Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Adiponectin receptor protein 2

Gene

ADIPOR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity).By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi202Zinc1 Publication1
Metal bindingi348Zinc1 Publication1
Metal bindingi352Zinc1 Publication1

GO - Molecular functioni

  • adipokinetic hormone receptor activity Source: UniProtKB
  • adiponectin binding Source: UniProtKB
  • identical protein binding Source: Ensembl
  • metal ion binding Source: UniProtKB-KW
  • protein heterodimerization activity Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processFatty acid metabolism, Lipid metabolism
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-163680 AMPK inhibits chREBP transcriptional activation activity
SIGNORiQ86V24

Names & Taxonomyi

Protein namesi
Recommended name:
Adiponectin receptor protein 21 Publication
Alternative name(s):
Progestin and adipoQ receptor family member 21 Publication
Progestin and adipoQ receptor family member II
Gene namesi
Name:ADIPOR2Imported
Synonyms:PAQR21 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000006831.9
HGNCiHGNC:24041 ADIPOR2
MIMi607946 gene
neXtProtiNX_Q86V24

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 147Cytoplasmic1 PublicationAdd BLAST147
Transmembranei148 – 168Helical; Name=11 PublicationAdd BLAST21
Topological domaini169 – 181Extracellular1 PublicationAdd BLAST13
Transmembranei182 – 202Helical; Name=21 PublicationAdd BLAST21
Topological domaini203 – 213Cytoplasmic1 PublicationAdd BLAST11
Transmembranei214 – 234Helical; Name=31 PublicationAdd BLAST21
Topological domaini235 – 245Extracellular1 PublicationAdd BLAST11
Transmembranei246 – 266Helical; Name=41 PublicationAdd BLAST21
Topological domaini267 – 273Cytoplasmic1 Publication7
Transmembranei274 – 294Helical; Name=51 PublicationAdd BLAST21
Topological domaini295 – 309Extracellular1 PublicationAdd BLAST15
Transmembranei310 – 330Helical; Name=61 PublicationAdd BLAST21
Topological domaini331 – 348Cytoplasmic1 PublicationAdd BLAST18
Transmembranei349 – 369Helical; Name=71 PublicationAdd BLAST21
Topological domaini370 – 386Extracellular1 PublicationAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi202H → A: Abolishes response to ADIPOQ binding; when associated with A-219; A-348 and A-352. 1 Publication1
Mutagenesisi219D → A: Impairs response to ADIPOQ binding. Abolishes response to ADIPOQ binding; when associated with A-202; A-348 and A-352. 1 Publication1
Mutagenesisi348H → A: Impairs response to ADIPOQ binding. Abolishes response to ADIPOQ binding; when associated with A-202; A-219 and A-352. 1 Publication1
Mutagenesisi352H → A: Abolishes response to ADIPOQ binding; when associated with A-202; A-219 and A-348. 1 Publication1

Organism-specific databases

DisGeNETi79602
OpenTargetsiENSG00000006831
PharmGKBiPA128394711

Chemistry databases

ChEMBLiCHEMBL3392947

Polymorphism and mutation databases

BioMutaiADIPOR2
DMDMi38372190

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002188291 – 386Adiponectin receptor protein 2Add BLAST386

Proteomic databases

EPDiQ86V24
MaxQBiQ86V24
PaxDbiQ86V24
PeptideAtlasiQ86V24
PRIDEiQ86V24
ProteomicsDBi69953

PTM databases

iPTMnetiQ86V24
PhosphoSitePlusiQ86V24

Expressioni

Tissue specificityi

Ubiquitous (PubMed:16044242). Highly expressed in skeletal muscle, liver and placenta (PubMed:12802337). Weakly expressed in brain, heart, colon, spleen, kidney, thymus, small intestine, peripheral blood leukocytes and lung (PubMed:12802337).2 Publications

Gene expression databases

BgeeiENSG00000006831
CleanExiHS_ADIPOR2
GenevisibleiQ86V24 HS

Organism-specific databases

HPAiHPA043737

Interactioni

Subunit structurei

May form homooligomers and heterooligomers with ADIPOR1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
APPL1Q9UKG13EBI-1769445,EBI-741243

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122739, 5 interactors
IntActiQ86V24, 4 interactors
STRINGi9606.ENSP00000349616

Chemistry databases

BindingDBiQ86V24

Structurei

Secondary structure

1386
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni108 – 110Combined sources3
Helixi113 – 115Combined sources3
Helixi132 – 137Combined sources6
Helixi138 – 140Combined sources3
Helixi146 – 168Combined sources23
Helixi171 – 173Combined sources3
Beta strandi174 – 176Combined sources3
Helixi180 – 203Combined sources24
Turni205 – 207Combined sources3
Helixi209 – 238Combined sources30
Turni239 – 241Combined sources3
Helixi243 – 263Combined sources21
Beta strandi266 – 268Combined sources3
Helixi272 – 274Combined sources3
Helixi275 – 287Combined sources13
Helixi290 – 299Combined sources10
Helixi302 – 306Combined sources5
Helixi314 – 330Combined sources17
Turni331 – 336Combined sources6
Beta strandi340 – 345Combined sources6
Helixi347 – 376Combined sources30

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WXWX-ray2.40A100-386[»]
5LWYX-ray2.40A100-386[»]
5LX9X-ray2.40A99-386[»]
5LXAX-ray3.00A100-386[»]
ProteinModelPortaliQ86V24
SMRiQ86V24
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminus is cytoplasmic and the C-terminus is extracellular, contrary to what is observed for G-protein coupled receptors. Unlike G-protein coupled receptors, transmembrane helices are not kinked or tilted relative to the plane of the membrane.1 Publication

Sequence similaritiesi

Belongs to the ADIPOR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0748 Eukaryota
COG1272 LUCA
GeneTreeiENSGT00530000062926
HOGENOMiHOG000197115
HOVERGENiHBG013916
InParanoidiQ86V24
KOiK07297
OMAiCDFFATP
OrthoDBiEOG091G04EU
PhylomeDBiQ86V24
TreeFamiTF313640

Family and domain databases

InterProiView protein in InterPro
IPR004254 AdipoR/HlyIII-related
PANTHERiPTHR20855 PTHR20855, 1 hit
PfamiView protein in Pfam
PF03006 HlyIII, 1 hit

Sequencei

Sequence statusi: Complete.

Q86V24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEPTENRLG CSRTPEPDIR LRKGHQLDGT RRGDNDSHQG DLEPILEASV
60 70 80 90 100
LSSHHKKSSE EHEYSDEAPQ EDEGFMGMSP LLQAHHAMEK MEEFVCKVWE
110 120 130 140 150
GRWRVIPHDV LPDWLKDNDF LLHGHRPPMP SFRACFKSIF RIHTETGNIW
160 170 180 190 200
THLLGCVFFL CLGIFYMFRP NISFVAPLQE KVVFGLFFLG AILCLSFSWL
210 220 230 240 250
FHTVYCHSEG VSRLFSKLDY SGIALLIMGS FVPWLYYSFY CNPQPCFIYL
260 270 280 290 300
IVICVLGIAA IIVSQWDMFA TPQYRGVRAG VFLGLGLSGI IPTLHYVISE
310 320 330 340 350
GFLKAATIGQ IGWLMLMASL YITGAALYAA RIPERFFPGK CDIWFHSHQL
360 370 380
FHIFVVAGAF VHFHGVSNLQ EFRFMIGGGC SEEDAL
Length:386
Mass (Da):43,884
Last modified:June 1, 2003 - v1
Checksum:iB3B0FF0BBF118AA1
GO

Sequence cautioni

The sequence BAB15062 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti158F → S in BAB15062 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07868731 – 386Missing Found in a patient with autism spectrum disorder; unknown pathological significance. 1 PublicationAdd BLAST356
Natural variantiVAR_04820339Q → R. Corresponds to variant dbSNP:rs12298275Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424280 mRNA Translation: AAR08368.1
AK025085 mRNA Translation: BAB15062.1 Different initiation.
AK127196 mRNA Translation: BAC86881.1
AK128511 mRNA Translation: BAC87473.1
CH471116 Genomic DNA Translation: EAW88924.1
BC051858 mRNA Translation: AAH51858.1
CCDSiCCDS8511.1
RefSeqiNP_078827.2, NM_024551.2
XP_005253846.1, XM_005253789.1
XP_006719081.1, XM_006719018.2
XP_011519326.1, XM_011521024.2
UniGeneiHs.371642

Genome annotation databases

EnsembliENST00000357103; ENSP00000349616; ENSG00000006831
ENST00000645126; ENSP00000495699; ENSG00000285070
GeneIDi79602
KEGGihsa:79602
UCSCiuc001qjm.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPAQR2_HUMAN
AccessioniPrimary (citable) accession number: Q86V24
Secondary accession number(s): Q53YY5, Q9H737
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: June 1, 2003
Last modified: June 20, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health