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Entry version 154 (13 Feb 2019)
Sequence version 1 (01 Jun 2003)
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Protein

Ubiquitin carboxyl-terminal hydrolase 48

Gene

USP48

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites.1 Publication

Caution

Was termed (PubMed:15354349 and PubMed:17081983) USP31.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).1 Publication EC:3.4.19.12

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei98NucleophilePROSITE-ProRule annotation1
Active sitei353Proton acceptorPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5689880 Ub-specific processing proteases

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C19.068

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 48 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 48
Ubiquitin thioesterase 48
Ubiquitin-specific peptidase 48
Ubiquitin-specific protease 48
Ubiquitin-specific-processing protease 48
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:USP48
Synonyms:USP31
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000090686.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18533 USP48

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617445 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86UV5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84196

Open Targets

More...
OpenTargetsi
ENSG00000090686

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134947522

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
USP48

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74750436

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002495231 – 1035Ubiquitin carboxyl-terminal hydrolase 48Add BLAST1035

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei886PhosphoserineCombined sources1
Modified residuei887PhosphoserineCombined sources1
Modified residuei888PhosphoserineCombined sources1
Modified residuei956N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86UV5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86UV5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86UV5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86UV5

PeptideAtlas

More...
PeptideAtlasi
Q86UV5

PRoteomics IDEntifications database

More...
PRIDEi
Q86UV5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
69905
69906 [Q86UV5-2]
69907 [Q86UV5-3]
69908 [Q86UV5-4]
69909 [Q86UV5-5]
69910 [Q86UV5-6]
69911 [Q86UV5-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86UV5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86UV5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000090686 Expressed in 225 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86UV5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86UV5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA030045
HPA030046

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TRAF2 and RELA.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123941, 38 interactors

Protein interaction database and analysis system

More...
IntActi
Q86UV5, 5 interactors

Molecular INTeraction database

More...
MINTi
Q86UV5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000309262

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q86UV5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86UV5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini89 – 421USPAdd BLAST333
Domaini460 – 554DUSP 1PROSITE-ProRule annotationAdd BLAST95
Domaini569 – 691DUSP 2PROSITE-ProRule annotationAdd BLAST123
Domaini711 – 824DUSP 3PROSITE-ProRule annotationAdd BLAST114
Domaini929 – 1009Ubiquitin-likePROSITE-ProRule annotationAdd BLAST81

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1863 Eukaryota
COG5077 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156015

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231639

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG080368

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86UV5

KEGG Orthology (KO)

More...
KOi
K11858

Identification of Orthologs from Complete Genome Data

More...
OMAi
MGDGIQE

Database of Orthologous Groups

More...
OrthoDBi
113272at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86UV5

TreeFam database of animal gene trees

More...
TreeFami
TF106280

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02668 Peptidase_C19L, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035927 DUSP-like_sf
IPR038765 Papain_like_cys_pep_sf
IPR006615 Pept_C19_DUSP
IPR001394 Peptidase_C19_UCH
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
IPR033841 USP48
IPR018200 USP_CS
IPR028889 USP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00443 UCH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF143791 SSF143791, 1 hit
SSF54001 SSF54001, 1 hit
SSF54236 SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51283 DUSP, 3 hits
PS50053 UBIQUITIN_2, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86UV5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPRLQLEKA AWRWAETVRP EEVSQEHIET AYRIWLEPCI RGVCRRNCKG
60 70 80 90 100
NPNCLVGIGE HIWLGEIDEN SFHNIDDPNC ERRKKNSFVG LTNLGATCYV
110 120 130 140 150
NTFLQVWFLN LELRQALYLC PSTCSDYMLG DGIQEEKDYE PQTICEHLQY
160 170 180 190 200
LFALLQNSNR RYIDPSGFVK ALGLDTGQQQ DAQEFSKLFM SLLEDTLSKQ
210 220 230 240 250
KNPDVRNIVQ QQFCGEYAYV TVCNQCGRES KLLSKFYELE LNIQGHKQLT
260 270 280 290 300
DCISEFLKEE KLEGDNRYFC ENCQSKQNAT RKIRLLSLPC TLNLQLMRFV
310 320 330 340 350
FDRQTGHKKK LNTYIGFSEI LDMEPYVEHK GGSYVYELSA VLIHRGVSAY
360 370 380 390 400
SGHYIAHVKD PQSGEWYKFN DEDIEKMEGK KLQLGIEEDL AEPSKSQTRK
410 420 430 440 450
PKCGKGTHCS RNAYMLVYRL QTQEKPNTTV QVPAFLQELV DRDNSKFEEW
460 470 480 490 500
CIEMAEMRKQ SVDKGKAKHE EVKELYQRLP AGAEPYEFVS LEWLQKWLDE
510 520 530 540 550
STPTKPIDNH ACLCSHDKLH PDKISIMKRI SEYAADIFYS RYGGGPRLTV
560 570 580 590 600
KALCKECVVE RCRILRLKNQ LNEDYKTVNN LLKAAVKGSD GFWVGKSSLR
610 620 630 640 650
SWRQLALEQL DEQDGDAEQS NGKMNGSTLN KDESKEERKE EEELNFNEDI
660 670 680 690 700
LCPHGELCIS ENERRLVSKE AWSKLQQYFP KAPEFPSYKE CCSQCKILER
710 720 730 740 750
EGEENEALHK MIANEQKTSL PNLFQDKNRP CLSNWPEDTD VLYIVSQFFV
760 770 780 790 800
EEWRKFVRKP TRCSPVSSVG NSALLCPHGG LMFTFASMTK EDSKLIALIW
810 820 830 840 850
PSEWQMIQKL FVVDHVIKIT RIEVGDVNPS ETQYISEPKL CPECREGLLC
860 870 880 890 900
QQQRDLREYT QATIYVHKVV DNKKVMKDSA PELNVSSSET EEDKEEAKPD
910 920 930 940 950
GEKDPDFNQS NGGTKRQKIS HQNYIAYQKQ VIRRSMRHRK VRGEKALLVS
960 970 980 990 1000
ANQTLKELKI QIMHAFSVAP FDQNLSIDGK ILSDDCATLG TLGVIPESVI
1010 1020 1030
LLKADEPIAD YAAMDDVMQV CMPEEGFKGT GLLGH
Length:1,035
Mass (Da):119,032
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6F7DAF88527E2627
GO
Isoform 2 (identifier: Q86UV5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     909-960: Missing.

Note: No experimental confirmation available.
Show »
Length:983
Mass (Da):112,959
Checksum:iB19F5EC40029858F
GO
Isoform 3 (identifier: Q86UV5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     704-1035: Missing.

Note: No experimental confirmation available.
Show »
Length:703
Mass (Da):81,449
Checksum:iA7608F78005CF98D
GO
Isoform 4 (identifier: Q86UV5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     369-392: FNDEDIEKMEGKKLQLGIEEDLAE → LILNTNYHLPPSPKPIKIKNYNKP
     393-1035: Missing.

Note: No experimental confirmation available.
Show »
Length:392
Mass (Da):45,481
Checksum:i675B208E4EFA5350
GO
Isoform 5 (identifier: Q86UV5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-469: Missing.
     470-483: EEVKELYQRLPAGA → MNLSLSQKTVKIHRLFPMLAFS
     589-589: Missing.
     909-960: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:521
Mass (Da):59,454
Checksum:i20D3FA1221CF6383
GO
Isoform 6 (identifier: Q86UV5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-875: Missing.
     1020-1035: VCMPEEGFKGTGLLGH → GKDEFVLGIC

Note: No experimental confirmation available.
Show »
Length:154
Mass (Da):17,094
Checksum:iC8309D66B49A9AF6
GO
Isoform 7 (identifier: Q86UV5-7) [UniParc]FASTAAdd to basket
Also known as: USP31S1

The sequence of this isoform differs from the canonical sequence as follows:
     484-485: EP → GL
     486-1035: Missing.

Show »
Length:485
Mass (Da):56,151
Checksum:iE519B70ABF229820
GO
Isoform 8 (identifier: Q86UV5-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     391-391: Missing.
     654-654: H → HAVFFFSKYIFLNS

Note: No experimental confirmation available.
Show »
Length:1,047
Mass (Da):120,526
Checksum:i6DD9F285164E7ADD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PJH5E9PJH5_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP48
135Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BLX5H3BLX5_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP48
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MRS6A0A0A0MRS6_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP48
521Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJ93E9PJ93_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP48
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRY5E9PRY5_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP48
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJ87E9PJ87_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP48
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH13567 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH67261 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAI03725 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA92128 differs from that shown. Reason: Erroneous initiation.Curated
Isoform 5 : The sequence BAB15533 differs from that shown. Reason: Frameshift at position 109.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_027427125S → C. Corresponds to variant dbSNP:rs4253886Ensembl.1
Natural variantiVAR_027428135E → K. Corresponds to variant dbSNP:rs12097805Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0204711 – 875Missing in isoform 6. 1 PublicationAdd BLAST875
Alternative sequenceiVSP_0204721 – 469Missing in isoform 5. 1 PublicationAdd BLAST469
Alternative sequenceiVSP_020473369 – 392FNDED…EDLAE → LILNTNYHLPPSPKPIKIKN YNKP in isoform 4. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_054487391Missing in isoform 8. 1 Publication1
Alternative sequenceiVSP_020474393 – 1035Missing in isoform 4. 1 PublicationAdd BLAST643
Alternative sequenceiVSP_020475470 – 483EEVKE…LPAGA → MNLSLSQKTVKIHRLFPMLA FS in isoform 5. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_020476484 – 485EP → GL in isoform 7. Curated2
Alternative sequenceiVSP_020477486 – 1035Missing in isoform 7. CuratedAdd BLAST550
Alternative sequenceiVSP_020478589Missing in isoform 5. 1 Publication1
Alternative sequenceiVSP_054488654H → HAVFFFSKYIFLNS in isoform 8. 1 Publication1
Alternative sequenceiVSP_020479704 – 1035Missing in isoform 3. 1 PublicationAdd BLAST332
Alternative sequenceiVSP_020480909 – 960Missing in isoform 2 and isoform 5. 2 PublicationsAdd BLAST52
Alternative sequenceiVSP_0204811020 – 1035VCMPE…GLLGH → GKDEFVLGIC in isoform 6. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF502942 mRNA Translation: AAP30832.1
AL359815 Genomic DNA No translation available.
AL590103 Genomic DNA No translation available.
AK000110 mRNA Translation: BAA90950.1
AK002190 mRNA Translation: BAA92128.1 Different initiation.
AK026707 mRNA Translation: BAB15533.1 Frameshift.
AK026930 mRNA Translation: BAB15591.1
BC007326 mRNA Translation: AAH07326.2
BC013567 mRNA Translation: AAH13567.1 Different initiation.
BC067261 mRNA Translation: AAH67261.1 Sequence problems.
BC103724 mRNA Translation: AAI03725.1 Sequence problems.
BC104896 mRNA Translation: AAI04897.1
BC143354 mRNA Translation: AAI43355.1
AL834375 mRNA Translation: CAD39038.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30623.1 [Q86UV5-1]
CCDS44084.1 [Q86UV5-7]
CCDS81277.1 [Q86UV5-2]

NCBI Reference Sequences

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RefSeqi
NP_001027902.1, NM_001032730.1 [Q86UV5-7]
NP_001317323.1, NM_001330394.1 [Q86UV5-2]
NP_115612.4, NM_032236.6 [Q86UV5-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.467524

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000308271; ENSP00000309262; ENSG00000090686 [Q86UV5-1]
ENST00000400301; ENSP00000383157; ENSG00000090686 [Q86UV5-2]
ENST00000421625; ENSP00000406256; ENSG00000090686 [Q86UV5-7]
ENST00000529637; ENSP00000431949; ENSG00000090686 [Q86UV5-8]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84196

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84196

UCSC genome browser

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UCSCi
uc001bfb.4 human [Q86UV5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF502942 mRNA Translation: AAP30832.1
AL359815 Genomic DNA No translation available.
AL590103 Genomic DNA No translation available.
AK000110 mRNA Translation: BAA90950.1
AK002190 mRNA Translation: BAA92128.1 Different initiation.
AK026707 mRNA Translation: BAB15533.1 Frameshift.
AK026930 mRNA Translation: BAB15591.1
BC007326 mRNA Translation: AAH07326.2
BC013567 mRNA Translation: AAH13567.1 Different initiation.
BC067261 mRNA Translation: AAH67261.1 Sequence problems.
BC103724 mRNA Translation: AAI03725.1 Sequence problems.
BC104896 mRNA Translation: AAI04897.1
BC143354 mRNA Translation: AAI43355.1
AL834375 mRNA Translation: CAD39038.1
CCDSiCCDS30623.1 [Q86UV5-1]
CCDS44084.1 [Q86UV5-7]
CCDS81277.1 [Q86UV5-2]
RefSeqiNP_001027902.1, NM_001032730.1 [Q86UV5-7]
NP_001317323.1, NM_001330394.1 [Q86UV5-2]
NP_115612.4, NM_032236.6 [Q86UV5-1]
UniGeneiHs.467524

3D structure databases

ProteinModelPortaliQ86UV5
SMRiQ86UV5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123941, 38 interactors
IntActiQ86UV5, 5 interactors
MINTiQ86UV5
STRINGi9606.ENSP00000309262

Protein family/group databases

MEROPSiC19.068

PTM databases

iPTMnetiQ86UV5
PhosphoSitePlusiQ86UV5

Polymorphism and mutation databases

BioMutaiUSP48
DMDMi74750436

Proteomic databases

EPDiQ86UV5
jPOSTiQ86UV5
MaxQBiQ86UV5
PaxDbiQ86UV5
PeptideAtlasiQ86UV5
PRIDEiQ86UV5
ProteomicsDBi69905
69906 [Q86UV5-2]
69907 [Q86UV5-3]
69908 [Q86UV5-4]
69909 [Q86UV5-5]
69910 [Q86UV5-6]
69911 [Q86UV5-7]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308271; ENSP00000309262; ENSG00000090686 [Q86UV5-1]
ENST00000400301; ENSP00000383157; ENSG00000090686 [Q86UV5-2]
ENST00000421625; ENSP00000406256; ENSG00000090686 [Q86UV5-7]
ENST00000529637; ENSP00000431949; ENSG00000090686 [Q86UV5-8]
GeneIDi84196
KEGGihsa:84196
UCSCiuc001bfb.4 human [Q86UV5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84196
DisGeNETi84196
EuPathDBiHostDB:ENSG00000090686.15

GeneCards: human genes, protein and diseases

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GeneCardsi
USP48
HGNCiHGNC:18533 USP48
HPAiHPA030045
HPA030046
MIMi617445 gene
neXtProtiNX_Q86UV5
OpenTargetsiENSG00000090686
PharmGKBiPA134947522

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1863 Eukaryota
COG5077 LUCA
GeneTreeiENSGT00940000156015
HOGENOMiHOG000231639
HOVERGENiHBG080368
InParanoidiQ86UV5
KOiK11858
OMAiMGDGIQE
OrthoDBi113272at2759
PhylomeDBiQ86UV5
TreeFamiTF106280

Enzyme and pathway databases

ReactomeiR-HSA-5689880 Ub-specific processing proteases

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
USP48 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
USP48

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84196

Protein Ontology

More...
PROi
PR:Q86UV5

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000090686 Expressed in 225 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ86UV5 baseline and differential
GenevisibleiQ86UV5 HS

Family and domain databases

CDDicd02668 Peptidase_C19L, 1 hit
InterProiView protein in InterPro
IPR035927 DUSP-like_sf
IPR038765 Papain_like_cys_pep_sf
IPR006615 Pept_C19_DUSP
IPR001394 Peptidase_C19_UCH
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
IPR033841 USP48
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF00443 UCH, 1 hit
SUPFAMiSSF143791 SSF143791, 1 hit
SSF54001 SSF54001, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS51283 DUSP, 3 hits
PS50053 UBIQUITIN_2, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBP48_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86UV5
Secondary accession number(s): B7ZKS7
, Q2M3I4, Q5SZI4, Q5T3T5, Q6NX53, Q8N3F6, Q96F64, Q96IQ3, Q9H5N3, Q9H5T7, Q9NUJ6, Q9NXR0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: June 1, 2003
Last modified: February 13, 2019
This is version 154 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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