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Protein

Paraneoplastic antigen-like protein 8A

Gene

PNMA8A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Paraneoplastic antigen-like protein 8AImported
Alternative name(s):
PNMA-like protein 1
Gene namesi
Name:PNMA8AImported
Synonyms:PNMAL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000182013.17
HGNCiHGNC:25578 PNMA8A
neXtProtiNX_Q86V59

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000182013
PharmGKBiPA162399835

Polymorphism and mutation databases

BioMutaiPNMAL1
DMDMi74727539

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003258361 – 439Paraneoplastic antigen-like protein 8AAdd BLAST439

Proteomic databases

EPDiQ86V59
MaxQBiQ86V59
PaxDbiQ86V59
PeptideAtlasiQ86V59
PRIDEiQ86V59
ProteomicsDBi69969
69970 [Q86V59-2]

PTM databases

iPTMnetiQ86V59
PhosphoSitePlusiQ86V59

Expressioni

Gene expression databases

BgeeiENSG00000182013 Expressed in 190 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_PNMAL1
ExpressionAtlasiQ86V59 baseline and differential
GenevisibleiQ86V59 HS

Organism-specific databases

HPAiHPA012956

Interactioni

Protein-protein interaction databases

BioGridi120523, 8 interactors
IntActiQ86V59, 2 interactors
STRINGi9606.ENSP00000318131

Structurei

3D structure databases

ProteinModelPortaliQ86V59
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PNMA family.Curated

Phylogenomic databases

eggNOGiENOG410IKIG Eukaryota
ENOG41116VX LUCA
GeneTreeiENSGT00530000062986
HOGENOMiHOG000115592
HOVERGENiHBG108276
InParanoidiQ86V59
OMAiEGRTWED
OrthoDBiEOG091G0BG9
PhylomeDBiQ86V59
TreeFamiTF335054

Family and domain databases

InterProiView protein in InterPro
IPR026523 PNMA
PANTHERiPTHR23095 PTHR23095, 1 hit
PfamiView protein in Pfam
PF14893 PNMA, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86V59-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKTMAMNLL EDWCRGMEVD IHRSLLVTGI PEDCGQAEIE ETLNGVLSPL
60 70 80 90 100
GPYRVLNKIF VREENVKAAL IEVGEGVNLS TIPREFPGRG GVWRVVCRDP
110 120 130 140 150
TQDAEFLKNL NEFLDAEGRT WEDVVRLLQL NHPTLSQNQH QPPENWAEAL
160 170 180 190 200
GVLLGAVVQI IFCMDAEIRS REEARAQEAA EFEEMAAWAL AAGRKVKKEP
210 220 230 240 250
GLAAEVGSAL KAETPNNWNA TEDQHEPTKP LVRRAGAKSR SRRKKQKKNS
260 270 280 290 300
RQEAVPWKKP KGINSNSTAN LEDPEVGDAE SMAISEPIKG SRKPCVNKEE
310 320 330 340 350
LALKKPMAKC AWKGPREPPQ DARAEAESPG GASESDQDGG HESPPKKKAV
360 370 380 390 400
AWVSAKNPAP MRKKKKVSLG PVSYVLVDSE DGRKKPVMPK KGPGSRREAS
410 420 430
DQKAPRGQQP AEATASTSRG PKAKPEGSPR RATNESRKV
Length:439
Mass (Da):48,161
Last modified:December 7, 2004 - v2
Checksum:i43E43FA1CAEC1E81
GO
Isoform 2 (identifier: Q86V59-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     367-378: VSLGPVSYVLVD → NPERFDLGDHPY
     379-439: Missing.

Show »
Length:378
Mass (Da):41,864
Checksum:i3386C5CAB2EBA3F6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R388M0R388_HUMAN
Paraneoplastic antigen-like protein...
PNMA8A
84Annotation score:

Sequence cautioni

The sequence BAA91804 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAF82907 differs from that shown. Probable cloning artifact. Aberrant splice sites.Curated
The sequence BAF82907 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence EAW57420 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti319P → S in AAH32508 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03993580S → T. Corresponds to variant dbSNP:rs12610254Ensembl.1
Natural variantiVAR_03993697C → Y. Corresponds to variant dbSNP:rs7248888Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032441367 – 378VSLGP…YVLVD → NPERFDLGDHPY in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_032442379 – 439Missing in isoform 2. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834344 mRNA Translation: CAD39010.1
CH471126 Genomic DNA Translation: EAW57420.1 Different initiation.
CH471126 Genomic DNA Translation: EAW57421.1
BC026026 mRNA Translation: AAH26026.2
BC032508 mRNA Translation: AAH32508.1
BC051688 mRNA Translation: AAH51688.2
AK001643 mRNA Translation: BAA91804.1 Different initiation.
AK290218 mRNA Translation: BAF82907.1 Sequence problems.
CCDSiCCDS33059.1 [Q86V59-1]
CCDS46124.1 [Q86V59-2]
RefSeqiNP_001096619.1, NM_001103149.1 [Q86V59-2]
NP_060685.2, NM_018215.3 [Q86V59-1]
UniGeneiHs.8395

Genome annotation databases

EnsembliENST00000313683; ENSP00000318131; ENSG00000182013 [Q86V59-1]
ENST00000438932; ENSP00000410273; ENSG00000182013 [Q86V59-2]
GeneIDi55228
KEGGihsa:55228
UCSCiuc002peq.5 human [Q86V59-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834344 mRNA Translation: CAD39010.1
CH471126 Genomic DNA Translation: EAW57420.1 Different initiation.
CH471126 Genomic DNA Translation: EAW57421.1
BC026026 mRNA Translation: AAH26026.2
BC032508 mRNA Translation: AAH32508.1
BC051688 mRNA Translation: AAH51688.2
AK001643 mRNA Translation: BAA91804.1 Different initiation.
AK290218 mRNA Translation: BAF82907.1 Sequence problems.
CCDSiCCDS33059.1 [Q86V59-1]
CCDS46124.1 [Q86V59-2]
RefSeqiNP_001096619.1, NM_001103149.1 [Q86V59-2]
NP_060685.2, NM_018215.3 [Q86V59-1]
UniGeneiHs.8395

3D structure databases

ProteinModelPortaliQ86V59
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120523, 8 interactors
IntActiQ86V59, 2 interactors
STRINGi9606.ENSP00000318131

PTM databases

iPTMnetiQ86V59
PhosphoSitePlusiQ86V59

Polymorphism and mutation databases

BioMutaiPNMAL1
DMDMi74727539

Proteomic databases

EPDiQ86V59
MaxQBiQ86V59
PaxDbiQ86V59
PeptideAtlasiQ86V59
PRIDEiQ86V59
ProteomicsDBi69969
69970 [Q86V59-2]

Protocols and materials databases

DNASUi55228
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313683; ENSP00000318131; ENSG00000182013 [Q86V59-1]
ENST00000438932; ENSP00000410273; ENSG00000182013 [Q86V59-2]
GeneIDi55228
KEGGihsa:55228
UCSCiuc002peq.5 human [Q86V59-1]

Organism-specific databases

CTDi55228
EuPathDBiHostDB:ENSG00000182013.17
GeneCardsiPNMA8A
H-InvDBiHIX0015252
HGNCiHGNC:25578 PNMA8A
HPAiHPA012956
neXtProtiNX_Q86V59
OpenTargetsiENSG00000182013
PharmGKBiPA162399835
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKIG Eukaryota
ENOG41116VX LUCA
GeneTreeiENSGT00530000062986
HOGENOMiHOG000115592
HOVERGENiHBG108276
InParanoidiQ86V59
OMAiEGRTWED
OrthoDBiEOG091G0BG9
PhylomeDBiQ86V59
TreeFamiTF335054

Miscellaneous databases

ChiTaRSiPNMAL1 human
GeneWikiiFLJ10781
GenomeRNAii55228
PROiPR:Q86V59

Gene expression databases

BgeeiENSG00000182013 Expressed in 190 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_PNMAL1
ExpressionAtlasiQ86V59 baseline and differential
GenevisibleiQ86V59 HS

Family and domain databases

InterProiView protein in InterPro
IPR026523 PNMA
PANTHERiPTHR23095 PTHR23095, 1 hit
PfamiView protein in Pfam
PF14893 PNMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPNM8A_HUMAN
AccessioniPrimary (citable) accession number: Q86V59
Secondary accession number(s): A8K2F3
, Q5U638, Q8N3H4, Q9NVE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 7, 2004
Last modified: September 12, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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