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Entry version 121 (12 Aug 2020)
Sequence version 2 (07 Dec 2004)
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Protein

Paraneoplastic antigen-like protein 8A

Gene

PNMA8A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q86V59

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Paraneoplastic antigen-like protein 8AImported
Alternative name(s):
PNMA-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PNMA8AImported
Synonyms:PNMAL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000182013.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25578, PNMA8A

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86V59

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000182013

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162399835

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86V59, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PNMA8A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74727539

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003258361 – 439Paraneoplastic antigen-like protein 8AAdd BLAST439

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86V59

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86V59

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q86V59

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86V59

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86V59

PeptideAtlas

More...
PeptideAtlasi
Q86V59

PRoteomics IDEntifications database

More...
PRIDEi
Q86V59

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
69969 [Q86V59-1]
69970 [Q86V59-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86V59

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86V59

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000182013, Expressed in cerebellar vermis and 205 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86V59, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86V59, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000182013, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120523, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q86V59, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000318131

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q86V59, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PNMA family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502TEDX, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01000000214513

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_050538_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86V59

Identification of Orthologs from Complete Genome Data

More...
OMAi
WEDVVHL

Database of Orthologous Groups

More...
OrthoDBi
820525at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86V59

TreeFam database of animal gene trees

More...
TreeFami
TF335054

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026523, PNMA

The PANTHER Classification System

More...
PANTHERi
PTHR23095, PTHR23095, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14893, PNMA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86V59-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKTMAMNLL EDWCRGMEVD IHRSLLVTGI PEDCGQAEIE ETLNGVLSPL
60 70 80 90 100
GPYRVLNKIF VREENVKAAL IEVGEGVNLS TIPREFPGRG GVWRVVCRDP
110 120 130 140 150
TQDAEFLKNL NEFLDAEGRT WEDVVRLLQL NHPTLSQNQH QPPENWAEAL
160 170 180 190 200
GVLLGAVVQI IFCMDAEIRS REEARAQEAA EFEEMAAWAL AAGRKVKKEP
210 220 230 240 250
GLAAEVGSAL KAETPNNWNA TEDQHEPTKP LVRRAGAKSR SRRKKQKKNS
260 270 280 290 300
RQEAVPWKKP KGINSNSTAN LEDPEVGDAE SMAISEPIKG SRKPCVNKEE
310 320 330 340 350
LALKKPMAKC AWKGPREPPQ DARAEAESPG GASESDQDGG HESPPKKKAV
360 370 380 390 400
AWVSAKNPAP MRKKKKVSLG PVSYVLVDSE DGRKKPVMPK KGPGSRREAS
410 420 430
DQKAPRGQQP AEATASTSRG PKAKPEGSPR RATNESRKV
Length:439
Mass (Da):48,161
Last modified:December 7, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i43E43FA1CAEC1E81
GO
Isoform 2 (identifier: Q86V59-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     367-378: VSLGPVSYVLVD → NPERFDLGDHPY
     379-439: Missing.

Show »
Length:378
Mass (Da):41,864
Checksum:i3386C5CAB2EBA3F6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R388M0R388_HUMAN
Paraneoplastic antigen-like protein...
PNMA8A
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91804 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAF82907 differs from that shown. Probable cloning artifact. Aberrant splice sites.Curated
The sequence BAF82907 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence EAW57420 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti319P → S in AAH32508 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03993580S → T. Corresponds to variant dbSNP:rs12610254Ensembl.1
Natural variantiVAR_03993697C → Y. Corresponds to variant dbSNP:rs7248888Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_032441367 – 378VSLGP…YVLVD → NPERFDLGDHPY in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_032442379 – 439Missing in isoform 2. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL834344 mRNA Translation: CAD39010.1
CH471126 Genomic DNA Translation: EAW57420.1 Different initiation.
CH471126 Genomic DNA Translation: EAW57421.1
BC026026 mRNA Translation: AAH26026.2
BC032508 mRNA Translation: AAH32508.1
BC051688 mRNA Translation: AAH51688.2
AK001643 mRNA Translation: BAA91804.1 Different initiation.
AK290218 mRNA Translation: BAF82907.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33059.1 [Q86V59-1]
CCDS46124.1 [Q86V59-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001096619.1, NM_001103149.1 [Q86V59-2]
NP_060685.2, NM_018215.3 [Q86V59-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000313683; ENSP00000318131; ENSG00000182013 [Q86V59-1]
ENST00000438932; ENSP00000410273; ENSG00000182013 [Q86V59-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55228

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55228

UCSC genome browser

More...
UCSCi
uc002peq.5, human [Q86V59-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834344 mRNA Translation: CAD39010.1
CH471126 Genomic DNA Translation: EAW57420.1 Different initiation.
CH471126 Genomic DNA Translation: EAW57421.1
BC026026 mRNA Translation: AAH26026.2
BC032508 mRNA Translation: AAH32508.1
BC051688 mRNA Translation: AAH51688.2
AK001643 mRNA Translation: BAA91804.1 Different initiation.
AK290218 mRNA Translation: BAF82907.1 Sequence problems.
CCDSiCCDS33059.1 [Q86V59-1]
CCDS46124.1 [Q86V59-2]
RefSeqiNP_001096619.1, NM_001103149.1 [Q86V59-2]
NP_060685.2, NM_018215.3 [Q86V59-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi120523, 9 interactors
IntActiQ86V59, 5 interactors
STRINGi9606.ENSP00000318131

PTM databases

iPTMnetiQ86V59
PhosphoSitePlusiQ86V59

Polymorphism and mutation databases

BioMutaiPNMA8A
DMDMi74727539

Proteomic databases

EPDiQ86V59
jPOSTiQ86V59
MassIVEiQ86V59
MaxQBiQ86V59
PaxDbiQ86V59
PeptideAtlasiQ86V59
PRIDEiQ86V59
ProteomicsDBi69969 [Q86V59-1]
69970 [Q86V59-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2037, 51 antibodies

The DNASU plasmid repository

More...
DNASUi
55228

Genome annotation databases

EnsembliENST00000313683; ENSP00000318131; ENSG00000182013 [Q86V59-1]
ENST00000438932; ENSP00000410273; ENSG00000182013 [Q86V59-2]
GeneIDi55228
KEGGihsa:55228
UCSCiuc002peq.5, human [Q86V59-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55228
EuPathDBiHostDB:ENSG00000182013.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PNMA8A
HGNCiHGNC:25578, PNMA8A
HPAiENSG00000182013, Tissue enhanced (brain)
neXtProtiNX_Q86V59
OpenTargetsiENSG00000182013
PharmGKBiPA162399835

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502TEDX, Eukaryota
GeneTreeiENSGT01000000214513
HOGENOMiCLU_050538_0_0_1
InParanoidiQ86V59
OMAiWEDVVHL
OrthoDBi820525at2759
PhylomeDBiQ86V59
TreeFamiTF335054

Enzyme and pathway databases

PathwayCommonsiQ86V59

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
55228, 2 hits in 869 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PNMAL1, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
FLJ10781

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55228
PharosiQ86V59, Tdark

Protein Ontology

More...
PROi
PR:Q86V59
RNActiQ86V59, protein

Gene expression databases

BgeeiENSG00000182013, Expressed in cerebellar vermis and 205 other tissues
ExpressionAtlasiQ86V59, baseline and differential
GenevisibleiQ86V59, HS

Family and domain databases

InterProiView protein in InterPro
IPR026523, PNMA
PANTHERiPTHR23095, PTHR23095, 1 hit
PfamiView protein in Pfam
PF14893, PNMA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPNM8A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86V59
Secondary accession number(s): A8K2F3
, Q5U638, Q8N3H4, Q9NVE8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 7, 2004
Last modified: August 12, 2020
This is version 121 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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