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Protein

B-cell CLL/lymphoma 9-like protein

Gene

BCL9L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity).By similarity

GO - Molecular functioni

  • beta-catenin binding Source: MGI
  • transcription coactivator activity Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-201722 Formation of the beta-catenin:TCF transactivating complex
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell CLL/lymphoma 9-like protein
Short name:
B-cell lymphoma 9-like protein
Short name:
BCL9-like protein
Alternative name(s):
Protein BCL9-2
Gene namesi
Name:BCL9L
Synonyms:DLNB11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000186174.12
HGNCiHGNC:23688 BCL9L
MIMi609004 gene
neXtProtiNX_Q86UU0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi283149
OpenTargetsiENSG00000186174
PharmGKBiPA134974002

Polymorphism and mutation databases

BioMutaiBCL9L
DMDMi74750433

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003140791 – 1499B-cell CLL/lymphoma 9-like proteinAdd BLAST1499

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphoserineCombined sources1
Modified residuei25PhosphoserineCombined sources1
Modified residuei36N6-acetyllysineCombined sources1
Modified residuei88PhosphoserineCombined sources1
Modified residuei108N6-acetyllysineCombined sources1
Modified residuei110N6-acetyllysineBy similarity1
Modified residuei116PhosphoserineCombined sources1
Modified residuei118PhosphoserineCombined sources1
Modified residuei137N6-acetyllysineCombined sources1
Modified residuei424PhosphoserineCombined sources1
Modified residuei514PhosphothreonineCombined sources1
Modified residuei680Asymmetric dimethylarginineBy similarity1
Modified residuei750PhosphoserineCombined sources1
Modified residuei813PhosphoserineCombined sources1
Modified residuei915PhosphoserineCombined sources1
Modified residuei926PhosphoserineBy similarity1
Modified residuei938PhosphoserineCombined sources1
Modified residuei942PhosphoserineBy similarity1
Modified residuei947PhosphoserineCombined sources1
Modified residuei975PhosphoserineCombined sources1
Modified residuei987PhosphoserineBy similarity1
Modified residuei991PhosphoserineBy similarity1
Modified residuei997PhosphoserineCombined sources1
Modified residuei1004PhosphoserineCombined sources1
Modified residuei1010PhosphoserineCombined sources1
Modified residuei1017PhosphoserineCombined sources1
Cross-linki1344Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ86UU0
MaxQBiQ86UU0
PaxDbiQ86UU0
PeptideAtlasiQ86UU0
PRIDEiQ86UU0
ProteomicsDBi69890
69891 [Q86UU0-2]
69892 [Q86UU0-3]
69893 [Q86UU0-4]

PTM databases

iPTMnetiQ86UU0
PhosphoSitePlusiQ86UU0

Expressioni

Tissue specificityi

Expressed in breast, ductal and invasive ductal carcinomas of the breast, sporadic colorectal adenomas and carcinomas (at protein level). Expressed in fetal brain. Expressed in lung, amygdala, eye, prostate, pancreatic and prostate cancers, head and neck tumors and embryonal tumor.3 Publications

Gene expression databases

BgeeiENSG00000186174 Expressed in 190 organ(s), highest expression level in cerebellum
CleanExiHS_BCL9L
ExpressionAtlasiQ86UU0 baseline and differential
GenevisibleiQ86UU0 HS

Organism-specific databases

HPAiHPA049370
HPA053421

Interactioni

Subunit structurei

Found in a complex with CDC73; CTNNB1 and PYGO1. Interacts with CTNNB1.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi129475, 6 interactors
IntActiQ86UU0, 4 interactors
MINTiQ86UU0
STRINGi9606.ENSP00000335320

Structurei

Secondary structure

11499
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ86UU0
SMRiQ86UU0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni304 – 533Necessary for interaction with CTNNB1By similarityAdd BLAST230

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi280 – 493Pro-richAdd BLAST214
Compositional biasi689 – 837Met-richAdd BLAST149
Compositional biasi891 – 1378Pro-richAdd BLAST488

Domaini

Tne C-terminal domain is important for its transactivation activity.By similarity

Sequence similaritiesi

Belongs to the BCL9 family.Curated

Phylogenomic databases

eggNOGiENOG410IEDB Eukaryota
ENOG410XRMX LUCA
GeneTreeiENSGT00730000110915
HOGENOMiHOG000060118
HOVERGENiHBG031116
InParanoidiQ86UU0
KOiK22649
OMAiMGGPQKM
OrthoDBiEOG091G00PV
PhylomeDBiQ86UU0
TreeFamiTF331144

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR015668 Bcl-9/Bcl-9l
IPR024670 BCL9_beta-catenin-bd_dom
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR15185 PTHR15185, 1 hit
PfamiView protein in Pfam
PF11502 BCL9, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86UU0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRILANKTRL PHPRRREAPG SPPLSPRGHC PPAPAKPMHP ENKLTNHGKT
60 70 80 90 100
GNGGAQSQHQ NVNQGPTCNV GSKGVGAGNH GAKANQISPS NSSLKNPQAG
110 120 130 140 150
VPPFSSLKGK VKRDRSVSVD SGEQREAGTP SLDSEAKEVA PRSKRRCVLE
160 170 180 190 200
RKQPYSGDEW CSGPDSEEDD KPIGATHNCN VADPAMAAPQ LGPGQTTQLP
210 220 230 240 250
LSESSVPGAP HGPPPGLRPD APGGGGGGGG VPGKPPSQFV YVFTTHLANT
260 270 280 290 300
AAEAVLQGRA DSILAYHQQN VPRAKLDQAP KVPPTPEPLP LSTPSAGTPQ
310 320 330 340 350
SQPPPLPPPP PPAPGSAPPA LPPEGPPEDS SQDLAPNSVG AASTGGGTGG
360 370 380 390 400
THPNTPTATT ANNPLPPGGD PSSAPGPALL GEAAAPGNGQ RSLVGSEGLS
410 420 430 440 450
KEQLEHRERS LQTLRDIERL LLRSGETEPF LKGPPGGAGE GGPPAQAPPP
460 470 480 490 500
PQQPPTAPPS GLKKYEEPLQ SMISQTQSLG GPPLEHEVPG HPPGGDMGQQ
510 520 530 540 550
MNMMIQRLGQ DSLTPEQVAW RKLQEEYYEE KRRKEEQIGL HGSRPLQDMM
560 570 580 590 600
GMGGMMVRGP PPPYHSKPGD QWPPGMGAQL RGPMDVQDPM QLRGGPPFPG
610 620 630 640 650
PRFPGNQIQR VPGFGGMQSM PMEVPMNAMQ RPVRPGMGWT EDLPPMGGPS
660 670 680 690 700
NFAQNTMPYP GGQGEAERFM TPRVREELLR HQLLEKRSMG MQRPLGMAGS
710 720 730 740 750
GMGQSMEMER MMQAHRQMDP AMFPGQMAGG EGLAGTPMGM EFGGGRGLLS
760 770 780 790 800
PPMGQSGLRE VDPPMGPGNL NMNMNVNMNM NMNLNVQMTP QQQMLMSQKM
810 820 830 840 850
RGPGDLMGPQ GLSPEEMARV RAQNSSGVMG GPQKMLMPSQ FPNQGQQGFS
860 870 880 890 900
GGQGPYQAMS QDMGNTQDMF SPDQSSMPMS NVGTTRLSHM PLPPASNPPG
910 920 930 940 950
TVHSAPNRGL GRRPSDLTIS INQMGSPGMG HLKSPTLSQV HSPLVTSPSA
960 970 980 990 1000
NLKSPQTPSQ MVPLPSANPP GPLKSPQVLG SSLSVRSPTG SPSRLKSPSM
1010 1020 1030 1040 1050
AVPSPGWVAS PKTAMPSPGV SQNKQPPLNM NSSTTLSNME QGTLPPSGPR
1060 1070 1080 1090 1100
SSSSAPPANP PSGLMNPSLP FTSSPDPTPS QNPLSLMMTQ MSKYAMPSST
1110 1120 1130 1140 1150
PLYHNAIKTI ATSDDELLPD RPLLPPPPPP QGSGPGISNS QPSQMHLNSA
1160 1170 1180 1190 1200
AAQSPMGMNL PGQQPLSHEP PPAMLPSPTP LGSNIPLHPN AQGTGGPPQN
1210 1220 1230 1240 1250
SMMMAPGGPD SLNAPCGPVP SSSQMMPFPP RLQQPHGAMA PTGGGGGGPG
1260 1270 1280 1290 1300
LQQHYPSGMA LPPEDLPNQP PGPMPPQQHL MGKAMAGRMG DAYPPGVLPG
1310 1320 1330 1340 1350
VASVLNDPEL SEVIRPTPTG IPEFDLSRII PSEKPSSTLQ YFPKSENQPP
1360 1370 1380 1390 1400
KAQPPNLHLM NLQNMMAEQT PSRPPNLPGQ QGVQRGLNMS MCHPGQMSLL
1410 1420 1430 1440 1450
GRTGVPPQQG MVPHGLHQGV MSPPQGLMTQ QNFMLMKQRG VGGEVYSQPP
1460 1470 1480 1490
HMLSPQGSLM GPPPQQNLMV SHPLRQRSVS LDSQMGYLPA PGGMANLPF
Length:1,499
Mass (Da):157,129
Last modified:June 1, 2003 - v1
Checksum:i8415C2EDB7AA9C0C
GO
Isoform 2 (identifier: Q86UU0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     9-13: Missing.

Show »
Length:1,494
Mass (Da):156,529
Checksum:i2D591F45FF3AEE36
GO
Isoform 3 (identifier: Q86UU0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1333-1394: EKPSSTLQYF...RGLNMSMCHP → WFLRTRPFSF...GLCVCCISVF
     1395-1499: Missing.

Note: No experimental confirmation available.
Show »
Length:1,395
Mass (Da):145,906
Checksum:i521D25B73F563E8E
GO
Isoform 4 (identifier: Q86UU0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1238-1283: Missing.

Note: No experimental confirmation available.
Show »
Length:1,453
Mass (Da):152,547
Checksum:iD325D91BF6C1ED29
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZX0A0A087WZX0_HUMAN
B-cell CLL/lymphoma 9-like protein
BCL9L
1,462Annotation score:
E9PNR0E9PNR0_HUMAN
B-cell CLL/lymphoma 9-like protein
BCL9L
88Annotation score:

Sequence cautioni

The sequence AAH33257 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC85500 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC85512 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0302059 – 13Missing in isoform 2. 1 Publication5
Alternative sequenceiVSP_0302061238 – 1283Missing in isoform 4. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_0302071333 – 1394EKPSS…SMCHP → WFLRTRPFSFCLYLLRILSL LMWLTPLPPLPAGGWPGGQV PAGAVNRALRFCAGLCVCCI SVF in isoform 3. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_0302081395 – 1499Missing in isoform 3. 1 PublicationAdd BLAST105

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY296059 mRNA Translation: AAQ62697.1
AB094091 mRNA Translation: BAC76045.1
CH471065 Genomic DNA Translation: EAW67418.1
BC033257 mRNA Translation: AAH33257.1 Different initiation.
AK122650 mRNA Translation: BAC85500.1 Different initiation.
AK122882 mRNA Translation: BAC85512.1 Different initiation.
CCDSiCCDS8403.1 [Q86UU0-1]
RefSeqiNP_872363.1, NM_182557.2 [Q86UU0-1]
XP_005271568.1, XM_005271511.2 [Q86UU0-1]
XP_006718878.1, XM_006718815.2 [Q86UU0-1]
UniGeneiHs.414740

Genome annotation databases

EnsembliENST00000334801; ENSP00000335320; ENSG00000186174 [Q86UU0-1]
GeneIDi283149
KEGGihsa:283149
UCSCiuc001pug.5 human [Q86UU0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY296059 mRNA Translation: AAQ62697.1
AB094091 mRNA Translation: BAC76045.1
CH471065 Genomic DNA Translation: EAW67418.1
BC033257 mRNA Translation: AAH33257.1 Different initiation.
AK122650 mRNA Translation: BAC85500.1 Different initiation.
AK122882 mRNA Translation: BAC85512.1 Different initiation.
CCDSiCCDS8403.1 [Q86UU0-1]
RefSeqiNP_872363.1, NM_182557.2 [Q86UU0-1]
XP_005271568.1, XM_005271511.2 [Q86UU0-1]
XP_006718878.1, XM_006718815.2 [Q86UU0-1]
UniGeneiHs.414740

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XB1X-ray1.90A/C237-271[»]
4UP0X-ray1.28A240-268[»]
4UP5X-ray1.65A240-268[»]
ProteinModelPortaliQ86UU0
SMRiQ86UU0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129475, 6 interactors
IntActiQ86UU0, 4 interactors
MINTiQ86UU0
STRINGi9606.ENSP00000335320

PTM databases

iPTMnetiQ86UU0
PhosphoSitePlusiQ86UU0

Polymorphism and mutation databases

BioMutaiBCL9L
DMDMi74750433

Proteomic databases

EPDiQ86UU0
MaxQBiQ86UU0
PaxDbiQ86UU0
PeptideAtlasiQ86UU0
PRIDEiQ86UU0
ProteomicsDBi69890
69891 [Q86UU0-2]
69892 [Q86UU0-3]
69893 [Q86UU0-4]

Protocols and materials databases

DNASUi283149
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334801; ENSP00000335320; ENSG00000186174 [Q86UU0-1]
GeneIDi283149
KEGGihsa:283149
UCSCiuc001pug.5 human [Q86UU0-1]

Organism-specific databases

CTDi283149
DisGeNETi283149
EuPathDBiHostDB:ENSG00000186174.12
GeneCardsiBCL9L
HGNCiHGNC:23688 BCL9L
HPAiHPA049370
HPA053421
MIMi609004 gene
neXtProtiNX_Q86UU0
OpenTargetsiENSG00000186174
PharmGKBiPA134974002
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEDB Eukaryota
ENOG410XRMX LUCA
GeneTreeiENSGT00730000110915
HOGENOMiHOG000060118
HOVERGENiHBG031116
InParanoidiQ86UU0
KOiK22649
OMAiMGGPQKM
OrthoDBiEOG091G00PV
PhylomeDBiQ86UU0
TreeFamiTF331144

Enzyme and pathway databases

ReactomeiR-HSA-201722 Formation of the beta-catenin:TCF transactivating complex
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex

Miscellaneous databases

ChiTaRSiBCL9L human
GenomeRNAii283149
PROiPR:Q86UU0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186174 Expressed in 190 organ(s), highest expression level in cerebellum
CleanExiHS_BCL9L
ExpressionAtlasiQ86UU0 baseline and differential
GenevisibleiQ86UU0 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR015668 Bcl-9/Bcl-9l
IPR024670 BCL9_beta-catenin-bd_dom
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR15185 PTHR15185, 1 hit
PfamiView protein in Pfam
PF11502 BCL9, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBCL9L_HUMAN
AccessioniPrimary (citable) accession number: Q86UU0
Secondary accession number(s): A1A4C1
, Q67FY1, Q6ZWJ0, Q6ZWK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2003
Last modified: September 12, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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