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Protein

Integral membrane protein GPR180

Gene

GPR180

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Integral membrane protein GPR180
Alternative name(s):
Intimal thickness-related receptor
Gene namesi
Name:GPR180
Synonyms:ITR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000152749.7
HGNCiHGNC:28899 GPR180
MIMi607787 gene
neXtProtiNX_Q86V85

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Transmembranei249 – 269HelicalSequence analysisAdd BLAST21
Transmembranei284 – 304HelicalSequence analysisAdd BLAST21
Transmembranei321 – 341HelicalSequence analysisAdd BLAST21
Transmembranei360 – 380HelicalSequence analysisAdd BLAST21
Transmembranei389 – 409HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi160897
OpenTargetsiENSG00000152749
PharmGKBiPA144596429

Polymorphism and mutation databases

BioMutaiGPR180
DMDMi74750449

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000023966223 – 440Integral membrane protein GPR180Add BLAST418

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ86V85
MaxQBiQ86V85
PaxDbiQ86V85
PeptideAtlasiQ86V85
PRIDEiQ86V85
ProteomicsDBi69975

PTM databases

iPTMnetiQ86V85
PhosphoSitePlusiQ86V85

Expressioni

Gene expression databases

BgeeiENSG00000152749 Expressed in 165 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_GPR180
GenevisibleiQ86V85 HS

Organism-specific databases

HPAiHPA047250

Interactioni

Protein-protein interaction databases

BioGridi127770, 4 interactors
IntActiQ86V85, 1 interactor
STRINGi9606.ENSP00000366157

Structurei

3D structure databases

ProteinModelPortaliQ86V85
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4290 Eukaryota
ENOG410XRGS LUCA
GeneTreeiENSGT00730000111205
HOGENOMiHOG000013021
HOVERGENiHBG056171
InParanoidiQ86V85
OMAiPGLACIS
OrthoDBiEOG091G0LC1
PhylomeDBiQ86V85
TreeFamiTF314975

Family and domain databases

InterProiView protein in InterPro
IPR019336 Intimal_thickness-rel_rcpt
PfamiView protein in Pfam
PF10192 GpcrRhopsn4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86V85-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGGLRLLAVA LTCCWWPQGS QGKTLRGSFS STAAQDAQGQ RIGHFEFHGD
60 70 80 90 100
HALLCVRINN IAVAVGKEAK LYLFQAQEWL KLQQSSHGYS CSEKLSKAQL
110 120 130 140 150
TMTMNQTEHN LTVSQIPSPQ TWHVFYADKY TCQDDKENSQ VEDIPFEMVL
160 170 180 190 200
LNPDAEGNPF DHFSAGESGL HEFFFLLVLV YFVIACIYAQ SLWQAIKKGG
210 220 230 240 250
PMHMILKVLT TALLLQAGSA LANYIHFSSY SKDGIGVPFM GSLAEFFDIA
260 270 280 290 300
SQIQMLYLLL SLCMGWTIVR MKKSQSRPLQ WDSTPASTGI AVFIVMTQSV
310 320 330 340 350
LLLWEQFEDI SHHSYHSHHN LAGILLIVLR ICLALSLGCG LYQIITVERS
360 370 380 390 400
TLKREFYITF AKGCILWFLC HPVLACISVI FSDYQRDKVI TIGVILCQSV
410 420 430 440
SMVILYRLFL SHSLYWEVSS LSSVTLPLTI SSGHKSRPHF
Length:440
Mass (Da):49,395
Last modified:June 1, 2003 - v1
Checksum:iCC703269832CF8A3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03592532T → N in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289850 mRNA Translation: BAF82539.1
AL359708 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX08944.1
BC052243 mRNA Translation: AAH52243.1
CCDSiCCDS9472.1
RefSeqiNP_851320.1, NM_180989.5
UniGeneiHs.439363

Genome annotation databases

EnsembliENST00000376958; ENSP00000366157; ENSG00000152749
GeneIDi160897
KEGGihsa:160897
UCSCiuc001vly.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289850 mRNA Translation: BAF82539.1
AL359708 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX08944.1
BC052243 mRNA Translation: AAH52243.1
CCDSiCCDS9472.1
RefSeqiNP_851320.1, NM_180989.5
UniGeneiHs.439363

3D structure databases

ProteinModelPortaliQ86V85
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127770, 4 interactors
IntActiQ86V85, 1 interactor
STRINGi9606.ENSP00000366157

PTM databases

iPTMnetiQ86V85
PhosphoSitePlusiQ86V85

Polymorphism and mutation databases

BioMutaiGPR180
DMDMi74750449

Proteomic databases

EPDiQ86V85
MaxQBiQ86V85
PaxDbiQ86V85
PeptideAtlasiQ86V85
PRIDEiQ86V85
ProteomicsDBi69975

Protocols and materials databases

DNASUi160897
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376958; ENSP00000366157; ENSG00000152749
GeneIDi160897
KEGGihsa:160897
UCSCiuc001vly.4 human

Organism-specific databases

CTDi160897
DisGeNETi160897
EuPathDBiHostDB:ENSG00000152749.7
GeneCardsiGPR180
HGNCiHGNC:28899 GPR180
HPAiHPA047250
MIMi607787 gene
neXtProtiNX_Q86V85
OpenTargetsiENSG00000152749
PharmGKBiPA144596429
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4290 Eukaryota
ENOG410XRGS LUCA
GeneTreeiENSGT00730000111205
HOGENOMiHOG000013021
HOVERGENiHBG056171
InParanoidiQ86V85
OMAiPGLACIS
OrthoDBiEOG091G0LC1
PhylomeDBiQ86V85
TreeFamiTF314975

Miscellaneous databases

ChiTaRSiGPR180 human
GenomeRNAii160897
PROiPR:Q86V85
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000152749 Expressed in 165 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_GPR180
GenevisibleiQ86V85 HS

Family and domain databases

InterProiView protein in InterPro
IPR019336 Intimal_thickness-rel_rcpt
PfamiView protein in Pfam
PF10192 GpcrRhopsn4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGP180_HUMAN
AccessioniPrimary (citable) accession number: Q86V85
Secondary accession number(s): A8K1D5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 1, 2003
Last modified: September 12, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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