Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 112 (22 Apr 2020)
Sequence version 1 (01 Jun 2003)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Tachykinin-4

Gene

TAC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHypotensive agent

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tachykinin-4
Alternative name(s):
Preprotachykinin-C
Short name:
PPT-C
Cleaved into the following 3 chains:
Endokinin-A
Short name:
EKA
Endokinin-A/B
Short name:
EKA/B
Endokinin-C
Short name:
EKC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TAC4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16641 TAC4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607833 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86UU9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
255061

Open Targets

More...
OpenTargetsi
ENSG00000176358

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134944925

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86UU9 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TAC4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74723510

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_500006334621 – 67Endokinin-AAdd BLAST47
PeptideiPRO_000032001158 – 67Endokinin-A/B10
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000032001271 – 79By similarity9
PeptideiPRO_500006334782 – 95Endokinin-CAdd BLAST14
PropeptideiPRO_000032001398 – 113By similarityAdd BLAST16

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei67Methionine amide1 PublicationSequence analysis1
Modified residuei95Leucine amide1 PublicationSequence analysis1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86UU9

PRoteomics IDEntifications database

More...
PRIDEi
Q86UU9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
69900 [Q86UU9-1]
69901 [Q86UU9-2]
69902 [Q86UU9-3]
69903 [Q86UU9-4]
69904 [Q86UU9-5]

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at low levels in the uterus of both pregnant and non-pregnant women. Isoform 1 is found only in the adrenal gland and fetal liver. Isoform 2 is found in heart, liver, bone marrow, prostate, adrenal gland and testis. Isoform 3 and isoform 4 are expressed predominantly in adrenal gland and placenta.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000176358 Expressed in amniotic fluid and 126 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86UU9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86UU9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000176358 Tissue enhanced (liver, pituitary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
129073, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000334042

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q86UU9 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1113
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86UU9

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tachykinin family.Sequence analysis

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J2QI Eukaryota
ENOG41113ZV LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015220

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_2677305_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86UU9

KEGG Orthology (KO)

More...
KOi
K05241

Identification of Orthologs from Complete Genome Data

More...
OMAi
LMELFVC

Database of Orthologous Groups

More...
OrthoDBi
1512743at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86UU9

TreeFam database of animal gene trees

More...
TreeFami
TF338519

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013055 Tachy_Neuro_lke_CS

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00267 TACHYKININ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q86UU9-1) [UniParc]FASTAAdd to basket
Also known as: Alpha1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLPCLALLLL MELSVCTVAG DGGEEQTLST EAETWVIVAL EEGAGPSIQL
60 70 80 90 100
QLQEVKTGKA SQFFGLMGKR VGGRPLIQPR RKKAYQLEHT FQGLLGKRSL
110
FTEGREDEAQ GSE
Length:113
Mass (Da):12,305
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB8772582351C9163
GO
Isoform 21 Publication (identifier: Q86UU9-2) [UniParc]FASTAAdd to basket
Also known as: Beta1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     36-41: Missing.
     73-83: Missing.

Show »
Length:96
Mass (Da):10,350
Checksum:iEAC9D18849DAA790
GO
Isoform 31 Publication (identifier: Q86UU9-3) [UniParc]FASTAAdd to basket
Also known as: Gamma1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     36-41: Missing.
     84-103: Missing.

Show »
Length:87
Mass (Da):9,360
Checksum:i293F46CBFA82D37C
GO
Isoform 41 Publication (identifier: Q86UU9-4) [UniParc]FASTAAdd to basket
Also known as: Delta1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     36-41: Missing.
     75-105: Missing.

Show »
Length:76
Mass (Da):8,029
Checksum:i7B555CEC96EC1668
GO
Isoform 5 (identifier: Q86UU9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-41: Missing.

Show »
Length:107
Mass (Da):11,680
Checksum:iE0DABEE064F1F94C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RAS6D6RAS6_HUMAN
Tachykinin-4
TAC4
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI00841 differs from that shown. Intron retention.Curated
The sequence AAI00843 differs from that shown. Intron retention.Curated
The sequence AAI00844 differs from that shown. Intron retention.Curated
The sequence AAN77128 differs from that shown. Intron retention.Curated
The sequence EAW94657 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05267636 – 41Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 2 Publications6
Alternative sequenceiVSP_05267773 – 83Missing in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_05268075 – 105Missing in isoform 4. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_05268184 – 103Missing in isoform 3. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF515828 mRNA Translation: AAP30874.1
AF515829 mRNA Translation: AAP30875.1
AF515830 mRNA Translation: AAP30876.1
AF515831 mRNA Translation: AAP30877.1
AY471574 mRNA Translation: AAS46596.1
CH471109 Genomic DNA Translation: EAW94657.1 Sequence problems.
AF521560 mRNA Translation: AAN77128.1 Sequence problems.
BC100840 mRNA Translation: AAI00841.1 Sequence problems.
BC100842 mRNA Translation: AAI00843.1 Sequence problems.
BC100843 mRNA Translation: AAI00844.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42357.1 [Q86UU9-1]
CCDS42358.1 [Q86UU9-4]
CCDS42359.1 [Q86UU9-2]
CCDS42360.1 [Q86UU9-3]
CCDS45727.1 [Q86UU9-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001070971.1, NM_001077503.1 [Q86UU9-2]
NP_001070972.1, NM_001077504.1 [Q86UU9-3]
NP_001070973.1, NM_001077505.1 [Q86UU9-4]
NP_001070974.1, NM_001077506.1 [Q86UU9-5]
NP_733786.2, NM_170685.2 [Q86UU9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000326219; ENSP00000325286; ENSG00000176358 [Q86UU9-3]
ENST00000334568; ENSP00000334042; ENSG00000176358 [Q86UU9-1]
ENST00000352793; ENSP00000340461; ENSG00000176358 [Q86UU9-4]
ENST00000398154; ENSP00000381221; ENSG00000176358 [Q86UU9-2]
ENST00000436235; ENSP00000399702; ENSG00000176358 [Q86UU9-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
255061

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:255061

UCSC genome browser

More...
UCSCi
uc002ipo.1 human [Q86UU9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF515828 mRNA Translation: AAP30874.1
AF515829 mRNA Translation: AAP30875.1
AF515830 mRNA Translation: AAP30876.1
AF515831 mRNA Translation: AAP30877.1
AY471574 mRNA Translation: AAS46596.1
CH471109 Genomic DNA Translation: EAW94657.1 Sequence problems.
AF521560 mRNA Translation: AAN77128.1 Sequence problems.
BC100840 mRNA Translation: AAI00841.1 Sequence problems.
BC100842 mRNA Translation: AAI00843.1 Sequence problems.
BC100843 mRNA Translation: AAI00844.1 Sequence problems.
CCDSiCCDS42357.1 [Q86UU9-1]
CCDS42358.1 [Q86UU9-4]
CCDS42359.1 [Q86UU9-2]
CCDS42360.1 [Q86UU9-3]
CCDS45727.1 [Q86UU9-5]
RefSeqiNP_001070971.1, NM_001077503.1 [Q86UU9-2]
NP_001070972.1, NM_001077504.1 [Q86UU9-3]
NP_001070973.1, NM_001077505.1 [Q86UU9-4]
NP_001070974.1, NM_001077506.1 [Q86UU9-5]
NP_733786.2, NM_170685.2 [Q86UU9-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MOCNMR-A57-67[»]
SMRiQ86UU9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi129073, 2 interactors
STRINGi9606.ENSP00000334042

Polymorphism and mutation databases

BioMutaiTAC4
DMDMi74723510

Proteomic databases

PaxDbiQ86UU9
PRIDEiQ86UU9
ProteomicsDBi69900 [Q86UU9-1]
69901 [Q86UU9-2]
69902 [Q86UU9-3]
69903 [Q86UU9-4]
69904 [Q86UU9-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
68331 68 antibodies

Genome annotation databases

EnsembliENST00000326219; ENSP00000325286; ENSG00000176358 [Q86UU9-3]
ENST00000334568; ENSP00000334042; ENSG00000176358 [Q86UU9-1]
ENST00000352793; ENSP00000340461; ENSG00000176358 [Q86UU9-4]
ENST00000398154; ENSP00000381221; ENSG00000176358 [Q86UU9-2]
ENST00000436235; ENSP00000399702; ENSG00000176358 [Q86UU9-5]
GeneIDi255061
KEGGihsa:255061
UCSCiuc002ipo.1 human [Q86UU9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
255061
DisGeNETi255061

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TAC4
HGNCiHGNC:16641 TAC4
HPAiENSG00000176358 Tissue enhanced (liver, pituitary gland)
MIMi607833 gene
neXtProtiNX_Q86UU9
OpenTargetsiENSG00000176358
PharmGKBiPA134944925

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J2QI Eukaryota
ENOG41113ZV LUCA
GeneTreeiENSGT00390000015220
HOGENOMiCLU_2677305_0_0_1
InParanoidiQ86UU9
KOiK05241
OMAiLMELFVC
OrthoDBi1512743at2759
PhylomeDBiQ86UU9
TreeFamiTF338519

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TAC4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
255061
PharosiQ86UU9 Tbio

Protein Ontology

More...
PROi
PR:Q86UU9
RNActiQ86UU9 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000176358 Expressed in amniotic fluid and 126 other tissues
ExpressionAtlasiQ86UU9 baseline and differential
GenevisibleiQ86UU9 HS

Family and domain databases

InterProiView protein in InterPro
IPR013055 Tachy_Neuro_lke_CS
PROSITEiView protein in PROSITE
PS00267 TACHYKININ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTKN4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86UU9
Secondary accession number(s): Q2M2P1
, Q6ECK8, Q86UU6, Q86UU7, Q86UU8, Q8IWZ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 1, 2003
Last modified: April 22, 2020
This is version 112 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again