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Entry version 137 (18 Sep 2019)
Sequence version 1 (01 Jun 2003)
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Protein

Kinesin-like protein KIF27

Gene

KIF27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an essential role in motile ciliogenesis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi84 – 91ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
Biological processCilium biogenesis/degradation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189 Kinesins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kinesin-like protein KIF27
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KIF27
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18632 KIF27

Online Mendelian Inheritance in Man (OMIM)

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MIMi
611253 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86VH2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55582

Open Targets

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OpenTargetsi
ENSG00000165115

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134912901

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3879867

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KIF27

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74750464

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003071431 – 1401Kinesin-like protein KIF27Add BLAST1401

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei643PhosphoserineBy similarity1
Modified residuei646PhosphoserineBy similarity1
Modified residuei672PhosphoserineBy similarity1
Modified residuei675PhosphoserineBy similarity1
Modified residuei704PhosphoserineBy similarity1
Modified residuei999PhosphoserineBy similarity1
Modified residuei1367PhosphoserineBy similarity1
Modified residuei1389PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86VH2

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q86VH2

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q86VH2

MaxQB - The MaxQuant DataBase

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MaxQBi
Q86VH2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86VH2

PeptideAtlas

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PeptideAtlasi
Q86VH2

PRoteomics IDEntifications database

More...
PRIDEi
Q86VH2

ProteomicsDB human proteome resource

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ProteomicsDBi
70013 [Q86VH2-1]
70014 [Q86VH2-2]
70015 [Q86VH2-3]
70016 [Q86VH2-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86VH2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q86VH2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Testis, pancreatic islet, germ cell tumors and Jurkat T-cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165115 Expressed in 90 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q86VH2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q86VH2 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with STK36.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
120730, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q86VH2, 6 interactors

Molecular INTeraction database

More...
MINTi
Q86VH2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000297814

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86VH2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 341Kinesin motorPROSITE-ProRule annotationAdd BLAST337

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili352 – 413Sequence analysisAdd BLAST62
Coiled coili489 – 557Sequence analysisAdd BLAST69
Coiled coili705 – 886Sequence analysisAdd BLAST182
Coiled coili916 – 1070Sequence analysisAdd BLAST155
Coiled coili1118 – 1154Sequence analysisAdd BLAST37
Coiled coili1190 – 1219Sequence analysisAdd BLAST30

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF27 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0244 Eukaryota
COG5059 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157487

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000068072

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q86VH2

KEGG Orthology (KO)

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KOi
K10395

Identification of Orthologs from Complete Genome Data

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OMAi
RDAWEWK

Database of Orthologous Groups

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OrthoDBi
369179at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86VH2

TreeFam database of animal gene trees

More...
TreeFami
TF325946

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase

The PANTHER Classification System

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PANTHERi
PTHR24115 PTHR24115, 4 hits

Pfam protein domain database

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Pfami
View protein in Pfam
PF00225 Kinesin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00380 KINESINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00129 KISc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86VH2-1) [UniParc]FASTAAdd to basket
Also known as: KIF27A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEIPVKVAV RIRPLLCKEA LHNHQVCVRV IPNSQQVIIG RDRVFTFDFV
60 70 80 90 100
FGKNSTQDEV YNTCIKPLVL SLIEGYNATV FAYGQTGSGK TYTIGGGHIA
110 120 130 140 150
SVVEGQKGII PRAIQEIFQS ISEHPSIDFN VKVSYIEVYK EDLRDLLELE
160 170 180 190 200
TSMKDLHIRE DEKGNTVIVG AKECHVESAG EVMSLLEMGN AARHTGTTQM
210 220 230 240 250
NEHSSRSHAI FTISICQVHK NMEAAEDGSW YSPRHIVSKF HFVDLAGSER
260 270 280 290 300
VTKTGNTGER FKESIQINSG LLALGNVISA LGDPRRKSSH IPYRDAKITR
310 320 330 340 350
LLKDSLGGSA KTVMITCVSP SSSNFDESLN SLKYANRARN IRNKPTVNFS
360 370 380 390 400
PESDRIDEME FEIKLLREAL QSQQAGVSQT TQINREGSPD TNRIHSLEEQ
410 420 430 440 450
VAQLQGECLG YQCCVEEAFT FLVDLKDTVR LNEKQQHKLQ EWFNMIQEVR
460 470 480 490 500
KAVLTSFRGI GGTASLEEGP QHVTVLQLKR ELKKCQCVLA ADEVVFNQKE
510 520 530 540 550
LEVKELKNQV QMMVQENKGH AVSLKEAQKV NRLQNEKIIE QQLLVDQLSE
560 570 580 590 600
ELTKLNLSVT SSAKENCGDG PDARIPERRP YTVPFDTHLG HYIYIPSRQD
610 620 630 640 650
SRKVHTSPPM YSLDRIFAGF RTRSQMLLGH IEEQDKVLHC QFSDNSDDEE
660 670 680 690 700
SEGQEKSGTR CRSRSWIQKP DSVCSLVELS DTQDETQKSD LENEDLKIDC
710 720 730 740 750
LQESQELNLQ KLKNSERILT EAKQKMRELT INIKMKEDLI KELIKTGNDA
760 770 780 790 800
KSVSKQYSLK VTKLEHDAEQ AKVELIETQK QLQELENKDL SDVAMKVKLQ
810 820 830 840 850
KEFRKKMDAA KLRVQVLQKK QQDSKKLASL SIQNEKRANE LEQSVDHMKY
860 870 880 890 900
QKIQLQRKLR EENEKRKQLD AVIKRDQQKI KEIQLKTGQE EGLKPKAEDL
910 920 930 940 950
DACNLKRRKG SFGSIDHLQK LDEQKKWLDE EVEKVLNQRQ ELEELEADLK
960 970 980 990 1000
KREAIVSKKE ALLQEKSHLE NKKLRSSQAL NTDSLKISTR LNLLEQELSE
1010 1020 1030 1040 1050
KNVQLQTSTA EEKTKISEQV EVLQKEKDQL QKRRHNVDEK LKNGRVLSPE
1060 1070 1080 1090 1100
EEHVLFQLEE GIEALEAAIE YRNESIQNRQ KSLRASFHNL SRGEANVLEK
1110 1120 1130 1140 1150
LACLSPVEIR TILFRYFNKV VNLREAERKQ QLYNEEMKMK VLERDNMVRE
1160 1170 1180 1190 1200
LESALDHLKL QCDRRLTLQQ KEHEQKMQLL LHHFKEQDGE GIMETFKTYE
1210 1220 1230 1240 1250
DKIQQLEKDL YFYKKTSRDH KKKLKELVGE AIRRQLAPSE YQEAGDGVLK
1260 1270 1280 1290 1300
PEGGGMLSEE LKWASRPESM KLSGREREMD SSASSLRTQP NPQKLWEDIP
1310 1320 1330 1340 1350
ELPPIHSSLA PPSGHMLGNE NKTETDDNQF TKSHSRLSSQ IQVVGNVGRL
1360 1370 1380 1390 1400
HGVTPVKLCR KELRQISALE LSLRRSSLGV GIGSMAADSI EVSRKPRDLK

T
Length:1,401
Mass (Da):160,283
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4563BA414C30DB21
GO
Isoform 2 (identifier: Q86VH2-2) [UniParc]FASTAAdd to basket
Also known as: KIF27B

The sequence of this isoform differs from the canonical sequence as follows:
     816-881: Missing.

Show »
Length:1,335
Mass (Da):152,314
Checksum:iD3D02A926D9E823F
GO
Isoform 3 (identifier: Q86VH2-3) [UniParc]FASTAAdd to basket
Also known as: KIF27C

The sequence of this isoform differs from the canonical sequence as follows:
     882-978: Missing.

Show »
Length:1,304
Mass (Da):148,978
Checksum:i7FEBD1BBC879016C
GO
Isoform 4 (identifier: Q86VH2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-609: Missing.
     882-896: EIQLKTGQEEGLKPK → VILSYIPAKYNMKC
     897-1401: Missing.

Show »
Length:286
Mass (Da):33,547
Checksum:iD68AE60C142EC48B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z355F2Z355_HUMAN
Kinesin-like protein KIF27
KIF27
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB63770 differs from that shown. Reason: Frameshift at position 728.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035361213I → V. Corresponds to variant dbSNP:rs12001918EnsemblClinVar.1
Natural variantiVAR_035362300R → Q. Corresponds to variant dbSNP:rs35594736Ensembl.1
Natural variantiVAR_0612861036N → D1 PublicationCorresponds to variant dbSNP:rs55654273EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0286021 – 609Missing in isoform 4. CuratedAdd BLAST609
Alternative sequenceiVSP_028603816 – 881Missing in isoform 2. 1 PublicationAdd BLAST66
Alternative sequenceiVSP_028604882 – 978Missing in isoform 3. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_028605882 – 896EIQLK…GLKPK → VILSYIPAKYNMKC in isoform 4. CuratedAdd BLAST15
Alternative sequenceiVSP_028606897 – 1401Missing in isoform 4. CuratedAdd BLAST505

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY237536 mRNA Translation: AAP04413.1
AY237537 mRNA Translation: AAP04414.1
AY237538 mRNA Translation: AAP04415.1
AL354733 Genomic DNA No translation available.
BC140788 mRNA Translation: AAI40789.1
AL133654 mRNA Translation: CAB63770.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS65071.1 [Q86VH2-2]
CCDS65072.1 [Q86VH2-3]
CCDS6665.1 [Q86VH2-1]

Protein sequence database of the Protein Information Resource

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PIRi
T43446

NCBI Reference Sequences

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RefSeqi
NP_001258856.1, NM_001271927.1 [Q86VH2-2]
NP_001258857.1, NM_001271928.1 [Q86VH2-3]
NP_060046.1, NM_017576.2 [Q86VH2-1]
XP_016870392.1, XM_017014903.1 [Q86VH2-1]
XP_016870393.1, XM_017014904.1 [Q86VH2-1]
XP_016870396.1, XM_017014907.1 [Q86VH2-2]
XP_016870397.1, XM_017014908.1 [Q86VH2-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000297814; ENSP00000297814; ENSG00000165115 [Q86VH2-1]
ENST00000334204; ENSP00000333928; ENSG00000165115 [Q86VH2-3]
ENST00000376347; ENSP00000365525; ENSG00000165115 [Q86VH2-4]
ENST00000413982; ENSP00000401688; ENSG00000165115 [Q86VH2-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55582

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55582

UCSC genome browser

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UCSCi
uc004ana.6 human [Q86VH2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY237536 mRNA Translation: AAP04413.1
AY237537 mRNA Translation: AAP04414.1
AY237538 mRNA Translation: AAP04415.1
AL354733 Genomic DNA No translation available.
BC140788 mRNA Translation: AAI40789.1
AL133654 mRNA Translation: CAB63770.1 Frameshift.
CCDSiCCDS65071.1 [Q86VH2-2]
CCDS65072.1 [Q86VH2-3]
CCDS6665.1 [Q86VH2-1]
PIRiT43446
RefSeqiNP_001258856.1, NM_001271927.1 [Q86VH2-2]
NP_001258857.1, NM_001271928.1 [Q86VH2-3]
NP_060046.1, NM_017576.2 [Q86VH2-1]
XP_016870392.1, XM_017014903.1 [Q86VH2-1]
XP_016870393.1, XM_017014904.1 [Q86VH2-1]
XP_016870396.1, XM_017014907.1 [Q86VH2-2]
XP_016870397.1, XM_017014908.1 [Q86VH2-3]

3D structure databases

SMRiQ86VH2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120730, 5 interactors
IntActiQ86VH2, 6 interactors
MINTiQ86VH2
STRINGi9606.ENSP00000297814

Chemistry databases

ChEMBLiCHEMBL3879867

PTM databases

iPTMnetiQ86VH2
PhosphoSitePlusiQ86VH2

Polymorphism and mutation databases

BioMutaiKIF27
DMDMi74750464

Proteomic databases

EPDiQ86VH2
jPOSTiQ86VH2
MassIVEiQ86VH2
MaxQBiQ86VH2
PaxDbiQ86VH2
PeptideAtlasiQ86VH2
PRIDEiQ86VH2
ProteomicsDBi70013 [Q86VH2-1]
70014 [Q86VH2-2]
70015 [Q86VH2-3]
70016 [Q86VH2-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297814; ENSP00000297814; ENSG00000165115 [Q86VH2-1]
ENST00000334204; ENSP00000333928; ENSG00000165115 [Q86VH2-3]
ENST00000376347; ENSP00000365525; ENSG00000165115 [Q86VH2-4]
ENST00000413982; ENSP00000401688; ENSG00000165115 [Q86VH2-2]
GeneIDi55582
KEGGihsa:55582
UCSCiuc004ana.6 human [Q86VH2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55582
DisGeNETi55582

GeneCards: human genes, protein and diseases

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GeneCardsi
KIF27
HGNCiHGNC:18632 KIF27
MIMi611253 gene
neXtProtiNX_Q86VH2
OpenTargetsiENSG00000165115
PharmGKBiPA134912901

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0244 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00940000157487
HOGENOMiHOG000068072
InParanoidiQ86VH2
KOiK10395
OMAiRDAWEWK
OrthoDBi369179at2759
PhylomeDBiQ86VH2
TreeFamiTF325946

Enzyme and pathway databases

ReactomeiR-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189 Kinesins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
KIF27 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55582

Pharos

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Pharosi
Q86VH2

Protein Ontology

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PROi
PR:Q86VH2

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000165115 Expressed in 90 organ(s), highest expression level in testis
ExpressionAtlasiQ86VH2 baseline and differential
GenevisibleiQ86VH2 HS

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 4 hits
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKIF27_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86VH2
Secondary accession number(s): B2RTR8
, Q5T6W0, Q86VH0, Q86VH1, Q9UF54
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: June 1, 2003
Last modified: September 18, 2019
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
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