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Protein

Organic solute transporter subunit beta

Gene

SLC51B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.82.1.2 the organic solute transporter (ost) family

Names & Taxonomyi

Protein namesi
Recommended name:
Organic solute transporter subunit beta
Short name:
OST-beta
Alternative name(s):
Solute carrier family 51 subunit beta
Gene namesi
Name:SLC51B
Synonyms:OSTB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000186198.3
HGNCiHGNC:29956 SLC51B
MIMi612085 gene
neXtProtiNX_Q86UW2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35ExtracellularSequence analysisAdd BLAST35
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Topological domaini57 – 128CytoplasmicSequence analysisAdd BLAST72

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi123264
OpenTargetsiENSG00000186198

Chemistry databases

DrugBankiDB00286 Conjugated Equine Estrogens
DB00390 Digoxin
DB00917 Dinoprostone
DB04348 Taurocholic Acid

Polymorphism and mutation databases

BioMutaiSLC51B
DMDMi187471105

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003315541 – 128Organic solute transporter subunit betaAdd BLAST128

Proteomic databases

PaxDbiQ86UW2
PeptideAtlasiQ86UW2
PRIDEiQ86UW2
ProteomicsDBi69916

Expressioni

Tissue specificityi

Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland and fat.2 Publications

Inductioni

Positively regulated via NR1H4/FXR.2 Publications

Gene expression databases

BgeeiENSG00000186198
GenevisibleiQ86UW2 HS

Organism-specific databases

HPAiHPA008398
HPA008533

Interactioni

Subunit structurei

Interacts with SLC51A. The Ost-alpha/Ost-beta complex is a heterodimer composed of alpha (SLC51A) and beta (SLC51B) subunit; induces the transport of SLC51A from the reticulum endoplasmic to the plasma membrane (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ86UW2, 2 interactors
STRINGi9606.ENSP00000335292

Structurei

3D structure databases

ProteinModelPortaliQ86UW2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The transmembrane domain (TM) is the major site of interaction with SLC51A. The extracellular-membrane interface is absolutely required for transport activity. The intracellular-membrane interface is necessary for establishing the correct membrane orientation that is essential for the heterodimer Ost-alpha/Ost-beta complex formation and transport activity at the cell membrane surface (By similarity).By similarity

Sequence similaritiesi

Belongs to the OST-beta family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZ3B Eukaryota
ENOG410Z0B8 LUCA
GeneTreeiENSGT00390000010409
HOGENOMiHOG000115298
HOVERGENiHBG095150
InParanoidiQ86UW2
KOiK14361
OMAiEDATPWN
OrthoDBiEOG091G15A3
PhylomeDBiQ86UW2

Family and domain databases

InterProiView protein in InterPro
IPR029387 OSTbeta
PfamiView protein in Pfam
PF15048 OSTbeta, 1 hit

Sequencei

Sequence statusi: Complete.

Q86UW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHSEGAPGD PAGTVVPQEL LEEMLWFFRV EDASPWNHSI LALAAVVVII
60 70 80 90 100
SMVLLGRSIQ ASRKEKMQPP EKETPEVLHL DEAKDHNSLN NLRETLLSEK
110 120
PNLAQVELEL KERDVLSVFL PDVPETES
Length:128
Mass (Da):14,346
Last modified:April 29, 2008 - v2
Checksum:iA6D6F9391CB15794
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66K → T in AAP23992 (PubMed:12719432).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY194242 mRNA Translation: AAP23992.1
CH471082 Genomic DNA Translation: EAW77708.1
BC103842 mRNA Translation: AAI03843.1
BC103843 mRNA Translation: AAI03844.1
BC103844 mRNA Translation: AAI03845.1
CCDSiCCDS10199.1
RefSeqiNP_849190.2, NM_178859.3
XP_005254216.1, XM_005254159.4
UniGeneiHs.27018
Hs.534533

Genome annotation databases

EnsembliENST00000334287; ENSP00000335292; ENSG00000186198
GeneIDi123264
KEGGihsa:123264
UCSCiuc002aog.3 human

Similar proteinsi

Entry informationi

Entry nameiOSTB_HUMAN
AccessioniPrimary (citable) accession number: Q86UW2
Secondary accession number(s): Q3SYF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: June 20, 2018
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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