UniProtKB - Q86VE3 (SATL1_HUMAN)
Protein
Spermidine/spermine N(1)-acetyltransferase-like protein 1
Gene
SATL1
Organism
Homo sapiens (Human)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 676 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- N-acetyltransferase activity Source: GO_Central
Keywordsi
Molecular function | Acyltransferase, Transferase |
Enzyme and pathway databases
PathwayCommonsi | Q86VE3 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:SATL1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:27992, SATL1 |
neXtProti | NX_Q86VE3 |
VEuPathDBi | HostDB:ENSG00000184788.12 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000184788 |
PharmGKBi | PA134969637 |
Miscellaneous databases
Pharosi | Q86VE3, Tdark |
Genetic variation databases
BioMutai | SATL1 |
DMDMi | 143583359 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000282928 | 1 – 695 | Spermidine/spermine N(1)-acetyltransferase-like protein 1Add BLAST | 695 |
Proteomic databases
jPOSTi | Q86VE3 |
MassIVEi | Q86VE3 |
PaxDbi | Q86VE3 |
PeptideAtlasi | Q86VE3 |
PRIDEi | Q86VE3 |
ProteomicsDBi | 19160 69991 [Q86VE3-1] 69992 [Q86VE3-2] |
PTM databases
iPTMneti | Q86VE3 |
PhosphoSitePlusi | Q86VE3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000184788, Expressed in dorsolateral prefrontal cortex and 27 other tissues |
ExpressionAtlasi | Q86VE3, baseline and differential |
Organism-specific databases
HPAi | ENSG00000184788, Group enriched (adrenal gland, brain, pituitary gland, testis) |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000425421 |
Miscellaneous databases
RNActi | Q86VE3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 529 – 695 | N-acetyltransferasePROSITE-ProRule annotationAdd BLAST | 167 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 552 – 553 | Substrate bindingBy similarity | 2 | |
Regioni | 618 – 620 | Acetyl-CoA bindingBy similarity | 3 | |
Regioni | 626 – 631 | Acetyl-CoA bindingBy similarity | 6 | |
Regioni | 650 – 652 | Substrate bindingBy similarity | 3 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 195 – 523 | Gln-richAdd BLAST | 329 |
Sequence similaritiesi
Belongs to the acetyltransferase family.Curated
Phylogenomic databases
eggNOGi | KOG3216, Eukaryota |
GeneTreei | ENSGT00950000183121 |
HOGENOMi | CLU_052128_1_0_1 |
InParanoidi | Q86VE3 |
OMAi | HPGMWQP |
OrthoDBi | 1228251at2759 |
PhylomeDBi | Q86VE3 |
TreeFami | TF319736 |
Family and domain databases
InterProi | View protein in InterPro IPR016181, Acyl_CoA_acyltransferase IPR000182, GNAT_dom IPR039533, Satl1 |
PANTHERi | PTHR10545:SF60, PTHR10545:SF60, 1 hit |
Pfami | View protein in Pfam PF00583, Acetyltransf_1, 1 hit |
SUPFAMi | SSF55729, SSF55729, 1 hit |
PROSITEi | View protein in PROSITE PS51186, GNAT, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q86VE3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNQSGTNQSS LSDSNQAGIN QPSTNSLGMN QMDMNQGSAS LYEMNQVDMK
60 70 80 90 100
QPSMSQAGMR QSGTNLPDIN QPDMKQPDTW QLGRSQPGML QQELSQLVLS
110 120 130 140 150
KAGISQPDPS QPGPSQSGPS QSRMRQIGTN QSGMSQPVMQ QLDSQSGGSQ
160 170 180 190 200
PSMRQVGTSQ LGTSQIGMSQ PGTWQTGLSQ PVLRQPNMSP PGMWQPGVQQ
210 220 230 240 250
PGISQQVPSH PDMSQPGMSQ QVPSQPGIRQ PDTSQSCKNQ TDMSQPDANQ
260 270 280 290 300
SSLSDSNQTG IIQPSPSLLG MNQMDMNQWS ASLYEMNQVD MKQPSMSQAG
310 320 330 340 350
MRQSGTNLPD INQPGMKQPG TWQLGRSQPG MWPQSLSELV LSEASISQPG
360 370 380 390 400
PPQRAPSQSG PRQSSTSQAG TNQSGISQPV MWQLDMRQSG GSQPSMRQVG
410 420 430 440 450
TSQSGTSQIG MSQPGTWQTG LSQPVPRQPN KSPPGMWQRG MWQPGMSQQV
460 470 480 490 500
PSQLGMRQPG TSQSSKNQTG MSHPGRGQPG IWEPGPSQPG LSQQDLNQLV
510 520 530 540 550
LSQPGLSQPG RSQPSVSQMG MRQTSMDYFQ IRHAEAGDCP EILRLIKELA
560 570 580 590 600
ACENMLDAME LTAADLLRDG FGDNPLFYCL IAEVNDQQKP SGKLTVGFAM
610 620 630 640 650
YYFTYDSWTG KVLYLEDFYV TQAYQGLGIG AEMLKRLSQI AITTQCNCMH
660 670 680 690
FLVVIWNQAS INYYTSRGAL DLSSEEGWHL FRFNREELLD MAWEE
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8YFQ0 | A0A2R8YFQ0_HUMAN | Spermidine/spermine N(1)-acetyltran... | SATL1 | 676 | Annotation score: | ||
A0A5F9UUY5 | A0A5F9UUY5_HUMAN | Spermidine/spermine N(1)-acetyltran... | SATL1 | 508 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 176 | T → S in AAH43215 (PubMed:15772651).Curated | 1 | |
Sequence conflicti | 179 | S → G in AAH43215 (PubMed:15772651).Curated | 1 | |
Sequence conflicti | 426 | P → L in AAI26402 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_031438 | 279 | W → R1 PublicationCorresponds to variant dbSNP:rs10126146Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_024253 | 626 – 632 | GLGIGAE → DSHHNSM in isoform 2. 1 Publication | 7 | |
Alternative sequenceiVSP_024254 | 633 – 695 | Missing in isoform 2. 1 PublicationAdd BLAST | 63 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z99571 Genomic DNA No translation available. BC043215 mRNA Translation: AAH43215.2 BC126401 mRNA Translation: AAI26402.1 |
CCDSi | CCDS35343.2 [Q86VE3-2] |
RefSeqi | NP_001012998.2, NM_001012980.2 [Q86VE3-2] |
Genome annotation databases
Ensembli | ENST00000509231; ENSP00000425421; ENSG00000184788 [Q86VE3-2] ENST00000644105; ENSP00000494345; ENSG00000184788 [Q86VE3-1] ENST00000646118; ENSP00000493598; ENSG00000184788 [Q86VE3-1] |
GeneIDi | 340562 |
KEGGi | hsa:340562 |
UCSCi | uc004een.4, human [Q86VE3-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z99571 Genomic DNA No translation available. BC043215 mRNA Translation: AAH43215.2 BC126401 mRNA Translation: AAI26402.1 |
CCDSi | CCDS35343.2 [Q86VE3-2] |
RefSeqi | NP_001012998.2, NM_001012980.2 [Q86VE3-2] |
3D structure databases
SMRi | Q86VE3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000425421 |
PTM databases
iPTMneti | Q86VE3 |
PhosphoSitePlusi | Q86VE3 |
Genetic variation databases
BioMutai | SATL1 |
DMDMi | 143583359 |
Proteomic databases
jPOSTi | Q86VE3 |
MassIVEi | Q86VE3 |
PaxDbi | Q86VE3 |
PeptideAtlasi | Q86VE3 |
PRIDEi | Q86VE3 |
ProteomicsDBi | 19160 69991 [Q86VE3-1] 69992 [Q86VE3-2] |
Protocols and materials databases
Antibodypediai | 54033, 60 antibodies |
Genome annotation databases
Ensembli | ENST00000509231; ENSP00000425421; ENSG00000184788 [Q86VE3-2] ENST00000644105; ENSP00000494345; ENSG00000184788 [Q86VE3-1] ENST00000646118; ENSP00000493598; ENSG00000184788 [Q86VE3-1] |
GeneIDi | 340562 |
KEGGi | hsa:340562 |
UCSCi | uc004een.4, human [Q86VE3-1] |
Organism-specific databases
CTDi | 340562 |
GeneCardsi | SATL1 |
HGNCi | HGNC:27992, SATL1 |
HPAi | ENSG00000184788, Group enriched (adrenal gland, brain, pituitary gland, testis) |
neXtProti | NX_Q86VE3 |
OpenTargetsi | ENSG00000184788 |
PharmGKBi | PA134969637 |
VEuPathDBi | HostDB:ENSG00000184788.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3216, Eukaryota |
GeneTreei | ENSGT00950000183121 |
HOGENOMi | CLU_052128_1_0_1 |
InParanoidi | Q86VE3 |
OMAi | HPGMWQP |
OrthoDBi | 1228251at2759 |
PhylomeDBi | Q86VE3 |
TreeFami | TF319736 |
Enzyme and pathway databases
PathwayCommonsi | Q86VE3 |
Miscellaneous databases
BioGRID-ORCSi | 340562, 4 hits in 501 CRISPR screens |
ChiTaRSi | SATL1, human |
GenomeRNAii | 340562 |
Pharosi | Q86VE3, Tdark |
PROi | PR:Q86VE3 |
RNActi | Q86VE3, protein |
Gene expression databases
Bgeei | ENSG00000184788, Expressed in dorsolateral prefrontal cortex and 27 other tissues |
ExpressionAtlasi | Q86VE3, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR016181, Acyl_CoA_acyltransferase IPR000182, GNAT_dom IPR039533, Satl1 |
PANTHERi | PTHR10545:SF60, PTHR10545:SF60, 1 hit |
Pfami | View protein in Pfam PF00583, Acetyltransf_1, 1 hit |
SUPFAMi | SSF55729, SSF55729, 1 hit |
PROSITEi | View protein in PROSITE PS51186, GNAT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SATL1_HUMAN | |
Accessioni | Q86VE3Primary (citable) accession number: Q86VE3 Secondary accession number(s): A0A2R8Y5C1 Q5H8V9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 3, 2007 |
Last sequence update: | September 18, 2019 | |
Last modified: | February 10, 2021 | |
This is version 127 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants