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Protein

5'-nucleotidase domain-containing protein 3

Gene

NT5DC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei102NucleophileBy similarity1
Metal bindingi102MagnesiumBy similarity1
Active sitei104Proton donorBy similarity1
Metal bindingi104Magnesium; via carbonyl oxygenBy similarity1
Metal bindingi389MagnesiumBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
5'-nucleotidase domain-containing protein 3 (EC:3.1.3.-)
Alternative name(s):
GRP94-neighboring nucleotidase
Gene namesi
Name:NT5DC3
Synonyms:GNN, TU12B1-TY
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111696.11
HGNCiHGNC:30826 NT5DC3
MIMi611076 gene
neXtProtiNX_Q86UY8

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi51559
OpenTargetsiENSG00000111696
PharmGKBiPA143485562

Polymorphism and mutation databases

BioMutaiNT5DC3
DMDMi74727508

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003262471 – 5485'-nucleotidase domain-containing protein 3Add BLAST548

Proteomic databases

EPDiQ86UY8
MaxQBiQ86UY8
PaxDbiQ86UY8
PeptideAtlasiQ86UY8
PRIDEiQ86UY8
ProteomicsDBi69939
69940 [Q86UY8-2]

PTM databases

DEPODiQ86UY8
iPTMnetiQ86UY8
PhosphoSitePlusiQ86UY8

Expressioni

Tissue specificityi

Expressed in brain, placenta, skeletal muscle, pancreas, testis, uterus, and small intestine. Reduced expression in pancreatic cancer cells.1 Publication

Gene expression databases

BgeeiENSG00000111696 Expressed in 146 organ(s), highest expression level in muscle layer of sigmoid colon
CleanExiHS_NT5DC3
ExpressionAtlasiQ86UY8 baseline and differential
GenevisibleiQ86UY8 HS

Organism-specific databases

HPAiHPA041634

Interactioni

Protein-protein interaction databases

BioGridi119609, 6 interactors
IntActiQ86UY8, 9 interactors
STRINGi9606.ENSP00000376615

Structurei

3D structure databases

ProteinModelPortaliQ86UY8
SMRiQ86UY8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni251 – 259Substrate bindingSequence analysis9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 7Poly-Ala4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2470 Eukaryota
ENOG410XT8W LUCA
GeneTreeiENSGT00550000074539
HOGENOMiHOG000230610
HOVERGENiHBG053334
OMAiHTMKQFM
OrthoDBiEOG091G048T
PhylomeDBiQ86UY8
TreeFamiTF323990

Family and domain databases

Gene3Di3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR036412 HAD-like_sf
IPR008380 HAD-SF_hydro_IG_5-nucl
IPR023214 HAD_sf
IPR016695 Pur_nucleotidase
PANTHERiPTHR12103 PTHR12103, 1 hit
PfamiView protein in Pfam
PF05761 5_nucleotid, 1 hit
PIRSFiPIRSF017434 Purine_5'-nucleotidase, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR02244 HAD-IG-Ncltidse, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q86UY8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTMAAAAVVA RGAGARAATA AALRGGCGTA ARGRPCAGPA RPLCTAPGTA
60 70 80 90 100
PDMKRYLWER YREAKRSTEE LVPSIMSNLL NPDAIFSNNE MSLSDIEIYG
110 120 130 140 150
FDYDYTLVFY SKHLHTLIFN AARDLLINEH RYPAEIRKYE YDPNFAIRGL
160 170 180 190 200
HYDVQRAVLM KIDAFHYIQL GTVYRGLSVV PDEEVIEMYE GSHVPLEQMS
210 220 230 240 250
DFYGKSSHGN TMKQFMDIFS LPEMTLLSCV NEYFLKNNID YEPVHLYKDV
260 270 280 290 300
KDSIRDVHIK GIMYRAIEAD IEKYICYAEQ TRAVLAKLAD HGKKMFLITN
310 320 330 340 350
SPSSFVDKGM SYIVGKDWRD LFDVVIVQAE KPNFFNDKRR PFRKMNEKGV
360 370 380 390 400
LLWDKIHKLQ KGQIYKQGNL YEFLKLTGWR GSRVLYFGDH IYSDLADLTL
410 420 430 440 450
KHGWRTGAII PELRSELKIM NTEQYIQTMT WLQTLTGLLE QMQVHRDAES
460 470 480 490 500
QLVLQEWKKE RKEMREMTKS FFNAQFGSLF RTDQNPTYFL RRLSRFADIY
510 520 530 540
MASLSCLLNY DVSHTFYPRR TPLQHELPAW SERPPTFGTP LLQEAQAK
Length:548
Mass (Da):63,420
Last modified:June 1, 2003 - v1
Checksum:i93B1C8CD7C2E0434
GO
Isoform 2 (identifier: Q86UY8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.
     466-474: Missing.

Show »
Length:464
Mass (Da):54,665
Checksum:iEB11B4E3E4C9D69E
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C193H7C193_HUMAN
5'-nucleotidase domain-containing p...
NT5DC3
135Annotation score:
H7C3S8H7C3S8_HUMAN
5'-nucleotidase domain-containing p...
NT5DC3
122Annotation score:

Sequence cautioni

The sequence BAA92095 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA93053 differs from that shown. Reason: Frameshift at position 62.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_040043266A → E. Corresponds to variant dbSNP:rs12184494Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0326431 – 75Missing in isoform 2. CuratedAdd BLAST75
Alternative sequenceiVSP_032644466 – 474Missing in isoform 2. Curated9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032773 mRNA Translation: BAA93053.1 Frameshift.
AB032786 Genomic DNA Translation: BAA93086.1
CH471054 Genomic DNA Translation: EAW97716.1
BC052293 mRNA Translation: AAH52293.1
AK002128 mRNA Translation: BAA92095.1 Different initiation.
CCDSiCCDS41824.1 [Q86UY8-1]
RefSeqiNP_001026871.1, NM_001031701.2 [Q86UY8-1]
UniGeneiHs.48428

Genome annotation databases

EnsembliENST00000392876; ENSP00000376615; ENSG00000111696 [Q86UY8-1]
GeneIDi51559
KEGGihsa:51559
UCSCiuc010swe.2 human [Q86UY8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNT5D3_HUMAN
AccessioniPrimary (citable) accession number: Q86UY8
Secondary accession number(s): Q9NUM7, Q9P2T2, Q9P2T3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2003
Last modified: September 12, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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