
Miscellaneous databases
Pharosi | Q86VH5, Tbio |
Genetic variation databases
BioMutai | LRRTM3 |
DMDMi | 68052341 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 30 | Sequence analysisAdd BLAST | 30 | |
ChainiPRO_0000018355 | 31 – 581 | Leucine-rich repeat transmembrane neuronal protein 3Add BLAST | 551 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 126 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 357 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MassIVEi | Q86VH5 |
MaxQBi | Q86VH5 |
PaxDbi | Q86VH5 |
PeptideAtlasi | Q86VH5 |
PRIDEi | Q86VH5 |
ProteomicsDBi | 70020 [Q86VH5-1] 70021 [Q86VH5-2] |
PTM databases
GlyGeni | Q86VH5, 2 sites |
iPTMneti | Q86VH5 |
PhosphoSitePlusi | Q86VH5 |
Expressioni
Tissue specificityi
Expressed in neuronal tissues.1 Publication
Gene expression databases
Bgeei | ENSG00000198739, Expressed in corpus callosum and 92 other tissues |
Organism-specific databases
HPAi | ENSG00000198739, Group enriched (adrenal gland, brain, ovary, pituitary gland) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 131481, 18 interactors |
STRINGi | 9606.ENSP00000355187 |
Miscellaneous databases
RNActi | Q86VH5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 61 | LRRNTAdd BLAST | 31 | |
Repeati | 63 – 83 | LRR 1Add BLAST | 21 | |
Repeati | 86 – 107 | LRR 2Add BLAST | 22 | |
Repeati | 110 – 131 | LRR 3Add BLAST | 22 | |
Repeati | 134 – 155 | LRR 4Add BLAST | 22 | |
Repeati | 158 – 179 | LRR 5Add BLAST | 22 | |
Repeati | 182 – 203 | LRR 6Add BLAST | 22 | |
Repeati | 206 – 226 | LRR 7Add BLAST | 21 | |
Repeati | 230 – 251 | LRR 8Add BLAST | 22 | |
Repeati | 254 – 275 | LRR 9Add BLAST | 22 | |
Repeati | 279 – 300 | LRR 10Add BLAST | 22 | |
Domaini | 312 – 363 | LRRCTAdd BLAST | 52 |
Sequence similaritiesi
Belongs to the LRRTM family.Curated
Keywords - Domaini
Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000160543 |
HOGENOMi | CLU_032965_0_0_1 |
InParanoidi | Q86VH5 |
OMAi | EDTMESH |
OrthoDBi | 650731at2759 |
PhylomeDBi | Q86VH5 |
TreeFami | TF332659 |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR000372, LRRNT |
Pfami | View protein in Pfam PF13855, LRR_8, 3 hits |
SMARTi | View protein in SMART SM00369, LRR_TYP, 9 hits SM00013, LRRNT, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 9 hits |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q86VH5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGFNVIRLLS GSAVALVIAP TVLLTMLSSA ERGCPKGCRC EGKMVYCESQ
60 70 80 90 100
KLQEIPSSIS AGCLGLSLRY NSLQKLKYNQ FKGLNQLTWL YLDHNHISNI
110 120 130 140 150
DENAFNGIRR LKELILSSNR ISYFLNNTFR PVTNLRNLDL SYNQLHSLGS
160 170 180 190 200
EQFRGLRKLL SLHLRSNSLR TIPVRIFQDC RNLELLDLGY NRIRSLARNV
210 220 230 240 250
FAGMIRLKEL HLEHNQFSKL NLALFPRLVS LQNLYLQWNK ISVIGQTMSW
260 270 280 290 300
TWSSLQRLDL SGNEIEAFSG PSVFQCVPNL QRLNLDSNKL TFIGQEILDS
310 320 330 340 350
WISLNDISLA GNIWECSRNI CSLVNWLKSF KGLRENTIIC ASPKELQGVN
360 370 380 390 400
VIDAVKNYSI CGKSTTERFD LARALPKPTF KPKLPRPKHE SKPPLPPTVG
410 420 430 440 450
ATEPGPETDA DAEHISFHKI IAGSVALFLS VLVILLVIYV SWKRYPASMK
460 470 480 490 500
QLQQRSLMRR HRKKKRQSLK QMTPSTQEFY VDYKPTNTET SEMLLNGTGP
510 520 530 540 550
CTYNKSGSRE CEIPLSMNVS TFLAYDQPTI SYCGVHHELL SHKSFETNAQ
560 570 580
EDTMETHLET ELDLSTITTA GRISDHKQQL A
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 266 | E → G in CAE45717 (PubMed:17974005).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_014189 | 513 | I → V in isoform 2. 2 Publications | 1 | |
Alternative sequenceiVSP_014190 | 514 – 581 | Missing in isoform 2. 2 PublicationsAdd BLAST | 68 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY182028 mRNA Translation: AAO67549.1 AY358315 mRNA Translation: AAQ88681.1 AK290168 mRNA Translation: BAF82857.1 BX640611 mRNA Translation: CAE45717.1 BC111492 mRNA Translation: AAI11493.1 BC113715 mRNA Translation: AAI13716.1 BC113717 mRNA Translation: AAI13718.1 |
CCDSi | CCDS7270.1 [Q86VH5-1] |
RefSeqi | NP_821079.3, NM_178011.4 [Q86VH5-1] |
Genome annotation databases
Ensembli | ENST00000361320; ENSP00000355187; ENSG00000198739 [Q86VH5-1] |
GeneIDi | 347731 |
KEGGi | hsa:347731 |
UCSCi | uc001jmz.2, human [Q86VH5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY182028 mRNA Translation: AAO67549.1 AY358315 mRNA Translation: AAQ88681.1 AK290168 mRNA Translation: BAF82857.1 BX640611 mRNA Translation: CAE45717.1 BC111492 mRNA Translation: AAI11493.1 BC113715 mRNA Translation: AAI13716.1 BC113717 mRNA Translation: AAI13718.1 |
CCDSi | CCDS7270.1 [Q86VH5-1] |
RefSeqi | NP_821079.3, NM_178011.4 [Q86VH5-1] |
3D structure databases
SMRi | Q86VH5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 131481, 18 interactors |
STRINGi | 9606.ENSP00000355187 |
PTM databases
GlyGeni | Q86VH5, 2 sites |
iPTMneti | Q86VH5 |
PhosphoSitePlusi | Q86VH5 |
Genetic variation databases
BioMutai | LRRTM3 |
DMDMi | 68052341 |
Proteomic databases
MassIVEi | Q86VH5 |
MaxQBi | Q86VH5 |
PaxDbi | Q86VH5 |
PeptideAtlasi | Q86VH5 |
PRIDEi | Q86VH5 |
ProteomicsDBi | 70020 [Q86VH5-1] 70021 [Q86VH5-2] |
Protocols and materials databases
Antibodypediai | 14490, 78 antibodies |
DNASUi | 347731 |
Genome annotation databases
Ensembli | ENST00000361320; ENSP00000355187; ENSG00000198739 [Q86VH5-1] |
GeneIDi | 347731 |
KEGGi | hsa:347731 |
UCSCi | uc001jmz.2, human [Q86VH5-1] |
Organism-specific databases
CTDi | 347731 |
DisGeNETi | 347731 |
GeneCardsi | LRRTM3 |
HGNCi | HGNC:19410, LRRTM3 |
HPAi | ENSG00000198739, Group enriched (adrenal gland, brain, ovary, pituitary gland) |
MIMi | 610869, gene |
neXtProti | NX_Q86VH5 |
OpenTargetsi | ENSG00000198739 |
PharmGKBi | PA134962991 |
VEuPathDBi | HostDB:ENSG00000198739.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000160543 |
HOGENOMi | CLU_032965_0_0_1 |
InParanoidi | Q86VH5 |
OMAi | EDTMESH |
OrthoDBi | 650731at2759 |
PhylomeDBi | Q86VH5 |
TreeFami | TF332659 |
Enzyme and pathway databases
PathwayCommonsi | Q86VH5 |
Reactomei | R-HSA-6794361, Neurexins and neuroligins |
Miscellaneous databases
BioGRID-ORCSi | 347731, 10 hits in 847 CRISPR screens |
ChiTaRSi | LRRTM3, human |
GenomeRNAii | 347731 |
Pharosi | Q86VH5, Tbio |
PROi | PR:Q86VH5 |
RNActi | Q86VH5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000198739, Expressed in corpus callosum and 92 other tissues |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR000372, LRRNT |
Pfami | View protein in Pfam PF13855, LRR_8, 3 hits |
SMARTi | View protein in SMART SM00369, LRR_TYP, 9 hits SM00013, LRRNT, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 9 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LRRT3_HUMAN | |
Accessioni | Q86VH5Primary (citable) accession number: Q86VH5 Secondary accession number(s): A8K2A3, Q2NKX7, Q6N0A3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 21, 2005 |
Last sequence update: | June 21, 2005 | |
Last modified: | February 10, 2021 | |
This is version 151 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families