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Entry version 100 (11 Dec 2019)
Sequence version 1 (01 Jun 2003)
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Protein
Submitted name:

Atrophin 1

Gene

ATN1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Atrophin 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATN1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27487

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
Q86V38

PeptideAtlas

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PeptideAtlasi
Q86V38

PRoteomics IDEntifications database

More...
PRIDEi
Q86V38

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q86V38 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P684004EBI-11954292,EBI-347804

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q86V38, 29 interactors

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 609DisorderedSequence analysisAdd BLAST609
Regioni623 – 768DisorderedSequence analysisAdd BLAST146
Regioni786 – 863DisorderedSequence analysisAdd BLAST78
Regioni929 – 948DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 31PolyampholyteSequence analysisAdd BLAST31
Compositional biasi48 – 95PolyampholyteSequence analysisAdd BLAST48
Compositional biasi109 – 127PolyampholyteSequence analysisAdd BLAST19
Compositional biasi128 – 154PolarSequence analysisAdd BLAST27
Compositional biasi156 – 178Pro-richSequence analysisAdd BLAST23
Compositional biasi203 – 220Pro-richSequence analysisAdd BLAST18
Compositional biasi255 – 271PolarSequence analysisAdd BLAST17
Compositional biasi272 – 311Pro-richSequence analysisAdd BLAST40
Compositional biasi347 – 368Pro-richSequence analysisAdd BLAST22
Compositional biasi370 – 404PolarSequence analysisAdd BLAST35
Compositional biasi414 – 436PolarSequence analysisAdd BLAST23
Compositional biasi459 – 508PolarSequence analysisAdd BLAST50
Compositional biasi554 – 591PolarSequence analysisAdd BLAST38
Compositional biasi592 – 606Pro-richSequence analysisAdd BLAST15
Compositional biasi684 – 719Pro-richSequence analysisAdd BLAST36
Compositional biasi737 – 755Pro-richSequence analysisAdd BLAST19
Compositional biasi792 – 844PolyampholyteSequence analysisAdd BLAST53

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2133 Eukaryota
ENOG410ZIND LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231091

KEGG Orthology (KO)

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KOi
K05626

Database of Orthologous Groups

More...
OrthoDBi
215918at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017993 Atrophin-1
IPR002951 Atrophin-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03154 Atrophin-1, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01222 ATROPHIN

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q86V38-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTRQNKDSM SMRSGRKKEA PGPREELRSR GRASPGGVST SSSDGKAEKS
60 70 80 90 100
RQTAKKARVE EASTPKVNKQ GRSEEISESE SEETNAPKKT KTEQELPRPQ
110 120 130 140 150
SPSDLDSLDG RSLNDDGSSD PRDIDQDNRS TSPSIYSPGS VENDSDSSSG
160 170 180 190 200
LSQGPARPYH PPPLFPPSPQ PPDSTPRQPE ASFEPHPSVT PTGYHAPMEP
210 220 230 240 250
PTSRMFQAPP GAPPPHPQLY PGGTGGVLSG PPMGPKGGGA ASSVGGPNGG
260 270 280 290 300
KQHPPPTTPI SVSSSGASGA PPTKPPTTPV GGGNLPSAPP PANFPHVTPN
310 320 330 340 350
LPPPPALRPL NNASASPPGL GAQPLPGHLP SPHAMGQGMG GLPPGPEKGP
360 370 380 390 400
TLAPSPHSLP PASSSAPAPP MRFPYSSSSS SSAAASSSSS SSSSSASPFP
410 420 430 440 450
ASQALPSYPH SFPPPTSLSV SNQPPKYTQP SLPSQAVWSQ GPPPPPPYGR
460 470 480 490 500
LLANSNAHPG PFPPSTGAQS TAHPPVSTHH HHHQQQQQQQ QQQQQQQQQQ
510 520 530 540 550
QQQHHGNSGP PPPGAFPHPL EGGSSHHAHP YAMSPSLGSL RPYPPGPAHL
560 570 580 590 600
PPPHSQVSYS QAGPNGPPVS SSSNSSSSTS QGSYPCSHPS PSQGPQGAPY
610 620 630 640 650
PFPPVPTVTT SSATLSTVIA TVASSPAGYK TASPPGPPPY GKRAPSPGAY
660 670 680 690 700
KTATPPGYKP GSPPSFRTGT PPGYRGTSPP AGPGTFKPGS PTVGPGPLPP
710 720 730 740 750
AGPSGLPSLP PPPAAPASGP PLSATQIKQE PAEEYETPES PVPPARSPSP
760 770 780 790 800
PPKVVDVPSH ASQSARFNKH LDRGFNSCAR SDLYFVPLEG SKLAKKRADL
810 820 830 840 850
VEKVRREAEQ RAREEKERER EREREKERER EKERELERSV KLAQEGRAPV
860 870 880 890 900
ECPSLGPVPH RPPFEPGSAV ATVPPYLGPD TPALRTLSEY ARPHVMSPGN
910 920 930 940 950
RNHPFYVPLG AVDPGLLGYN VPALYSSDPA AREREREARE RDLRDRLKPG
960 970 980 990 1000
FEVKPSELEP LHGVPGPGLD PFPRHGGLAL QPGPPGLHPF PFHPSLGPLE
1010 1020 1030 1040 1050
RERLALAAGP ALRPDMSYAE RLAAERQHAE RVAALGNDPL ARLQMLNVTP
1060 1070 1080 1090 1100
HHHQHSHIHS HLHLHQQDAI HAASASVHPL IDPLASGSHL TRIPYPAGTL
1110 1120 1130 1140 1150
PNPLLPHPLH ENEVLRHQLF AAPYRDLPAS LSAPMSAAHQ LQAMHAQSAE
1160 1170 1180 1190
LQRLALEQQQ WLHAHHPLHS VPLPAQEDYY SHLKKESDKP L
Length:1,191
Mass (Da):125,542
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4301148834EA6714
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BC051795 mRNA Translation: AAH51795.1

NCBI Reference Sequences

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RefSeqi
NP_001007027.1, NM_001007026.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
1822

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1822

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC051795 mRNA Translation: AAH51795.1
RefSeqiNP_001007027.1, NM_001007026.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ86V38, 29 interactors

Proteomic databases

MaxQBiQ86V38
PeptideAtlasiQ86V38
PRIDEiQ86V38

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1822

Genome annotation databases

GeneIDi1822
KEGGihsa:1822

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1822
PharmGKBiPA27487

Phylogenomic databases

eggNOGiKOG2133 Eukaryota
ENOG410ZIND LUCA
HOGENOMiHOG000231091
KOiK05626
OrthoDBi215918at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ATN1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1822

Gene expression databases

GenevisibleiQ86V38 HS

Family and domain databases

InterProiView protein in InterPro
IPR017993 Atrophin-1
IPR002951 Atrophin-like
PfamiView protein in Pfam
PF03154 Atrophin-1, 2 hits
PRINTSiPR01222 ATROPHIN

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ86V38_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86V38
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: December 11, 2019
This is version 100 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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