UniProtKB - Q86V15 (CASZ1_HUMAN)
Protein
Zinc finger protein castor homolog 1
Gene
CASZ1
Organism
Homo sapiens (Human)
Status
Functioni
Transcriptional activator (PubMed:23639441, PubMed:27693370). Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed:23639441).2 Publications
Miscellaneous
Endothelial cells depleted in CASZ1 by siRNAs display dramatic alterations in adhesion, morphology and sprouting; normal behavior can be rescued by restoration of EGFL7 expression. The defects are in part due to diminished RhoA expression and impaired focal adhesion localization.
Caution
According to PubMed:16322216, another protein (SRG) is encoded on the 3'-UTR of the CASZ1 gene. The existence of this protein that may play a role in apoptosis is extremely dubious despite the fact it was localized in the cytoplasm with the help of a polyclonal antibody.Curated
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 551 – 575 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 610 – 634 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 668 – 692 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 1031 – 1055 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 1300 – 1324 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 1457 – 1481 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 1515 – 1537 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1571 – 1595 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: ARUK-UCL
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: ARUK-UCL
GO - Biological processi
- multicellular organism development Source: UniProtKB-KW
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: ARUK-UCL
- regulation of neuron differentiation Source: GO_Central
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q86V15 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein castor homolog 1Alternative name(s): Castor-related protein Putative survival-related protein Zinc finger protein 693 |
Gene namesi | Name:CASZ1 Synonyms:CST, SRG, ZNF693 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26002, CASZ1 |
MIMi | 609895, gene |
neXtProti | NX_Q86V15 |
VEuPathDBi | HostDB:ENSG00000130940.14 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Other locations
- chromatin Source: ARUK-UCL
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 54897 |
OpenTargetsi | ENSG00000130940 |
PharmGKBi | PA142672203 |
Miscellaneous databases
Pharosi | Q86V15, Tbio |
Genetic variation databases
BioMutai | CASZ1 |
DMDMi | 300669712 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046912 | 1 – 1759 | Zinc finger protein castor homolog 1Add BLAST | 1759 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 288 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 720 | PhosphoserineBy similarity | 1 | |
Modified residuei | 721 | PhosphoserineBy similarity | 1 | |
Cross-linki | 975 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 981 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q86V15 |
jPOSTi | Q86V15 |
MassIVEi | Q86V15 |
MaxQBi | Q86V15 |
PaxDbi | Q86V15 |
PeptideAtlasi | Q86V15 |
PRIDEi | Q86V15 |
ProteomicsDBi | 69945 [Q86V15-1] 69946 [Q86V15-2] |
PTM databases
iPTMneti | Q86V15 |
PhosphoSitePlusi | Q86V15 |
Expressioni
Tissue specificityi
Expressed in heart, lung, skeletal muscle, pancreas, testis, small intestine, and stomach, but it is not detectable in the adult brain.1 Publication
Gene expression databases
Bgeei | ENSG00000130940, Expressed in skin of leg and 211 other tissues |
ExpressionAtlasi | Q86V15, baseline and differential |
Genevisiblei | Q86V15, HS |
Organism-specific databases
HPAi | ENSG00000130940, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 120243, 17 interactors |
IntActi | Q86V15, 12 interactors |
MINTi | Q86V15 |
STRINGi | 9606.ENSP00000366221 |
Miscellaneous databases
RNActi | Q86V15, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 384 – 417 | Pro-richAdd BLAST | 34 | |
Compositional biasi | 1080 – 1143 | Pro-richAdd BLAST | 64 | |
Compositional biasi | 1635 – 1670 | Ala-richAdd BLAST | 36 | |
Compositional biasi | 1672 – 1729 | Glu-richAdd BLAST | 58 | |
Compositional biasi | 1691 – 1718 | Asp-richAdd BLAST | 28 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 551 – 575 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 610 – 634 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 668 – 692 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 1031 – 1055 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 1300 – 1324 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 1457 – 1481 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 1515 – 1537 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1571 – 1595 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG4377, Eukaryota |
GeneTreei | ENSGT00390000008187 |
HOGENOMi | CLU_003385_0_0_1 |
InParanoidi | Q86V15 |
OMAi | RCHFSTD |
OrthoDBi | 31485at2759 |
PhylomeDBi | Q86V15 |
TreeFami | TF324787 |
Family and domain databases
InterProi | View protein in InterPro IPR040373, CASZ1 IPR013087, Znf_C2H2_type |
PANTHERi | PTHR12451, PTHR12451, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 11 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 9 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q86V15-1) [UniParc]FASTAAdd to basket
Also known as: hCASZ11
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDLGTAEGTR CTDPPAGKPA MAPKRKGGLK LNAICAKLSR QVVVEKRADA
60 70 80 90 100
GSHTEGSPSQ PRDQERSGPE SGAARAPRSE EDKRRAVIEK WVNGEYSEEP
110 120 130 140 150
APTPVLGRIA REGLELPPEG VYMVQPQGCS DEEDHAEEPS KDGGALEEKD
160 170 180 190 200
SDGAASKEDS GPSTRQASGE ASSLRDYAAS TMTEFLGMFG YDDQNTRDEL
210 220 230 240 250
ARKISFEKLH AGSTPEAATS SMLPTSEDTL SKRARFSKYE EYIRKLKAGE
260 270 280 290 300
QLSWPAPSTK TEERVGKEVV GTLPGLRLPS STAHLETKAT ILPLPSHSSV
310 320 330 340 350
QMQNLVARAS KYDFFIQKLK TGENLRPQNG STYKKPSKYD LENVKYLHLF
360 370 380 390 400
KPGEGSPDMG GAIAFKTGKV GRPSKYDVRG IQKPGPAKVP PTPSLAPAPL
410 420 430 440 450
ASVPSAPSAP GPGPEPPASL SFNTPEYLKS TFSKTDSITT GTVSTVKNGL
460 470 480 490 500
PTDKPAVTED VNIYQKYIAR FSGSQHCGHI HCAYQYREHY HCLDPECNYQ
510 520 530 540 550
RFTSKQDVIR HYNMHKKRDN SLQHGFMRFS PLDDCSVYYH GCHLNGKSTH
560 570 580 590 600
YHCMQVGCNK VYTSTSDVMT HENFHKKNTQ LINDGFQRFR ATEDCGTADC
610 620 630 640 650
QFYGQKTTHF HCRRPGCTFT FKNKCDIEKH KSYHIKDDAY AKDGFKKFYK
660 670 680 690 700
YEECKYEGCV YSKATNHFHC IRAGCGFTFT STSQMTSHKR KHERRHIRSS
710 720 730 740 750
GALGLPPSLL GAKDTEHEES SNDDLVDFSA LSSKNSSLSA SPTSQQSSAS
760 770 780 790 800
LAAATAATEA GPSATKPPNS KISGLLPQGL PGSIPLALAL SNSGLPTPTP
810 820 830 840 850
YFPILAGRGS TSLPVGTPSL LGAVSSGSAA SATPDTPTLV ASGAGDSAPV
860 870 880 890 900
AAASVPAPPA SIMERISASK GLISPMMARL AAAALKPSAT FDPGSGQQVT
910 920 930 940 950
PARFPPAQVK PEPGESTGAP GPHEASQDRS LDLTVKEPSN ESNGHAVPAN
960 970 980 990 1000
SSLLSSLMNK MSQGNPGLGS LLNIKAEAEG SPAAEPSPFL GKAVKALVQE
1010 1020 1030 1040 1050
KLAEPWKVYL RRFGTKDFCD GQCDFLHKAH FHCVVEECGA LFSTLDGAIK
1060 1070 1080 1090 1100
HANFHFRTEG GAAKGNTEAA FPASAAETKP PMAPSSPPVP PVTTATVSSL
1110 1120 1130 1140 1150
EGPAPSPASV PSTPTLLAWK QLASTIPQMP QIPASVPHLP ASPLATTSLE
1160 1170 1180 1190 1200
NAKPQVKPGF LQFQENDPCL ATDCKYANKF HFHCLFGNCK YVCKTSGKAE
1210 1220 1230 1240 1250
SHCLDHINPN NNLVNVRDQF AYYSLQCLCP NQHCEFRMRG HYHCLRTGCY
1260 1270 1280 1290 1300
FVTNITTKLP WHIKKHEKAE RRAANGFKYF TKREECGRLG CKYNQVNSHF
1310 1320 1330 1340 1350
HCIREGCQFS FLLKHQMTSH ARKHMRRMLG KNFDRVPPSQ GPPGLMDAET
1360 1370 1380 1390 1400
DECMDYTGCS PGAMSSESST MDRSCSSTPV GNESTAAGNT ISMPTASGAK
1410 1420 1430 1440 1450
KRFWIIEDMS PFGKRRKTAS SRKMLDEGMM LEGFRRFDLY EDCKDAACQF
1460 1470 1480 1490 1500
SLKVTHYHCT RENCGYKFCG RTHMYKHAQH HDRVDNLVLD DFKRFKASLS
1510 1520 1530 1540 1550
CHFADCPFSG TSTHFHCLRC RFRCTDSTKV TAHRKHHGKQ DVISAAGFCQ
1560 1570 1580 1590 1600
FSSSADCAVP DCKYKLKCSH FHCTFPGCRH TVVGMSQMDS HKRKHEKQER
1610 1620 1630 1640 1650
GEPAAEGPAP GPPISLDGSL SLGAEPGSLL FLQSAAAGLG LALGDAGDPG
1660 1670 1680 1690 1700
PPDAAAPGPR EGAAAAAAAA GESSQEDEEE ELELPEEEAE DDEDEDDDED
1710 1720 1730 1740 1750
DDDEDDDEDD DDEDLRTDSE ESLPEAAAEA AGAGARTPAL AALAALGAPG
PAPTAASSP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketK7EQC6 | K7EQC6_HUMAN | Zinc finger protein castor homolog ... | CASZ1 | 231 | Annotation score: |
Sequence cautioni
The sequence ABD14411 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence BAA91089 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC85474 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 192 | D → N in ABB29845 (PubMed:16631614).Curated | 1 | |
Sequence conflicti | 273 | L → P in ABB29845 (PubMed:16631614).Curated | 1 | |
Sequence conflicti | 408 | S → N in BAA91089 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 486 | Y → H in ABB29845 (PubMed:16631614).Curated | 1 | |
Sequence conflicti | 650 | K → E in ABB29845 (PubMed:16631614).Curated | 1 | |
Sequence conflicti | 813 | L → P in AAH51883 (PubMed:16710414).Curated | 1 | |
Sequence conflicti | 961 | M → T in ABB29845 (PubMed:16631614).Curated | 1 | |
Sequence conflicti | 989 | F → S in ABB29845 (PubMed:16631614).Curated | 1 | |
Sequence conflicti | 1061 | G → E in BAA91089 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1297 | N → S in ABB29845 (PubMed:16631614).Curated | 1 | |
Sequence conflicti | 1501 | C → R in ABB29845 (PubMed:16631614).Curated | 1 | |
Sequence conflicti | 1549 | C → R in ABB29845 (PubMed:16631614).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_077466 | 38 | L → P Probable disease-associated variant found in a patient with congenital heart defect; severe decrease of positive regulation of transcription from TH promoter. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027093 | 1166 | N → K in isoform 2. 2 Publications | 1 | |
Alternative sequenceiVSP_027094 | 1167 – 1759 | Missing in isoform 2. 2 PublicationsAdd BLAST | 593 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ372703 mRNA Translation: ABD14411.1 Sequence problems. DQ217660 mRNA Translation: ABB29845.1 AL139423 Genomic DNA No translation available. BC004410 mRNA Translation: AAH04410.2 BC051883 mRNA Translation: AAH51883.2 AK000328 mRNA Translation: BAA91089.1 Different initiation. AK130996 mRNA Translation: BAC85474.1 Sequence problems. |
CCDSi | CCDS120.2 [Q86V15-2] CCDS41246.1 [Q86V15-1] |
RefSeqi | NP_001073312.1, NM_001079843.2 [Q86V15-1] NP_060236.3, NM_017766.4 [Q86V15-2] |
Genome annotation databases
Ensembli | ENST00000344008; ENSP00000339445; ENSG00000130940 [Q86V15-2] ENST00000377022; ENSP00000366221; ENSG00000130940 [Q86V15-1] |
GeneIDi | 54897 |
KEGGi | hsa:54897 |
UCSCi | uc001aro.6, human [Q86V15-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ372703 mRNA Translation: ABD14411.1 Sequence problems. DQ217660 mRNA Translation: ABB29845.1 AL139423 Genomic DNA No translation available. BC004410 mRNA Translation: AAH04410.2 BC051883 mRNA Translation: AAH51883.2 AK000328 mRNA Translation: BAA91089.1 Different initiation. AK130996 mRNA Translation: BAC85474.1 Sequence problems. |
CCDSi | CCDS120.2 [Q86V15-2] CCDS41246.1 [Q86V15-1] |
RefSeqi | NP_001073312.1, NM_001079843.2 [Q86V15-1] NP_060236.3, NM_017766.4 [Q86V15-2] |
3D structure databases
SMRi | Q86V15 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120243, 17 interactors |
IntActi | Q86V15, 12 interactors |
MINTi | Q86V15 |
STRINGi | 9606.ENSP00000366221 |
PTM databases
iPTMneti | Q86V15 |
PhosphoSitePlusi | Q86V15 |
Genetic variation databases
BioMutai | CASZ1 |
DMDMi | 300669712 |
Proteomic databases
EPDi | Q86V15 |
jPOSTi | Q86V15 |
MassIVEi | Q86V15 |
MaxQBi | Q86V15 |
PaxDbi | Q86V15 |
PeptideAtlasi | Q86V15 |
PRIDEi | Q86V15 |
ProteomicsDBi | 69945 [Q86V15-1] 69946 [Q86V15-2] |
Protocols and materials databases
Antibodypediai | 27940, 169 antibodies |
DNASUi | 54897 |
Genome annotation databases
Ensembli | ENST00000344008; ENSP00000339445; ENSG00000130940 [Q86V15-2] ENST00000377022; ENSP00000366221; ENSG00000130940 [Q86V15-1] |
GeneIDi | 54897 |
KEGGi | hsa:54897 |
UCSCi | uc001aro.6, human [Q86V15-1] |
Organism-specific databases
CTDi | 54897 |
DisGeNETi | 54897 |
GeneCardsi | CASZ1 |
HGNCi | HGNC:26002, CASZ1 |
HPAi | ENSG00000130940, Low tissue specificity |
MIMi | 609895, gene |
neXtProti | NX_Q86V15 |
OpenTargetsi | ENSG00000130940 |
PharmGKBi | PA142672203 |
VEuPathDBi | HostDB:ENSG00000130940.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4377, Eukaryota |
GeneTreei | ENSGT00390000008187 |
HOGENOMi | CLU_003385_0_0_1 |
InParanoidi | Q86V15 |
OMAi | RCHFSTD |
OrthoDBi | 31485at2759 |
PhylomeDBi | Q86V15 |
TreeFami | TF324787 |
Enzyme and pathway databases
PathwayCommonsi | Q86V15 |
Miscellaneous databases
BioGRID-ORCSi | 54897, 22 hits in 986 CRISPR screens |
ChiTaRSi | CASZ1, human |
GeneWikii | CASZ1 |
GenomeRNAii | 54897 |
Pharosi | Q86V15, Tbio |
PROi | PR:Q86V15 |
RNActi | Q86V15, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000130940, Expressed in skin of leg and 211 other tissues |
ExpressionAtlasi | Q86V15, baseline and differential |
Genevisiblei | Q86V15, HS |
Family and domain databases
InterProi | View protein in InterPro IPR040373, CASZ1 IPR013087, Znf_C2H2_type |
PANTHERi | PTHR12451, PTHR12451, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 11 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 9 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CASZ1_HUMAN | |
Accessioni | Q86V15Primary (citable) accession number: Q86V15 Secondary accession number(s): Q078S9 Q9NXC6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 24, 2004 |
Last sequence update: | July 13, 2010 | |
Last modified: | April 7, 2021 | |
This is version 151 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot