UniProtKB - Q86VE0 (MYPOP_HUMAN)
Protein
Myb-related transcription factor, partner of profilin
Gene
MYPOP
Organism
Homo sapiens (Human)
Status
Functioni
Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5'-YAAC[GT]G-3'. Dimerization with PFN1 reduces its DNA-binding capacity (By similarity).By similarity
GO - Molecular functioni
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: ARUK-UCL
- identical protein binding Source: Ensembl
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: ARUK-UCL
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q86VE0 |
Names & Taxonomyi
Protein namesi | Recommended name: Myb-related transcription factor, partner of profilinAlternative name(s): Myb-related protein p42POP Partner of profilin |
Gene namesi | Name:MYPOP Synonyms:P42POP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20178, MYPOP |
MIMi | 617861, gene |
neXtProti | NX_Q86VE0 |
VEuPathDBi | HostDB:ENSG00000176182.5 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 339344 |
OpenTargetsi | ENSG00000176182 |
PharmGKBi | PA164723403 |
Miscellaneous databases
Pharosi | Q86VE0, Tbio |
Genetic variation databases
BioMutai | MYPOP |
DMDMi | 74759426 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000344799 | 1 – 399 | Myb-related transcription factor, partner of profilinAdd BLAST | 399 |
Proteomic databases
EPDi | Q86VE0 |
jPOSTi | Q86VE0 |
MassIVEi | Q86VE0 |
MaxQBi | Q86VE0 |
PaxDbi | Q86VE0 |
PeptideAtlasi | Q86VE0 |
PRIDEi | Q86VE0 |
ProteomicsDBi | 69990 |
PTM databases
iPTMneti | Q86VE0 |
PhosphoSitePlusi | Q86VE0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000176182, Expressed in prefrontal cortex and 151 other tissues |
Genevisiblei | Q86VE0, HS |
Organism-specific databases
HPAi | ENSG00000176182, Tissue enhanced (skeletal) |
Interactioni
Subunit structurei
Interacts with PFN1. Homodimer and heterodimer with PFN1 (By similarity).
By similarityBinary interactionsi
Hide detailsQ86VE0
GO - Molecular functioni
- identical protein binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 130870, 51 interactors |
IntActi | Q86VE0, 39 interactors |
STRINGi | 9606.ENSP00000325402 |
Miscellaneous databases
RNActi | Q86VE0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 12 – 84 | Myb-likePROSITE-ProRule annotationAdd BLAST | 73 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 83 – 86 | Nuclear localization signalBy similarity | 4 | |
Motifi | 382 – 385 | Nuclear localization signalBy similarity | 4 | |
Motifi | 390 – 393 | Nuclear localization signalBy similarity | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 136 – 380 | Pro-richAdd BLAST | 245 |
Domaini
The proline-rich region is required for PFN1 interaction.By similarity
Phylogenomic databases
eggNOGi | ENOG502RV5V, Eukaryota |
GeneTreei | ENSGT00450000040421 |
HOGENOMi | CLU_046143_2_0_1 |
InParanoidi | Q86VE0 |
OMAi | QEGGCPR |
OrthoDBi | 1378970at2759 |
PhylomeDBi | Q86VE0 |
TreeFami | TF338618 |
Family and domain databases
InterProi | View protein in InterPro IPR017877, Myb-like_dom IPR028002, Myb_DNA-bind_5 IPR001005, SANT/Myb |
Pfami | View protein in Pfam PF13873, Myb_DNA-bind_5, 1 hit |
SMARTi | View protein in SMART SM00717, SANT, 1 hit |
PROSITEi | View protein in PROSITE PS50090, MYB_LIKE, 1 hit |
i Sequence
Sequence statusi: Complete.
Q86VE0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASAAAGEAE ETTRLRKPRF SFEENQILIR EVRAHYPQLY GAQSRRVSVA
60 70 80 90 100
ERRRVWDGIA AKINGITSWK RTGQEVQKRW NDFKRRTKEK LARVPHSTQG
110 120 130 140 150
AGPAAEDAFS AEEETIFAIL GPGVAAPGAG AGAEEPPAAP SSQPPPPSAC
160 170 180 190 200
PQRYVLSEDR REDRRADTSA HSKAGSSSPE PWARPSCTPQ EGGCPRPKER
210 220 230 240 250
ESPPPSALQP VQLPRLALSP PPPAPPLPPP PPLAQVAPSP PSPPPPPRPP
260 270 280 290 300
PTLSASDPSL DFLRAQQETA NAIRELAGTL RQGLAKLSEA LSALLPLLPG
310 320 330 340 350
TPVDSLPPPL PPPPPPPPPP RPVLPPPAPK VEITPEPVSV VAAVVDGAVV
360 370 380 390
AARGVIIAPR SEEGAPRPPP APLPPHDSPP HKRRKGFPTR KRRGRWKSP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC044311 mRNA Translation: AAH44311.2 |
CCDSi | CCDS33055.1 |
RefSeqi | NP_001012661.1, NM_001012643.3 |
Genome annotation databases
Ensembli | ENST00000322217; ENSP00000325402; ENSG00000176182 |
GeneIDi | 339344 |
KEGGi | hsa:339344 |
UCSCi | uc002pdt.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC044311 mRNA Translation: AAH44311.2 |
CCDSi | CCDS33055.1 |
RefSeqi | NP_001012661.1, NM_001012643.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 130870, 51 interactors |
IntActi | Q86VE0, 39 interactors |
STRINGi | 9606.ENSP00000325402 |
PTM databases
iPTMneti | Q86VE0 |
PhosphoSitePlusi | Q86VE0 |
Genetic variation databases
BioMutai | MYPOP |
DMDMi | 74759426 |
Proteomic databases
EPDi | Q86VE0 |
jPOSTi | Q86VE0 |
MassIVEi | Q86VE0 |
MaxQBi | Q86VE0 |
PaxDbi | Q86VE0 |
PeptideAtlasi | Q86VE0 |
PRIDEi | Q86VE0 |
ProteomicsDBi | 69990 |
Protocols and materials databases
Antibodypediai | 45635, 23 antibodies |
Genome annotation databases
Ensembli | ENST00000322217; ENSP00000325402; ENSG00000176182 |
GeneIDi | 339344 |
KEGGi | hsa:339344 |
UCSCi | uc002pdt.4, human |
Organism-specific databases
CTDi | 339344 |
DisGeNETi | 339344 |
GeneCardsi | MYPOP |
HGNCi | HGNC:20178, MYPOP |
HPAi | ENSG00000176182, Tissue enhanced (skeletal) |
MIMi | 617861, gene |
neXtProti | NX_Q86VE0 |
OpenTargetsi | ENSG00000176182 |
PharmGKBi | PA164723403 |
VEuPathDBi | HostDB:ENSG00000176182.5 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RV5V, Eukaryota |
GeneTreei | ENSGT00450000040421 |
HOGENOMi | CLU_046143_2_0_1 |
InParanoidi | Q86VE0 |
OMAi | QEGGCPR |
OrthoDBi | 1378970at2759 |
PhylomeDBi | Q86VE0 |
TreeFami | TF338618 |
Enzyme and pathway databases
PathwayCommonsi | Q86VE0 |
Miscellaneous databases
BioGRID-ORCSi | 339344, 7 hits in 877 CRISPR screens |
GenomeRNAii | 339344 |
Pharosi | Q86VE0, Tbio |
PROi | PR:Q86VE0 |
RNActi | Q86VE0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000176182, Expressed in prefrontal cortex and 151 other tissues |
Genevisiblei | Q86VE0, HS |
Family and domain databases
InterProi | View protein in InterPro IPR017877, Myb-like_dom IPR028002, Myb_DNA-bind_5 IPR001005, SANT/Myb |
Pfami | View protein in Pfam PF13873, Myb_DNA-bind_5, 1 hit |
SMARTi | View protein in SMART SM00717, SANT, 1 hit |
PROSITEi | View protein in PROSITE PS50090, MYB_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MYPOP_HUMAN | |
Accessioni | Q86VE0Primary (citable) accession number: Q86VE0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 22, 2008 |
Last sequence update: | April 26, 2005 | |
Last modified: | February 10, 2021 | |
This is version 138 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot