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UniProtKB - Q86UW9 (DTX2_HUMAN)

Entry version 149 (08 May 2019)
Sequence version 3 (21 Jun 2005)
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Protein

Probable E3 ubiquitin-protein ligase DTX2

Gene

DTX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.By similarity EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri412 – 473RING-typePROSITE-ProRule annotationAdd BLAST62

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processNotch signaling pathway, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable E3 ubiquitin-protein ligase DTX2 (EC:2.3.2.27By similarity)
Alternative name(s):
Protein deltex-2
Short name:
Deltex2
Short name:
hDTX2
RING finger protein 58
RING-type E3 ubiquitin transferase DTX2Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DTX2
Synonyms:KIAA1528, RNF58
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:15973 DTX2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613141 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q86UW9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		113878

Open Targets

More...OpenTargetsi		ENSG00000091073

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27515

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DTX2

Domain mapping of disease mutations (DMDM)

More...DMDMi		68067880

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002190831 – 622Probable E3 ubiquitin-protein ligase DTX2Add BLAST622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei213Asymmetric dimethylarginineCombined sources1
Modified residuei215Asymmetric dimethylarginineCombined sources1
Modified residuei233Asymmetric dimethylarginineCombined sources1
Modified residuei249N6-acetyllysineCombined sources1
Modified residuei256Omega-N-methylarginineCombined sources1
Modified residuei360PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q86UW9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q86UW9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q86UW9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q86UW9

PeptideAtlas

More...PeptideAtlasi		Q86UW9

PRoteomics IDEntifications database

More...PRIDEi		Q86UW9

ProteomicsDB human proteome resource

More...ProteomicsDBi		69923
69924 [Q86UW9-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q86UW9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q86UW9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000091073 Expressed in 142 organ(s), highest expression level in lower esophagus mucosa

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q86UW9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q86UW9 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA042931

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. May form a heterodimer with other members of the Deltex family. Interacts with NOTCH1.By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		125266, 48 interactors

Protein interaction database and analysis system

More...IntActi		Q86UW9, 126 interactors

Molecular INTeraction database

More...MINTi		Q86UW9

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000322885

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q86UW9

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 97WWE 1PROSITE-ProRule annotationAdd BLAST90
Domaini98 – 174WWE 2PROSITE-ProRule annotationAdd BLAST77

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Deltex family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri412 – 473RING-typePROSITE-ProRule annotationAdd BLAST62

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IEMS Eukaryota
ENOG4111EY2 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157641

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000007352

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q86UW9

KEGG Orthology (KO)

More...KOi		K06058

Identification of Orthologs from Complete Genome Data

More...OMAi		ICYLPDC

Database of Orthologous Groups

More...OrthoDBi		600021at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q86UW9

Family and domain databases

Conserved Domains Database

More...CDDi		cd09633 Deltex_C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.390.130, 1 hit
3.30.40.10, 1 hit
3.30.720.50, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039396 Deltex_C
IPR039399 Deltex_C_sf
IPR039398 Deltex_fam
IPR004170 WWE-dom
IPR018123 WWE-dom_subgr
IPR037197 WWE_dom_sf
IPR018957 Znf_C3HC4_RING-type
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD

The PANTHER Classification System

More...PANTHERi		PTHR12622 PTHR12622, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF18102 DTC, 1 hit
PF02825 WWE, 2 hits
PF00097 zf-C3HC4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00184 RING, 1 hit
SM00678 WWE, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF117839 SSF117839, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50918 WWE, 2 hits
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86UW9-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAMAPSPSLV QVYTSPAAVA VWEWQDGLGT WHPYSATVCS FIEQQFVQQK 
        60         70         80         90        100
GQRFGLGSLA HSIPLGQADP SLAPYIIDLP SWTQFRQDTG TMRAVRRHLF 
       110        120        130        140        150
PQHSAPGRGV VWEWLSDDGS WTAYEASVCD YLEQQVARGN QLVDLAPLGY 
       160        170        180        190        200
NYTVNYTTHT QTNKTSSFCR SVRRQAGPPY PVTTIIAPPG HTGVACSCHQ 
       210        220        230        240        250
CLSGSRTGPV SGRYRHSMTN LPAYPVPQHP PHRTASVFGT HQAFAPYNKP 
       260        270        280        290        300
SLSGARSAPR LNTTNAWGAA PPSLGSQPLY RSSLSHLGPQ HLPPGSSTSG 
       310        320        330        340        350
AVSASLPSGP SSSPGSVPAT VPMQMPKPSR VQQALAGMTS VLMSAIGLPV 
       360        370        380        390        400
CLSRAPQPTS PPASRLASKS HGSVKRLRKM SVKGATPKPE PEPEQVIKNY 
       410        420        430        440        450
TEELKVPPDE DCIICMEKLS TASGYSDVTD SKAIGSLAVG HLTKCSHAFH 
       460        470        480        490        500
LLCLLAMYCN GNKDGSLQCP SCKTIYGEKT GTQPQGKMEV LRFQMSLPGH 
       510        520        530        540        550
EDCGTILIVY SIPHGIQGPE HPNPGKPFTA RGFPRQCYLP DNAQGRKVLE 
       560        570        580        590        600
LLKVAWKRRL IFTVGTSSTT GETDTVVWNE IHHKTEMDRN ITGHGYPDPN 
       610        620 
YLQNVLAELA AQGVTEDCLE QQ
Length:622
Mass (Da):67,246
Last modified:June 21, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iABE1398204F2273A
GO
Isoform 2 (identifier: Q86UW9-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     337-383: Missing.

Show »
Length:575
Mass (Da):62,344
Checksum:i449202FB53C026B3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ET89E7ET89_HUMAN
Probable E3 ubiquitin-protein ligas...
DTX2
531Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JII1C9JII1_HUMAN
Probable E3 ubiquitin-protein ligas...
DTX2
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JEH4C9JEH4_HUMAN
Probable E3 ubiquitin-protein ligas...
DTX2
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JY61C9JY61_HUMAN
Probable E3 ubiquitin-protein ligas...
DTX2
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q75MM6Q75MM6_HUMAN
Probable E3 ubiquitin-protein ligas...
DTX2
212Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JF39C9JF39_HUMAN
Probable E3 ubiquitin-protein ligas...
DTX2
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JVC8C9JVC8_HUMAN
Probable E3 ubiquitin-protein ligas...
DTX2
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3B8H7C3B8_HUMAN
Probable E3 ubiquitin-protein ligas...
DTX2
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JS11C9JS11_HUMAN
Probable E3 ubiquitin-protein ligas...
DTX2
28Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JLU8C9JLU8_HUMAN
Probable E3 ubiquitin-protein ligas...
DTX2
25Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA96052 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01692094A → T. Corresponds to variant dbSNP:rs2462312Ensembl.1
Natural variantiVAR_016921384G → E3 PublicationsCorresponds to variant dbSNP:rs1638152Ensembl.1
Natural variantiVAR_016922421T → A3 PublicationsCorresponds to variant dbSNP:rs6979487Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_008350337 – 383Missing in isoform 2. CuratedAdd BLAST47

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY225124 mRNA Translation: AAP57518.1
AY225125 mRNA Translation: AAP57519.1
DQ010329 mRNA Translation: AAY27263.1
AB040961 mRNA Translation: BAA96052.1 Different initiation.
AK023924 mRNA Translation: BAB14727.1
AC005522 Genomic DNA Translation: AAP21881.1
AC007078 Genomic DNA No translation available.
BC008856 mRNA Translation: AAH08856.1
BC018555 mRNA Translation: AAH18555.1
BC026059 mRNA Translation: AAH26059.1
BC093079 mRNA Translation: AAH93079.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS43605.1 [Q86UW9-2]
CCDS5587.1 [Q86UW9-1]

NCBI Reference Sequences

More...RefSeqi		NP_001096064.1, NM_001102594.1 [Q86UW9-1]
NP_001096065.1, NM_001102595.1 [Q86UW9-1]
NP_001096066.1, NM_001102596.1 [Q86UW9-2]
NP_065943.2, NM_020892.2 [Q86UW9-1]
XP_005250188.1, XM_005250131.1 [Q86UW9-1]
XP_005250189.1, XM_005250132.1 [Q86UW9-1]
XP_011514074.1, XM_011515772.1 [Q86UW9-1]
XP_011514075.1, XM_011515773.2 [Q86UW9-1]
XP_011514076.1, XM_011515774.1 [Q86UW9-1]
XP_011514077.1, XM_011515775.1 [Q86UW9-1]
XP_016867212.1, XM_017011723.1 [Q86UW9-1]
XP_016867213.1, XM_017011724.1 [Q86UW9-1]
XP_016867214.1, XM_017011725.1 [Q86UW9-1]
XP_016867215.1, XM_017011726.1 [Q86UW9-2]
XP_016867216.1, XM_017011727.1 [Q86UW9-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000324432; ENSP00000322885; ENSG00000091073 [Q86UW9-1]
ENST00000413936; ENSP00000390218; ENSG00000091073 [Q86UW9-1]
ENST00000430490; ENSP00000411986; ENSG00000091073 [Q86UW9-1]
ENST00000446820; ENSP00000392545; ENSG00000091073 [Q86UW9-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		113878

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:113878

UCSC genome browser

More...UCSCi		uc003uff.5 human [Q86UW9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY225124 mRNA Translation: AAP57518.1
AY225125 mRNA Translation: AAP57519.1
DQ010329 mRNA Translation: AAY27263.1
AB040961 mRNA Translation: BAA96052.1 Different initiation.
AK023924 mRNA Translation: BAB14727.1
AC005522 Genomic DNA Translation: AAP21881.1
AC007078 Genomic DNA No translation available.
BC008856 mRNA Translation: AAH08856.1
BC018555 mRNA Translation: AAH18555.1
BC026059 mRNA Translation: AAH26059.1
BC093079 mRNA Translation: AAH93079.1
CCDSiCCDS43605.1 [Q86UW9-2]
CCDS5587.1 [Q86UW9-1]
RefSeqiNP_001096064.1, NM_001102594.1 [Q86UW9-1]
NP_001096065.1, NM_001102595.1 [Q86UW9-1]
NP_001096066.1, NM_001102596.1 [Q86UW9-2]
NP_065943.2, NM_020892.2 [Q86UW9-1]
XP_005250188.1, XM_005250131.1 [Q86UW9-1]
XP_005250189.1, XM_005250132.1 [Q86UW9-1]
XP_011514074.1, XM_011515772.1 [Q86UW9-1]
XP_011514075.1, XM_011515773.2 [Q86UW9-1]
XP_011514076.1, XM_011515774.1 [Q86UW9-1]
XP_011514077.1, XM_011515775.1 [Q86UW9-1]
XP_016867212.1, XM_017011723.1 [Q86UW9-1]
XP_016867213.1, XM_017011724.1 [Q86UW9-1]
XP_016867214.1, XM_017011725.1 [Q86UW9-1]
XP_016867215.1, XM_017011726.1 [Q86UW9-2]
XP_016867216.1, XM_017011727.1 [Q86UW9-2]

3D structure databases

SMRiQ86UW9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125266, 48 interactors
IntActiQ86UW9, 126 interactors
MINTiQ86UW9
STRINGi9606.ENSP00000322885

PTM databases

iPTMnetiQ86UW9
PhosphoSitePlusiQ86UW9

Polymorphism and mutation databases

BioMutaiDTX2
DMDMi68067880

Proteomic databases

EPDiQ86UW9
jPOSTiQ86UW9
MaxQBiQ86UW9
PaxDbiQ86UW9
PeptideAtlasiQ86UW9
PRIDEiQ86UW9
ProteomicsDBi69923
69924 [Q86UW9-2]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		113878
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324432; ENSP00000322885; ENSG00000091073 [Q86UW9-1]
ENST00000413936; ENSP00000390218; ENSG00000091073 [Q86UW9-1]
ENST00000430490; ENSP00000411986; ENSG00000091073 [Q86UW9-1]
ENST00000446820; ENSP00000392545; ENSG00000091073 [Q86UW9-2]
GeneIDi113878
KEGGihsa:113878
UCSCiuc003uff.5 human [Q86UW9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		113878
DisGeNETi113878

GeneCards: human genes, protein and diseases

More...GeneCardsi		DTX2
HGNCiHGNC:15973 DTX2
HPAiHPA042931
MIMi613141 gene
neXtProtiNX_Q86UW9
OpenTargetsiENSG00000091073
PharmGKBiPA27515

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IEMS Eukaryota
ENOG4111EY2 LUCA
GeneTreeiENSGT00940000157641
HOGENOMiHOG000007352
InParanoidiQ86UW9
KOiK06058
OMAiICYLPDC
OrthoDBi600021at2759
PhylomeDBiQ86UW9

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DTX2 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		DTX2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		113878

Protein Ontology

More...PROi		PR:Q86UW9

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000091073 Expressed in 142 organ(s), highest expression level in lower esophagus mucosa
ExpressionAtlasiQ86UW9 baseline and differential
GenevisibleiQ86UW9 HS

Family and domain databases

CDDicd09633 Deltex_C, 1 hit
Gene3Di3.30.390.130, 1 hit
3.30.40.10, 1 hit
3.30.720.50, 2 hits
InterProiView protein in InterPro
IPR039396 Deltex_C
IPR039399 Deltex_C_sf
IPR039398 Deltex_fam
IPR004170 WWE-dom
IPR018123 WWE-dom_subgr
IPR037197 WWE_dom_sf
IPR018957 Znf_C3HC4_RING-type
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR12622 PTHR12622, 1 hit
PfamiView protein in Pfam
PF18102 DTC, 1 hit
PF02825 WWE, 2 hits
PF00097 zf-C3HC4, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
SM00678 WWE, 2 hits
SUPFAMiSSF117839 SSF117839, 2 hits
PROSITEiView protein in PROSITE
PS50918 WWE, 2 hits
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDTX2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86UW9
Secondary accession number(s): Q4ZH49
, Q6XM87, Q6XM88, Q96H69, Q9H890, Q9P200
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: June 21, 2005
Last modified: May 8, 2019
This is version 149 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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