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Entry version 133 (10 Apr 2019)
Sequence version 2 (03 Oct 2006)
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Protein

Nebulin-related-anchoring protein

Gene

NRAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: UniProtKB
  • actin filament binding Source: GO_Central
  • metal ion binding Source: UniProtKB-KW
  • muscle alpha-actinin binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nebulin-related-anchoring protein
Short name:
N-RAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NRAPImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000197893.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7988 NRAP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602873 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86VF7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
4892

Open Targets

More...
OpenTargetsi
ENSG00000197893

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31767

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NRAP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
115502505

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002504251 – 1730Nebulin-related-anchoring proteinAdd BLAST1730

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1081PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86VF7

PeptideAtlas

More...
PeptideAtlasi
Q86VF7

PRoteomics IDEntifications database

More...
PRIDEi
Q86VF7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
70004
70005 [Q86VF7-2]
70006 [Q86VF7-3]
70007 [Q86VF7-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86VF7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86VF7

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q86VF7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in cardiac and skeletal muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197893 Expressed in 108 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86VF7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86VF7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA037953
HPA037954

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with actin, alpha-actinin, KLHL41, TLN1 and VCL. Interacts with CSRP3.By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110951, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q86VF7, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000358365

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q86VF7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86VF7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 64LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST61
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati63 – 97Nebulin 1Sequence analysisAdd BLAST35
Repeati156 – 166Nebulin 2Sequence analysisAdd BLAST11
Repeati175 – 202Nebulin 3Sequence analysisAdd BLAST28
Repeati203 – 237Nebulin 4Sequence analysisAdd BLAST35
Repeati246 – 273Nebulin 5Sequence analysisAdd BLAST28
Repeati298 – 307Nebulin 6Sequence analysis10
Repeati316 – 343Nebulin 7Sequence analysisAdd BLAST28
Repeati348 – 382Nebulin 8Sequence analysisAdd BLAST35
Repeati389 – 417Nebulin 9Sequence analysisAdd BLAST29
Repeati419 – 453Nebulin 10Sequence analysisAdd BLAST35
Repeati487 – 521Nebulin 11Sequence analysisAdd BLAST35
Repeati522 – 556Nebulin 12Sequence analysisAdd BLAST35
Repeati558 – 592Nebulin 13Sequence analysisAdd BLAST35
Repeati602 – 626Nebulin 14Sequence analysisAdd BLAST25
Repeati627 – 661Nebulin 15Sequence analysisAdd BLAST35
Repeati662 – 692Nebulin 16Sequence analysisAdd BLAST31
Repeati702 – 724Nebulin 17Sequence analysisAdd BLAST23
Repeati726 – 760Nebulin 18Sequence analysisAdd BLAST35
Repeati761 – 795Nebulin 19Sequence analysisAdd BLAST35
Repeati797 – 831Nebulin 20Sequence analysisAdd BLAST35
Repeati844 – 869Nebulin 21Sequence analysisAdd BLAST26
Repeati870 – 896Nebulin 22Sequence analysisAdd BLAST27
Repeati901 – 935Nebulin 23Sequence analysisAdd BLAST35
Repeati945 – 963Nebulin 24Sequence analysisAdd BLAST19
Repeati969 – 1003Nebulin 25Sequence analysisAdd BLAST35
Repeati1004 – 1038Nebulin 26Sequence analysisAdd BLAST35
Repeati1040 – 1074Nebulin 27Sequence analysisAdd BLAST35
Repeati1078 – 1112Nebulin 28Sequence analysisAdd BLAST35
Repeati1113 – 1139Nebulin 29Sequence analysisAdd BLAST27
Repeati1144 – 1178Nebulin 30Sequence analysisAdd BLAST35
Repeati1183 – 1206Nebulin 31Sequence analysisAdd BLAST24
Repeati1212 – 1246Nebulin 32Sequence analysisAdd BLAST35
Repeati1247 – 1281Nebulin 33Sequence analysisAdd BLAST35
Repeati1283 – 1317Nebulin 34Sequence analysisAdd BLAST35
Repeati1321 – 1355Nebulin 35Sequence analysisAdd BLAST35
Repeati1356 – 1390Nebulin 36Sequence analysisAdd BLAST35
Repeati1391 – 1421Nebulin 37Sequence analysisAdd BLAST31
Repeati1429 – 1449Nebulin 38Sequence analysisAdd BLAST21
Repeati1455 – 1481Nebulin 39Sequence analysisAdd BLAST27
Repeati1490 – 1524Nebulin 40Sequence analysisAdd BLAST35
Repeati1526 – 1560Nebulin 41Sequence analysisAdd BLAST35
Repeati1564 – 1598Nebulin 42Sequence analysisAdd BLAST35
Repeati1599 – 1626Nebulin 43Sequence analysisAdd BLAST28
Repeati1640 – 1664Nebulin 44Sequence analysisAdd BLAST25

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1702 Eukaryota
ENOG4111GQ8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158418

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052905

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86VF7

Database of Orthologous Groups

More...
OrthoDBi
1549538at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86VF7

TreeFam database of animal gene trees

More...
TreeFami
TF313758

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013998 Nebulin-like
IPR000900 Nebulin_repeat
IPR001781 Znf_LIM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00412 LIM, 1 hit
PF00880 Nebulin, 13 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00510 NEBULIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00132 LIM, 1 hit
SM00227 NEBU, 41 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit
PS51216 NEBULIN, 44 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q86VF7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNVQPCSRCG YGVYPAEKIS CIDQIWHKAC FHCEVCKMML SVNNFVSHQK
60 70 80 90 100
KPYCHAHNPK NNTFTSVYHT PLNLNVRTFP EAISGIHDQE DGEQCKSVFH
110 120 130 140 150
WDMKSKDKEG APNRQPLANE RAYWTGYGEG NAWCPGALPD PEIVRMVEAR
160 170 180 190 200
KSLGEEYTED YEQPRGKGSF PAMITPAYQR AKKANQLASQ VEYKRGHDER
210 220 230 240 250
ISRFSTVVDT PELLRSKAGA QLQSDVRYTE DYEQQRGKGS FPAMITPAYQ
260 270 280 290 300
IAKRANELAS DVRYHQQYQK EMRGMAGPAI GAEGILTREC ADQYGQGYPE
310 320 330 340 350
EYEEHRGKGS FPAMITPAYQ NAKKAHELAS DIKYRQDFNK MKGAAHYHSL
360 370 380 390 400
PAQDNLVLKQ AQSVNKLVSE VEYKKDLESS RGHSINYCET PQFRNVSKIS
410 420 430 440 450
KFTSDNKYKE NYQNHMRGRY EGVGMDRRTL HAMKVGSLAS NVAYKADYKH
460 470 480 490 500
DIVDYNYPAT LTPSYQTAMK LVPLKDANYR QSIDKLKYSS VTDTPQIVQA
510 520 530 540 550
KINAQQLSHV NYRADYEKNK LNYTLPQDVP QLVKAKTNAK LFSEVKYKEG
560 570 580 590 600
WEKTKGKGFE MKLDAMSLLA AKASGELASN IKYKEEYEKT KGKAMGTADS
610 620 630 640 650
RLLHSLQIAK MSSEVEYKKG FEESKTRFHL PMDMVNIRHA KKAQTLASDL
660 670 680 690 700
DYRKKLHEYT VLPEDMKTQW AKKAYGLQSE LQYKADLAWM KGVGWLTEGS
710 720 730 740 750
LNLEQAKKAG QLVSEKNYRQ RVDELKFTSV TDSSQMEHAK KSQELQSGVA
760 770 780 790 800
YKAGNEQSVH QYTISKDEPL FLQARANAAN LSEKLYKSSW ENQKAKGFEL
810 820 830 840 850
RLDSLTFLAA KAKRDLASEV KYKEDYERSR GKLIGAKDVQ GDSQMSHSLQ
860 870 880 890 900
MSKLQSELEY KKGFEDTKSQ CHVSLDMVHL VHARKAQHLA TDVGYKTAEH
910 920 930 940 950
HFTALPTDMK VEWAKKAYGL QSDNQYRADV KWMKGMGWVA TGSLNVEQAK
960 970 980 990 1000
KAGELISEKK YRQHPDALKF TSIKDTPEMV QARISYTQAV DRLYREQGEN
1010 1020 1030 1040 1050
IKHHYTPTAD LPEVLLAKLN AMNISETRYK ESWSKLRDGG YKLRLDALPF
1060 1070 1080 1090 1100
QAAKASGEII SDYKYKEAFE KMKGQMLGSR SLEDDISLAH SVYATSLQSD
1110 1120 1130 1140 1150
VNYKKGFEHS KAQFHLPLDM AALVHAKKAQ TLASNQDYKH PLPQYTSLAE
1160 1170 1180 1190 1200
DLRLSCAKKA HKLQSENLYR SDLNFMRGVA CVIPGTLEIE GRKKASELIS
1210 1220 1230 1240 1250
ESKYRQHPHS FKYTAVTDTP NLLHAKFSNQ ITNERLYKAA GEDARHEYTM
1260 1270 1280 1290 1300
TLGLPEFIRA KTNAANLSDA RYKESWRNLR AQGYKLTIEA LPFQAARASG
1310 1320 1330 1340 1350
DIASDFLYRH DFVKERGKLI GPQSVRDDPR IQHCRRMGQL QSELQYRRGA
1360 1370 1380 1390 1400
TSSQAQFHLP MDMVHLVHAK NAQALASDHD YRTQYHKFTA LPEDLKMAWA
1410 1420 1430 1440 1450
KKAHALQSEL RYKSDLIGMK GIGWLALRSP QMESAKKAGE LISETKYRKK
1460 1470 1480 1490 1500
PDSIKFTTVV DSPDLVHAKN SYMHCNERMY RSGDAESLHR YTLIPDHPDF
1510 1520 1530 1540 1550
TRARLNALHL SDKVYRNSWE QTRAGSYDFR LDAIPFQTAR ASREIASDFR
1560 1570 1580 1590 1600
YKEAFLRDRG LQIGYRSVDD DPRMKHFLNV GRLQSDNEYK KDFAKSRSQF
1610 1620 1630 1640 1650
HSSTDQPGLL QAKRSQQLAS DVHYRQPLPQ PTCDPEQLGL RHAQKAHQLQ
1660 1670 1680 1690 1700
SDVKYKSDLN LTRGVGWTPP GSYKVEMARR AAELANARGL GLQGAYRGAE
1710 1720 1730
AVEAGDHQSG EVNPDATEIL HVKKKKALLL
Length:1,730
Mass (Da):197,074
Last modified:October 3, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2F6AD0C7C07EC797
GO
Isoform 21 Publication (identifier: Q86VF7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     580-580: N → NVHLLLSLK

Note: Gene prediction based on EST data.Curated
Show »
Length:1,738
Mass (Da):197,978
Checksum:iD6A39759359FB9BF
GO
Isoform 31 Publication (identifier: Q86VF7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     371-405: Missing.
     580-580: N → NVHLLLSLK

Note: Gene prediction based on EST data.Curated
Show »
Length:1,703
Mass (Da):193,902
Checksum:iE7FA287C6611A0CD
GO
Isoform 42 Publications (identifier: Q86VF7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     371-405: Missing.

Show »
Length:1,695
Mass (Da):192,997
Checksum:iFA5D00F9978B811A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MRM2A0A0A0MRM2_HUMAN
Nebulin-related-anchoring protein
NRAP
1,731Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH58825 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH70130 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAQ09536 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC04884 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti224S → N in CAD38623 (PubMed:17974005).Curated1
Sequence conflicti261D → G in CAD89910 (PubMed:17974005).Curated1
Sequence conflicti338F → S in CAE45846 (PubMed:17974005).Curated1
Sequence conflicti395N → D in CAD38623 (PubMed:17974005).Curated1
Sequence conflicti488Y → H in CAE45811 (PubMed:17974005).Curated1
Sequence conflicti545V → A in BAB71328 (PubMed:14702039).Curated1
Sequence conflicti658E → G in CAD89910 (PubMed:17974005).Curated1
Sequence conflicti862K → E in CAD89910 (PubMed:17974005).Curated1
Sequence conflicti862K → E in CAE45846 (PubMed:17974005).Curated1
Sequence conflicti1210S → P in CAE45846 (PubMed:17974005).Curated1
Sequence conflicti1236L → F in CAD89910 (PubMed:17974005).Curated1
Sequence conflicti1260A → V in CAE45846 (PubMed:17974005).Curated1
Sequence conflicti1348R → K in CAE45846 (PubMed:17974005).Curated1
Sequence conflicti1357F → L in CAD89899 (PubMed:17974005).Curated1
Sequence conflicti1414S → L in CAE45846 (PubMed:17974005).Curated1
Sequence conflicti1563I → V in CAD89910 (PubMed:17974005).Curated1
Sequence conflicti1607P → H in CAD89910 (PubMed:17974005).Curated1
Sequence conflicti1672S → P in CAD38623 (PubMed:17974005).Curated1
Sequence conflicti1696Y → YQ in CAD89910 (PubMed:17974005).Curated1
Sequence conflicti1696Y → YQ in CAD89998 (PubMed:17974005).Curated1
Sequence conflicti1696Y → YQ (PubMed:15164054).Curated1
Sequence conflicti1697R → Q in CAD89899 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034073132A → S. Corresponds to variant dbSNP:rs34700024Ensembl.1
Natural variantiVAR_034074186Q → E. Corresponds to variant dbSNP:rs35049661Ensembl.1
Natural variantiVAR_027556208V → A4 PublicationsCorresponds to variant dbSNP:rs2154028Ensembl.1
Natural variantiVAR_027557249Y → C1 PublicationCorresponds to variant dbSNP:rs2185913Ensembl.1
Natural variantiVAR_034075282A → T. Corresponds to variant dbSNP:rs2275799Ensembl.1
Natural variantiVAR_027558344A → T3 PublicationsCorresponds to variant dbSNP:rs3121478Ensembl.1
Natural variantiVAR_027559360Q → R3 PublicationsCorresponds to variant dbSNP:rs3127106Ensembl.1
Natural variantiVAR_050160484D → N. Corresponds to variant dbSNP:rs11196400Ensembl.1
Natural variantiVAR_034076490S → L2 PublicationsCorresponds to variant dbSNP:rs3189030Ensembl.1
Natural variantiVAR_034077519N → I. Corresponds to variant dbSNP:rs2270182Ensembl.1
Natural variantiVAR_050161647A → S. Corresponds to variant dbSNP:rs2286734Ensembl.1
Natural variantiVAR_034078674A → V1 PublicationCorresponds to variant dbSNP:rs2286735Ensembl.1
Natural variantiVAR_034079884R → C1 PublicationCorresponds to variant dbSNP:rs868738Ensembl.1
Natural variantiVAR_0613571022M → V. Corresponds to variant dbSNP:rs34523503Ensembl.1
Natural variantiVAR_0340801112A → V1 PublicationCorresponds to variant dbSNP:rs1539587Ensembl.1
Natural variantiVAR_0501621183I → V2 PublicationsCorresponds to variant dbSNP:rs10749138Ensembl.1
Natural variantiVAR_0275601531L → P1 PublicationCorresponds to variant dbSNP:rs11196389Ensembl.1
Natural variantiVAR_0501631566R → C1 PublicationCorresponds to variant dbSNP:rs1885434Ensembl.1
Natural variantiVAR_0501641569D → N. Corresponds to variant dbSNP:rs11575798Ensembl.1
Natural variantiVAR_0501651643A → S. Corresponds to variant dbSNP:rs11575797Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_052165371 – 405Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST35
Alternative sequenceiVSP_052166580N → NVHLLLSLK in isoform 2 and isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY177620 mRNA Translation: AAO47073.1
AY177621 mRNA Translation: AAO47074.1
AY081943 mRNA Translation: AAL99185.2
AL831980 mRNA Translation: CAD89899.1
AL832025 mRNA Translation: CAD89910.1
AL832330 mRNA Translation: CAD38623.1
AL832457 mRNA Translation: CAD89998.1
BX640682 mRNA Translation: CAE45811.1
BX640730 mRNA Translation: CAE45846.1
BX641052 mRNA Translation: CAE46027.1
AL390197 Genomic DNA No translation available.
AK056969 mRNA Translation: BAB71328.1
AK096886 mRNA Translation: BAC04884.1 Different initiation.
BC058825 mRNA Translation: AAH58825.1 Sequence problems.
BC070130 mRNA Translation: AAH70130.1 Sequence problems.
U96486 Genomic DNA Translation: AAC51786.1
AF542553 mRNA Translation: AAQ09536.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7578.1 [Q86VF7-4]
CCDS7579.1 [Q86VF7-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001248392.1, NM_001261463.1
NP_006166.3, NM_006175.4 [Q86VF7-4]
NP_932326.2, NM_198060.3 [Q86VF7-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.268788

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000359988; ENSP00000353078; ENSG00000197893 [Q86VF7-1]
ENST00000360478; ENSP00000353666; ENSG00000197893 [Q86VF7-4]
ENST00000369360; ENSP00000358367; ENSG00000197893 [Q86VF7-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4892

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4892

UCSC genome browser

More...
UCSCi
uc001laj.5 human [Q86VF7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY177620 mRNA Translation: AAO47073.1
AY177621 mRNA Translation: AAO47074.1
AY081943 mRNA Translation: AAL99185.2
AL831980 mRNA Translation: CAD89899.1
AL832025 mRNA Translation: CAD89910.1
AL832330 mRNA Translation: CAD38623.1
AL832457 mRNA Translation: CAD89998.1
BX640682 mRNA Translation: CAE45811.1
BX640730 mRNA Translation: CAE45846.1
BX641052 mRNA Translation: CAE46027.1
AL390197 Genomic DNA No translation available.
AK056969 mRNA Translation: BAB71328.1
AK096886 mRNA Translation: BAC04884.1 Different initiation.
BC058825 mRNA Translation: AAH58825.1 Sequence problems.
BC070130 mRNA Translation: AAH70130.1 Sequence problems.
U96486 Genomic DNA Translation: AAC51786.1
AF542553 mRNA Translation: AAQ09536.1 Different initiation.
CCDSiCCDS7578.1 [Q86VF7-4]
CCDS7579.1 [Q86VF7-1]
RefSeqiNP_001248392.1, NM_001261463.1
NP_006166.3, NM_006175.4 [Q86VF7-4]
NP_932326.2, NM_198060.3 [Q86VF7-1]
UniGeneiHs.268788

3D structure databases

ProteinModelPortaliQ86VF7
SMRiQ86VF7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110951, 4 interactors
IntActiQ86VF7, 4 interactors
STRINGi9606.ENSP00000358365

PTM databases

iPTMnetiQ86VF7
PhosphoSitePlusiQ86VF7
SwissPalmiQ86VF7

Polymorphism and mutation databases

BioMutaiNRAP
DMDMi115502505

Proteomic databases

PaxDbiQ86VF7
PeptideAtlasiQ86VF7
PRIDEiQ86VF7
ProteomicsDBi70004
70005 [Q86VF7-2]
70006 [Q86VF7-3]
70007 [Q86VF7-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4892
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359988; ENSP00000353078; ENSG00000197893 [Q86VF7-1]
ENST00000360478; ENSP00000353666; ENSG00000197893 [Q86VF7-4]
ENST00000369360; ENSP00000358367; ENSG00000197893 [Q86VF7-3]
GeneIDi4892
KEGGihsa:4892
UCSCiuc001laj.5 human [Q86VF7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4892
DisGeNETi4892
EuPathDBiHostDB:ENSG00000197893.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NRAP

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0009218
HGNCiHGNC:7988 NRAP
HPAiHPA037953
HPA037954
MIMi602873 gene
neXtProtiNX_Q86VF7
OpenTargetsiENSG00000197893
PharmGKBiPA31767

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1702 Eukaryota
ENOG4111GQ8 LUCA
GeneTreeiENSGT00940000158418
HOVERGENiHBG052905
InParanoidiQ86VF7
OrthoDBi1549538at2759
PhylomeDBiQ86VF7
TreeFamiTF313758

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NRAP human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
NRAP

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4892

Protein Ontology

More...
PROi
PR:Q86VF7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000197893 Expressed in 108 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis
ExpressionAtlasiQ86VF7 baseline and differential
GenevisibleiQ86VF7 HS

Family and domain databases

InterProiView protein in InterPro
IPR013998 Nebulin-like
IPR000900 Nebulin_repeat
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 1 hit
PF00880 Nebulin, 13 hits
PRINTSiPR00510 NEBULIN
SMARTiView protein in SMART
SM00132 LIM, 1 hit
SM00227 NEBU, 41 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit
PS51216 NEBULIN, 44 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNRAP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86VF7
Secondary accession number(s): O15500
, Q5VWI3, Q5VWI4, Q6MZK3, Q6N026, Q6N059, Q6NSH8, Q6PDB0, Q719H6, Q86TC5, Q86TD6, Q86TE6, Q86VF6, Q8N3R6, Q8N8F9, Q8TCH0, Q96MG4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: April 10, 2019
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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