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Protein

Calcium-dependent secretion activator 2

Gene

CADPS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca2+-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processExocytosis, Protein transport, Transport
LigandCalcium, Lipid-binding, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-dependent secretion activator 2
Alternative name(s):
Calcium-dependent activator protein for secretion 2
Short name:
CAPS-2
Gene namesi
Name:CADPS2
Synonyms:CAPS2, KIAA1591
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000081803.15
HGNCiHGNC:16018 CADPS2
MIMi609978 gene
neXtProtiNX_Q86UW7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi93664
OpenTargetsiENSG00000081803
PharmGKBiPA26025

Polymorphism and mutation databases

BioMutaiCADPS2
DMDMi85540964

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000538681 – 1296Calcium-dependent secretion activator 2Add BLAST1296

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei56PhosphoserineCombined sources1
Modified residuei58PhosphoserineCombined sources1
Modified residuei1290PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86UW7
MaxQBiQ86UW7
PaxDbiQ86UW7
PeptideAtlasiQ86UW7
PRIDEiQ86UW7
ProteomicsDBi69919
69920 [Q86UW7-2]
69921 [Q86UW7-3]

PTM databases

iPTMnetiQ86UW7
PhosphoSitePlusiQ86UW7

Expressioni

Tissue specificityi

Widely expressed. Expressed in all adult and fetal tissues examined, with the strongest expression in kidney and pancreas. In brain, it is expressed at high levels in cerebellum, to a lesser degree in cerebral cortex, occipital pole, and frontal and temporal lobes. Only weakly expressed in medulla, spinal cord and putamen.1 Publication

Gene expression databases

BgeeiENSG00000081803 Expressed in 197 organ(s), highest expression level in cerebellar vermis
CleanExiHS_CAPS2
ExpressionAtlasiQ86UW7 baseline and differential
GenevisibleiQ86UW7 HS

Organism-specific databases

HPAiHPA056398

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with the dopamine receptor DRD2.By similarity1 Publication

Protein-protein interaction databases

BioGridi125051, 14 interactors
IntActiQ86UW7, 13 interactors
STRINGi9606.ENSP00000398481

Structurei

3D structure databases

ProteinModelPortaliQ86UW7
SMRiQ86UW7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini367 – 447C2Add BLAST81
Domaini487 – 590PHPROSITE-ProRule annotationAdd BLAST104
Domaini885 – 1056MHD1PROSITE-ProRule annotationAdd BLAST172

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni755 – 1074Interaction with DRD21 PublicationAdd BLAST320

Domaini

The PH domain is essential for regulated exocytosis and binds phospholipids.By similarity

Phylogenomic databases

eggNOGiKOG3543 Eukaryota
ENOG410Y0FD LUCA
GeneTreeiENSGT00590000083094
HOVERGENiHBG080678
InParanoidiQ86UW7
KOiK19933
PhylomeDBiQ86UW7

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR033227 CAPS
IPR010439 CAPS_dom
IPR014770 Munc13_1
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR12166 PTHR12166, 1 hit
PfamiView protein in Pfam
PF06292 DUF1041, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM01145 DUF1041, 1 hit
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS51258 MHD1, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86UW7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLDPSSSEEE SDEGLEEESR DVLVAAGSSQ RAPPAPTREG RRDAPGRAGG
60 70 80 90 100
GGAARSVSPS PSVLSEGRDE PQRQLDDEQE RRIRLQLYVF VVRCIAYPFN
110 120 130 140 150
AKQPTDMARR QQKLNKQQLQ LLKERFQAFL NGETQIVADE AFCNAVRSYY
160 170 180 190 200
EVFLKSDRVA RMVQSGGCSA NDFREVFKKN IEKRVRSLPE IDGLSKETVL
210 220 230 240 250
SSWIAKYDAI YRGEEDLCKQ PNRMALSAVS ELILSKEQLY EMFQQILGIK
260 270 280 290 300
KLEHQLLYNA CQLDNADEQA AQIRRELDGR LQLADKMAKE RKFPKFIAKD
310 320 330 340 350
MENMYIEELR SSVNLLMANL ESLPVSKGGP EFKLQKLKRS QNSAFLDIGD
360 370 380 390 400
ENEIQLSKSD VVLSFTLEIV IMEVQGLKSV APNRIVYCTM EVEGEKLQTD
410 420 430 440 450
QAEASRPQWG TQGDFTTTHP RPVVKVKLFT ESTGVLALED KELGRVILYP
460 470 480 490 500
TSNSSKSAEL HRMVVPKNSQ DSDLKIKLAV RMDKPAHMKH SGYLYALGQK
510 520 530 540 550
VWKRWKKRYF VLVQVSQYTF AMCSYREKKS EPQELMQLEG YTVDYTDPHP
560 570 580 590 600
GLQGGCMFFN AVKEGDTVIF ASDDEQDRIL WVQAMYRATG QSYKPVPAIQ
610 620 630 640 650
TQKLNPKGGT LHADAQLSGK DADRFQKHGM DEFISANPCK LDHAFLFRIL
660 670 680 690 700
QRQTLDHRLN DSYSCLGWFS PGQVFVLDEY CARYGVRGCH RHLCYLAELM
710 720 730 740 750
EHSENGAVID PTLLHYSFAF CASHVHGNRP DGIGTVSVEE KERFEEIKER
760 770 780 790 800
LSSLLENQIS HFRYCFPFGR PEGALKATLS LLERVLMKDI ATPIPAEEVK
810 820 830 840 850
KVVRKCLEKA ALINYTRLTE YAKIEETMNQ ASPARKLEEI LHLAELCIEV
860 870 880 890 900
LQQNEEHHAE GREAFAWWPD LLAEHAEKFW ALFTVDMDTA LEAQPQDSWD
910 920 930 940 950
SFPLFQLLNN FLRNDTLLCN GKFHKHLQEI FVPLVVRYVD LMESSIAQSI
960 970 980 990 1000
HRGFEQETWQ PVKNIANSLP NVALPKVPSL PLNLPQIPNI STASWMPSLY
1010 1020 1030 1040 1050
ESTNGSATSE DLFWKLDALQ MFVFDLHWPE QEFAHHLEQR LKLMASDMLE
1060 1070 1080 1090 1100
ACVKRTRTAF ELKLQKASKT TDLRIPASVC TMFNVLVDAK KQSTKLCALD
1110 1120 1130 1140 1150
GGQEQQYHSK IDDLIDNSVK EIISLLVSKF VSVLEGVLSK LSRYDEGTFF
1160 1170 1180 1190 1200
SSILSFTVKA AAKYVDVPKP GMDLADTYIM FVRQNQDILR EKVNEEMYIE
1210 1220 1230 1240 1250
KLFDQWYSSS MKVICVWLTD RLDLQLHIYQ LKTLIKIVKK TYRDFRLQGV
1260 1270 1280 1290
LEGTLNSKTY DTVHRRLTVE EATASVSEGG GLQGITMKDS DEEEEG
Length:1,296
Mass (Da):147,735
Last modified:January 10, 2006 - v2
Checksum:i7BF3456F3D90410C
GO
Isoform 2 (identifier: Q86UW7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     618-621: SGKD → Y
     860-862: Missing.
     963-1003: KNIANSLPNVALPKVPSLPLNLPQIPNISTASWMPSLYEST → N
     1104-1104: E → EFGSQW

Show »
Length:1,255
Mass (Da):143,489
Checksum:iD13DA3579388CC04
GO
Isoform 3 (identifier: Q86UW7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     618-621: SGKD → Y
     860-862: Missing.
     963-1003: KNIANSLPNVALPKVPSLPLNLPQIPNISTASWMPSLYEST → N

Note: No experimental confirmation available.
Show »
Length:1,250
Mass (Da):142,883
Checksum:iC13FA0A5AC04DD7F
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9IYE1C9IYE1_HUMAN
Calcium-dependent secretion activat...
CADPS2
1,294Annotation score:
A0A087X1P3A0A087X1P3_HUMAN
Calcium-dependent secretion activat...
CADPS2
1,301Annotation score:
F8W8P5F8W8P5_HUMAN
Calcium-dependent secretion activat...
CADPS2
1,194Annotation score:
H0Y8B5H0Y8B5_HUMAN
Calcium-dependent secretion activat...
CADPS2
490Annotation score:
H7BYR4H7BYR4_HUMAN
Calcium-dependent secretion activat...
CADPS2
899Annotation score:

Sequence cautioni

The sequence AAH54339 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AK098170 differs from that shown. Chimera.Curated
The sequence BAA91372 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15210 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44 – 47APGR → GRG in AAN38707 (PubMed:12659812).Curated4
Sequence conflicti90F → L in AAP22132 (PubMed:14530279).Curated1
Sequence conflicti360D → G in AAP22132 (PubMed:14530279).Curated1
Sequence conflicti457S → T in AK098170 (PubMed:14702039).Curated1
Sequence conflicti488M → I in AAN38707 (PubMed:12659812).Curated1
Sequence conflicti579I → V in BAB15210 (PubMed:14702039).Curated1
Sequence conflicti1068S → G in BAB15210 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024786298A → T1 PublicationCorresponds to variant dbSNP:rs17144625Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016815618 – 621SGKD → Y in isoform 2 and isoform 3. 5 Publications4
Alternative sequenceiVSP_016816860 – 862Missing in isoform 2 and isoform 3. 5 Publications3
Alternative sequenceiVSP_016817963 – 1003KNIAN…LYEST → N in isoform 2 and isoform 3. 5 PublicationsAdd BLAST41
Alternative sequenceiVSP_0168181104E → EFGSQW in isoform 2. 5 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY264289 mRNA Translation: AAP22132.1
AF401638 mRNA Translation: AAN38707.1
AC004594 Genomic DNA No translation available.
AC004838 Genomic DNA No translation available.
AC004986 Genomic DNA No translation available.
AC006009 Genomic DNA No translation available.
AC006463 Genomic DNA No translation available.
AC015983 Genomic DNA No translation available.
AC091438 Genomic DNA No translation available.
CH236947 Genomic DNA Translation: EAL24339.1
BC054339 mRNA Translation: AAH54339.1 Sequence problems.
BC136601 mRNA Translation: AAI36602.1
BC144278 mRNA Translation: AAI44279.1
AK000768 mRNA Translation: BAA91372.1 Different initiation.
AK025672 mRNA Translation: BAB15210.1 Different initiation.
AK098170 mRNA No translation available.
AB046811 mRNA Translation: BAB13417.1
AL833058 mRNA Translation: CAH56288.1
CCDSiCCDS47691.1 [Q86UW7-2]
CCDS55158.1 [Q86UW7-1]
RefSeqiNP_001009571.2, NM_001009571.3 [Q86UW7-2]
NP_001161412.1, NM_001167940.1
NP_060424.9, NM_017954.10 [Q86UW7-1]
UniGeneiHs.649459

Genome annotation databases

EnsembliENST00000412584; ENSP00000400401; ENSG00000081803 [Q86UW7-2]
ENST00000449022; ENSP00000398481; ENSG00000081803 [Q86UW7-1]
GeneIDi93664
KEGGihsa:93664
UCSCiuc064hnn.1 human [Q86UW7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY264289 mRNA Translation: AAP22132.1
AF401638 mRNA Translation: AAN38707.1
AC004594 Genomic DNA No translation available.
AC004838 Genomic DNA No translation available.
AC004986 Genomic DNA No translation available.
AC006009 Genomic DNA No translation available.
AC006463 Genomic DNA No translation available.
AC015983 Genomic DNA No translation available.
AC091438 Genomic DNA No translation available.
CH236947 Genomic DNA Translation: EAL24339.1
BC054339 mRNA Translation: AAH54339.1 Sequence problems.
BC136601 mRNA Translation: AAI36602.1
BC144278 mRNA Translation: AAI44279.1
AK000768 mRNA Translation: BAA91372.1 Different initiation.
AK025672 mRNA Translation: BAB15210.1 Different initiation.
AK098170 mRNA No translation available.
AB046811 mRNA Translation: BAB13417.1
AL833058 mRNA Translation: CAH56288.1
CCDSiCCDS47691.1 [Q86UW7-2]
CCDS55158.1 [Q86UW7-1]
RefSeqiNP_001009571.2, NM_001009571.3 [Q86UW7-2]
NP_001161412.1, NM_001167940.1
NP_060424.9, NM_017954.10 [Q86UW7-1]
UniGeneiHs.649459

3D structure databases

ProteinModelPortaliQ86UW7
SMRiQ86UW7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125051, 14 interactors
IntActiQ86UW7, 13 interactors
STRINGi9606.ENSP00000398481

PTM databases

iPTMnetiQ86UW7
PhosphoSitePlusiQ86UW7

Polymorphism and mutation databases

BioMutaiCADPS2
DMDMi85540964

Proteomic databases

EPDiQ86UW7
MaxQBiQ86UW7
PaxDbiQ86UW7
PeptideAtlasiQ86UW7
PRIDEiQ86UW7
ProteomicsDBi69919
69920 [Q86UW7-2]
69921 [Q86UW7-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000412584; ENSP00000400401; ENSG00000081803 [Q86UW7-2]
ENST00000449022; ENSP00000398481; ENSG00000081803 [Q86UW7-1]
GeneIDi93664
KEGGihsa:93664
UCSCiuc064hnn.1 human [Q86UW7-1]

Organism-specific databases

CTDi93664
DisGeNETi93664
EuPathDBiHostDB:ENSG00000081803.15
GeneCardsiCADPS2
HGNCiHGNC:16018 CADPS2
HPAiHPA056398
MIMi609978 gene
neXtProtiNX_Q86UW7
OpenTargetsiENSG00000081803
PharmGKBiPA26025
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3543 Eukaryota
ENOG410Y0FD LUCA
GeneTreeiENSGT00590000083094
HOVERGENiHBG080678
InParanoidiQ86UW7
KOiK19933
PhylomeDBiQ86UW7

Miscellaneous databases

ChiTaRSiCADPS2 human
GeneWikiiCADPS2
GenomeRNAii93664
PROiPR:Q86UW7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000081803 Expressed in 197 organ(s), highest expression level in cerebellar vermis
CleanExiHS_CAPS2
ExpressionAtlasiQ86UW7 baseline and differential
GenevisibleiQ86UW7 HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR033227 CAPS
IPR010439 CAPS_dom
IPR014770 Munc13_1
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR12166 PTHR12166, 1 hit
PfamiView protein in Pfam
PF06292 DUF1041, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM01145 DUF1041, 1 hit
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS51258 MHD1, 1 hit
PS50003 PH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCAPS2_HUMAN
AccessioniPrimary (citable) accession number: Q86UW7
Secondary accession number(s): A4D0X3
, B7ZM56, Q658Q2, Q7Z5T7, Q8IZW9, Q8N7M4, Q9H6P4, Q9HCI1, Q9NWK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: October 10, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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