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Protein

Protein FAM83A

Gene

FAM83A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell proliferation Source: UniProtKB
  • epidermal growth factor receptor signaling pathway Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM83ACurated
Alternative name(s):
Tumor antigen BJ-TSA-91 Publication
Tumor-specific gene expressed in prostate protein1 Publication
Gene namesi
Name:FAM83AImported
Synonyms:TSGP1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000147689.16
HGNCiHGNC:28210 FAM83A
neXtProtiNX_Q86UY5

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi84985
OpenTargetsiENSG00000147689
PharmGKBiPA142671851

Polymorphism and mutation databases

BioMutaiFAM83A
DMDMi74727505

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002868131 – 434Protein FAM83AAdd BLAST434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei301PhosphoserineCombined sources1
Modified residuei327PhosphoserineCombined sources1
Modified residuei348PhosphoserineCombined sources1
Modified residuei357PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated upon EGFR activation.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86UY5
MaxQBiQ86UY5
PaxDbiQ86UY5
PeptideAtlasiQ86UY5
PRIDEiQ86UY5
ProteomicsDBi69935
69936 [Q86UY5-2]
69937 [Q86UY5-3]

PTM databases

iPTMnetiQ86UY5
PhosphoSitePlusiQ86UY5

Expressioni

Gene expression databases

BgeeiENSG00000147689 Expressed in 124 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_FAM83A
GenevisibleiQ86UY5 HS

Organism-specific databases

HPAiHPA052615

Interactioni

Subunit structurei

Interacts with the regulatory subunit p85 of PI3-kinase; increased by EGFR activation (PubMed:22886303). Interacts with RAF1; increased by EGFR activation it activates RAF1 (PubMed:22886303, PubMed:24736947).2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124411, 8 interactors
IntActiQ86UY5, 27 interactors

Structurei

Secondary structure

1434
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ86UY5
SMRiQ86UY5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi320 – 357Ser-richAdd BLAST38
Compositional biasi355 – 394Pro-richAdd BLAST40

Sequence similaritiesi

Belongs to the FAM83 family.Curated

Phylogenomic databases

eggNOGiENOG410IGUW Eukaryota
ENOG410XSTH LUCA
GeneTreeiENSGT00760000119168
HOGENOMiHOG000112483
HOVERGENiHBG107905
InParanoidiQ86UY5
OMAiYSFSWLC
OrthoDBiEOG091G04SR
PhylomeDBiQ86UY5
TreeFamiTF330777

Family and domain databases

InterProiView protein in InterPro
IPR012461 FAM83
PANTHERiPTHR16181 PTHR16181, 1 hit
PfamiView protein in Pfam
PF07894 DUF1669, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q86UY5-1) [UniParc]FASTAAdd to basket
Also known as: TSGP-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRSRHLGKI RKRLEDVKSQ WVRPARADFS DNESARLATD ALLDGGSEAY
60 70 80 90 100
WRVLSQEGEV DFLSSVEAQY IQAQAREPPC PPDTLGGAEA GPKGLDSSSL
110 120 130 140 150
QSGTYFPVAS EGSEPALLHS WASAEKPYLK EKSSATVYFQ TVKHNNIRDL
160 170 180 190 200
VRRCITRTSQ VLVILMDVFT DVEIFCDILE AANKRGVFVC VLLDQGGVKL
210 220 230 240 250
FQEMCDKVQI SDSHLKNISI RSVEGEIYCA KSGRKFAGQI REKFIISDWR
260 270 280 290 300
FVLSGSYSFT WLCGHVHRNI LSKFTGQAVE LFDEEFRHLY ASSKPVMGLK
310 320 330 340 350
SPRLVAPVPP GAAPANGRLS SSSGSASDRT SSNPFSGRSA GSHPGTRSVS
360 370 380 390 400
ASSGPCSPAA PHPPPPPRFQ PHQGPWGAPS PQAHLSPRPH DGPPAAVYSN
410 420 430
LGAYRPTRLQ LEQLGLVPRL TPTWRPFLQA SPHF
Length:434
Mass (Da):47,458
Last modified:June 1, 2003 - v1
Checksum:i63D09D927D452FCC
GO
Isoform 2 (identifier: Q86UY5-2) [UniParc]FASTAAdd to basket
Also known as: TSGP-S

The sequence of this isoform differs from the canonical sequence as follows:
     161-216: Missing.
     348-350: SVS → TDG
     351-434: Missing.

Show »
Length:294
Mass (Da):32,158
Checksum:i73D90BAEC4F5B8E3
GO
Isoform 3 (identifier: Q86UY5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     345-367: GTRSVSASSGPCSPAAPHPPPPP → VPESKQNKTKTKKQTTLWFLMAF
     368-434: Missing.

Show »
Length:367
Mass (Da):40,576
Checksum:i849DCF2B4F8A681C
GO

Sequence cautioni

The sequence BAC05299 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032178237A → T3 PublicationsCorresponds to variant dbSNP:rs7813708Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_025187161 – 216Missing in isoform 2. 2 PublicationsAdd BLAST56
Alternative sequenceiVSP_025188345 – 367GTRSV…PPPPP → VPESKQNKTKTKKQTTLWFL MAF in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_025190348 – 350SVS → TDG in isoform 2. 2 Publications3
Alternative sequenceiVSP_025191351 – 434Missing in isoform 2. 2 PublicationsAdd BLAST84
Alternative sequenceiVSP_025189368 – 434Missing in isoform 3. 1 PublicationAdd BLAST67

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ280322 mRNA Translation: ABB91800.1
DQ280323 mRNA Translation: ABB91801.1
AF497803 mRNA Translation: AAQ07260.1
BC007828 mRNA Translation: AAH07828.1
BC052300 mRNA Translation: AAH52300.1
AK098407 mRNA Translation: BAC05299.1 Different initiation.
CCDSiCCDS6339.1 [Q86UY5-3]
CCDS6340.1 [Q86UY5-1]
CCDS75784.1 [Q86UY5-2]
RefSeqiNP_001275516.1, NM_001288587.2 [Q86UY5-2]
NP_116288.2, NM_032899.6 [Q86UY5-1]
NP_996889.1, NM_207006.2 [Q86UY5-3]
UniGeneiHs.379821
Hs.677705
Hs.679530

Genome annotation databases

EnsembliENST00000276699; ENSP00000276699; ENSG00000147689 [Q86UY5-3]
ENST00000518448; ENSP00000428876; ENSG00000147689 [Q86UY5-1]
ENST00000522648; ENSP00000427979; ENSG00000147689 [Q86UY5-2]
ENST00000536633; ENSP00000445218; ENSG00000147689 [Q86UY5-3]
GeneIDi84985
KEGGihsa:84985
UCSCiuc003ypv.5 human [Q86UY5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ280322 mRNA Translation: ABB91800.1
DQ280323 mRNA Translation: ABB91801.1
AF497803 mRNA Translation: AAQ07260.1
BC007828 mRNA Translation: AAH07828.1
BC052300 mRNA Translation: AAH52300.1
AK098407 mRNA Translation: BAC05299.1 Different initiation.
CCDSiCCDS6339.1 [Q86UY5-3]
CCDS6340.1 [Q86UY5-1]
CCDS75784.1 [Q86UY5-2]
RefSeqiNP_001275516.1, NM_001288587.2 [Q86UY5-2]
NP_116288.2, NM_032899.6 [Q86UY5-1]
NP_996889.1, NM_207006.2 [Q86UY5-3]
UniGeneiHs.379821
Hs.677705
Hs.679530

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4URJX-ray2.68A/B/C/D122-304[»]
ProteinModelPortaliQ86UY5
SMRiQ86UY5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124411, 8 interactors
IntActiQ86UY5, 27 interactors

PTM databases

iPTMnetiQ86UY5
PhosphoSitePlusiQ86UY5

Polymorphism and mutation databases

BioMutaiFAM83A
DMDMi74727505

Proteomic databases

EPDiQ86UY5
MaxQBiQ86UY5
PaxDbiQ86UY5
PeptideAtlasiQ86UY5
PRIDEiQ86UY5
ProteomicsDBi69935
69936 [Q86UY5-2]
69937 [Q86UY5-3]

Protocols and materials databases

DNASUi84985
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276699; ENSP00000276699; ENSG00000147689 [Q86UY5-3]
ENST00000518448; ENSP00000428876; ENSG00000147689 [Q86UY5-1]
ENST00000522648; ENSP00000427979; ENSG00000147689 [Q86UY5-2]
ENST00000536633; ENSP00000445218; ENSG00000147689 [Q86UY5-3]
GeneIDi84985
KEGGihsa:84985
UCSCiuc003ypv.5 human [Q86UY5-1]

Organism-specific databases

CTDi84985
DisGeNETi84985
EuPathDBiHostDB:ENSG00000147689.16
GeneCardsiFAM83A
H-InvDBiHIX0007762
HGNCiHGNC:28210 FAM83A
HPAiHPA052615
neXtProtiNX_Q86UY5
OpenTargetsiENSG00000147689
PharmGKBiPA142671851
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGUW Eukaryota
ENOG410XSTH LUCA
GeneTreeiENSGT00760000119168
HOGENOMiHOG000112483
HOVERGENiHBG107905
InParanoidiQ86UY5
OMAiYSFSWLC
OrthoDBiEOG091G04SR
PhylomeDBiQ86UY5
TreeFamiTF330777

Miscellaneous databases

ChiTaRSiFAM83A human
GeneWikiiFAM83A
GenomeRNAii84985
PROiPR:Q86UY5

Gene expression databases

BgeeiENSG00000147689 Expressed in 124 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_FAM83A
GenevisibleiQ86UY5 HS

Family and domain databases

InterProiView protein in InterPro
IPR012461 FAM83
PANTHERiPTHR16181 PTHR16181, 1 hit
PfamiView protein in Pfam
PF07894 DUF1669, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFA83A_HUMAN
AccessioniPrimary (citable) accession number: Q86UY5
Secondary accession number(s): Q71HL2, Q8N7I1, Q96I47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 2003
Last modified: November 7, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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