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Protein

Leucine-rich repeat transmembrane neuronal protein 3

Gene

LRRTM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Exhibits a limited synaptogenic activity in vitro, restricted to excitatory presynaptic differentiation (By similarity). May play a role in the development and maintenance of the vertebrate nervous system.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6794361 Neurexins and neuroligins

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat transmembrane neuronal protein 3
Gene namesi
Name:LRRTM3
ORF Names:UNQ803/PRO1693
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000198739.10
HGNCiHGNC:19410 LRRTM3
MIMi610869 gene
neXtProtiNX_Q86VH5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 419ExtracellularSequence analysisAdd BLAST389
Transmembranei420 – 440HelicalSequence analysisAdd BLAST21
Topological domaini441 – 581CytoplasmicSequence analysisAdd BLAST141

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi347731
OpenTargetsiENSG00000198739
PharmGKBiPA134962991

Polymorphism and mutation databases

BioMutaiLRRTM3
DMDMi68052341

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000001835531 – 581Leucine-rich repeat transmembrane neuronal protein 3Add BLAST551

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi126N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi357N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ86VH5
PaxDbiQ86VH5
PeptideAtlasiQ86VH5
PRIDEiQ86VH5
ProteomicsDBi70020
70021 [Q86VH5-2]

PTM databases

iPTMnetiQ86VH5
PhosphoSitePlusiQ86VH5

Expressioni

Tissue specificityi

Expressed in neuronal tissues.1 Publication

Gene expression databases

BgeeiENSG00000198739
CleanExiHS_LRRTM3

Interactioni

Protein-protein interaction databases

BioGridi131481, 18 interactors
STRINGi9606.ENSP00000355187

Structurei

3D structure databases

ProteinModelPortaliQ86VH5
SMRiQ86VH5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 61LRRNTAdd BLAST31
Repeati63 – 83LRR 1Add BLAST21
Repeati86 – 107LRR 2Add BLAST22
Repeati110 – 131LRR 3Add BLAST22
Repeati134 – 155LRR 4Add BLAST22
Repeati158 – 179LRR 5Add BLAST22
Repeati182 – 203LRR 6Add BLAST22
Repeati206 – 226LRR 7Add BLAST21
Repeati230 – 251LRR 8Add BLAST22
Repeati254 – 275LRR 9Add BLAST22
Repeati279 – 300LRR 10Add BLAST22
Domaini312 – 363LRRCTAdd BLAST52

Sequence similaritiesi

Belongs to the LRRTM family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00920000148957
HOGENOMiHOG000290681
HOVERGENiHBG052362
InParanoidiQ86VH5
OMAiGPCTYSK
OrthoDBiEOG091G03BI
PhylomeDBiQ86VH5
TreeFamiTF332659

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF13855 LRR_8, 3 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 9 hits
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 9 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86VH5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGFNVIRLLS GSAVALVIAP TVLLTMLSSA ERGCPKGCRC EGKMVYCESQ
60 70 80 90 100
KLQEIPSSIS AGCLGLSLRY NSLQKLKYNQ FKGLNQLTWL YLDHNHISNI
110 120 130 140 150
DENAFNGIRR LKELILSSNR ISYFLNNTFR PVTNLRNLDL SYNQLHSLGS
160 170 180 190 200
EQFRGLRKLL SLHLRSNSLR TIPVRIFQDC RNLELLDLGY NRIRSLARNV
210 220 230 240 250
FAGMIRLKEL HLEHNQFSKL NLALFPRLVS LQNLYLQWNK ISVIGQTMSW
260 270 280 290 300
TWSSLQRLDL SGNEIEAFSG PSVFQCVPNL QRLNLDSNKL TFIGQEILDS
310 320 330 340 350
WISLNDISLA GNIWECSRNI CSLVNWLKSF KGLRENTIIC ASPKELQGVN
360 370 380 390 400
VIDAVKNYSI CGKSTTERFD LARALPKPTF KPKLPRPKHE SKPPLPPTVG
410 420 430 440 450
ATEPGPETDA DAEHISFHKI IAGSVALFLS VLVILLVIYV SWKRYPASMK
460 470 480 490 500
QLQQRSLMRR HRKKKRQSLK QMTPSTQEFY VDYKPTNTET SEMLLNGTGP
510 520 530 540 550
CTYNKSGSRE CEIPLSMNVS TFLAYDQPTI SYCGVHHELL SHKSFETNAQ
560 570 580
EDTMETHLET ELDLSTITTA GRISDHKQQL A
Length:581
Mass (Da):65,896
Last modified:June 21, 2005 - v2
Checksum:iA025CF13AA663730
GO
Isoform 2 (identifier: Q86VH5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     513-513: I → V
     514-581: Missing.

Show »
Length:513
Mass (Da):58,267
Checksum:i9D909E8F917A26F4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti266E → G in CAE45717 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014189513I → V in isoform 2. 2 Publications1
Alternative sequenceiVSP_014190514 – 581Missing in isoform 2. 2 PublicationsAdd BLAST68

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY182028 mRNA Translation: AAO67549.1
AY358315 mRNA Translation: AAQ88681.1
AK290168 mRNA Translation: BAF82857.1
BX640611 mRNA Translation: CAE45717.1
BC111492 mRNA Translation: AAI11493.1
BC113715 mRNA Translation: AAI13716.1
BC113717 mRNA Translation: AAI13718.1
CCDSiCCDS7270.1 [Q86VH5-1]
RefSeqiNP_821079.3, NM_178011.4 [Q86VH5-1]
UniGeneiHs.652155
Hs.712279

Genome annotation databases

EnsembliENST00000361320; ENSP00000355187; ENSG00000198739 [Q86VH5-1]
GeneIDi347731
KEGGihsa:347731
UCSCiuc001jmz.2 human [Q86VH5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiLRRT3_HUMAN
AccessioniPrimary (citable) accession number: Q86VH5
Secondary accession number(s): A8K2A3, Q2NKX7, Q6N0A3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: June 20, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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