UniProtKB - Q86VB7 (C163A_HUMAN)
Protein
Scavenger receptor cysteine-rich type 1 protein M130
Gene
CD163
Organism
Homo sapiens (Human)
Status
Functioni
Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.
After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.
Miscellaneous
Intravenous lipopolysaccharide (LPS) produces a rapid rise of sCD163 in plasma of patient as it induces metalloproteinase-mediated shedding from monocytes surface. Long-term LPS infusion finally increases expression of the membrane-bound form on circulating monocytes.
The soluble form (sCD163) in plasma is a novel parameter in diseases affecting macrophage function and monocyte/macrophage load in the body. The concentration of sCD163 is probably reflecting the number of macrophages of the 'alternative macrophage activation' phenotype with a high CD163 expression playing a major role in dampening the inflammatory response and scavenging components of damaged cells. This has initiated a number of clinical studies for evaluation of sCD163 as a disease marker in inflammatory conditions e.g. infection, autoimmune disease, transplantation, atherosclerosis and cancer.
Caution
It is uncertain whether Met-1 or Met-6 is the initiator.Curated
Kineticsi
- KM=2.0 nM for hemoglobin/haptoglobin of HP*1S phenotype1 Publication
- KM=0.2 nM for hemoglobin/haptoglobin of HP*1F phenotype1 Publication
GO - Molecular functioni
- scavenger receptor activity Source: ProtInc
GO - Biological processi
- acute-phase response Source: UniProtKB-KW
- negative regulation of inflammatory response to antigenic stimulus Source: Reactome
- receptor-mediated endocytosis Source: Reactome
Keywordsi
Biological process | Acute phase, Inflammatory response |
Enzyme and pathway databases
PathwayCommonsi | Q86VB7 |
Reactomei | R-HSA-2168880, Scavenging of heme from plasma R-HSA-9662834, CD163 mediating an anti-inflammatory response |
SIGNORi | Q86VB7 |
Names & Taxonomyi
Protein namesi | Recommended name: Scavenger receptor cysteine-rich type 1 protein M130Alternative name(s): Hemoglobin scavenger receptor CD_antigen: CD163 Cleaved into the following chain: |
Gene namesi | Name:CD163 Synonyms:M130 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1631, CD163 |
MIMi | 605545, gene |
neXtProti | NX_Q86VB7 |
VEuPathDBi | HostDB:ENSG00000177575.12 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Plasma membrane
- Cell membrane 2 Publications; Single-pass type I membrane protein 2 Publications
Note: Isoform 1 and isoform 2 show a lower surface expression when expressed in cells.
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular region Source: Reactome
Plasma Membrane
- external side of plasma membrane Source: CAFA
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: HPA
Other locations
- endocytic vesicle membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 42 – 1050 | ExtracellularSequence analysisAdd BLAST | 1009 | |
Transmembranei | 1051 – 1071 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1072 – 1156 | CytoplasmicSequence analysisAdd BLAST | 85 |
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 1072 | T → A: Impaired phosphorylation by PRKCA. 1 Publication | 1 | |
Mutagenesisi | 1084 | S → A: Impaired phosphorylation by PRKCA. 1 Publication | 1 | |
Mutagenesisi | 1096 | Y → A: Massive decrease of endocytotic activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 9332 |
OpenTargetsi | ENSG00000177575 |
PharmGKBi | PA26190 |
Miscellaneous databases
Pharosi | Q86VB7, Tbio |
Chemistry databases
DrugBanki | DB05389, Tetrachlorodecaoxide |
Genetic variation databases
BioMutai | CD163 |
DMDMi | 313104083 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 41 | Sequence analysisAdd BLAST | 41 | |
ChainiPRO_0000238938 | 42 – 1156 | Scavenger receptor cysteine-rich type 1 protein M130Add BLAST | 1115 | |
ChainiPRO_0000238939 | 42 – ? | Soluble CD163 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 76 ↔ 141 | PROSITE-ProRule annotation | ||
Disulfide bondi | 89 ↔ 151 | PROSITE-ProRule annotation | ||
Glycosylationi | 105 | N-linked (GlcNAc...) (complex) asparagine3 Publications | 1 | |
Disulfide bondi | 120 ↔ 130 | PROSITE-ProRule annotation | ||
Glycosylationi | 140 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 184 ↔ 248 | PROSITE-ProRule annotation | ||
Disulfide bondi | 197 ↔ 258 | PROSITE-ProRule annotation | ||
Disulfide bondi | 228 ↔ 238 | PROSITE-ProRule annotation | ||
Disulfide bondi | 291 ↔ 355 | PROSITE-ProRule annotation | ||
Disulfide bondi | 304 ↔ 365 | PROSITE-ProRule annotation | ||
Disulfide bondi | 335 ↔ 345 | PROSITE-ProRule annotation | ||
Disulfide bondi | 398 ↔ 462 | PROSITE-ProRule annotation | ||
Disulfide bondi | 411 ↔ 472 | PROSITE-ProRule annotation | ||
Disulfide bondi | 442 ↔ 452 | PROSITE-ProRule annotation | ||
Disulfide bondi | 503 ↔ 567 | PROSITE-ProRule annotation | ||
Disulfide bondi | 516 ↔ 577 | PROSITE-ProRule annotation | ||
Disulfide bondi | 547 ↔ 557 | PROSITE-ProRule annotation | ||
Disulfide bondi | 608 ↔ 672 | PROSITE-ProRule annotation | ||
Disulfide bondi | 621 ↔ 682 | PROSITE-ProRule annotation | ||
Disulfide bondi | 652 ↔ 662 | PROSITE-ProRule annotation | ||
Disulfide bondi | 744 ↔ 808 | PROSITE-ProRule annotation | ||
Disulfide bondi | 757 ↔ 818 | PROSITE-ProRule annotation | ||
Glycosylationi | 767 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 788 ↔ 798 | PROSITE-ProRule annotation | ||
Disulfide bondi | 864 ↔ 925 | PROSITE-ProRule annotation | ||
Disulfide bondi | 895 ↔ 905 | PROSITE-ProRule annotation | ||
Disulfide bondi | 954 ↔ 1018 | PROSITE-ProRule annotation | ||
Disulfide bondi | 967 ↔ 1028 | PROSITE-ProRule annotation | ||
Disulfide bondi | 998 ↔ 1008 | PROSITE-ProRule annotation | ||
Glycosylationi | 1027 | N-linked (GlcNAc...) asparagine1 Publication | 1 |
Post-translational modificationi
A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3, and thus probably induced by membrane-bound metalloproteinases ADAMs.4 Publications
Phosphorylated.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 269 – 270 | Cleavage; in calcium-free condition | 2 | |
Sitei | 281 – 282 | Cleavage; in calcium-free condition | 2 | |
Sitei | 333 – 334 | Cleavage; in calcium-free condition | 2 | |
Sitei | 360 – 361 | Cleavage; in calcium-free condition | 2 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | Q86VB7 |
MassIVEi | Q86VB7 |
PaxDbi | Q86VB7 |
PeptideAtlasi | Q86VB7 |
PRIDEi | Q86VB7 |
ProteomicsDBi | 69982 [Q86VB7-1] 69983 [Q86VB7-2] 69984 [Q86VB7-3] 69985 [Q86VB7-4] |
PTM databases
GlyConnecti | 1723, 14 N-Linked glycans (6 sites) |
GlyGeni | Q86VB7, 11 sites, 2 O-linked glycans (3 sites) |
iPTMneti | Q86VB7 |
PhosphoSitePlusi | Q86VB7 |
Expressioni
Tissue specificityi
Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal macrophages of the central nervous system. Expressed also in blood. Isoform 1 is the lowest abundant in the blood. Isoform 2 is the lowest abundant in the liver and the spleen. Isoform 3 is the predominant isoform detected in the blood.3 Publications
Inductioni
Induced by anti-inflammatory mediators such as glucocorticoids, interleukin-6/IL6 and interleukin-10/IL10; suppressed by proinflammatory mediators like bacterial lipopolysaccharides (LPS), IFNG/IFN-gamma and TNF.2 Publications
Gene expression databases
Bgeei | ENSG00000177575, Expressed in esophagus and 204 other tissues |
ExpressionAtlasi | Q86VB7, baseline and differential |
Genevisiblei | Q86VB7, HS |
Organism-specific databases
HPAi | ENSG00000177575, Tissue enhanced (lymphoid) |
Interactioni
Subunit structurei
Interacts with CSNK2B.
1 PublicationBinary interactionsi
Q86VB7
With | #Exp. | IntAct |
---|---|---|
FCGR1A [P12314] | 3 | EBI-2808455,EBI-2869867 |
Protein-protein interaction databases
BioGRIDi | 114741, 3 interactors |
IntActi | Q86VB7, 3 interactors |
STRINGi | 9606.ENSP00000352071 |
Miscellaneous databases
RNActi | Q86VB7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 51 – 152 | SRCR 1PROSITE-ProRule annotationAdd BLAST | 102 | |
Domaini | 159 – 259 | SRCR 2PROSITE-ProRule annotationAdd BLAST | 101 | |
Domaini | 266 – 366 | SRCR 3PROSITE-ProRule annotationAdd BLAST | 101 | |
Domaini | 373 – 473 | SRCR 4PROSITE-ProRule annotationAdd BLAST | 101 | |
Domaini | 478 – 578 | SRCR 5PROSITE-ProRule annotationAdd BLAST | 101 | |
Domaini | 583 – 683 | SRCR 6PROSITE-ProRule annotationAdd BLAST | 101 | |
Domaini | 719 – 819 | SRCR 7PROSITE-ProRule annotationAdd BLAST | 101 | |
Domaini | 824 – 926 | SRCR 8PROSITE-ProRule annotationAdd BLAST | 103 | |
Domaini | 929 – 1029 | SRCR 9PROSITE-ProRule annotationAdd BLAST | 101 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 1096 – 1099 | Internalization signal | 4 |
Domaini
The SRCR domain 3 mediates calcium-sensitive interaction with hemoglobin/haptoglobin complexes.1 Publication
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QQ5W, Eukaryota |
GeneTreei | ENSGT00940000155987 |
HOGENOMi | CLU_002555_0_1_1 |
InParanoidi | Q86VB7 |
OMAi | SGQVWRH |
OrthoDBi | 1095487at2759 |
PhylomeDBi | Q86VB7 |
TreeFami | TF329295 |
Family and domain databases
Gene3Di | 3.10.250.10, 9 hits |
InterProi | View protein in InterPro IPR001190, SRCR IPR017448, SRCR-like_dom IPR036772, SRCR-like_dom_sf |
Pfami | View protein in Pfam PF00530, SRCR, 9 hits |
PRINTSi | PR00258, SPERACTRCPTR |
SMARTi | View protein in SMART SM00202, SR, 9 hits |
SUPFAMi | SSF56487, SSF56487, 9 hits |
PROSITEi | View protein in PROSITE PS00420, SRCR_1, 4 hits PS50287, SRCR_2, 9 hits |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q86VB7-1) [UniParc]FASTAAdd to basket
Also known as: Long tail variant 1
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSKLRMVLLE DSGSADFRRH FVNLSPFTIT VVLLLSACFV TSSLGGTDKE
60 70 80 90 100
LRLVDGENKC SGRVEVKVQE EWGTVCNNGW SMEAVSVICN QLGCPTAIKA
110 120 130 140 150
PGWANSSAGS GRIWMDHVSC RGNESALWDC KHDGWGKHSN CTHQQDAGVT
160 170 180 190 200
CSDGSNLEMR LTRGGNMCSG RIEIKFQGRW GTVCDDNFNI DHASVICRQL
210 220 230 240 250
ECGSAVSFSG SSNFGEGSGP IWFDDLICNG NESALWNCKH QGWGKHNCDH
260 270 280 290 300
AEDAGVICSK GADLSLRLVD GVTECSGRLE VRFQGEWGTI CDDGWDSYDA
310 320 330 340 350
AVACKQLGCP TAVTAIGRVN ASKGFGHIWL DSVSCQGHEP AIWQCKHHEW
360 370 380 390 400
GKHYCNHNED AGVTCSDGSD LELRLRGGGS RCAGTVEVEI QRLLGKVCDR
410 420 430 440 450
GWGLKEADVV CRQLGCGSAL KTSYQVYSKI QATNTWLFLS SCNGNETSLW
460 470 480 490 500
DCKNWQWGGL TCDHYEEAKI TCSAHREPRL VGGDIPCSGR VEVKHGDTWG
510 520 530 540 550
SICDSDFSLE AASVLCRELQ CGTVVSILGG AHFGEGNGQI WAEEFQCEGH
560 570 580 590 600
ESHLSLCPVA PRPEGTCSHS RDVGVVCSRY TEIRLVNGKT PCEGRVELKT
610 620 630 640 650
LGAWGSLCNS HWDIEDAHVL CQQLKCGVAL STPGGARFGK GNGQIWRHMF
660 670 680 690 700
HCTGTEQHMG DCPVTALGAS LCPSEQVASV ICSGNQSQTL SSCNSSSLGP
710 720 730 740 750
TRPTIPEESA VACIESGQLR LVNGGGRCAG RVEIYHEGSW GTICDDSWDL
760 770 780 790 800
SDAHVVCRQL GCGEAINATG SAHFGEGTGP IWLDEMKCNG KESRIWQCHS
810 820 830 840 850
HGWGQQNCRH KEDAGVICSE FMSLRLTSEA SREACAGRLE VFYNGAWGTV
860 870 880 890 900
GKSSMSETTV GVVCRQLGCA DKGKINPASL DKAMSIPMWV DNVQCPKGPD
910 920 930 940 950
TLWQCPSSPW EKRLASPSEE TWITCDNKIR LQEGPTSCSG RVEIWHGGSW
960 970 980 990 1000
GTVCDDSWDL DDAQVVCQQL GCGPALKAFK EAEFGQGTGP IWLNEVKCKG
1010 1020 1030 1040 1050
NESSLWDCPA RRWGHSECGH KEDAAVNCTD ISVQKTPQKA TTGRSSRQSS
1060 1070 1080 1090 1100
FIAVGILGVV LLAIFVALFF LTKKRRQRQR LAVSSRGENL VHQIQYREMN
1110 1120 1130 1140 1150
SCLNADDLDL MNSSENSHES ADFSAAELIS VSKFLPISGM EKEAILSHTE
KENGNL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5GZZ9 | F5GZZ9_HUMAN | Scavenger receptor cysteine-rich ty... | CD163 | 1,109 | Annotation score: | ||
C9JHR8 | C9JHR8_HUMAN | Scavenger receptor cysteine-rich ty... | CD163 | 1,154 | Annotation score: | ||
H0YFM0 | H0YFM0_HUMAN | Scavenger receptor cysteine-rich ty... | CD163 | 137 | Annotation score: | ||
H0YGZ7 | H0YGZ7_HUMAN | Scavenger receptor cysteine-rich ty... | CD163 | 124 | Annotation score: |
Sequence cautioni
The sequence CAA80541 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAA80542 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAA80543 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAA80544 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAB45233 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_026574 | 342 | I → V4 PublicationsCorresponds to variant dbSNP:rs4883263Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_019013 | 579 | R → SKTQKTSLIGSYTVKGTGLG SHSCLFLKPCLLPG in isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_019014 | 1115 – 1156 | ENSHE…ENGNL → GLWVLGGSIAQGFRSVAAVE AQTFYFDKQLKKSKNVIGSL DAYNGQE in isoform 2. 1 PublicationAdd BLAST | 42 | |
Alternative sequenceiVSP_019015 | 1115 – 1156 | ENSHE…ENGNL → GGHSEPH in isoform 3 and isoform 4. 2 PublicationsAdd BLAST | 42 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z22968 mRNA Translation: CAA80541.1 Different initiation. Z22969 mRNA Translation: CAA80542.1 Different initiation. Z22970 mRNA Translation: CAA80543.1 Different initiation. Z22971 mRNA Translation: CAA80544.1 Different initiation. Y18388 , Y18389, Y18390, Y18391, Y18392, Y18393, Y18394, Y18395, Y18396, Y18397, Y18398, Y18399, Y18400, Y18401, Y18402, Y18403 Genomic DNA Translation: CAB45233.1 Different initiation. DQ058615 mRNA Translation: AAY99762.1 AC131206 Genomic DNA No translation available. BC051281 mRNA Translation: AAH51281.1 |
CCDSi | CCDS53742.1 [Q86VB7-3] CCDS8578.1 [Q86VB7-1] |
PIRi | I38004 I38005 I38006 |
RefSeqi | NP_004235.4, NM_004244.5 [Q86VB7-1] NP_981961.2, NM_203416.3 [Q86VB7-3] XP_016875720.1, XM_017020231.1 |
Genome annotation databases
Ensembli | ENST00000359156; ENSP00000352071; ENSG00000177575 [Q86VB7-1] ENST00000432237; ENSP00000403885; ENSG00000177575 [Q86VB7-3] |
GeneIDi | 9332 |
KEGGi | hsa:9332 |
UCSCi | uc001qsz.4, human [Q86VB7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z22968 mRNA Translation: CAA80541.1 Different initiation. Z22969 mRNA Translation: CAA80542.1 Different initiation. Z22970 mRNA Translation: CAA80543.1 Different initiation. Z22971 mRNA Translation: CAA80544.1 Different initiation. Y18388 , Y18389, Y18390, Y18391, Y18392, Y18393, Y18394, Y18395, Y18396, Y18397, Y18398, Y18399, Y18400, Y18401, Y18402, Y18403 Genomic DNA Translation: CAB45233.1 Different initiation. DQ058615 mRNA Translation: AAY99762.1 AC131206 Genomic DNA No translation available. BC051281 mRNA Translation: AAH51281.1 |
CCDSi | CCDS53742.1 [Q86VB7-3] CCDS8578.1 [Q86VB7-1] |
PIRi | I38004 I38005 I38006 |
RefSeqi | NP_004235.4, NM_004244.5 [Q86VB7-1] NP_981961.2, NM_203416.3 [Q86VB7-3] XP_016875720.1, XM_017020231.1 |
3D structure databases
SMRi | Q86VB7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114741, 3 interactors |
IntActi | Q86VB7, 3 interactors |
STRINGi | 9606.ENSP00000352071 |
Chemistry databases
DrugBanki | DB05389, Tetrachlorodecaoxide |
PTM databases
GlyConnecti | 1723, 14 N-Linked glycans (6 sites) |
GlyGeni | Q86VB7, 11 sites, 2 O-linked glycans (3 sites) |
iPTMneti | Q86VB7 |
PhosphoSitePlusi | Q86VB7 |
Genetic variation databases
BioMutai | CD163 |
DMDMi | 313104083 |
Proteomic databases
jPOSTi | Q86VB7 |
MassIVEi | Q86VB7 |
PaxDbi | Q86VB7 |
PeptideAtlasi | Q86VB7 |
PRIDEi | Q86VB7 |
ProteomicsDBi | 69982 [Q86VB7-1] 69983 [Q86VB7-2] 69984 [Q86VB7-3] 69985 [Q86VB7-4] |
Protocols and materials databases
Antibodypediai | 3721, 1490 antibodies |
Genome annotation databases
Ensembli | ENST00000359156; ENSP00000352071; ENSG00000177575 [Q86VB7-1] ENST00000432237; ENSP00000403885; ENSG00000177575 [Q86VB7-3] |
GeneIDi | 9332 |
KEGGi | hsa:9332 |
UCSCi | uc001qsz.4, human [Q86VB7-1] |
Organism-specific databases
CTDi | 9332 |
DisGeNETi | 9332 |
GeneCardsi | CD163 |
HGNCi | HGNC:1631, CD163 |
HPAi | ENSG00000177575, Tissue enhanced (lymphoid) |
MIMi | 605545, gene |
neXtProti | NX_Q86VB7 |
OpenTargetsi | ENSG00000177575 |
PharmGKBi | PA26190 |
VEuPathDBi | HostDB:ENSG00000177575.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQ5W, Eukaryota |
GeneTreei | ENSGT00940000155987 |
HOGENOMi | CLU_002555_0_1_1 |
InParanoidi | Q86VB7 |
OMAi | SGQVWRH |
OrthoDBi | 1095487at2759 |
PhylomeDBi | Q86VB7 |
TreeFami | TF329295 |
Enzyme and pathway databases
PathwayCommonsi | Q86VB7 |
Reactomei | R-HSA-2168880, Scavenging of heme from plasma R-HSA-9662834, CD163 mediating an anti-inflammatory response |
SIGNORi | Q86VB7 |
Miscellaneous databases
BioGRID-ORCSi | 9332, 6 hits in 981 CRISPR screens |
ChiTaRSi | CD163, human |
GeneWikii | CD163 |
GenomeRNAii | 9332 |
Pharosi | Q86VB7, Tbio |
PROi | PR:Q86VB7 |
RNActi | Q86VB7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000177575, Expressed in esophagus and 204 other tissues |
ExpressionAtlasi | Q86VB7, baseline and differential |
Genevisiblei | Q86VB7, HS |
Family and domain databases
Gene3Di | 3.10.250.10, 9 hits |
InterProi | View protein in InterPro IPR001190, SRCR IPR017448, SRCR-like_dom IPR036772, SRCR-like_dom_sf |
Pfami | View protein in Pfam PF00530, SRCR, 9 hits |
PRINTSi | PR00258, SPERACTRCPTR |
SMARTi | View protein in SMART SM00202, SR, 9 hits |
SUPFAMi | SSF56487, SSF56487, 9 hits |
PROSITEi | View protein in PROSITE PS00420, SRCR_1, 4 hits PS50287, SRCR_2, 9 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | C163A_HUMAN | |
Accessioni | Q86VB7Primary (citable) accession number: Q86VB7 Secondary accession number(s): C9JIG2 Q2VLH7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2006 |
Last sequence update: | November 30, 2010 | |
Last modified: | April 7, 2021 | |
This is version 148 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot