UniProtKB - Q86UT8 (CATAC_HUMAN)
Protein
Centrosomal AT-AC splicing factor
Gene
CENATAC
Organism
Homo sapiens (Human)
Status
Functioni
Negative regulator of centrosome duplication (PubMed:31722219). Constrains centriole number by modulating the degradation of the centrosome-duplication-associated protein SASS6 in an acetylation-dependent manner. SIRT1 deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly. The CENATAC acetylation level is restored in mitosis by NAT10, promoting SASS6 proteasome degradation by facilitating SASS6 binding to APC/C E3 ubiquitin-protein ligase complex/FZR1 (PubMed:31722219).1 Publication
GO - Biological processi
- negative regulation of centrosome duplication Source: UniProtKB
- regulation of protein catabolic process Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q86UT8 |
Names & Taxonomyi
Protein namesi | Recommended name: Centrosomal AT-AC splicing factorCuratedAlternative name(s): Coiled-coil domain-containing protein 84 |
Gene namesi | Name:CENATACImported ORF Names:CCDC84, DLNB14 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000186166.8 |
HGNCi | HGNC:30460, CENATAC |
neXtProti | NX_Q86UT8 |
Subcellular locationi
Cytoskeleton
- centrosome 1 Publication
Note: Localizes to the proximal end of the mother centriole. During the cell cycle, from G1 to metaphase, gradually accumulates on the centrosome and then decreased significantly upon entry into anaphase.1 Publication
Cytoskeleton
- centrosome Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 31 | K → Q: Increases interaction with SASS6. 1 Publication | 1 | |
Mutagenesisi | 31 | K → R: Strongly reduces acetylation. No effect on interaction with SASS6. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 338657 |
OpenTargetsi | ENSG00000186166 |
PharmGKBi | PA144596451 |
Miscellaneous databases
Pharosi | Q86UT8, Tdark |
Polymorphism and mutation databases
BioMutai | CCDC84 |
DMDMi | 74714025 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000271022 | 1 – 332 | Centrosomal AT-AC splicing factorAdd BLAST | 332 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 31 | N6-acetyllysine; by NAT101 Publication | 1 |
Post-translational modificationi
Acetylated. Acetylation oscillates throughout the cell cycle, and the acetylation state at Lys-31 is regulated by the deacetylase SIRT1 and the acetyltransferase NAT10. Deacetylated CENATAC is responsible for its centrosome targeting, and acetylated CENATAC promotes SASS6 degradation by enhancing the binding affinity of SASS6 for APC/C E3 ubiquitin-protein ligase complex/FZR1.1 Publication
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q86UT8 |
jPOSTi | Q86UT8 |
MassIVEi | Q86UT8 |
MaxQBi | Q86UT8 |
PaxDbi | Q86UT8 |
PeptideAtlasi | Q86UT8 |
PRIDEi | Q86UT8 |
ProteomicsDBi | 69889 |
PTM databases
iPTMneti | Q86UT8 |
PhosphoSitePlusi | Q86UT8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000186166, Expressed in small intestine Peyer's patch and 215 other tissues |
ExpressionAtlasi | Q86UT8, baseline and differential |
Genevisiblei | Q86UT8, HS |
Organism-specific databases
HPAi | ENSG00000186166, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with SASS6; the interaction increases with CENATAC acetylation.
1 PublicationBinary interactionsi
Hide detailsQ86UT8
Protein-protein interaction databases
BioGRIDi | 130775, 42 interactors |
IntActi | Q86UT8, 24 interactors |
STRINGi | 9606.ENSP00000334767 |
Miscellaneous databases
RNActi | Q86UT8, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 169 | Required for centrosome location1 PublicationAdd BLAST | 169 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 137 – 168 | Sequence analysisAdd BLAST | 32 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 63 – 71 | Cys-rich | 9 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QS8B, Eukaryota |
GeneTreei | ENSGT00390000007799 |
HOGENOMi | CLU_041370_1_0_1 |
InParanoidi | Q86UT8 |
OMAi | SHTDANW |
OrthoDBi | 1213548at2759 |
PhylomeDBi | Q86UT8 |
TreeFami | TF324670 |
Family and domain databases
InterProi | View protein in InterPro IPR028015, CCDC84 |
PANTHERi | PTHR31198, PTHR31198, 2 hits |
Pfami | View protein in Pfam PF14968, CCDC84, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q86UT8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPAQRCPLC RQTFFCGRGH VYSRKHQRQL KEALERLLPQ VEAARKAIRA
60 70 80 90 100
AQVERYVPEH ERCCWCLCCG CEVREHLSHG NLTVLYGGLL EHLASPEHKK
110 120 130 140 150
ATNKFWWENK AEVQMKEKFL VTPQDYARFK KSMVKGLDSY EEKEDKVIKE
160 170 180 190 200
MAAQIREVEQ SRQEVVRSVL EPQAVPDPEE GSSAPRSWKG MNSQVASSLQ
210 220 230 240 250
QPSNLDLPPA PELDWMETGP SLTFIGHQDI PGVGNIHSGA TPPWMIQDEE
260 270 280 290 300
YIAGNQEIGP SYEEFLKEKE KQKLKKLPPD RVGANFDHSS RTSAGWLPSF
310 320 330
GRVWNNGRRW QSRHQFKTEA AAMKKQSHTE KS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PJ16 | E9PJ16_HUMAN | Centrosomal AT-AC-splicing factor | CENATAC CCDC84 | 194 | Annotation score: | ||
E9PPT8 | E9PPT8_HUMAN | Centrosomal AT-AC-splicing factor | CENATAC CCDC84 | 148 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029848 | 244 | W → G. Corresponds to variant dbSNP:rs600648Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB094093 mRNA Translation: BAC76047.1 BC126469 mRNA Translation: AAI26470.1 BC126471 mRNA Translation: AAI26472.1 |
CCDSi | CCDS8405.1 |
RefSeqi | NP_940891.1, NM_198489.2 |
Genome annotation databases
Ensembli | ENST00000334418; ENSP00000334767; ENSG00000186166 ENST00000625528; ENSP00000487197; ENSG00000280975 |
GeneIDi | 338657 |
KEGGi | hsa:338657 |
UCSCi | uc001pul.5, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB094093 mRNA Translation: BAC76047.1 BC126469 mRNA Translation: AAI26470.1 BC126471 mRNA Translation: AAI26472.1 |
CCDSi | CCDS8405.1 |
RefSeqi | NP_940891.1, NM_198489.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 130775, 42 interactors |
IntActi | Q86UT8, 24 interactors |
STRINGi | 9606.ENSP00000334767 |
PTM databases
iPTMneti | Q86UT8 |
PhosphoSitePlusi | Q86UT8 |
Polymorphism and mutation databases
BioMutai | CCDC84 |
DMDMi | 74714025 |
Proteomic databases
EPDi | Q86UT8 |
jPOSTi | Q86UT8 |
MassIVEi | Q86UT8 |
MaxQBi | Q86UT8 |
PaxDbi | Q86UT8 |
PeptideAtlasi | Q86UT8 |
PRIDEi | Q86UT8 |
ProteomicsDBi | 69889 |
Protocols and materials databases
Antibodypediai | 54439, 81 antibodies |
DNASUi | 338657 |
Genome annotation databases
Ensembli | ENST00000334418; ENSP00000334767; ENSG00000186166 ENST00000625528; ENSP00000487197; ENSG00000280975 |
GeneIDi | 338657 |
KEGGi | hsa:338657 |
UCSCi | uc001pul.5, human |
Organism-specific databases
CTDi | 338657 |
DisGeNETi | 338657 |
EuPathDBi | HostDB:ENSG00000186166.8 |
GeneCardsi | CENATAC |
HGNCi | HGNC:30460, CENATAC |
HPAi | ENSG00000186166, Low tissue specificity |
neXtProti | NX_Q86UT8 |
OpenTargetsi | ENSG00000186166 |
PharmGKBi | PA144596451 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QS8B, Eukaryota |
GeneTreei | ENSGT00390000007799 |
HOGENOMi | CLU_041370_1_0_1 |
InParanoidi | Q86UT8 |
OMAi | SHTDANW |
OrthoDBi | 1213548at2759 |
PhylomeDBi | Q86UT8 |
TreeFami | TF324670 |
Enzyme and pathway databases
PathwayCommonsi | Q86UT8 |
Miscellaneous databases
BioGRID-ORCSi | 338657, 572 hits in 850 CRISPR screens |
ChiTaRSi | CCDC84, human |
GenomeRNAii | 338657 |
Pharosi | Q86UT8, Tdark |
PROi | PR:Q86UT8 |
RNActi | Q86UT8, protein |
Gene expression databases
Bgeei | ENSG00000186166, Expressed in small intestine Peyer's patch and 215 other tissues |
ExpressionAtlasi | Q86UT8, baseline and differential |
Genevisiblei | Q86UT8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR028015, CCDC84 |
PANTHERi | PTHR31198, PTHR31198, 2 hits |
Pfami | View protein in Pfam PF14968, CCDC84, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CATAC_HUMAN | |
Accessioni | Q86UT8Primary (citable) accession number: Q86UT8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 9, 2007 |
Last sequence update: | June 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations