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Protein

5'-nucleotidase domain-containing protein 3

Gene

NT5DC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei102NucleophileBy similarity1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi102MagnesiumBy similarity1
Active sitei104Proton donorBy similarity1
Metal bindingi104Magnesium; via carbonyl oxygenBy similarity1
Metal bindingi389MagnesiumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • 5'-nucleotidase activity Source: GO_Central
  • metal ion binding Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandMagnesium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
5'-nucleotidase domain-containing protein 3 (EC:3.1.3.-)
Alternative name(s):
GRP94-neighboring nucleotidase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NT5DC3
Synonyms:GNN, TU12B1-TY
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000111696.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30826 NT5DC3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611076 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86UY8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
51559

Open Targets

More...
OpenTargetsi
ENSG00000111696

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485562

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NT5DC3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74727508

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003262471 – 5485'-nucleotidase domain-containing protein 3Add BLAST548

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86UY8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86UY8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86UY8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86UY8

PeptideAtlas

More...
PeptideAtlasi
Q86UY8

PRoteomics IDEntifications database

More...
PRIDEi
Q86UY8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
69939
69940 [Q86UY8-2]

PTM databases

DEPOD human dephosphorylation database

More...
DEPODi
Q86UY8

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86UY8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86UY8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, placenta, skeletal muscle, pancreas, testis, uterus, and small intestine. Reduced expression in pancreatic cancer cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000111696 Expressed in 146 organ(s), highest expression level in muscle layer of sigmoid colon

CleanEx database of gene expression profiles

More...
CleanExi
HS_NT5DC3

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86UY8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86UY8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA041634

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119609, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q86UY8, 9 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000376615

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q86UY8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86UY8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni251 – 259Substrate bindingSequence analysis9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4 – 7Poly-Ala4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2470 Eukaryota
ENOG410XT8W LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158637

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230610

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG053334

Identification of Orthologs from Complete Genome Data

More...
OMAi
HTMKQFM

Database of Orthologous Groups

More...
OrthoDBi
858908at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86UY8

TreeFam database of animal gene trees

More...
TreeFami
TF323990

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1000, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036412 HAD-like_sf
IPR008380 HAD-SF_hydro_IG_5-nucl
IPR023214 HAD_sf
IPR016695 Pur_nucleotidase

The PANTHER Classification System

More...
PANTHERi
PTHR12103 PTHR12103, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05761 5_nucleotid, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF017434 Purine_5'-nucleotidase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56784 SSF56784, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02244 HAD-IG-Ncltidse, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86UY8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTMAAAAVVA RGAGARAATA AALRGGCGTA ARGRPCAGPA RPLCTAPGTA
60 70 80 90 100
PDMKRYLWER YREAKRSTEE LVPSIMSNLL NPDAIFSNNE MSLSDIEIYG
110 120 130 140 150
FDYDYTLVFY SKHLHTLIFN AARDLLINEH RYPAEIRKYE YDPNFAIRGL
160 170 180 190 200
HYDVQRAVLM KIDAFHYIQL GTVYRGLSVV PDEEVIEMYE GSHVPLEQMS
210 220 230 240 250
DFYGKSSHGN TMKQFMDIFS LPEMTLLSCV NEYFLKNNID YEPVHLYKDV
260 270 280 290 300
KDSIRDVHIK GIMYRAIEAD IEKYICYAEQ TRAVLAKLAD HGKKMFLITN
310 320 330 340 350
SPSSFVDKGM SYIVGKDWRD LFDVVIVQAE KPNFFNDKRR PFRKMNEKGV
360 370 380 390 400
LLWDKIHKLQ KGQIYKQGNL YEFLKLTGWR GSRVLYFGDH IYSDLADLTL
410 420 430 440 450
KHGWRTGAII PELRSELKIM NTEQYIQTMT WLQTLTGLLE QMQVHRDAES
460 470 480 490 500
QLVLQEWKKE RKEMREMTKS FFNAQFGSLF RTDQNPTYFL RRLSRFADIY
510 520 530 540
MASLSCLLNY DVSHTFYPRR TPLQHELPAW SERPPTFGTP LLQEAQAK
Length:548
Mass (Da):63,420
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i93B1C8CD7C2E0434
GO
Isoform 2 (identifier: Q86UY8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.
     466-474: Missing.

Show »
Length:464
Mass (Da):54,665
Checksum:iEB11B4E3E4C9D69E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C193H7C193_HUMAN
5'-nucleotidase domain-containing p...
NT5DC3
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3S8H7C3S8_HUMAN
5'-nucleotidase domain-containing p...
NT5DC3
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA92095 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA93053 differs from that shown. Reason: Frameshift at position 62.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_040043266A → E. Corresponds to variant dbSNP:rs12184494Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0326431 – 75Missing in isoform 2. CuratedAdd BLAST75
Alternative sequenceiVSP_032644466 – 474Missing in isoform 2. Curated9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB032773 mRNA Translation: BAA93053.1 Frameshift.
AB032786 Genomic DNA Translation: BAA93086.1
CH471054 Genomic DNA Translation: EAW97716.1
BC052293 mRNA Translation: AAH52293.1
AK002128 mRNA Translation: BAA92095.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41824.1 [Q86UY8-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001026871.1, NM_001031701.2 [Q86UY8-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.48428

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000392876; ENSP00000376615; ENSG00000111696 [Q86UY8-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51559

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51559

UCSC genome browser

More...
UCSCi
uc010swe.2 human [Q86UY8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032773 mRNA Translation: BAA93053.1 Frameshift.
AB032786 Genomic DNA Translation: BAA93086.1
CH471054 Genomic DNA Translation: EAW97716.1
BC052293 mRNA Translation: AAH52293.1
AK002128 mRNA Translation: BAA92095.1 Different initiation.
CCDSiCCDS41824.1 [Q86UY8-1]
RefSeqiNP_001026871.1, NM_001031701.2 [Q86UY8-1]
UniGeneiHs.48428

3D structure databases

ProteinModelPortaliQ86UY8
SMRiQ86UY8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119609, 6 interactors
IntActiQ86UY8, 9 interactors
STRINGi9606.ENSP00000376615

PTM databases

DEPODiQ86UY8
iPTMnetiQ86UY8
PhosphoSitePlusiQ86UY8

Polymorphism and mutation databases

BioMutaiNT5DC3
DMDMi74727508

Proteomic databases

EPDiQ86UY8
jPOSTiQ86UY8
MaxQBiQ86UY8
PaxDbiQ86UY8
PeptideAtlasiQ86UY8
PRIDEiQ86UY8
ProteomicsDBi69939
69940 [Q86UY8-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392876; ENSP00000376615; ENSG00000111696 [Q86UY8-1]
GeneIDi51559
KEGGihsa:51559
UCSCiuc010swe.2 human [Q86UY8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51559
DisGeNETi51559
EuPathDBiHostDB:ENSG00000111696.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NT5DC3
HGNCiHGNC:30826 NT5DC3
HPAiHPA041634
MIMi611076 gene
neXtProtiNX_Q86UY8
OpenTargetsiENSG00000111696
PharmGKBiPA143485562

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2470 Eukaryota
ENOG410XT8W LUCA
GeneTreeiENSGT00940000158637
HOGENOMiHOG000230610
HOVERGENiHBG053334
OMAiHTMKQFM
OrthoDBi858908at2759
PhylomeDBiQ86UY8
TreeFamiTF323990

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NT5DC3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51559

Protein Ontology

More...
PROi
PR:Q86UY8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000111696 Expressed in 146 organ(s), highest expression level in muscle layer of sigmoid colon
CleanExiHS_NT5DC3
ExpressionAtlasiQ86UY8 baseline and differential
GenevisibleiQ86UY8 HS

Family and domain databases

Gene3Di3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR036412 HAD-like_sf
IPR008380 HAD-SF_hydro_IG_5-nucl
IPR023214 HAD_sf
IPR016695 Pur_nucleotidase
PANTHERiPTHR12103 PTHR12103, 1 hit
PfamiView protein in Pfam
PF05761 5_nucleotid, 1 hit
PIRSFiPIRSF017434 Purine_5'-nucleotidase, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR02244 HAD-IG-Ncltidse, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNT5D3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86UY8
Secondary accession number(s): Q9NUM7, Q9P2T2, Q9P2T3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2003
Last modified: January 16, 2019
This is version 124 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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