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Protein

Tripartite motif-containing protein 74

Gene

TRIM74

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 57RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri84 – 125B box-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 74
Alternative name(s):
Tripartite motif-containing protein 50C
Gene namesi
Name:TRIM74
Synonyms:TRIM50C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000155428.12
HGNCiHGNC:17453 TRIM74
MIMi612550 gene
neXtProtiNX_Q86UV6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi378108
OpenTargetsiENSG00000155428
PharmGKBiPA38454

Polymorphism and mutation databases

BioMutaiTRIM74
DMDMi56404879

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562791 – 250Tripartite motif-containing protein 74Add BLAST250

Proteomic databases

PaxDbiQ86UV6
PeptideAtlasiQ86UV6
PRIDEiQ86UV6
ProteomicsDBi69912
69913 [Q86UV6-2]

Expressioni

Gene expression databases

BgeeiENSG00000155428
CleanExiHS_TRIM74
GenevisibleiQ86UV6 HS

Organism-specific databases

HPAiHPA047843

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RELQ048643EBI-10259086,EBI-307352

Protein-protein interaction databases

BioGridi132031, 15 interactors
IntActiQ86UV6, 25 interactors
STRINGi9606.ENSP00000285805

Structurei

3D structure databases

ProteinModelPortaliQ86UV6
SMRiQ86UV6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili125 – 169Sequence analysisAdd BLAST45
Coiled coili204 – 235Sequence analysisAdd BLAST32

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 57RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri84 – 125B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
GeneTreeiENSGT00760000118838
HOGENOMiHOG000081784
HOVERGENiHBG094091
InParanoidiQ86UV6
KOiK12024
OMAiYCERIRE
OrthoDBiEOG091G04WT
PhylomeDBiQ86UV6
TreeFamiTF342569

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR027370 Znf-RING_LisH
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF00643 zf-B_box, 1 hit
PF13445 zf-RING_UBOX, 1 hit
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86UV6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAWQVSLLEL EDWLQCPICL EVFKESLMLQ CGHSYCKGCL VSLSYHLDTK
60 70 80 90 100
VRCPMCWQVV DGSSSLPNVS LAWVIEALRL PGDPEPKVCV HHRNPLSLFC
110 120 130 140 150
EKDQELICGL CGLLGSHQHH PVTPVSTVCS RMKEELAALF SELKQEQKKV
160 170 180 190 200
DELIAKLVKN RTRIVNESDV FSWVIRREFQ ELRHPVDEEK ARCLEGIGGH
210 220 230 240 250
TRGLVASLDM QLEQAQGTRE RLAQAECVLE QFGNEDHHEF IWKFHSMASR
Length:250
Mass (Da):28,547
Last modified:June 1, 2003 - v1
Checksum:i6B2F10940B04AC2B
GO
Isoform 2 (identifier: Q86UV6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     243-243: Missing.

Note: No experimental confirmation available.
Show »
Length:249
Mass (Da):28,419
Checksum:i5EB8FF5830F401E7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti128V → I in AAH33871 (PubMed:15489334).Curated1
Sequence conflicti159K → N in AAH33871 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03957613W → R1 PublicationCorresponds to variant dbSNP:rs121966Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032087243Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF498999 mRNA Translation: AAP30736.1
AC005488 Genomic DNA No translation available.
BC033871 mRNA Translation: AAH33871.1
CCDSiCCDS5545.1 [Q86UV6-1]
RefSeqiNP_001304744.1, NM_001317815.1 [Q86UV6-1]
NP_942150.1, NM_198853.2 [Q86UV6-1]
XP_011514489.1, XM_011516187.2 [Q86UV6-1]
XP_011514491.1, XM_011516189.2 [Q86UV6-2]
UniGeneiHs.645328

Genome annotation databases

EnsembliENST00000285805; ENSP00000285805; ENSG00000155428 [Q86UV6-1]
ENST00000395244; ENSP00000378665; ENSG00000155428 [Q86UV6-2]
GeneIDi378108
KEGGihsa:378108
UCSCiuc003tws.1 human [Q86UV6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTRI74_HUMAN
AccessioniPrimary (citable) accession number: Q86UV6
Secondary accession number(s): B7WP46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: June 1, 2003
Last modified: July 18, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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