Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Myb-related transcription factor, partner of profilin

Gene

MYPOP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5'-YAAC[GT]G-3'. Dimerization with PFN1 reduces its DNA-binding capacity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Myb-related transcription factor, partner of profilin
Alternative name(s):
Myb-related protein p42POP
Partner of profilin
Gene namesi
Name:MYPOP
Synonyms:P42POP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000176182.5
HGNCiHGNC:20178 MYPOP
MIMi617861 gene
neXtProtiNX_Q86VE0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176182
PharmGKBiPA164723403

Polymorphism and mutation databases

BioMutaiMYPOP
DMDMi74759426

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003447991 – 399Myb-related transcription factor, partner of profilinAdd BLAST399

Proteomic databases

EPDiQ86VE0
MaxQBiQ86VE0
PaxDbiQ86VE0
PeptideAtlasiQ86VE0
PRIDEiQ86VE0
ProteomicsDBi69990

PTM databases

iPTMnetiQ86VE0
PhosphoSitePlusiQ86VE0

Expressioni

Gene expression databases

BgeeiENSG00000176182
GenevisibleiQ86VE0 HS

Organism-specific databases

HPAiHPA065307

Interactioni

Subunit structurei

Interacts with PFN1. Homodimer and heterodimer with PFN1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi130870, 10 interactors
IntActiQ86VE0, 39 interactors
STRINGi9606.ENSP00000325402

Structurei

3D structure databases

ProteinModelPortaliQ86VE0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 84Myb-likePROSITE-ProRule annotationAdd BLAST73

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi83 – 86Nuclear localization signalBy similarity4
Motifi382 – 385Nuclear localization signalBy similarity4
Motifi390 – 393Nuclear localization signalBy similarity4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi136 – 380Pro-richAdd BLAST245

Domaini

The proline-rich region is required for PFN1 interaction.By similarity

Phylogenomic databases

eggNOGiENOG410IEV7 Eukaryota
ENOG410XX4G LUCA
GeneTreeiENSGT00450000040421
HOGENOMiHOG000113710
InParanoidiQ86VE0
OMAiACPQRYV
OrthoDBiEOG091G1BN9
PhylomeDBiQ86VE0
TreeFamiTF338618

Family and domain databases

InterProiView protein in InterPro
IPR017877 Myb-like_dom
IPR028002 Myb_DNA-bind_5
IPR001005 SANT/Myb
PfamiView protein in Pfam
PF13873 Myb_DNA-bind_5, 1 hit
SMARTiView protein in SMART
SM00717 SANT, 1 hit
PROSITEiView protein in PROSITE
PS50090 MYB_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Q86VE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASAAAGEAE ETTRLRKPRF SFEENQILIR EVRAHYPQLY GAQSRRVSVA
60 70 80 90 100
ERRRVWDGIA AKINGITSWK RTGQEVQKRW NDFKRRTKEK LARVPHSTQG
110 120 130 140 150
AGPAAEDAFS AEEETIFAIL GPGVAAPGAG AGAEEPPAAP SSQPPPPSAC
160 170 180 190 200
PQRYVLSEDR REDRRADTSA HSKAGSSSPE PWARPSCTPQ EGGCPRPKER
210 220 230 240 250
ESPPPSALQP VQLPRLALSP PPPAPPLPPP PPLAQVAPSP PSPPPPPRPP
260 270 280 290 300
PTLSASDPSL DFLRAQQETA NAIRELAGTL RQGLAKLSEA LSALLPLLPG
310 320 330 340 350
TPVDSLPPPL PPPPPPPPPP RPVLPPPAPK VEITPEPVSV VAAVVDGAVV
360 370 380 390
AARGVIIAPR SEEGAPRPPP APLPPHDSPP HKRRKGFPTR KRRGRWKSP
Length:399
Mass (Da):42,508
Last modified:April 26, 2005 - v2
Checksum:iF949A70588E0C454
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC044311 mRNA Translation: AAH44311.2
CCDSiCCDS33055.1
RefSeqiNP_001012661.1, NM_001012643.3
UniGeneiHs.515478

Genome annotation databases

EnsembliENST00000322217; ENSP00000325402; ENSG00000176182
GeneIDi339344
KEGGihsa:339344
UCSCiuc002pdt.4 human

Similar proteinsi

Entry informationi

Entry nameiMYPOP_HUMAN
AccessioniPrimary (citable) accession number: Q86VE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: April 26, 2005
Last modified: July 18, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health