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Entry version 137 (31 Jul 2019)
Sequence version 1 (01 Jun 2003)
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Protein

Pleckstrin homology-like domain family B member 1

Gene

PHLDB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pleckstrin homology-like domain family B member 1
Alternative name(s):
Protein LL5-alpha
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PHLDB1
Synonyms:KIAA0638, LL5A
ORF Names:DLNB07
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23697 PHLDB1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612834 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86UU1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23187

Open Targets

More...
OpenTargetsi
ENSG00000019144

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134917952

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PHLDB1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74723506

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000538911 – 1377Pleckstrin homology-like domain family B member 1Add BLAST1377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei51PhosphoserineBy similarity1
Modified residuei131Asymmetric dimethylarginineBy similarity1
Modified residuei192PhosphoserineCombined sources1
Modified residuei220PhosphoserineCombined sources1
Modified residuei223PhosphoserineCombined sources1
Modified residuei324PhosphoserineCombined sources1
Modified residuei334PhosphoserineCombined sources1
Modified residuei381PhosphoserineBy similarity1
Modified residuei404PhosphoserineCombined sources1
Modified residuei430PhosphoserineCombined sources1
Modified residuei443PhosphoserineCombined sources1
Modified residuei461PhosphoserineCombined sources1
Modified residuei470PhosphoserineBy similarity1
Modified residuei489PhosphoserineCombined sources1
Modified residuei501PhosphoserineCombined sources1
Modified residuei512Omega-N-methylarginineBy similarity1
Modified residuei518PhosphoserineCombined sources1
Modified residuei520PhosphoserineCombined sources1
Modified residuei522PhosphothreonineCombined sources1
Modified residuei533PhosphoserineBy similarity1
Modified residuei539PhosphoserineBy similarity1
Modified residuei551PhosphoserineCombined sources1
Modified residuei555PhosphoserineCombined sources1
Modified residuei563PhosphoserineCombined sources1
Modified residuei578PhosphoserineCombined sources1
Modified residuei583PhosphoserineCombined sources1
Modified residuei678PhosphoserineCombined sources1
Modified residuei971PhosphoserineCombined sources1
Modified residuei1017PhosphoserineBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86UU1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86UU1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86UU1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86UU1

PeptideAtlas

More...
PeptideAtlasi
Q86UU1

PRoteomics IDEntifications database

More...
PRIDEi
Q86UU1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
69894 [Q86UU1-1]
69895 [Q86UU1-2]
69896 [Q86UU1-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86UU1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86UU1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000019144 Expressed in 232 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86UU1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86UU1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA037959
HPA038448
HPA061506

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116797, 13 interactors

Protein interaction database and analysis system

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IntActi
Q86UU1, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000354498

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86UU1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini64 – 125FHAAdd BLAST62
Domaini1256 – 1370PHPROSITE-ProRule annotationAdd BLAST115

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili683 – 809Sequence analysisAdd BLAST127
Coiled coili1144 – 1208Sequence analysisAdd BLAST65

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PH domain mediates the binding to phosphoinositides.

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410ISGZ Eukaryota
ENOG41101DY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155231

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000286004

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86UU1

Identification of Orthologs from Complete Genome Data

More...
OMAi
PKFGNGM

Database of Orthologous Groups

More...
OrthoDBi
70229at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86UU1

TreeFam database of animal gene trees

More...
TreeFami
TF329165

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00060 FHA, 1 hit
cd14673 PH_PHLDB1_2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000253 FHA_dom
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR037810 PHLDB1/2/3_PH
IPR008984 SMAD_FHA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00169 PH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49879 SSF49879, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86UU1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDALNRNQIG PGCQTQTMVQ KGPLDLIETG KGLKVQTDKP HLVSLGSGRL
60 70 80 90 100
STAITLLPLE EGRTVIGSAA RDISLQGPGL APEHCYIENL RGTLTLYPCG
110 120 130 140 150
NACTIDGLPV RQPTRLTQGC MLCLGQSTFL RFNHPAEAKW MKSMIPAGGR
160 170 180 190 200
APGPPYSPVP AESESLVNGN HTPQTATRGP SACASHSSLV SSIEKDLQEI
210 220 230 240 250
MDSLVLEEPG AAGKKPAATS PLSPMANGGR YLLSPPTSPG AMSVGSSYEN
260 270 280 290 300
TSPAFSPLSS PASSGSCASH SPSGQEPGPS VPPLVPARSS SYHLALQPPQ
310 320 330 340 350
SRPSGARSES PRLSRKGGHE RPPSPGLRGL LTDSPAATVL AEARRATESP
360 370 380 390 400
RLGGQLPVVA ISLSEYPASG ALSQPTSIPG SPKFQPPVPA PRNKIGTLQD
410 420 430 440 450
RPPSPFREPP GSERVLTTSP SRQLVGRTFS DGLATRTLQP PESPRLGRRG
460 470 480 490 500
LDSMRELPPL SPSLSRRALS PLPTRTTPDP KLNREVAESP RPRRWAAHGA
510 520 530 540 550
SPEDFSLTLG ARGRRTRSPS PTLGESLAPH KGSFSGRLSP AYSLGSLTGA
560 570 580 590 600
SPCQSPCVQR KLSSGDLRVP VTRERKNSIT EISDNEDDLL EYHRRQRQER
610 620 630 640 650
LREQEMERLE RQRLETILNL CAEYSRADGG PEAGELPSIG EATAALALAG
660 670 680 690 700
RRPSRGLAGA SGRSSEEPGV ATQRLWESME RSDEENLKEE CSSTESTQQE
710 720 730 740 750
HEDAPSTKLQ GEVLALEEER AQVLGHVEQL KVRVKELEQQ LQESAREAEM
760 770 780 790 800
ERALLQGERE AERALLQKEQ KAVDQLQEKL VALETGIQKE RDKEAEALET
810 820 830 840 850
ETKLFEDLEF QQLERESRVE EERELAGQGL LRSKAELLRS IAKRKERLAI
860 870 880 890 900
LDSQAGQIRA QAVQESERLA RDKNASLQLL QKEKEKLTVL ERRYHSLTGG
910 920 930 940 950
RPFPKTTSTL KEMEKLLLPA VDLEQWYQEL MAGLGTGPAA ASPHSSPPPL
960 970 980 990 1000
PAKASRQLQV YRSKMDGEAT SPLPRTRSGP LPSSSGSSSS SSQLSVATLG
1010 1020 1030 1040 1050
RSPSPKSALL TQNGTGSLPR NLAATLQDIE TKRQLALQQK GQQVIEEQRR
1060 1070 1080 1090 1100
RLAELKQKAA AEAQCQWDAL HGAAPFPAGP SGFPPLMHHS ILHHLPAGRE
1110 1120 1130 1140 1150
RGEEGEHAYD TLSLESSDSM ETSISTGGNS ACSPDNMSSA SGLDMGKIEE
1160 1170 1180 1190 1200
MEKMLKEAHA EKNRLMESRE REMELRRQAL EEERRRREQV ERRLQSESAR
1210 1220 1230 1240 1250
RQQLVEKEVK MREKQFSQAR PLTRYLPIRK EDFDLKTHIE SSGHGVDTCL
1260 1270 1280 1290 1300
HVVLSSKVCR GYLVKMGGKI KSWKKRWFVF DRLKRTLSYY VDKHETKLKG
1310 1320 1330 1340 1350
VIYFQAIEEV YYDHLRSAAK KRFFRFTMVT ESPNPALTFC VKTHDRLYYM
1360 1370
VAPSAEAMRI WMDVIVTGAE GYTQFMN
Note: Minor.
Length:1,377
Mass (Da):151,162
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDA2829CC9C2ECD3D
GO
Isoform 2 (identifier: Q86UU1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     913-959: Missing.
     1321-1331: Missing.

Note: Major.
Show »
Length:1,319
Mass (Da):144,739
Checksum:iFC6698DAB7F99188
GO
Isoform 3 (identifier: Q86UU1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     913-959: Missing.
     1042-1042: Q → E
     1043-1377: Missing.

Note: No experimental confirmation available.
Show »
Length:995
Mass (Da):107,381
Checksum:iD11D43C8C73BB999
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZL0A0A087WZL0_HUMAN
Pleckstrin homology-like domain fam...
PHLDB1
641Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WTZ7A0A087WTZ7_HUMAN
Pleckstrin homology-like domain fam...
PHLDB1
209Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WXY7A0A087WXY7_HUMAN
Pleckstrin homology-like domain fam...
PHLDB1
247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA31613 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB84896 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_016737913 – 959Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST47
Alternative sequenceiVSP_0167381042Q → E in isoform 3. 1 Publication1
Alternative sequenceiVSP_0167391043 – 1377Missing in isoform 3. 1 PublicationAdd BLAST335
Alternative sequenceiVSP_0167401321 – 1331Missing in isoform 2. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB094090 mRNA Translation: BAC76044.1
AB014538 mRNA Translation: BAA31613.2 Different initiation.
AK074070 mRNA Translation: BAB84896.2 Different initiation.
EF445008 Genomic DNA Translation: ACA06043.1
EF445008 Genomic DNA Translation: ACA06041.1
AP000941 Genomic DNA No translation available.
AP002954 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67401.1
BC098586 mRNA Translation: AAH98586.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44750.1 [Q86UU1-2]
CCDS8401.1 [Q86UU1-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001138230.1, NM_001144758.2 [Q86UU1-1]
NP_001138231.1, NM_001144759.2 [Q86UU1-2]
NP_055972.1, NM_015157.3 [Q86UU1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000356063; ENSP00000348359; ENSG00000019144 [Q86UU1-2]
ENST00000361417; ENSP00000354498; ENSG00000019144 [Q86UU1-1]
ENST00000528594; ENSP00000435520; ENSG00000019144 [Q86UU1-3]
ENST00000530994; ENSP00000431508; ENSG00000019144 [Q86UU1-3]
ENST00000600882; ENSP00000469820; ENSG00000019144 [Q86UU1-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23187

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23187

UCSC genome browser

More...
UCSCi
uc001ptr.3 human [Q86UU1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB094090 mRNA Translation: BAC76044.1
AB014538 mRNA Translation: BAA31613.2 Different initiation.
AK074070 mRNA Translation: BAB84896.2 Different initiation.
EF445008 Genomic DNA Translation: ACA06043.1
EF445008 Genomic DNA Translation: ACA06041.1
AP000941 Genomic DNA No translation available.
AP002954 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67401.1
BC098586 mRNA Translation: AAH98586.1
CCDSiCCDS44750.1 [Q86UU1-2]
CCDS8401.1 [Q86UU1-1]
RefSeqiNP_001138230.1, NM_001144758.2 [Q86UU1-1]
NP_001138231.1, NM_001144759.2 [Q86UU1-2]
NP_055972.1, NM_015157.3 [Q86UU1-1]

3D structure databases

SMRiQ86UU1
ModBaseiSearch...

Protein-protein interaction databases

BioGridi116797, 13 interactors
IntActiQ86UU1, 7 interactors
STRINGi9606.ENSP00000354498

PTM databases

iPTMnetiQ86UU1
PhosphoSitePlusiQ86UU1

Polymorphism and mutation databases

BioMutaiPHLDB1
DMDMi74723506

Proteomic databases

EPDiQ86UU1
jPOSTiQ86UU1
MaxQBiQ86UU1
PaxDbiQ86UU1
PeptideAtlasiQ86UU1
PRIDEiQ86UU1
ProteomicsDBi69894 [Q86UU1-1]
69895 [Q86UU1-2]
69896 [Q86UU1-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
23187
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356063; ENSP00000348359; ENSG00000019144 [Q86UU1-2]
ENST00000361417; ENSP00000354498; ENSG00000019144 [Q86UU1-1]
ENST00000528594; ENSP00000435520; ENSG00000019144 [Q86UU1-3]
ENST00000530994; ENSP00000431508; ENSG00000019144 [Q86UU1-3]
ENST00000600882; ENSP00000469820; ENSG00000019144 [Q86UU1-1]
GeneIDi23187
KEGGihsa:23187
UCSCiuc001ptr.3 human [Q86UU1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23187
DisGeNETi23187

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PHLDB1
HGNCiHGNC:23697 PHLDB1
HPAiHPA037959
HPA038448
HPA061506
MIMi612834 gene
neXtProtiNX_Q86UU1
OpenTargetsiENSG00000019144
PharmGKBiPA134917952

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410ISGZ Eukaryota
ENOG41101DY LUCA
GeneTreeiENSGT00940000155231
HOGENOMiHOG000286004
InParanoidiQ86UU1
OMAiPKFGNGM
OrthoDBi70229at2759
PhylomeDBiQ86UU1
TreeFamiTF329165

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PHLDB1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PHLDB1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23187

Protein Ontology

More...
PROi
PR:Q86UU1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000019144 Expressed in 232 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ86UU1 baseline and differential
GenevisibleiQ86UU1 HS

Family and domain databases

CDDicd00060 FHA, 1 hit
cd14673 PH_PHLDB1_2, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR037810 PHLDB1/2/3_PH
IPR008984 SMAD_FHA_dom_sf
PfamiView protein in Pfam
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPHLB1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86UU1
Secondary accession number(s): B0YJ63
, B0YJ64, O75133, Q4KMF8, Q8TEQ2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2003
Last modified: July 31, 2019
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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