Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein kinase 32C

Gene

STK32C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei122ATPPROSITE-ProRule annotationBy similarity1
Active sitei216Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi99 – 107ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ86UX6

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 32C (EC:2.7.11.1)
Alternative name(s):
PKE
Yet another novel kinase 3
Gene namesi
Name:STK32CImported
Synonyms:YANK3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000165752.16
HGNCiHGNC:21332 STK32C
neXtProtiNX_Q86UX6

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi282974
OpenTargetsiENSG00000165752
PharmGKBiPA134888050

Chemistry databases

ChEMBLiCHEMBL5405

Polymorphism and mutation databases

BioMutaiSTK32C
DMDMi74762451

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002324151 – 486Serine/threonine-protein kinase 32CAdd BLAST486

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineBy similarity1
Modified residuei15PhosphoserineCombined sources1
Modified residuei18PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86UX6
MaxQBiQ86UX6
PaxDbiQ86UX6
PeptideAtlasiQ86UX6
PRIDEiQ86UX6
ProteomicsDBi69930
69931 [Q86UX6-2]

PTM databases

iPTMnetiQ86UX6
PhosphoSitePlusiQ86UX6

Expressioni

Gene expression databases

BgeeiENSG00000165752 Expressed in 140 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_STK32C
ExpressionAtlasiQ86UX6 baseline and differential
GenevisibleiQ86UX6 HS

Organism-specific databases

HPAiHPA017894

Interactioni

Protein-protein interaction databases

BioGridi129429, 9 interactors
IntActiQ86UX6, 3 interactors
STRINGi9606.ENSP00000298630

Chemistry databases

BindingDBiQ86UX6

Structurei

3D structure databases

ProteinModelPortaliQ86UX6
SMRiQ86UX6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini93 – 353Protein kinasePROSITE-ProRule annotationAdd BLAST261

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0598 Eukaryota
ENOG410XNPH LUCA
GeneTreeiENSGT00920000148962
HOGENOMiHOG000021314
HOVERGENiHBG106458
InParanoidiQ86UX6
KOiK08793
OMAiWSKEMVA
OrthoDBiEOG091G0XV4
PhylomeDBiQ86UX6
TreeFamiTF313395

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86UX6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRSGAERRGS SAAASPGSPP PGRARPAGSD APSALPPPAA GQPRARDSGD
60 70 80 90 100
VRSQPRPLFQ WSKWKKRMGS SMSAATARRP VFDDKEDVNF DHFQILRAIG
110 120 130 140 150
KGSFGKVCIV QKRDTEKMYA MKYMNKQQCI ERDEVRNVFR ELEILQEIEH
160 170 180 190 200
VFLVNLWYSF QDEEDMFMVV DLLLGGDLRY HLQQNVQFSE DTVRLYICEM
210 220 230 240 250
ALALDYLRGQ HIIHRDVKPD NILLDERGHA HLTDFNIATI IKDGERATAL
260 270 280 290 300
AGTKPYMAPE IFHSFVNGGT GYSFEVDWWS VGVMAYELLR GWRPYDIHSS
310 320 330 340 350
NAVESLVQLF STVSVQYVPT WSKEMVALLR KLLTVNPEHR LSSLQDVQAA
360 370 380 390 400
PALAGVLWDH LSEKRVEPGF VPNKGRLHCD PTFELEEMIL ESRPLHKKKK
410 420 430 440 450
RLAKNKSRDN SRDSSQSEND YLQDCLDAIQ QDFVIFNREK LKRSQDLPRE
460 470 480
PLPAPESRDA AEPVEDEAER SALPMCGPIC PSAGSG
Length:486
Mass (Da):54,994
Last modified:June 1, 2003 - v1
Checksum:i38FEFBB3863B21F3
GO
Isoform 21 Publication (identifier: Q86UX6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-117: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:369
Mass (Da):42,425
Checksum:i83C54C4AF7D792E5
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y349H0Y349_HUMAN
Serine/threonine-protein kinase 32C
STK32C
146Annotation score:
H0Y431H0Y431_HUMAN
Serine/threonine-protein kinase 32C
STK32C
102Annotation score:
A0A0A0MRK9A0A0A0MRK9_HUMAN
Serine/threonine-protein kinase 32C
STK32C
239Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025900334T → A1 PublicationCorresponds to variant dbSNP:rs17854384Ensembl.1
Natural variantiVAR_035637376R → H in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs764558009Ensembl.1
Natural variantiVAR_041170454A → T1 PublicationCorresponds to variant dbSNP:rs56109103Ensembl.1
Natural variantiVAR_041171467E → K1 PublicationCorresponds to variant dbSNP:rs55812591Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0519981 – 117Missing in isoform 2. 1 PublicationAdd BLAST117

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY098866 mRNA Translation: AAM21719.1
AL512622 Genomic DNA No translation available.
AL590105 Genomic DNA No translation available.
BC045760 mRNA Translation: AAH45760.1
CCDSiCCDS7666.1 [Q86UX6-1]
CCDS81525.1 [Q86UX6-2]
RefSeqiNP_001305808.1, NM_001318879.1 [Q86UX6-2]
NP_775846.2, NM_173575.3 [Q86UX6-1]
XP_011537995.1, XM_011539693.2 [Q86UX6-2]
XP_011537996.1, XM_011539694.1 [Q86UX6-2]
XP_011537997.1, XM_011539695.1 [Q86UX6-2]
XP_011537998.1, XM_011539696.1 [Q86UX6-2]
UniGeneiHs.469002
Hs.665362
Hs.671431
Hs.729440

Genome annotation databases

EnsembliENST00000298630; ENSP00000298630; ENSG00000165752 [Q86UX6-1]
ENST00000368622; ENSP00000357611; ENSG00000165752 [Q86UX6-2]
GeneIDi282974
KEGGihsa:282974
UCSCiuc001lld.2 human [Q86UX6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY098866 mRNA Translation: AAM21719.1
AL512622 Genomic DNA No translation available.
AL590105 Genomic DNA No translation available.
BC045760 mRNA Translation: AAH45760.1
CCDSiCCDS7666.1 [Q86UX6-1]
CCDS81525.1 [Q86UX6-2]
RefSeqiNP_001305808.1, NM_001318879.1 [Q86UX6-2]
NP_775846.2, NM_173575.3 [Q86UX6-1]
XP_011537995.1, XM_011539693.2 [Q86UX6-2]
XP_011537996.1, XM_011539694.1 [Q86UX6-2]
XP_011537997.1, XM_011539695.1 [Q86UX6-2]
XP_011537998.1, XM_011539696.1 [Q86UX6-2]
UniGeneiHs.469002
Hs.665362
Hs.671431
Hs.729440

3D structure databases

ProteinModelPortaliQ86UX6
SMRiQ86UX6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129429, 9 interactors
IntActiQ86UX6, 3 interactors
STRINGi9606.ENSP00000298630

Chemistry databases

BindingDBiQ86UX6
ChEMBLiCHEMBL5405

PTM databases

iPTMnetiQ86UX6
PhosphoSitePlusiQ86UX6

Polymorphism and mutation databases

BioMutaiSTK32C
DMDMi74762451

Proteomic databases

EPDiQ86UX6
MaxQBiQ86UX6
PaxDbiQ86UX6
PeptideAtlasiQ86UX6
PRIDEiQ86UX6
ProteomicsDBi69930
69931 [Q86UX6-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298630; ENSP00000298630; ENSG00000165752 [Q86UX6-1]
ENST00000368622; ENSP00000357611; ENSG00000165752 [Q86UX6-2]
GeneIDi282974
KEGGihsa:282974
UCSCiuc001lld.2 human [Q86UX6-1]

Organism-specific databases

CTDi282974
DisGeNETi282974
EuPathDBiHostDB:ENSG00000165752.16
GeneCardsiSTK32C
HGNCiHGNC:21332 STK32C
HPAiHPA017894
neXtProtiNX_Q86UX6
OpenTargetsiENSG00000165752
PharmGKBiPA134888050
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0598 Eukaryota
ENOG410XNPH LUCA
GeneTreeiENSGT00920000148962
HOGENOMiHOG000021314
HOVERGENiHBG106458
InParanoidiQ86UX6
KOiK08793
OMAiWSKEMVA
OrthoDBiEOG091G0XV4
PhylomeDBiQ86UX6
TreeFamiTF313395

Enzyme and pathway databases

SignaLinkiQ86UX6

Miscellaneous databases

ChiTaRSiSTK32C human
GenomeRNAii282974
PROiPR:Q86UX6

Gene expression databases

BgeeiENSG00000165752 Expressed in 140 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_STK32C
ExpressionAtlasiQ86UX6 baseline and differential
GenevisibleiQ86UX6 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiST32C_HUMAN
AccessioniPrimary (citable) accession number: Q86UX6
Secondary accession number(s): Q5T0Q5, Q86UE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: June 1, 2003
Last modified: October 10, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again