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Entry version 128 (08 May 2019)
Sequence version 2 (26 Apr 2005)
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Protein

Myb-related transcription factor, partner of profilin

Gene

MYPOP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5'-YAAC[GT]G-3'. Dimerization with PFN1 reduces its DNA-binding capacity (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myb-related transcription factor, partner of profilin
Alternative name(s):
Myb-related protein p42POP
Partner of profilin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYPOP
Synonyms:P42POP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:20178 MYPOP

Online Mendelian Inheritance in Man (OMIM)

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MIMi
617861 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86VE0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000176182

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164723403

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
MYPOP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74759426

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003447991 – 399Myb-related transcription factor, partner of profilinAdd BLAST399

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q86VE0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86VE0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86VE0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86VE0

PeptideAtlas

More...
PeptideAtlasi
Q86VE0

PRoteomics IDEntifications database

More...
PRIDEi
Q86VE0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
69990

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86VE0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86VE0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000176182 Expressed in 135 organ(s), highest expression level in prefrontal cortex

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86VE0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA065307

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PFN1. Homodimer and heterodimer with PFN1 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
130870, 10 interactors

Protein interaction database and analysis system

More...
IntActi
Q86VE0, 38 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000325402

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 84Myb-likePROSITE-ProRule annotationAdd BLAST73

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi83 – 86Nuclear localization signalBy similarity4
Motifi382 – 385Nuclear localization signalBy similarity4
Motifi390 – 393Nuclear localization signalBy similarity4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi136 – 380Pro-richAdd BLAST245

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The proline-rich region is required for PFN1 interaction.By similarity

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEV7 Eukaryota
ENOG410XX4G LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00450000040421

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113710

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86VE0

Identification of Orthologs from Complete Genome Data

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OMAi
QEGGCPR

Database of Orthologous Groups

More...
OrthoDBi
1378970at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86VE0

TreeFam database of animal gene trees

More...
TreeFami
TF338618

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017877 Myb-like_dom
IPR028002 Myb_DNA-bind_5
IPR001005 SANT/Myb

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13873 Myb_DNA-bind_5, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00717 SANT, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50090 MYB_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q86VE0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASAAAGEAE ETTRLRKPRF SFEENQILIR EVRAHYPQLY GAQSRRVSVA
60 70 80 90 100
ERRRVWDGIA AKINGITSWK RTGQEVQKRW NDFKRRTKEK LARVPHSTQG
110 120 130 140 150
AGPAAEDAFS AEEETIFAIL GPGVAAPGAG AGAEEPPAAP SSQPPPPSAC
160 170 180 190 200
PQRYVLSEDR REDRRADTSA HSKAGSSSPE PWARPSCTPQ EGGCPRPKER
210 220 230 240 250
ESPPPSALQP VQLPRLALSP PPPAPPLPPP PPLAQVAPSP PSPPPPPRPP
260 270 280 290 300
PTLSASDPSL DFLRAQQETA NAIRELAGTL RQGLAKLSEA LSALLPLLPG
310 320 330 340 350
TPVDSLPPPL PPPPPPPPPP RPVLPPPAPK VEITPEPVSV VAAVVDGAVV
360 370 380 390
AARGVIIAPR SEEGAPRPPP APLPPHDSPP HKRRKGFPTR KRRGRWKSP
Length:399
Mass (Da):42,508
Last modified:April 26, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF949A70588E0C454
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC044311 mRNA Translation: AAH44311.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33055.1

NCBI Reference Sequences

More...
RefSeqi
NP_001012661.1, NM_001012643.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000322217; ENSP00000325402; ENSG00000176182

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
339344

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:339344

UCSC genome browser

More...
UCSCi
uc002pdt.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC044311 mRNA Translation: AAH44311.2
CCDSiCCDS33055.1
RefSeqiNP_001012661.1, NM_001012643.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi130870, 10 interactors
IntActiQ86VE0, 38 interactors
STRINGi9606.ENSP00000325402

PTM databases

iPTMnetiQ86VE0
PhosphoSitePlusiQ86VE0

Polymorphism and mutation databases

BioMutaiMYPOP
DMDMi74759426

Proteomic databases

EPDiQ86VE0
jPOSTiQ86VE0
MaxQBiQ86VE0
PaxDbiQ86VE0
PeptideAtlasiQ86VE0
PRIDEiQ86VE0
ProteomicsDBi69990

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322217; ENSP00000325402; ENSG00000176182
GeneIDi339344
KEGGihsa:339344
UCSCiuc002pdt.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
339344

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MYPOP
HGNCiHGNC:20178 MYPOP
HPAiHPA065307
MIMi617861 gene
neXtProtiNX_Q86VE0
OpenTargetsiENSG00000176182
PharmGKBiPA164723403

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEV7 Eukaryota
ENOG410XX4G LUCA
GeneTreeiENSGT00450000040421
HOGENOMiHOG000113710
InParanoidiQ86VE0
OMAiQEGGCPR
OrthoDBi1378970at2759
PhylomeDBiQ86VE0
TreeFamiTF338618

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MYPOP human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
339344

Protein Ontology

More...
PROi
PR:Q86VE0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000176182 Expressed in 135 organ(s), highest expression level in prefrontal cortex
GenevisibleiQ86VE0 HS

Family and domain databases

InterProiView protein in InterPro
IPR017877 Myb-like_dom
IPR028002 Myb_DNA-bind_5
IPR001005 SANT/Myb
PfamiView protein in Pfam
PF13873 Myb_DNA-bind_5, 1 hit
SMARTiView protein in SMART
SM00717 SANT, 1 hit
PROSITEiView protein in PROSITE
PS50090 MYB_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYPOP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86VE0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: April 26, 2005
Last modified: May 8, 2019
This is version 128 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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