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Entry version 127 (12 Aug 2020)
Sequence version 2 (29 Apr 2008)
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Protein

Inter-alpha-trypsin inhibitor heavy chain H5

Gene

ITIH5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a tumor suppressor.

Caution

Conflict in position 933 in the human genome assembly due to a frameshift.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q86UX2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inter-alpha-trypsin inhibitor heavy chain H5
Short name:
ITI heavy chain H5
Short name:
ITI-HC5
Short name:
Inter-alpha-inhibitor heavy chain 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ITIH5
Synonyms:KIAA1953
ORF Names:PP14776, UNQ311/PRO354
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21449, ITIH5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609783, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86UX2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
80760

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134899668

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86UX2, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ITIH5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
187609608

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 16Sequence analysisAdd BLAST16
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000033140817 – 942Inter-alpha-trypsin inhibitor heavy chain H5Add BLAST926

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi231N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi421N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi508N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi776N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi795N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi862N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86UX2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q86UX2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86UX2

PeptideAtlas

More...
PeptideAtlasi
Q86UX2

PRoteomics IDEntifications database

More...
PRIDEi
Q86UX2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
69925 [Q86UX2-1]
69926 [Q86UX2-2]
69927 [Q86UX2-3]
69928 [Q86UX2-4]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1422, 5 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q86UX2, 8 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86UX2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86UX2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundantly expressed in placenta. Less abundant expression in mammary gland and ovary. Expression is barely detectable levels in all other tissues tested.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated in breast tumors.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
123294, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q86UX2, 9 interactors

Molecular INTeraction database

More...
MINTi
Q86UX2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000380333

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q86UX2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86UX2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 161VITPROSITE-ProRule annotationAdd BLAST127
Domaini295 – 478VWFAPROSITE-ProRule annotationAdd BLAST184

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ITIH family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QPS2, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86UX2

Database of Orthologous Groups

More...
OrthoDBi
955432at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86UX2

TreeFam database of animal gene trees

More...
TreeFami
TF328982

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010600, ITI_HC_C
IPR013694, VIT
IPR002035, VWF_A
IPR036465, vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06668, ITI_HC_C, 1 hit
PF08487, VIT, 1 hit
PF00092, VWA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00609, VIT, 1 hit
SM00327, VWA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300, SSF53300, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51468, VIT, 1 hit
PS50234, VWFA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86UX2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLLLGLCLG LSLCVGSQEE AQSWGHSSEQ DGLRVPRQVR LLQRLKTKPL
60 70 80 90 100
MTEFSVKSTI ISRYAFTTVS CRMLNRASED QDIEFQMQIP AAAFITNFTM
110 120 130 140 150
LIGDKVYQGE ITEREKKSGD RVKEKRNKTT EENGEKGTEI FRASAVIPSK
160 170 180 190 200
DKAAFFLSYE ELLQRRLGKY EHSISVRPQQ LSGRLSVDVN ILESAGIASL
210 220 230 240 250
EVLPLHNSRQ RGSGRGEDDS GPPPSTVINQ NETFANIIFK PTVVQQARIA
260 270 280 290 300
QNGILGDFII RYDVNREQSI GDIQVLNGYF VHYFAPKDLP PLPKNVVFVL
310 320 330 340 350
DSSASMVGTK LRQTKDALFT ILHDLRPQDR FSIIGFSNRI KVWKDHLISV
360 370 380 390 400
TPDSIRDGKV YIHHMSPTGG TDINGALQRA IRLLNKYVAH SGIGDRSVSL
410 420 430 440 450
IVFLTDGKPT VGETHTLKIL NNTREAARGQ VCIFTIGIGN DVDFRLLEKL
460 470 480 490 500
SLENCGLTRR VHEEEDAGSQ LIGFYDEIRT PLLSDIRIDY PPSSVVQATK
510 520 530 540 550
TLFPNYFNGS EIIIAGKLVD RKLDHLHVEV TASNSKKFII LKTDVPVRPQ
560 570 580 590 600
KAGKDVTGSP RPGGDGEGDT NHIERLWSYL TTKELLSSWL QSDDEPEKER
610 620 630 640 650
LRQRAQALAV SYRFLTPFTS MKLRGPVPRM DGLEEAHGMS AAMGPEPVVQ
660 670 680 690 700
SVRGAGTQPG PLLKKPYQPR IKISKTSVDG DPHFVVDFPL SRLTVCFNID
710 720 730 740 750
GQPGDILRLV SDHRDSGVTV NGELIGAPAP PNGHKKQRTY LRTITILINK
760 770 780 790 800
PERSYLEITP SRVILDGGDR LVLPCNQSVV VGSWGLEVSV SANANVTVTI
810 820 830 840 850
QGSIAFVILI HLYKKPAPFQ RHHLGFYIAN SEGLSSNCHG LLGQFLNQDA
860 870 880 890 900
RLTEDPAGPS QNLTHPLLLQ VGEGPEAVLT VKGHQVPVVW KQRKIYNGEE
910 920 930 940
QIDCWFARNN AAKLIDGEYK DYLAFHPFDT GMTLGQGMSR EL
Length:942
Mass (Da):104,576
Last modified:April 29, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1666BE1C9B90ED61
GO
Isoform 2 (identifier: Q86UX2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     667-694: YQPRIKISKTSVDGDPHFVVDFPLSRLT → NSVKKKQNKTKKRHGRDGVFPLHHLGIR
     695-942: Missing.

Show »
Length:694
Mass (Da):77,401
Checksum:i42882C40AA8E4634
GO
Isoform 3 (identifier: Q86UX2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-214: Missing.
     215-218: RGED → MRNY

Show »
Length:728
Mass (Da):80,664
Checksum:i11911A82F89BCECA
GO
Isoform 4 (identifier: Q86UX2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-449: Missing.
     450-473: LSLENCGLTRRVHEEEDAGSQLIG → MRTYDTPGTSMCIIPDDPHRNPRR
     678-693: VDGDPHFVVDFPLSRL → GKAKDAVVCGLRVRDV
     694-942: Missing.

Show »
Length:244
Mass (Da):27,191
Checksum:i5E73E0B94241F8AB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J2H1C9J2H1_HUMAN
Inter-alpha-trypsin inhibitor heavy...
ITIH5
942Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A096LP62A0A096LP62_HUMAN
Inter-alpha-trypsin inhibitor heavy...
ITIH5
728Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5E9D8G5E9D8_HUMAN
Inter-alpha (Globulin) inhibitor H5...
ITIH5 hCG_25113
702Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5A6H7C5A6_HUMAN
Inter-alpha-trypsin inhibitor heavy...
ITIH5
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAI12953 differs from that shown. Reason: Frameshift.Curated
The sequence CAI12955 differs from that shown. Reason: Frameshift.Curated
The sequence CAI16360 differs from that shown. Reason: Frameshift.Curated
The sequence CAI16363 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti188D → G in BAB55070 (PubMed:14702039).Curated1
Sequence conflicti337S → P in BAB55070 (PubMed:14702039).Curated1
Sequence conflicti343W → R in CAH10363 (PubMed:17974005).Curated1
Sequence conflicti936Q → R in AAO49812 (PubMed:14744536).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_042847139E → K. Corresponds to variant dbSNP:rs12761771Ensembl.1
Natural variantiVAR_042848207N → H. Corresponds to variant dbSNP:rs36056263Ensembl.1
Natural variantiVAR_055973421N → H. Corresponds to variant dbSNP:rs36056263Ensembl.1
Natural variantiVAR_061276496V → M. Corresponds to variant dbSNP:rs35892621Ensembl.1
Natural variantiVAR_042849570T → P4 PublicationsCorresponds to variant dbSNP:rs2275069Ensembl.1
Natural variantiVAR_042850629R → C. Corresponds to variant dbSNP:rs34213756Ensembl.1
Natural variantiVAR_055974925F → S2 PublicationsCorresponds to variant dbSNP:rs10795551Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0357271 – 449Missing in isoform 4. 1 PublicationAdd BLAST449
Alternative sequenceiVSP_0331881 – 214Missing in isoform 3. CuratedAdd BLAST214
Alternative sequenceiVSP_033189215 – 218RGED → MRNY in isoform 3. Curated4
Alternative sequenceiVSP_035728450 – 473LSLEN…SQLIG → MRTYDTPGTSMCIIPDDPHR NPRR in isoform 4. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_033190667 – 694YQPRI…LSRLT → NSVKKKQNKTKKRHGRDGVF PLHHLGIR in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_035729678 – 693VDGDP…PLSRL → GKAKDAVVCGLRVRDV in isoform 4. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_035730694 – 942Missing in isoform 4. 1 PublicationAdd BLAST249
Alternative sequenceiVSP_033191695 – 942Missing in isoform 2. 1 PublicationAdd BLAST248

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY238437 mRNA Translation: AAO49812.1
AY358426 mRNA Translation: AAQ88792.1
AK027375 mRNA Translation: BAB55070.1
AF318347 mRNA Translation: AAL55854.1
AL158044, AL355374 Genomic DNA Translation: CAI12953.1 Frameshift.
AL158044, AL355374 Genomic DNA Translation: CAI12955.1 Frameshift.
AL355374, AL158044 Genomic DNA Translation: CAI16360.1 Frameshift.
AL355374 Genomic DNA Translation: CAI16362.1
AL355374, AL158044 Genomic DNA Translation: CAI16363.1 Frameshift.
CH471072 Genomic DNA Translation: EAW86379.1
AB075833 mRNA Translation: BAB85539.1
CR627109 mRNA Translation: CAH10363.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS31139.2 [Q86UX2-1]
CCDS31140.2 [Q86UX2-3]

NCBI Reference Sequences

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RefSeqi
NP_001001851.1, NM_001001851.2
NP_085046.5, NM_030569.6

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000256861; ENSP00000256861; ENSG00000123243
ENST00000298441; ENSP00000298441; ENSG00000123243

Database of genes from NCBI RefSeq genomes

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GeneIDi
80760

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:80760

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY238437 mRNA Translation: AAO49812.1
AY358426 mRNA Translation: AAQ88792.1
AK027375 mRNA Translation: BAB55070.1
AF318347 mRNA Translation: AAL55854.1
AL158044, AL355374 Genomic DNA Translation: CAI12953.1 Frameshift.
AL158044, AL355374 Genomic DNA Translation: CAI12955.1 Frameshift.
AL355374, AL158044 Genomic DNA Translation: CAI16360.1 Frameshift.
AL355374 Genomic DNA Translation: CAI16362.1
AL355374, AL158044 Genomic DNA Translation: CAI16363.1 Frameshift.
CH471072 Genomic DNA Translation: EAW86379.1
AB075833 mRNA Translation: BAB85539.1
CR627109 mRNA Translation: CAH10363.1
CCDSiCCDS31139.2 [Q86UX2-1]
CCDS31140.2 [Q86UX2-3]
RefSeqiNP_001001851.1, NM_001001851.2
NP_085046.5, NM_030569.6

3D structure databases

SMRiQ86UX2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123294, 11 interactors
IntActiQ86UX2, 9 interactors
MINTiQ86UX2
STRINGi9606.ENSP00000380333

PTM databases

GlyConnecti1422, 5 N-Linked glycans (1 site)
GlyGeniQ86UX2, 8 sites
iPTMnetiQ86UX2
PhosphoSitePlusiQ86UX2

Polymorphism and mutation databases

BioMutaiITIH5
DMDMi187609608

Proteomic databases

jPOSTiQ86UX2
MassIVEiQ86UX2
PaxDbiQ86UX2
PeptideAtlasiQ86UX2
PRIDEiQ86UX2
ProteomicsDBi69925 [Q86UX2-1]
69926 [Q86UX2-2]
69927 [Q86UX2-3]
69928 [Q86UX2-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
80760

Genome annotation databases

EnsembliENST00000256861; ENSP00000256861; ENSG00000123243
ENST00000298441; ENSP00000298441; ENSG00000123243
GeneIDi80760
KEGGihsa:80760

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
80760
DisGeNETi80760

GeneCards: human genes, protein and diseases

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GeneCardsi
ITIH5
HGNCiHGNC:21449, ITIH5
MIMi609783, gene
neXtProtiNX_Q86UX2
PharmGKBiPA134899668

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QPS2, Eukaryota
InParanoidiQ86UX2
OrthoDBi955432at2759
PhylomeDBiQ86UX2
TreeFamiTF328982

Enzyme and pathway databases

PathwayCommonsiQ86UX2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
80760, 1 hit in 94 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ITIH5, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
80760
PharosiQ86UX2, Tbio

Protein Ontology

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PROi
PR:Q86UX2
RNActiQ86UX2, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR010600, ITI_HC_C
IPR013694, VIT
IPR002035, VWF_A
IPR036465, vWFA_dom_sf
PfamiView protein in Pfam
PF06668, ITI_HC_C, 1 hit
PF08487, VIT, 1 hit
PF00092, VWA, 1 hit
SMARTiView protein in SMART
SM00609, VIT, 1 hit
SM00327, VWA, 1 hit
SUPFAMiSSF53300, SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS51468, VIT, 1 hit
PS50234, VWFA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITIH5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86UX2
Secondary accession number(s): Q5T664
, Q5T665, Q5T666, Q6AI60, Q6UXB7, Q8TF48, Q8WYV2, Q96K70
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: August 12, 2020
This is version 127 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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