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UniProtKB - Q86V71 (ZN429_HUMAN)
Protein
Zinc finger protein 429
Gene
ZNF429
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 145 – 167 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 173 – 195 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 201 – 223 | C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 229 – 251 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 257 – 279 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 285 – 307 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 313 – 335 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 341 – 363 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 369 – 391 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 397 – 419 | C2H2-type 10; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 425 – 447 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 453 – 475 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 481 – 503 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 509 – 531 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 537 – 559 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 565 – 587 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 593 – 615 | C2H2-type 17PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 621 – 643 | C2H2-type 18PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q86V71 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 429 |
Gene namesi | Name:ZNF429 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20817, ZNF429 |
neXtProti | NX_Q86V71 |
VEuPathDBi | HostDB:ENSG00000197013 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 353088 |
OpenTargetsi | ENSG00000197013 |
PharmGKBi | PA134910790 |
Miscellaneous databases
Pharosi | Q86V71, Tdark |
Genetic variation databases
BioMutai | ZNF429 |
DMDMi | 218511972 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047577 | 1 – 674 | Zinc finger protein 429Add BLAST | 674 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 605 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q86V71 |
MassIVEi | Q86V71 |
MaxQBi | Q86V71 |
PaxDbi | Q86V71 |
PeptideAtlasi | Q86V71 |
PRIDEi | Q86V71 |
PTM databases
iPTMneti | Q86V71 |
PhosphoSitePlusi | Q86V71 |
Expressioni
Gene expression databases
Bgeei | ENSG00000197013, Expressed in C1 segment of cervical spinal cord and 161 other tissues |
ExpressionAtlasi | Q86V71, baseline and differential |
Organism-specific databases
HPAi | ENSG00000197013, Low tissue specificity |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000351280 |
Miscellaneous databases
RNActi | Q86V71, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 75 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 653 – 674 | DisorderedSequence analysisAdd BLAST | 22 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 145 – 167 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 173 – 195 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 201 – 223 | C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 229 – 251 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 257 – 279 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 285 – 307 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 313 – 335 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 341 – 363 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 369 – 391 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 397 – 419 | C2H2-type 10; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 425 – 447 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 453 – 475 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 481 – 503 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 509 – 531 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 537 – 559 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 565 – 587 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 593 – 615 | C2H2-type 17PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 621 – 643 | C2H2-type 18PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000153165 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | Q86V71 |
OMAi | CKKCFAD |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q86V71 |
TreeFami | TF342117 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 15 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 15 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 10 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 15 hits PS50157, ZINC_FINGER_C2H2_2, 17 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q86V71-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGPLTFTDVA IEFSLEEWQC LDTAQQNLYR NVMLENYRNL VFLGIAVSKP
60 70 80 90 100
DLITCLEKEK EPCKMKRHEM VDEPPVVCSH FAEDFWPEQD IKDSFQKVTL
110 120 130 140 150
RRYDKRGHEN LQLRKGYKTV GDCKLYKGGY NGLNQCLTLT QSKMYHCDIY
160 170 180 190 200
VKVFYAFSNA DRYKTRHTGK KPFQCKKCGK SFCMLSQLTQ HKKIHIRENT
210 220 230 240 250
YRCKEFGNAF NQSSALTNHK RIYVGEKHYR CEECGKAFNH YSTLTNHKRI
260 270 280 290 300
HTGEKPYKCK ECGKAFSRYS TLTTHKRIHS GEKPYKCDEC GKTFSISSTF
310 320 330 340 350
TKHKIIHTEE KPYKCKECGK AFNRSSTLTS HKRIHTGEKP YKCEECGKAF
360 370 380 390 400
NWSSTLTKHK VIHTGEKPYK CEECGKAFNQ SSRLTRHKKI HTGEEPYKFE
410 420 430 440 450
KCGRVFTCSS TLTQDKKIHT GEKPYNCEEC GKVFTYSSTL TRHKRIHTEE
460 470 480 490 500
KPYKCNECGK AFNRSSHLTS HRRIHTGEKP YKCEECGKAF KQSSNLNSHK
510 520 530 540 550
KIHSGEKPYK CEECGKAFIL SSRLTQHKKI HTGEKPYKCE ECGKAFNRSS
560 570 580 590 600
RLTQHKKIHT GEKPYKCKQC DKAFTHSSNL SSHKKIHSGE KPYKCEECGK
610 620 630 640 650
AFNRSSRLTQ HKKIHTREKP YKCEECAKAF TRSSRLTQHK KIHRMGVVAH
660 670
ACNPSTLGGR GGRITRSGDR DRPG
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0QZ47 | M0QZ47_HUMAN | Zinc finger protein 429 | ZNF429 | 122 | Annotation score: | ||
M0QYC4 | M0QYC4_HUMAN | Zinc finger protein 429 | ZNF429 | 93 | Annotation score: |
Sequence cautioni
The sequence AAK01422 differs from that shown.Curated
The sequence AAK01422 differs from that shown. Reason: Frameshift.Curated
The sequence AAP30884 differs from that shown.Curated
The sequence AAP30884 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 167 | H → Y in AAP30884 (Ref. 2) Curated | 1 | |
Sequence conflicti | 167 | H → Y in AAK01422 (PubMed:7865130).Curated | 1 | |
Sequence conflicti | 206 – 207 | FG → CC in AAP30884 (Ref. 2) Curated | 2 | |
Sequence conflicti | 206 – 207 | FG → CC in AAK01422 (PubMed:7865130).Curated | 2 | |
Sequence conflicti | 249 – 276 | Missing in AAP30884 (Ref. 2) CuratedAdd BLAST | 28 | |
Sequence conflicti | 249 – 276 | Missing in AAK01422 (PubMed:7865130).CuratedAdd BLAST | 28 | |
Sequence conflicti | 252 | T → S in AAP30884 (Ref. 2) Curated | 1 | |
Sequence conflicti | 252 | T → S in AAK01422 (PubMed:7865130).Curated | 1 | |
Sequence conflicti | 337 | G → V in AAP30884 (Ref. 2) Curated | 1 | |
Sequence conflicti | 337 | G → V in AAK01422 (PubMed:7865130).Curated | 1 | |
Sequence conflicti | 361 | V → I in AAP30884 (Ref. 2) Curated | 1 | |
Sequence conflicti | 361 | V → I in AAK01422 (PubMed:7865130).Curated | 1 | |
Sequence conflicti | 367 | K → N in AAK01422 (PubMed:7865130).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_047848 | 650 | H → Y. Corresponds to variant dbSNP:rs2562473Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC010615 Genomic DNA No translation available. AY269786 mRNA Translation: AAP30884.1 Sequence problems. AF325191 mRNA Translation: AAK01422.1 Sequence problems. BM996292 mRNA No translation available. |
CCDSi | CCDS42537.1 |
RefSeqi | NP_001001415.2, NM_001001415.3 |
Genome annotation databases
Ensembli | ENST00000358491.9; ENSP00000351280.3; ENSG00000197013.11 |
GeneIDi | 353088 |
KEGGi | hsa:353088 |
MANE-Selecti | ENST00000358491.9; ENSP00000351280.3; NM_001001415.4; NP_001001415.2 |
UCSCi | uc002nqd.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC010615 Genomic DNA No translation available. AY269786 mRNA Translation: AAP30884.1 Sequence problems. AF325191 mRNA Translation: AAK01422.1 Sequence problems. BM996292 mRNA No translation available. |
CCDSi | CCDS42537.1 |
RefSeqi | NP_001001415.2, NM_001001415.3 |
3D structure databases
AlphaFoldDBi | Q86V71 |
SMRi | Q86V71 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000351280 |
PTM databases
iPTMneti | Q86V71 |
PhosphoSitePlusi | Q86V71 |
Genetic variation databases
BioMutai | ZNF429 |
DMDMi | 218511972 |
Proteomic databases
jPOSTi | Q86V71 |
MassIVEi | Q86V71 |
MaxQBi | Q86V71 |
PaxDbi | Q86V71 |
PeptideAtlasi | Q86V71 |
PRIDEi | Q86V71 |
Protocols and materials databases
Antibodypediai | 44155, 70 antibodies from 13 providers |
DNASUi | 353088 |
Genome annotation databases
Ensembli | ENST00000358491.9; ENSP00000351280.3; ENSG00000197013.11 |
GeneIDi | 353088 |
KEGGi | hsa:353088 |
MANE-Selecti | ENST00000358491.9; ENSP00000351280.3; NM_001001415.4; NP_001001415.2 |
UCSCi | uc002nqd.2, human |
Organism-specific databases
CTDi | 353088 |
DisGeNETi | 353088 |
GeneCardsi | ZNF429 |
HGNCi | HGNC:20817, ZNF429 |
HPAi | ENSG00000197013, Low tissue specificity |
neXtProti | NX_Q86V71 |
OpenTargetsi | ENSG00000197013 |
PharmGKBi | PA134910790 |
VEuPathDBi | HostDB:ENSG00000197013 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000153165 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | Q86V71 |
OMAi | CKKCFAD |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q86V71 |
TreeFami | TF342117 |
Enzyme and pathway databases
PathwayCommonsi | Q86V71 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 353088, 38 hits in 1035 CRISPR screens |
ChiTaRSi | ZNF429, human |
GenomeRNAii | 353088 |
Pharosi | Q86V71, Tdark |
PROi | PR:Q86V71 |
RNActi | Q86V71, protein |
Gene expression databases
Bgeei | ENSG00000197013, Expressed in C1 segment of cervical spinal cord and 161 other tissues |
ExpressionAtlasi | Q86V71, baseline and differential |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 15 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 15 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 10 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 15 hits PS50157, ZINC_FINGER_C2H2_2, 17 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN429_HUMAN | |
Accessioni | Q86V71Primary (citable) accession number: Q86V71 Secondary accession number(s): A6NLV7, Q9BZE6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2003 |
Last sequence update: | December 16, 2008 | |
Last modified: | May 25, 2022 | |
This is version 164 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports