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Protein

Adiponectin receptor protein 2

Gene

ADIPOR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity).By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi202Zinc1 Publication1
Metal bindingi348Zinc1 Publication1
Metal bindingi352Zinc1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • adipokinetic hormone receptor activity Source: UniProtKB
  • adiponectin binding Source: UniProtKB
  • identical protein binding Source: Ensembl
  • metal ion binding Source: UniProtKB-KW
  • protein heterodimerization activity Source: Ensembl
  • signaling receptor activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processFatty acid metabolism, Lipid metabolism
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-163680 AMPK inhibits chREBP transcriptional activation activity

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q86V24

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adiponectin receptor protein 21 Publication
Alternative name(s):
Progestin and adipoQ receptor family member 21 Publication
Progestin and adipoQ receptor family member II
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADIPOR2Imported
Synonyms:PAQR21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000006831.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24041 ADIPOR2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607946 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86V24

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 147Cytoplasmic1 PublicationAdd BLAST147
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei148 – 168Helical; Name=11 PublicationAdd BLAST21
Topological domaini169 – 181Extracellular1 PublicationAdd BLAST13
Transmembranei182 – 202Helical; Name=21 PublicationAdd BLAST21
Topological domaini203 – 213Cytoplasmic1 PublicationAdd BLAST11
Transmembranei214 – 234Helical; Name=31 PublicationAdd BLAST21
Topological domaini235 – 245Extracellular1 PublicationAdd BLAST11
Transmembranei246 – 266Helical; Name=41 PublicationAdd BLAST21
Topological domaini267 – 273Cytoplasmic1 Publication7
Transmembranei274 – 294Helical; Name=51 PublicationAdd BLAST21
Topological domaini295 – 309Extracellular1 PublicationAdd BLAST15
Transmembranei310 – 330Helical; Name=61 PublicationAdd BLAST21
Topological domaini331 – 348Cytoplasmic1 PublicationAdd BLAST18
Transmembranei349 – 369Helical; Name=71 PublicationAdd BLAST21
Topological domaini370 – 386Extracellular1 PublicationAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi202H → A: Abolishes response to ADIPOQ binding; when associated with A-219; A-348 and A-352. 1 Publication1
Mutagenesisi219D → A: Impairs response to ADIPOQ binding. Abolishes response to ADIPOQ binding; when associated with A-202; A-348 and A-352. 1 Publication1
Mutagenesisi348H → A: Impairs response to ADIPOQ binding. Abolishes response to ADIPOQ binding; when associated with A-202; A-219 and A-352. 1 Publication1
Mutagenesisi352H → A: Abolishes response to ADIPOQ binding; when associated with A-202; A-219 and A-348. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
79602

Open Targets

More...
OpenTargetsi
ENSG00000006831

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128394711

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3392947

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ADIPOR2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
38372190

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002188291 – 386Adiponectin receptor protein 2Add BLAST386

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86V24

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86V24

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86V24

PeptideAtlas

More...
PeptideAtlasi
Q86V24

PRoteomics IDEntifications database

More...
PRIDEi
Q86V24

ProteomicsDB human proteome resource

More...
ProteomicsDBi
69953

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86V24

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86V24

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous (PubMed:16044242). Highly expressed in skeletal muscle, liver and placenta (PubMed:12802337). Weakly expressed in brain, heart, colon, spleen, kidney, thymus, small intestine, peripheral blood leukocytes and lung (PubMed:12802337).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000006831 Expressed in 238 organ(s), highest expression level in inferior olivary complex

CleanEx database of gene expression profiles

More...
CleanExi
HS_ADIPOR2

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86V24 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043737

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May form homooligomers and heterooligomers with ADIPOR1.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
APPL1Q9UKG13EBI-1769445,EBI-741243

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122739, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q86V24, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000349616

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q86V24

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1386
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q86V24

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86V24

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminus is cytoplasmic and the C-terminus is extracellular, contrary to what is observed for G-protein coupled receptors. Unlike G-protein coupled receptors, transmembrane helices are not kinked or tilted relative to the plane of the membrane.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ADIPOR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0748 Eukaryota
COG1272 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156451

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000197115

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG013916

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86V24

KEGG Orthology (KO)

More...
KOi
K07297

Identification of Orthologs from Complete Genome Data

More...
OMAi
CDFFATP

Database of Orthologous Groups

More...
OrthoDBi
EOG091G04EU

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86V24

TreeFam database of animal gene trees

More...
TreeFami
TF313640

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004254 AdipoR/HlyIII-related

The PANTHER Classification System

More...
PANTHERi
PTHR20855 PTHR20855, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03006 HlyIII, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q86V24-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNEPTENRLG CSRTPEPDIR LRKGHQLDGT RRGDNDSHQG DLEPILEASV
60 70 80 90 100
LSSHHKKSSE EHEYSDEAPQ EDEGFMGMSP LLQAHHAMEK MEEFVCKVWE
110 120 130 140 150
GRWRVIPHDV LPDWLKDNDF LLHGHRPPMP SFRACFKSIF RIHTETGNIW
160 170 180 190 200
THLLGCVFFL CLGIFYMFRP NISFVAPLQE KVVFGLFFLG AILCLSFSWL
210 220 230 240 250
FHTVYCHSEG VSRLFSKLDY SGIALLIMGS FVPWLYYSFY CNPQPCFIYL
260 270 280 290 300
IVICVLGIAA IIVSQWDMFA TPQYRGVRAG VFLGLGLSGI IPTLHYVISE
310 320 330 340 350
GFLKAATIGQ IGWLMLMASL YITGAALYAA RIPERFFPGK CDIWFHSHQL
360 370 380
FHIFVVAGAF VHFHGVSNLQ EFRFMIGGGC SEEDAL
Length:386
Mass (Da):43,884
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB3B0FF0BBF118AA1
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15062 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti158F → S in BAB15062 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07868731 – 386Missing Found in a patient with autism spectrum disorder; unknown pathological significance. 1 PublicationAdd BLAST356
Natural variantiVAR_04820339Q → R. Corresponds to variant dbSNP:rs12298275Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY424280 mRNA Translation: AAR08368.1
AK025085 mRNA Translation: BAB15062.1 Different initiation.
AK127196 mRNA Translation: BAC86881.1
AK128511 mRNA Translation: BAC87473.1
CH471116 Genomic DNA Translation: EAW88924.1
BC051858 mRNA Translation: AAH51858.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8511.1

NCBI Reference Sequences

More...
RefSeqi
NP_078827.2, NM_024551.2
XP_005253846.1, XM_005253789.1
XP_006719081.1, XM_006719018.2
XP_011519326.1, XM_011521024.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.371642

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000357103; ENSP00000349616; ENSG00000006831
ENST00000645126; ENSP00000495699; ENSG00000285070

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79602

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79602

UCSC genome browser

More...
UCSCi
uc001qjm.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Adiponectin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424280 mRNA Translation: AAR08368.1
AK025085 mRNA Translation: BAB15062.1 Different initiation.
AK127196 mRNA Translation: BAC86881.1
AK128511 mRNA Translation: BAC87473.1
CH471116 Genomic DNA Translation: EAW88924.1
BC051858 mRNA Translation: AAH51858.1
CCDSiCCDS8511.1
RefSeqiNP_078827.2, NM_024551.2
XP_005253846.1, XM_005253789.1
XP_006719081.1, XM_006719018.2
XP_011519326.1, XM_011521024.2
UniGeneiHs.371642

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WXWX-ray2.40A100-386[»]
5LWYX-ray2.40A100-386[»]
5LX9X-ray2.40A99-386[»]
5LXAX-ray3.00A100-386[»]
ProteinModelPortaliQ86V24
SMRiQ86V24
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122739, 5 interactors
IntActiQ86V24, 4 interactors
STRINGi9606.ENSP00000349616

Chemistry databases

BindingDBiQ86V24
ChEMBLiCHEMBL3392947

PTM databases

iPTMnetiQ86V24
PhosphoSitePlusiQ86V24

Polymorphism and mutation databases

BioMutaiADIPOR2
DMDMi38372190

Proteomic databases

EPDiQ86V24
MaxQBiQ86V24
PaxDbiQ86V24
PeptideAtlasiQ86V24
PRIDEiQ86V24
ProteomicsDBi69953

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
79602
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357103; ENSP00000349616; ENSG00000006831
ENST00000645126; ENSP00000495699; ENSG00000285070
GeneIDi79602
KEGGihsa:79602
UCSCiuc001qjm.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79602
DisGeNETi79602
EuPathDBiHostDB:ENSG00000006831.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ADIPOR2
HGNCiHGNC:24041 ADIPOR2
HPAiHPA043737
MIMi607946 gene
neXtProtiNX_Q86V24
OpenTargetsiENSG00000006831
PharmGKBiPA128394711

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0748 Eukaryota
COG1272 LUCA
GeneTreeiENSGT00940000156451
HOGENOMiHOG000197115
HOVERGENiHBG013916
InParanoidiQ86V24
KOiK07297
OMAiCDFFATP
OrthoDBiEOG091G04EU
PhylomeDBiQ86V24
TreeFamiTF313640

Enzyme and pathway databases

ReactomeiR-HSA-163680 AMPK inhibits chREBP transcriptional activation activity
SIGNORiQ86V24

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ADIPOR2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ADIPOR2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79602

Protein Ontology

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PROi
PR:Q86V24

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000006831 Expressed in 238 organ(s), highest expression level in inferior olivary complex
CleanExiHS_ADIPOR2
GenevisibleiQ86V24 HS

Family and domain databases

InterProiView protein in InterPro
IPR004254 AdipoR/HlyIII-related
PANTHERiPTHR20855 PTHR20855, 1 hit
PfamiView protein in Pfam
PF03006 HlyIII, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPAQR2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86V24
Secondary accession number(s): Q53YY5, Q9H737
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: June 1, 2003
Last modified: December 5, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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