UniProtKB - Q86UT8 (CCD84_HUMAN)

BLAST

>sp|Q86UT8|CCD84_HUMAN Coiled-coil domain-containing protein 84 OS=Homo sapiens OX=9606 GN=CCDC84 PE=1 SV=1
MAPAQRCPLCRQTFFCGRGHVYSRKHQRQLKEALERLLPQVEAARKAIRAAQVERYVPEH
ERCCWCLCCGCEVREHLSHGNLTVLYGGLLEHLASPEHKKATNKFWWENKAEVQMKEKFL
VTPQDYARFKKSMVKGLDSYEEKEDKVIKEMAAQIREVEQSRQEVVRSVLEPQAVPDPEE
GSSAPRSWKGMNSQVASSLQQPSNLDLPPAPELDWMETGPSLTFIGHQDIPGVGNIHSGA
TPPWMIQDEEYIAGNQEIGPSYEEFLKEKEKQKLKKLPPDRVGANFDHSSRTSAGWLPSF
GRVWNNGRRWQSRHQFKTEAAAMKKQSHTEKS

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History
Entry version 97 (12 Sep 2018)
Sequence version 1 (01 Jun 2003)
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Protein

Coiled-coil domain-containing protein 84

Gene

CCDC84

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Coiled-coil domain-containing protein 84
Gene namesⁱ	Name:CCDC84 ORF Names:DLNB14
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000186166.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30460 CCDC84
neXtProtⁱ	NX_Q86UT8

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000186166
PharmGKBⁱ	PA144596451

Polymorphism and mutation databases

DMDMⁱ	74714025

DMDMⁱ

74714025

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000271022	1 – 332	Coiled-coil domain-containing protein 84Add BLAST		332

Proteomic databases

EPDⁱ	Q86UT8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q86UT8
PaxDbⁱ	Q86UT8
PeptideAtlas More...PeptideAtlasⁱ	Q86UT8
PRIDEⁱ	Q86UT8
ProteomicsDBⁱ	69889

PTM databases

iPTMnetⁱ	Q86UT8
PhosphoSitePlusⁱ	Q86UT8

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000186166 Expressed in 200 organ(s), highest expression level in small intestine Peyer's patch
CleanExⁱ	HS_CCDC84
ExpressionAtlasⁱ	Q86UT8 baseline and differential
Genevisibleⁱ	Q86UT8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA039906 HPA071715

HPAⁱ

HPA039906
HPA071715

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	130775, 23 interactors
IntActⁱ	Q86UT8, 17 interactors
STRINGⁱ	9606.ENSP00000334767

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q86UT8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	137 – 168	Sequence analysisAdd BLAST		32

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	63 – 71	Cys-rich		9

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IGQ1 Eukaryota ENOG410ZPSB LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007799
HOGENOMⁱ	HOG000111440
HOVERGENⁱ	HBG081049
InParanoidⁱ	Q86UT8
OMAⁱ	PELDWME
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0C3X
PhylomeDBⁱ	Q86UT8
TreeFamⁱ	TF324670

Family and domain databases

InterProⁱ	View protein in InterPro IPR028015 CCDC84
PANTHERⁱ	PTHR31198 PTHR31198, 2 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF14968 CCDC84, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q86UT8-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MAPAQRCPLC RQTFFCGRGH VYSRKHQRQL KEALERLLPQ VEAARKAIRA 
        60         70         80         90        100
AQVERYVPEH ERCCWCLCCG CEVREHLSHG NLTVLYGGLL EHLASPEHKK 
       110        120        130        140        150
ATNKFWWENK AEVQMKEKFL VTPQDYARFK KSMVKGLDSY EEKEDKVIKE 
       160        170        180        190        200
MAAQIREVEQ SRQEVVRSVL EPQAVPDPEE GSSAPRSWKG MNSQVASSLQ 
       210        220        230        240        250
QPSNLDLPPA PELDWMETGP SLTFIGHQDI PGVGNIHSGA TPPWMIQDEE 
       260        270        280        290        300
YIAGNQEIGP SYEEFLKEKE KQKLKKLPPD RVGANFDHSS RTSAGWLPSF 
       310        320        330 
GRVWNNGRRW QSRHQFKTEA AAMKKQSHTE KS

Length:332

Mass (Da):37,974

Last modified:June 1, 2003 - v1

Checksum:ⁱ341209B75BE56349

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PJ16	E9PJ16_HUMAN	Coiled-coil domain-containing prote... Coiled-coil domain-containing protein 84	CCDC84	194	Annotation score:
E9PPT8	E9PPT8_HUMAN	Coiled-coil domain-containing prote... Coiled-coil domain-containing protein 84	CCDC84	148	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_029848	244	W → G. Corresponds to variant dbSNP:rs600648Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB094093 mRNA Translation: BAC76047.1 BC126469 mRNA Translation: AAI26470.1 BC126471 mRNA Translation: AAI26472.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8405.1
NCBI Reference Sequences More...RefSeqⁱ	NP_940891.1, NM_198489.2
UniGeneⁱ	Hs.534613

Genome annotation databases

Ensemblⁱ	ENST00000334418; ENSP00000334767; ENSG00000186166 ENST00000625528; ENSP00000487197; ENSG00000280975
GeneIDⁱ	338657
KEGGⁱ	hsa:338657
UCSC genome browser More...UCSCⁱ	uc001pul.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q86UT8	Uncharacterized protein		SAIBB		341	UniRef90_Q86UT8
Coiled-coil domain containing 84		GORGO		332
CCDC84 isoform 2		PANTR		332
Uncharacterized protein		PANPA		332
Uncharacterized protein		AOTNA		331
+18

Protein	Similar proteins		Species	Score	Length	Source
Q86UT8	Uncharacterized protein		SAIBB		341	UniRef50_Q86UT8
CCDC84 isoform 2		PANTR		332
Uncharacterized protein		PANPA		332
Coiled-coil domain containing 84		GORGO		332
Uncharacterized protein		PAPAN		331
+76

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB094093 mRNA Translation: BAC76047.1 BC126469 mRNA Translation: AAI26470.1 BC126471 mRNA Translation: AAI26472.1
CCDSⁱ	CCDS8405.1
RefSeqⁱ	NP_940891.1, NM_198489.2
UniGeneⁱ	Hs.534613

3D structure databases

ProteinModelPortalⁱ	Q86UT8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	130775, 23 interactors
IntActⁱ	Q86UT8, 17 interactors
STRINGⁱ	9606.ENSP00000334767

PTM databases

iPTMnetⁱ	Q86UT8
PhosphoSitePlusⁱ	Q86UT8

Polymorphism and mutation databases

DMDMⁱ	74714025

DMDMⁱ

74714025

Proteomic databases

EPDⁱ	Q86UT8
MaxQBⁱ	Q86UT8
PaxDbⁱ	Q86UT8
PeptideAtlasⁱ	Q86UT8
PRIDEⁱ	Q86UT8
ProteomicsDBⁱ	69889

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	338657
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000334418; ENSP00000334767; ENSG00000186166 ENST00000625528; ENSP00000487197; ENSG00000280975
GeneIDⁱ	338657
KEGGⁱ	hsa:338657
UCSCⁱ	uc001pul.5 human

Organism-specific databases

CTDⁱ	338657
EuPathDBⁱ	HostDB:ENSG00000186166.8
GeneCardsⁱ	CCDC84
HGNCⁱ	HGNC:30460 CCDC84
HPAⁱ	HPA039906 HPA071715
neXtProtⁱ	NX_Q86UT8
OpenTargetsⁱ	ENSG00000186166
PharmGKBⁱ	PA144596451
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IGQ1 Eukaryota ENOG410ZPSB LUCA
GeneTreeⁱ	ENSGT00390000007799
HOGENOMⁱ	HOG000111440
HOVERGENⁱ	HBG081049
InParanoidⁱ	Q86UT8
OMAⁱ	PELDWME
OrthoDBⁱ	EOG091G0C3X
PhylomeDBⁱ	Q86UT8
TreeFamⁱ	TF324670

Miscellaneous databases

ChiTaRSⁱ	CCDC84 human
GenomeRNAiⁱ	338657
Protein Ontology More...PROⁱ	PR:Q86UT8

Gene expression databases

Bgeeⁱ	ENSG00000186166 Expressed in 200 organ(s), highest expression level in small intestine Peyer's patch
CleanExⁱ	HS_CCDC84
ExpressionAtlasⁱ	Q86UT8 baseline and differential
Genevisibleⁱ	Q86UT8 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR028015 CCDC84
PANTHERⁱ	PTHR31198 PTHR31198, 2 hits
Pfamⁱ	View protein in Pfam PF14968 CCDC84, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CCD84_HUMAN
Accessionⁱ	Q86UT8Primary (citable) accession number: Q86UT8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
	Last sequence update:	June 1, 2003
	Last modified:	September 12, 2018
	This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

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UniProtKB - Q86UT8 (CCD84_HUMAN)

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Coiled-coil domain-containing protein 84

CCDC84

Select a section on the left to see content.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Compositional bias

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ