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Protein

Coiled-coil domain-containing protein 84

Gene

CCDC84

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 84
Gene namesi
Name:CCDC84
ORF Names:DLNB14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000186166.8
HGNCiHGNC:30460 CCDC84
neXtProtiNX_Q86UT8

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186166
PharmGKBiPA144596451

Polymorphism and mutation databases

DMDMi74714025

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002710221 – 332Coiled-coil domain-containing protein 84Add BLAST332

Proteomic databases

EPDiQ86UT8
MaxQBiQ86UT8
PaxDbiQ86UT8
PeptideAtlasiQ86UT8
PRIDEiQ86UT8
ProteomicsDBi69889

PTM databases

iPTMnetiQ86UT8
PhosphoSitePlusiQ86UT8

Expressioni

Gene expression databases

BgeeiENSG00000186166 Expressed in 200 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_CCDC84
ExpressionAtlasiQ86UT8 baseline and differential
GenevisibleiQ86UT8 HS

Organism-specific databases

HPAiHPA039906
HPA071715

Interactioni

Protein-protein interaction databases

BioGridi130775, 23 interactors
IntActiQ86UT8, 17 interactors
STRINGi9606.ENSP00000334767

Structurei

3D structure databases

ProteinModelPortaliQ86UT8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili137 – 168Sequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi63 – 71Cys-rich9

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGQ1 Eukaryota
ENOG410ZPSB LUCA
GeneTreeiENSGT00390000007799
HOGENOMiHOG000111440
HOVERGENiHBG081049
InParanoidiQ86UT8
OMAiPELDWME
OrthoDBiEOG091G0C3X
PhylomeDBiQ86UT8
TreeFamiTF324670

Family and domain databases

InterProiView protein in InterPro
IPR028015 CCDC84
PANTHERiPTHR31198 PTHR31198, 2 hits
PfamiView protein in Pfam
PF14968 CCDC84, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q86UT8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPAQRCPLC RQTFFCGRGH VYSRKHQRQL KEALERLLPQ VEAARKAIRA
60 70 80 90 100
AQVERYVPEH ERCCWCLCCG CEVREHLSHG NLTVLYGGLL EHLASPEHKK
110 120 130 140 150
ATNKFWWENK AEVQMKEKFL VTPQDYARFK KSMVKGLDSY EEKEDKVIKE
160 170 180 190 200
MAAQIREVEQ SRQEVVRSVL EPQAVPDPEE GSSAPRSWKG MNSQVASSLQ
210 220 230 240 250
QPSNLDLPPA PELDWMETGP SLTFIGHQDI PGVGNIHSGA TPPWMIQDEE
260 270 280 290 300
YIAGNQEIGP SYEEFLKEKE KQKLKKLPPD RVGANFDHSS RTSAGWLPSF
310 320 330
GRVWNNGRRW QSRHQFKTEA AAMKKQSHTE KS
Length:332
Mass (Da):37,974
Last modified:June 1, 2003 - v1
Checksum:i341209B75BE56349
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PJ16E9PJ16_HUMAN
Coiled-coil domain-containing prote...
CCDC84
194Annotation score:
E9PPT8E9PPT8_HUMAN
Coiled-coil domain-containing prote...
CCDC84
148Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029848244W → G. Corresponds to variant dbSNP:rs600648Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB094093 mRNA Translation: BAC76047.1
BC126469 mRNA Translation: AAI26470.1
BC126471 mRNA Translation: AAI26472.1
CCDSiCCDS8405.1
RefSeqiNP_940891.1, NM_198489.2
UniGeneiHs.534613

Genome annotation databases

EnsembliENST00000334418; ENSP00000334767; ENSG00000186166
ENST00000625528; ENSP00000487197; ENSG00000280975
GeneIDi338657
KEGGihsa:338657
UCSCiuc001pul.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB094093 mRNA Translation: BAC76047.1
BC126469 mRNA Translation: AAI26470.1
BC126471 mRNA Translation: AAI26472.1
CCDSiCCDS8405.1
RefSeqiNP_940891.1, NM_198489.2
UniGeneiHs.534613

3D structure databases

ProteinModelPortaliQ86UT8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130775, 23 interactors
IntActiQ86UT8, 17 interactors
STRINGi9606.ENSP00000334767

PTM databases

iPTMnetiQ86UT8
PhosphoSitePlusiQ86UT8

Polymorphism and mutation databases

DMDMi74714025

Proteomic databases

EPDiQ86UT8
MaxQBiQ86UT8
PaxDbiQ86UT8
PeptideAtlasiQ86UT8
PRIDEiQ86UT8
ProteomicsDBi69889

Protocols and materials databases

DNASUi338657
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334418; ENSP00000334767; ENSG00000186166
ENST00000625528; ENSP00000487197; ENSG00000280975
GeneIDi338657
KEGGihsa:338657
UCSCiuc001pul.5 human

Organism-specific databases

CTDi338657
EuPathDBiHostDB:ENSG00000186166.8
GeneCardsiCCDC84
HGNCiHGNC:30460 CCDC84
HPAiHPA039906
HPA071715
neXtProtiNX_Q86UT8
OpenTargetsiENSG00000186166
PharmGKBiPA144596451
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGQ1 Eukaryota
ENOG410ZPSB LUCA
GeneTreeiENSGT00390000007799
HOGENOMiHOG000111440
HOVERGENiHBG081049
InParanoidiQ86UT8
OMAiPELDWME
OrthoDBiEOG091G0C3X
PhylomeDBiQ86UT8
TreeFamiTF324670

Miscellaneous databases

ChiTaRSiCCDC84 human
GenomeRNAii338657
PROiPR:Q86UT8

Gene expression databases

BgeeiENSG00000186166 Expressed in 200 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_CCDC84
ExpressionAtlasiQ86UT8 baseline and differential
GenevisibleiQ86UT8 HS

Family and domain databases

InterProiView protein in InterPro
IPR028015 CCDC84
PANTHERiPTHR31198 PTHR31198, 2 hits
PfamiView protein in Pfam
PF14968 CCDC84, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCD84_HUMAN
AccessioniPrimary (citable) accession number: Q86UT8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: June 1, 2003
Last modified: September 12, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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