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UniProtKB - Q86V15 (CASZ1_HUMAN)

Entry version 155 (25 May 2022)
Sequence version 4 (13 Jul 2010)
Previous versions | rss
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Protein

Zinc finger protein castor homolog 1

Gene

CASZ1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional activator (PubMed:23639441, PubMed:27693370).

Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed:23639441).

2 Publications

Miscellaneous

Endothelial cells depleted in CASZ1 by siRNAs display dramatic alterations in adhesion, morphology and sprouting; normal behavior can be rescued by restoration of EGFL7 expression. The defects are in part due to diminished RhoA expression and impaired focal adhesion localization.

Caution

According to PubMed:16322216, another protein (SRG) is encoded on the 3'-UTR of the CASZ1 gene. The existence of this protein that may play a role in apoptosis is extremely dubious despite the fact it was localized in the cytoplasm with the help of a polyclonal antibody.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri551 – 575C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri610 – 634C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri668 – 692C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1031 – 1055C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1300 – 1324C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1457 – 1481C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1515 – 1537C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1571 – 1595C2H2-type 8PROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q86V15

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q86V15

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q86V15

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein castor homolog 1
Alternative name(s):
Castor-related protein
Putative survival-related protein
Zinc finger protein 693
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CASZ1
Synonyms:CST, SRG, ZNF693
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:26002, CASZ1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609895, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q86V15

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000130940

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		54897

Open Targets

More...OpenTargetsi		ENSG00000130940

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		1606, 1p36 deletion syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142672203

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q86V15, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CASZ1

Domain mapping of disease mutations (DMDM)

More...DMDMi		300669712

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000469121 – 1759Zinc finger protein castor homolog 1Add BLAST1759

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki288Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei720PhosphoserineBy similarity1
Modified residuei721PhosphoserineBy similarity1
Cross-linki975Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei981PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q86V15

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q86V15

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q86V15

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q86V15

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q86V15

PeptideAtlas

More...PeptideAtlasi		Q86V15

PRoteomics IDEntifications database

More...PRIDEi		Q86V15

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		69945 [Q86V15-1]
69946 [Q86V15-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q86V15, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q86V15

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q86V15

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart, lung, skeletal muscle, pancreas, testis, small intestine, and stomach, but it is not detectable in the adult brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000130940, Expressed in skin of leg and 212 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q86V15, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q86V15, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000130940, Tissue enhanced (skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120243, 29 interactors

Protein interaction database and analysis system

More...IntActi		Q86V15, 15 interactors

Molecular INTeraction database

More...MINTi		Q86V15

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000366221

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q86V15, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q86V15

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 26DisorderedSequence analysisAdd BLAST26
Regioni46 – 175DisorderedSequence analysisAdd BLAST130
Regioni374 – 420DisorderedSequence analysisAdd BLAST47
Regioni686 – 723DisorderedSequence analysisAdd BLAST38
Regioni736 – 776DisorderedSequence analysisAdd BLAST41
Regioni824 – 843DisorderedSequence analysisAdd BLAST20
Regioni889 – 949DisorderedSequence analysisAdd BLAST61
Regioni1067 – 1111DisorderedSequence analysisAdd BLAST45
Regioni1367 – 1392DisorderedSequence analysisAdd BLAST26
Regioni1589 – 1620DisorderedSequence analysisAdd BLAST32
Regioni1643 – 1736DisorderedSequence analysisAdd BLAST94

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi75 – 92Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi130 – 156Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi157 – 175Polar residuesSequence analysisAdd BLAST19
Compositional biasi386 – 419Pro residuesSequence analysisAdd BLAST34
Compositional biasi736 – 754Polar residuesSequence analysisAdd BLAST19
Compositional biasi824 – 840Polar residuesSequence analysisAdd BLAST17
Compositional biasi1092 – 1111Polar residuesSequence analysisAdd BLAST20
Compositional biasi1589 – 1603Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1673 – 1719Acidic residuesSequence analysisAdd BLAST47

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri551 – 575C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri610 – 634C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri668 – 692C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1031 – 1055C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1300 – 1324C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1457 – 1481C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1515 – 1537C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1571 – 1595C2H2-type 8PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4377, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000008187

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003385_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q86V15

Identification of Orthologs from Complete Genome Data

More...OMAi		WPVHASP

Database of Orthologous Groups

More...OrthoDBi		31485at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q86V15

TreeFam database of animal gene trees

More...TreeFami		TF324787

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR040373, CASZ1
IPR013087, Znf_C2H2_type

The PANTHER Classification System

More...PANTHERi		PTHR12451, PTHR12451, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355, ZnF_C2H2, 11 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 9 hits
PS50157, ZINC_FINGER_C2H2_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86V15-1) [UniParc]FASTAAdd to basket
Also known as: hCASZ11

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDLGTAEGTR CTDPPAGKPA MAPKRKGGLK LNAICAKLSR QVVVEKRADA 
        60         70         80         90        100
GSHTEGSPSQ PRDQERSGPE SGAARAPRSE EDKRRAVIEK WVNGEYSEEP 
       110        120        130        140        150
APTPVLGRIA REGLELPPEG VYMVQPQGCS DEEDHAEEPS KDGGALEEKD 
       160        170        180        190        200
SDGAASKEDS GPSTRQASGE ASSLRDYAAS TMTEFLGMFG YDDQNTRDEL 
       210        220        230        240        250
ARKISFEKLH AGSTPEAATS SMLPTSEDTL SKRARFSKYE EYIRKLKAGE 
       260        270        280        290        300
QLSWPAPSTK TEERVGKEVV GTLPGLRLPS STAHLETKAT ILPLPSHSSV 
       310        320        330        340        350
QMQNLVARAS KYDFFIQKLK TGENLRPQNG STYKKPSKYD LENVKYLHLF 
       360        370        380        390        400
KPGEGSPDMG GAIAFKTGKV GRPSKYDVRG IQKPGPAKVP PTPSLAPAPL 
       410        420        430        440        450
ASVPSAPSAP GPGPEPPASL SFNTPEYLKS TFSKTDSITT GTVSTVKNGL 
       460        470        480        490        500
PTDKPAVTED VNIYQKYIAR FSGSQHCGHI HCAYQYREHY HCLDPECNYQ 
       510        520        530        540        550
RFTSKQDVIR HYNMHKKRDN SLQHGFMRFS PLDDCSVYYH GCHLNGKSTH 
       560        570        580        590        600
YHCMQVGCNK VYTSTSDVMT HENFHKKNTQ LINDGFQRFR ATEDCGTADC 
       610        620        630        640        650
QFYGQKTTHF HCRRPGCTFT FKNKCDIEKH KSYHIKDDAY AKDGFKKFYK 
       660        670        680        690        700
YEECKYEGCV YSKATNHFHC IRAGCGFTFT STSQMTSHKR KHERRHIRSS 
       710        720        730        740        750
GALGLPPSLL GAKDTEHEES SNDDLVDFSA LSSKNSSLSA SPTSQQSSAS 
       760        770        780        790        800
LAAATAATEA GPSATKPPNS KISGLLPQGL PGSIPLALAL SNSGLPTPTP 
       810        820        830        840        850
YFPILAGRGS TSLPVGTPSL LGAVSSGSAA SATPDTPTLV ASGAGDSAPV 
       860        870        880        890        900
AAASVPAPPA SIMERISASK GLISPMMARL AAAALKPSAT FDPGSGQQVT 
       910        920        930        940        950
PARFPPAQVK PEPGESTGAP GPHEASQDRS LDLTVKEPSN ESNGHAVPAN 
       960        970        980        990       1000
SSLLSSLMNK MSQGNPGLGS LLNIKAEAEG SPAAEPSPFL GKAVKALVQE 
      1010       1020       1030       1040       1050
KLAEPWKVYL RRFGTKDFCD GQCDFLHKAH FHCVVEECGA LFSTLDGAIK 
      1060       1070       1080       1090       1100
HANFHFRTEG GAAKGNTEAA FPASAAETKP PMAPSSPPVP PVTTATVSSL 
      1110       1120       1130       1140       1150
EGPAPSPASV PSTPTLLAWK QLASTIPQMP QIPASVPHLP ASPLATTSLE 
      1160       1170       1180       1190       1200
NAKPQVKPGF LQFQENDPCL ATDCKYANKF HFHCLFGNCK YVCKTSGKAE 
      1210       1220       1230       1240       1250
SHCLDHINPN NNLVNVRDQF AYYSLQCLCP NQHCEFRMRG HYHCLRTGCY 
      1260       1270       1280       1290       1300
FVTNITTKLP WHIKKHEKAE RRAANGFKYF TKREECGRLG CKYNQVNSHF 
      1310       1320       1330       1340       1350
HCIREGCQFS FLLKHQMTSH ARKHMRRMLG KNFDRVPPSQ GPPGLMDAET 
      1360       1370       1380       1390       1400
DECMDYTGCS PGAMSSESST MDRSCSSTPV GNESTAAGNT ISMPTASGAK 
      1410       1420       1430       1440       1450
KRFWIIEDMS PFGKRRKTAS SRKMLDEGMM LEGFRRFDLY EDCKDAACQF 
      1460       1470       1480       1490       1500
SLKVTHYHCT RENCGYKFCG RTHMYKHAQH HDRVDNLVLD DFKRFKASLS 
      1510       1520       1530       1540       1550
CHFADCPFSG TSTHFHCLRC RFRCTDSTKV TAHRKHHGKQ DVISAAGFCQ 
      1560       1570       1580       1590       1600
FSSSADCAVP DCKYKLKCSH FHCTFPGCRH TVVGMSQMDS HKRKHEKQER 
      1610       1620       1630       1640       1650
GEPAAEGPAP GPPISLDGSL SLGAEPGSLL FLQSAAAGLG LALGDAGDPG 
      1660       1670       1680       1690       1700
PPDAAAPGPR EGAAAAAAAA GESSQEDEEE ELELPEEEAE DDEDEDDDED 
      1710       1720       1730       1740       1750
DDDEDDDEDD DDEDLRTDSE ESLPEAAAEA AGAGARTPAL AALAALGAPG 

PAPTAASSP
Length:1,759
Mass (Da):190,069
Last modified:July 13, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4F5146BE72606654
GO
Isoform 2 (identifier: Q86V15-2) [UniParc]FASTAAdd to basket
Also known as: hCASZ5

The sequence of this isoform differs from the canonical sequence as follows:
     1166-1166: N → K
     1167-1759: Missing.

Show »
Length:1,166
Mass (Da):124,788
Checksum:i920E46461E4BC1A5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EQC6K7EQC6_HUMAN
Zinc finger protein castor homolog ...
CASZ1
231Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence ABD14411 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence BAA91089 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC85474 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti192D → N in ABB29845 (PubMed:16631614).Curated1
Sequence conflicti273L → P in ABB29845 (PubMed:16631614).Curated1
Sequence conflicti408S → N in BAA91089 (PubMed:15489334).Curated1
Sequence conflicti486Y → H in ABB29845 (PubMed:16631614).Curated1
Sequence conflicti650K → E in ABB29845 (PubMed:16631614).Curated1
Sequence conflicti813L → P in AAH51883 (PubMed:16710414).Curated1
Sequence conflicti961M → T in ABB29845 (PubMed:16631614).Curated1
Sequence conflicti989F → S in ABB29845 (PubMed:16631614).Curated1
Sequence conflicti1061G → E in BAA91089 (PubMed:15489334).Curated1
Sequence conflicti1297N → S in ABB29845 (PubMed:16631614).Curated1
Sequence conflicti1501C → R in ABB29845 (PubMed:16631614).Curated1
Sequence conflicti1549C → R in ABB29845 (PubMed:16631614).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07746638L → P Probable disease-associated variant found in a patient with congenital heart defect; severe decrease of positive regulation of transcription from TH promoter. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0270931166N → K in isoform 2. 2 Publications1
Alternative sequenceiVSP_0270941167 – 1759Missing in isoform 2. 2 PublicationsAdd BLAST593

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
DQ372703 mRNA Translation: ABD14411.1 Sequence problems.
DQ217660 mRNA Translation: ABB29845.1
AL139423 Genomic DNA No translation available.
BC004410 mRNA Translation: AAH04410.2
BC051883 mRNA Translation: AAH51883.2
AK000328 mRNA Translation: BAA91089.1 Different initiation.
AK130996 mRNA Translation: BAC85474.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS120.2 [Q86V15-2]
CCDS41246.1 [Q86V15-1]

NCBI Reference Sequences

More...RefSeqi		NP_001073312.1, NM_001079843.2 [Q86V15-1]
NP_060236.3, NM_017766.4 [Q86V15-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000344008.5; ENSP00000339445.5; ENSG00000130940.15 [Q86V15-2]
ENST00000377022.8; ENSP00000366221.3; ENSG00000130940.15

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54897

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54897

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000377022.8; ENSP00000366221.3; NM_001079843.3; NP_001073312.1

UCSC genome browser

More...UCSCi		uc001aro.6, human [Q86V15-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ372703 mRNA Translation: ABD14411.1 Sequence problems.
DQ217660 mRNA Translation: ABB29845.1
AL139423 Genomic DNA No translation available.
BC004410 mRNA Translation: AAH04410.2
BC051883 mRNA Translation: AAH51883.2
AK000328 mRNA Translation: BAA91089.1 Different initiation.
AK130996 mRNA Translation: BAC85474.1 Sequence problems.
CCDSiCCDS120.2 [Q86V15-2]
CCDS41246.1 [Q86V15-1]
RefSeqiNP_001073312.1, NM_001079843.2 [Q86V15-1]
NP_060236.3, NM_017766.4 [Q86V15-2]

3D structure databases

AlphaFoldDBiQ86V15
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

BioGRIDi120243, 29 interactors
IntActiQ86V15, 15 interactors
MINTiQ86V15
STRINGi9606.ENSP00000366221

PTM databases

GlyGeniQ86V15, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ86V15
PhosphoSitePlusiQ86V15

Genetic variation databases

BioMutaiCASZ1
DMDMi300669712

Proteomic databases

EPDiQ86V15
jPOSTiQ86V15
MassIVEiQ86V15
MaxQBiQ86V15
PaxDbiQ86V15
PeptideAtlasiQ86V15
PRIDEiQ86V15
ProteomicsDBi69945 [Q86V15-1]
69946 [Q86V15-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		27940, 173 antibodies from 24 providers

The DNASU plasmid repository

More...DNASUi		54897

Genome annotation databases

EnsembliENST00000344008.5; ENSP00000339445.5; ENSG00000130940.15 [Q86V15-2]
ENST00000377022.8; ENSP00000366221.3; ENSG00000130940.15
GeneIDi54897
KEGGihsa:54897
MANE-SelectiENST00000377022.8; ENSP00000366221.3; NM_001079843.3; NP_001073312.1
UCSCiuc001aro.6, human [Q86V15-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54897
DisGeNETi54897

GeneCards: human genes, protein and diseases

More...GeneCardsi		CASZ1
HGNCiHGNC:26002, CASZ1
HPAiENSG00000130940, Tissue enhanced (skin)
MIMi609895, gene
neXtProtiNX_Q86V15
OpenTargetsiENSG00000130940
Orphaneti1606, 1p36 deletion syndrome
PharmGKBiPA142672203
VEuPathDBiHostDB:ENSG00000130940

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4377, Eukaryota
GeneTreeiENSGT00390000008187
HOGENOMiCLU_003385_0_0_1
InParanoidiQ86V15
OMAiWPVHASP
OrthoDBi31485at2759
PhylomeDBiQ86V15
TreeFamiTF324787

Enzyme and pathway databases

PathwayCommonsiQ86V15
SignaLinkiQ86V15
SIGNORiQ86V15

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54897, 24 hits in 1065 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CASZ1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CASZ1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54897
PharosiQ86V15, Tbio

Protein Ontology

More...PROi		PR:Q86V15
RNActiQ86V15, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000130940, Expressed in skin of leg and 212 other tissues
ExpressionAtlasiQ86V15, baseline and differential
GenevisibleiQ86V15, HS

Family and domain databases

InterProiView protein in InterPro
IPR040373, CASZ1
IPR013087, Znf_C2H2_type
PANTHERiPTHR12451, PTHR12451, 2 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 11 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 9 hits
PS50157, ZINC_FINGER_C2H2_2, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCASZ1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86V15
Secondary accession number(s): Q078S9
, Q2EN02, Q5T9S1, Q6ZNM8, Q8WX49, Q8WX50, Q9BT16, Q9NXC6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: July 13, 2010
Last modified: May 25, 2022
This is version 155 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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