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Entry version 158 (02 Jun 2021)
Sequence version 2 (10 Jan 2006)
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Protein

Calcium-dependent secretion activator 2

Gene

CADPS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca2+-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processExocytosis, Protein transport, Transport
LigandCalcium, Lipid-binding, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q86UW7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcium-dependent secretion activator 2
Alternative name(s):
Calcium-dependent activator protein for secretion 2
Short name:
CAPS-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CADPS2
Synonyms:CAPS2, KIAA1591
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16018, CADPS2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609978, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86UW7

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000081803.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
93664

Open Targets

More...
OpenTargetsi
ENSG00000081803

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26025

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86UW7, Tbio

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB11093, Calcium citrate
DB11348, Calcium Phosphate
DB14481, Calcium phosphate dihydrate

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CADPS2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
85540964

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000538681 – 1296Calcium-dependent secretion activator 2Add BLAST1296

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei56PhosphoserineCombined sources1
Modified residuei58PhosphoserineCombined sources1
Modified residuei1290PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86UW7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86UW7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q86UW7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86UW7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86UW7

PeptideAtlas

More...
PeptideAtlasi
Q86UW7

PRoteomics IDEntifications database

More...
PRIDEi
Q86UW7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
69919 [Q86UW7-1]
69920 [Q86UW7-2]
69921 [Q86UW7-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86UW7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86UW7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed in all adult and fetal tissues examined, with the strongest expression in kidney and pancreas. In brain, it is expressed at high levels in cerebellum, to a lesser degree in cerebral cortex, occipital pole, and frontal and temporal lobes. Only weakly expressed in medulla, spinal cord and putamen.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000081803, Expressed in cerebellar vermis and 207 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86UW7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86UW7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000081803, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (By similarity).

Interacts with the dopamine receptor DRD2.

By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
125051, 15 interactors

Protein interaction database and analysis system

More...
IntActi
Q86UW7, 17 interactors

Molecular INTeraction database

More...
MINTi
Q86UW7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000398481

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q86UW7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86UW7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini350 – 464C2PROSITE-ProRule annotationAdd BLAST115
Domaini487 – 590PHPROSITE-ProRule annotationAdd BLAST104
Domaini885 – 1056MHD1PROSITE-ProRule annotationAdd BLAST172

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 78DisorderedSequence analysisAdd BLAST78
Regioni755 – 1074Interaction with DRD21 PublicationAdd BLAST320
Regioni1274 – 1296DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 17Acidic residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PH domain is essential for regulated exocytosis and binds phospholipids.By similarity

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3543, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00590000083094

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86UW7

Database of Orthologous Groups

More...
OrthoDBi
138870at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86UW7

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033227, CAPS
IPR010439, CAPS_dom
IPR014770, Munc13_1
IPR011993, PH-like_dom_sf
IPR001849, PH_domain

The PANTHER Classification System

More...
PANTHERi
PTHR12166, PTHR12166, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06292, DUF1041, 1 hit
PF00169, PH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01145, DUF1041, 1 hit
SM00233, PH, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004, C2, 1 hit
PS51258, MHD1, 1 hit
PS50003, PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86UW7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLDPSSSEEE SDEGLEEESR DVLVAAGSSQ RAPPAPTREG RRDAPGRAGG
60 70 80 90 100
GGAARSVSPS PSVLSEGRDE PQRQLDDEQE RRIRLQLYVF VVRCIAYPFN
110 120 130 140 150
AKQPTDMARR QQKLNKQQLQ LLKERFQAFL NGETQIVADE AFCNAVRSYY
160 170 180 190 200
EVFLKSDRVA RMVQSGGCSA NDFREVFKKN IEKRVRSLPE IDGLSKETVL
210 220 230 240 250
SSWIAKYDAI YRGEEDLCKQ PNRMALSAVS ELILSKEQLY EMFQQILGIK
260 270 280 290 300
KLEHQLLYNA CQLDNADEQA AQIRRELDGR LQLADKMAKE RKFPKFIAKD
310 320 330 340 350
MENMYIEELR SSVNLLMANL ESLPVSKGGP EFKLQKLKRS QNSAFLDIGD
360 370 380 390 400
ENEIQLSKSD VVLSFTLEIV IMEVQGLKSV APNRIVYCTM EVEGEKLQTD
410 420 430 440 450
QAEASRPQWG TQGDFTTTHP RPVVKVKLFT ESTGVLALED KELGRVILYP
460 470 480 490 500
TSNSSKSAEL HRMVVPKNSQ DSDLKIKLAV RMDKPAHMKH SGYLYALGQK
510 520 530 540 550
VWKRWKKRYF VLVQVSQYTF AMCSYREKKS EPQELMQLEG YTVDYTDPHP
560 570 580 590 600
GLQGGCMFFN AVKEGDTVIF ASDDEQDRIL WVQAMYRATG QSYKPVPAIQ
610 620 630 640 650
TQKLNPKGGT LHADAQLSGK DADRFQKHGM DEFISANPCK LDHAFLFRIL
660 670 680 690 700
QRQTLDHRLN DSYSCLGWFS PGQVFVLDEY CARYGVRGCH RHLCYLAELM
710 720 730 740 750
EHSENGAVID PTLLHYSFAF CASHVHGNRP DGIGTVSVEE KERFEEIKER
760 770 780 790 800
LSSLLENQIS HFRYCFPFGR PEGALKATLS LLERVLMKDI ATPIPAEEVK
810 820 830 840 850
KVVRKCLEKA ALINYTRLTE YAKIEETMNQ ASPARKLEEI LHLAELCIEV
860 870 880 890 900
LQQNEEHHAE GREAFAWWPD LLAEHAEKFW ALFTVDMDTA LEAQPQDSWD
910 920 930 940 950
SFPLFQLLNN FLRNDTLLCN GKFHKHLQEI FVPLVVRYVD LMESSIAQSI
960 970 980 990 1000
HRGFEQETWQ PVKNIANSLP NVALPKVPSL PLNLPQIPNI STASWMPSLY
1010 1020 1030 1040 1050
ESTNGSATSE DLFWKLDALQ MFVFDLHWPE QEFAHHLEQR LKLMASDMLE
1060 1070 1080 1090 1100
ACVKRTRTAF ELKLQKASKT TDLRIPASVC TMFNVLVDAK KQSTKLCALD
1110 1120 1130 1140 1150
GGQEQQYHSK IDDLIDNSVK EIISLLVSKF VSVLEGVLSK LSRYDEGTFF
1160 1170 1180 1190 1200
SSILSFTVKA AAKYVDVPKP GMDLADTYIM FVRQNQDILR EKVNEEMYIE
1210 1220 1230 1240 1250
KLFDQWYSSS MKVICVWLTD RLDLQLHIYQ LKTLIKIVKK TYRDFRLQGV
1260 1270 1280 1290
LEGTLNSKTY DTVHRRLTVE EATASVSEGG GLQGITMKDS DEEEEG
Length:1,296
Mass (Da):147,735
Last modified:January 10, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7BF3456F3D90410C
GO
Isoform 2 (identifier: Q86UW7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     618-621: SGKD → Y
     860-862: Missing.
     963-1003: KNIANSLPNVALPKVPSLPLNLPQIPNISTASWMPSLYEST → N
     1104-1104: E → EFGSQW

Show »
Length:1,255
Mass (Da):143,489
Checksum:iD13DA3579388CC04
GO
Isoform 3 (identifier: Q86UW7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     618-621: SGKD → Y
     860-862: Missing.
     963-1003: KNIANSLPNVALPKVPSLPLNLPQIPNISTASWMPSLYEST → N

Show »
Length:1,250
Mass (Da):142,883
Checksum:iC13FA0A5AC04DD7F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9IYE1C9IYE1_HUMAN
Calcium-dependent secretion activat...
CADPS2
1,294Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X1P3A0A087X1P3_HUMAN
Calcium-dependent secretion activat...
CADPS2
1,301Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W8P5F8W8P5_HUMAN
Calcium-dependent secretion activat...
CADPS2
1,194Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8B5H0Y8B5_HUMAN
Calcium-dependent secretion activat...
CADPS2
490Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BYR4H7BYR4_HUMAN
Calcium-dependent secretion activat...
CADPS2
899Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH54339 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AK098170 differs from that shown. Chimera.Curated
The sequence BAA91372 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15210 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti44 – 47APGR → GRG in AAN38707 (PubMed:12659812).Curated4
Sequence conflicti90F → L in AAP22132 (PubMed:14530279).Curated1
Sequence conflicti360D → G in AAP22132 (PubMed:14530279).Curated1
Sequence conflicti457S → T in AK098170 (PubMed:14702039).Curated1
Sequence conflicti488M → I in AAN38707 (PubMed:12659812).Curated1
Sequence conflicti579I → V in BAB15210 (PubMed:14702039).Curated1
Sequence conflicti1068S → G in BAB15210 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_024786298A → T1 PublicationCorresponds to variant dbSNP:rs17144625EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_016815618 – 621SGKD → Y in isoform 2 and isoform 3. 5 Publications4
Alternative sequenceiVSP_016816860 – 862Missing in isoform 2 and isoform 3. 5 Publications3
Alternative sequenceiVSP_016817963 – 1003KNIAN…LYEST → N in isoform 2 and isoform 3. 5 PublicationsAdd BLAST41
Alternative sequenceiVSP_0168181104E → EFGSQW in isoform 2. 5 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY264289 mRNA Translation: AAP22132.1
AF401638 mRNA Translation: AAN38707.1
AC004594 Genomic DNA No translation available.
AC004838 Genomic DNA No translation available.
AC004986 Genomic DNA No translation available.
AC006009 Genomic DNA No translation available.
AC006463 Genomic DNA No translation available.
AC015983 Genomic DNA No translation available.
AC091438 Genomic DNA No translation available.
CH236947 Genomic DNA Translation: EAL24339.1
BC054339 mRNA Translation: AAH54339.1 Sequence problems.
BC136601 mRNA Translation: AAI36602.1
BC144278 mRNA Translation: AAI44279.1
AK000768 mRNA Translation: BAA91372.1 Different initiation.
AK025672 mRNA Translation: BAB15210.1 Different initiation.
AK098170 mRNA No translation available.
AB046811 mRNA Translation: BAB13417.1
AL833058 mRNA Translation: CAH56288.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS47691.1 [Q86UW7-2]
CCDS55158.1 [Q86UW7-1]

NCBI Reference Sequences

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RefSeqi
NP_001009571.2, NM_001009571.3 [Q86UW7-2]
NP_001161412.1, NM_001167940.1
NP_060424.9, NM_017954.10 [Q86UW7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000412584; ENSP00000400401; ENSG00000081803 [Q86UW7-2]
ENST00000449022; ENSP00000398481; ENSG00000081803 [Q86UW7-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
93664

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:93664

UCSC genome browser

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UCSCi
uc064hnn.1, human [Q86UW7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY264289 mRNA Translation: AAP22132.1
AF401638 mRNA Translation: AAN38707.1
AC004594 Genomic DNA No translation available.
AC004838 Genomic DNA No translation available.
AC004986 Genomic DNA No translation available.
AC006009 Genomic DNA No translation available.
AC006463 Genomic DNA No translation available.
AC015983 Genomic DNA No translation available.
AC091438 Genomic DNA No translation available.
CH236947 Genomic DNA Translation: EAL24339.1
BC054339 mRNA Translation: AAH54339.1 Sequence problems.
BC136601 mRNA Translation: AAI36602.1
BC144278 mRNA Translation: AAI44279.1
AK000768 mRNA Translation: BAA91372.1 Different initiation.
AK025672 mRNA Translation: BAB15210.1 Different initiation.
AK098170 mRNA No translation available.
AB046811 mRNA Translation: BAB13417.1
AL833058 mRNA Translation: CAH56288.1
CCDSiCCDS47691.1 [Q86UW7-2]
CCDS55158.1 [Q86UW7-1]
RefSeqiNP_001009571.2, NM_001009571.3 [Q86UW7-2]
NP_001161412.1, NM_001167940.1
NP_060424.9, NM_017954.10 [Q86UW7-1]

3D structure databases

SMRiQ86UW7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi125051, 15 interactors
IntActiQ86UW7, 17 interactors
MINTiQ86UW7
STRINGi9606.ENSP00000398481

Chemistry databases

DrugBankiDB11093, Calcium citrate
DB11348, Calcium Phosphate
DB14481, Calcium phosphate dihydrate

PTM databases

iPTMnetiQ86UW7
PhosphoSitePlusiQ86UW7

Genetic variation databases

BioMutaiCADPS2
DMDMi85540964

Proteomic databases

EPDiQ86UW7
jPOSTiQ86UW7
MassIVEiQ86UW7
MaxQBiQ86UW7
PaxDbiQ86UW7
PeptideAtlasiQ86UW7
PRIDEiQ86UW7
ProteomicsDBi69919 [Q86UW7-1]
69920 [Q86UW7-2]
69921 [Q86UW7-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
31729, 61 antibodies

The DNASU plasmid repository

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DNASUi
93664

Genome annotation databases

EnsembliENST00000412584; ENSP00000400401; ENSG00000081803 [Q86UW7-2]
ENST00000449022; ENSP00000398481; ENSG00000081803 [Q86UW7-1]
GeneIDi93664
KEGGihsa:93664
UCSCiuc064hnn.1, human [Q86UW7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
93664
DisGeNETi93664

GeneCards: human genes, protein and diseases

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GeneCardsi
CADPS2
HGNCiHGNC:16018, CADPS2
HPAiENSG00000081803, Tissue enriched (brain)
MIMi609978, gene
neXtProtiNX_Q86UW7
OpenTargetsiENSG00000081803
PharmGKBiPA26025
VEuPathDBiHostDB:ENSG00000081803.15

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3543, Eukaryota
GeneTreeiENSGT00590000083094
InParanoidiQ86UW7
OrthoDBi138870at2759
PhylomeDBiQ86UW7

Enzyme and pathway databases

PathwayCommonsiQ86UW7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
93664, 6 hits in 985 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CADPS2, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CADPS2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
93664
PharosiQ86UW7, Tbio

Protein Ontology

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PROi
PR:Q86UW7
RNActiQ86UW7, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000081803, Expressed in cerebellar vermis and 207 other tissues
ExpressionAtlasiQ86UW7, baseline and differential
GenevisibleiQ86UW7, HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR033227, CAPS
IPR010439, CAPS_dom
IPR014770, Munc13_1
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
PANTHERiPTHR12166, PTHR12166, 1 hit
PfamiView protein in Pfam
PF06292, DUF1041, 1 hit
PF00169, PH, 1 hit
SMARTiView protein in SMART
SM01145, DUF1041, 1 hit
SM00233, PH, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 1 hit
PS51258, MHD1, 1 hit
PS50003, PH_DOMAIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAPS2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86UW7
Secondary accession number(s): A4D0X3
, B7ZM56, Q658Q2, Q7Z5T7, Q8IZW9, Q8N7M4, Q9H6P4, Q9HCI1, Q9NWK8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: June 2, 2021
This is version 158 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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