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UniProtKB - Q86UT6 (NLRX1_HUMAN)

Entry version 159 (23 Feb 2022)
Sequence version 1 (01 Jun 2003)
Previous versions | rss
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Protein

NLR family member X1

Gene

NLRX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010).

Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12 (PubMed:22749352).

Regulates also MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis (PubMed:27393910).

Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313).

4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi166 – 173ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHost-virus interaction, Immunity, Innate immunity
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q86UT6

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-168928, DDX58/IFIH1-mediated induction of interferon-alpha/beta
R-HSA-936440, Negative regulators of DDX58/IFIH1 signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q86UT6

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q86UT6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NLR family member X1
Alternative name(s):
Caterpiller protein 11.3
Short name:
CLR11.3
Nucleotide-binding oligomerization domain protein 26
Nucleotide-binding oligomerization domain protein 5
Nucleotide-binding oligomerization domain protein 9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NLRX1
Synonyms:NOD26, NOD5, NOD9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29890, NLRX1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611947, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q86UT6

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000160703

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		79671

Open Targets

More...OpenTargetsi		ENSG00000160703

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162398052

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q86UT6, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NLRX1

Domain mapping of disease mutations (DMDM)

More...DMDMi		74759406

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 86MitochondrionAdd BLAST86
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000029619087 – 975NLR family member X1Add BLAST889

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q86UT6

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q86UT6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q86UT6

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q86UT6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q86UT6

PeptideAtlas

More...PeptideAtlasi		Q86UT6

PRoteomics IDEntifications database

More...PRIDEi		Q86UT6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		69887 [Q86UT6-1]
69888 [Q86UT6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q86UT6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q86UT6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HeLa, HEK293T, THP-1, HL-60, Raji and Jurkat cell lines (at protein level).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000160703, Expressed in lower esophagus mucosa and 217 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q86UT6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q86UT6, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000160703, Tissue enhanced (esophagus)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homohexamer.

Interacts with MAVS (PubMed:18200010).

Interacts with TUFM (PubMed:22749352).

3 Publications

(Microbial infection) Interacts with influenza A virus protein PB1-F2.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122796, 63 interactors

Database of interacting proteins

More...DIPi		DIP-60637N

Protein interaction database and analysis system

More...IntActi		Q86UT6, 29 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000387334

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q86UT6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1975
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q86UT6

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini160 – 483NACHTPROSITE-ProRule annotationAdd BLAST324
Domaini667 – 694LRRNTAdd BLAST28
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati695 – 718LRR 11 PublicationAdd BLAST24
Repeati724 – 747LRR 21 PublicationAdd BLAST24
Repeati749 – 777LRR 31 PublicationAdd BLAST29
Repeati778 – 801LRR 41 PublicationAdd BLAST24
Repeati811 – 834LRR 51 PublicationAdd BLAST24
Repeati835 – 857LRR 61 PublicationAdd BLAST23
Repeati858 – 877LRR 71 PublicationAdd BLAST20
Repeati878 – 899LRR 81 PublicationAdd BLAST22
Domaini906 – 970LRRCTAdd BLAST65

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni75 – 556Required for interaction with MAVS1 PublicationAdd BLAST482
Regioni556 – 974Required for the repression of MAVS-induced interferon signalingAdd BLAST419

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The LRRCT domain mediates homodimerization and LRRNT mediates trimerization of the dimers.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NLRP family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4308, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159493

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_016769_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q86UT6

Identification of Orthologs from Complete Genome Data

More...OMAi		NQPDCGC

Database of Orthologous Groups

More...OrthoDBi		114368at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q86UT6

TreeFam database of animal gene trees

More...TreeFami		TF331068

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.300, 1 hit
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001611, Leu-rich_rpt
IPR032675, LRR_dom_sf
IPR007111, NACHT_NTPase
IPR027417, P-loop_NTPase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13516, LRR_6, 1 hit
PF05729, NACHT, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50837, NACHT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86UT6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRWGHHLPRA SWGSGFRRAL QRPDDRIPFL IHWSWPLQGE RPFGPPRAFI 
        60         70         80         90        100
RHHGSSVDSA PPPGRHGRLF PSASATEAIQ RHRRNLAEWF SRLPREERQF 
       110        120        130        140        150
GPTFALDTVH VDPVIRESTP DELLRPPAEL ALEHQPPQAG LPPLALSQLF 
       160        170        180        190        200
NPDACGRRVQ TVVLYGTVGT GKSTLVRKMV LDWCYGRLPA FELLIPFSCE 
       210        220        230        240        250
DLSSLGPAPA SLCQLVAQRY TPLKEVLPLM AAAGSHLLFV LHGLEHLNLD 
       260        270        280        290        300
FRLAGTGLCS DPEEPQEPAA IIVNLLRKYM LPQASILVTT RPSAIGRIPS 
       310        320        330        340        350
KYVGRYGEIC GFSDTNLQKL YFQLRLNQPY CGYAVGGSGV SATPAQRDHL 
       360        370        380        390        400
VQMLSRNLEG HHQIAAACFL PSYCWLVCAT LHFLHAPTPA GQTLTSIYTS 
       410        420        430        440        450
FLRLNFSGET LDSTDPSNLS LMAYAARTMG KLAYEGVSSR KTYFSEEDVC 
       460        470        480        490        500
GCLEAGIRTE EEFQLLHIFR RDALRFFLAP CVEPGRAGTF VFTVPAMQEY 
       510        520        530        540        550
LAALYIVLGL RKTTLQKVGK EVAELVGRVG EDVSLVLGIM AKLLPLRALP 
       560        570        580        590        600
LLFNLIKVVP RVFGRMVGKS REAVAQAMVL EMFREEDYYN DDVLDQMGAS 
       610        620        630        640        650
ILGVEGPRRH PDEPPEDEVF ELFPMFMGGL LSAHNRAVLA QLGCPIKNLD 
       660        670        680        690        700
ALENAQAIKK KLGKLGRQVL PPSELLDHLF FHYEFQNQRF SAEVLSSLRQ 
       710        720        730        740        750
LNLAGVRMTP VKCTVVAAVL GSGRHALDEV NLASCQLDPA GLRTLLPVFL 
       760        770        780        790        800
RARKLGLQLN SLGPEACKDL RDLLLHDQCQ ITTLRLSNNP LTAAGVAVLM 
       810        820        830        840        850
EGLAGNTSVT HLSLLHTGLG DEGLELLAAQ LDRNRQLQEL NVAYNGAGDT 
       860        870        880        890        900
AALALARAAR EHPSLELLHL YFNELSSEGR QVLRDLGGAA EGGARVVVSL 
       910        920        930        940        950
TEGTAVSEYW SVILSEVQRN LNSWDRARVQ RHLELLLRDL EDSRGATLNP 
       960        970 
WRKAQLLRVE GEVRALLEQL GSSGS
Length:975
Mass (Da):107,616
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i25B6624FC13217FF
GO
Isoform 2 (identifier: Q86UT6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     869-921: HLYFNELSSE...VILSEVQRNL → QGVAIQMCWK...GLVAPRGRCT
     922-975: Missing.

Show »
Length:921
Mass (Da):101,876
Checksum:i1F67611ADB9FAA36
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J0R6C9J0R6_HUMAN
NLR family member X1
NLRX1
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JLK8C9JLK8_HUMAN
NLR family member X1
NLRX1
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JQE9C9JQE9_HUMAN
NLR family member X1
NLRX1
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15075 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG51714 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAG51714 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti325R → C in BAG53014 (PubMed:14702039).Curated1
Sequence conflicti575A → T in BAG51714 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03461463P → S2 PublicationsCorresponds to variant dbSNP:rs643423Ensembl.1
Natural variantiVAR_034615125R → L. Corresponds to variant dbSNP:rs3809045Ensembl.1
Natural variantiVAR_034616793A → E3 PublicationsCorresponds to variant dbSNP:rs4245191Ensembl.1
Natural variantiVAR_034617843A → S. Corresponds to variant dbSNP:rs35500631Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_027158869 – 921HLYFN…VQRNL → QGVAIQMCWKLPLLPYAHLW TPRMPSHWCFLLILMPPLPQ WYDGLVAPRGRCT in isoform 2. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_027159922 – 975Missing in isoform 2. 1 PublicationAdd BLAST54

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY245437 mRNA Translation: AAP31240.1
BK001111 mRNA Translation: DAA01244.1
EF452237 mRNA Translation: ABO40480.1
AB094095 mRNA Translation: BAC76049.1
AK025131 mRNA Translation: BAB15075.1 Different initiation.
AK056454 mRNA Translation: BAG51714.1 Sequence problems.
AK095247 mRNA Translation: BAG53014.1
AK291716 mRNA Translation: BAF84405.1
BC013199 mRNA Translation: AAH13199.3
BC110890 mRNA Translation: AAI10891.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8416.1 [Q86UT6-1]

NCBI Reference Sequences

More...RefSeqi		NP_001269072.1, NM_001282143.1 [Q86UT6-1]
NP_001269073.1, NM_001282144.1 [Q86UT6-1]
NP_001269287.1, NM_001282358.1 [Q86UT6-1]
NP_078894.2, NM_024618.3 [Q86UT6-1]
XP_005271726.1, XM_005271669.1 [Q86UT6-1]
XP_006718967.1, XM_006718904.1 [Q86UT6-2]
XP_011541282.1, XM_011542980.1 [Q86UT6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000292199; ENSP00000292199; ENSG00000160703
ENST00000409109; ENSP00000387334; ENSG00000160703
ENST00000409265; ENSP00000386858; ENSG00000160703
ENST00000409991; ENSP00000386851; ENSG00000160703
ENST00000525863; ENSP00000433442; ENSG00000160703 [Q86UT6-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		79671

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:79671

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000409109.6; ENSP00000387334.1; NM_001282144.2; NP_001269073.1

UCSC genome browser

More...UCSCi		uc001pvu.5, human [Q86UT6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY245437 mRNA Translation: AAP31240.1
BK001111 mRNA Translation: DAA01244.1
EF452237 mRNA Translation: ABO40480.1
AB094095 mRNA Translation: BAC76049.1
AK025131 mRNA Translation: BAB15075.1 Different initiation.
AK056454 mRNA Translation: BAG51714.1 Sequence problems.
AK095247 mRNA Translation: BAG53014.1
AK291716 mRNA Translation: BAF84405.1
BC013199 mRNA Translation: AAH13199.3
BC110890 mRNA Translation: AAI10891.1
CCDSiCCDS8416.1 [Q86UT6-1]
RefSeqiNP_001269072.1, NM_001282143.1 [Q86UT6-1]
NP_001269073.1, NM_001282144.1 [Q86UT6-1]
NP_001269287.1, NM_001282358.1 [Q86UT6-1]
NP_078894.2, NM_024618.3 [Q86UT6-1]
XP_005271726.1, XM_005271669.1 [Q86UT6-1]
XP_006718967.1, XM_006718904.1 [Q86UT6-2]
XP_011541282.1, XM_011542980.1 [Q86UT6-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3UN9X-ray2.65A/B/C629-975[»]
SMRiQ86UT6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi122796, 63 interactors
DIPiDIP-60637N
IntActiQ86UT6, 29 interactors
STRINGi9606.ENSP00000387334

PTM databases

iPTMnetiQ86UT6
PhosphoSitePlusiQ86UT6

Genetic variation databases

BioMutaiNLRX1
DMDMi74759406

Proteomic databases

EPDiQ86UT6
jPOSTiQ86UT6
MassIVEiQ86UT6
MaxQBiQ86UT6
PaxDbiQ86UT6
PeptideAtlasiQ86UT6
PRIDEiQ86UT6
ProteomicsDBi69887 [Q86UT6-1]
69888 [Q86UT6-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		45879, 234 antibodies from 36 providers

The DNASU plasmid repository

More...DNASUi		79671

Genome annotation databases

EnsembliENST00000292199; ENSP00000292199; ENSG00000160703
ENST00000409109; ENSP00000387334; ENSG00000160703
ENST00000409265; ENSP00000386858; ENSG00000160703
ENST00000409991; ENSP00000386851; ENSG00000160703
ENST00000525863; ENSP00000433442; ENSG00000160703 [Q86UT6-2]
GeneIDi79671
KEGGihsa:79671
MANE-SelectiENST00000409109.6; ENSP00000387334.1; NM_001282144.2; NP_001269073.1
UCSCiuc001pvu.5, human [Q86UT6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79671
DisGeNETi79671

GeneCards: human genes, protein and diseases

More...GeneCardsi		NLRX1
HGNCiHGNC:29890, NLRX1
HPAiENSG00000160703, Tissue enhanced (esophagus)
MIMi611947, gene
neXtProtiNX_Q86UT6
OpenTargetsiENSG00000160703
PharmGKBiPA162398052
VEuPathDBiHostDB:ENSG00000160703

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4308, Eukaryota
GeneTreeiENSGT00940000159493
HOGENOMiCLU_016769_0_0_1
InParanoidiQ86UT6
OMAiNQPDCGC
OrthoDBi114368at2759
PhylomeDBiQ86UT6
TreeFamiTF331068

Enzyme and pathway databases

PathwayCommonsiQ86UT6
ReactomeiR-HSA-168928, DDX58/IFIH1-mediated induction of interferon-alpha/beta
R-HSA-936440, Negative regulators of DDX58/IFIH1 signaling
SignaLinkiQ86UT6
SIGNORiQ86UT6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		79671, 6 hits in 1045 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NLRX1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		NLRX1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		79671
PharosiQ86UT6, Tbio

Protein Ontology

More...PROi		PR:Q86UT6
RNActiQ86UT6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000160703, Expressed in lower esophagus mucosa and 217 other tissues
ExpressionAtlasiQ86UT6, baseline and differential
GenevisibleiQ86UT6, HS

Family and domain databases

Gene3Di3.40.50.300, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611, Leu-rich_rpt
IPR032675, LRR_dom_sf
IPR007111, NACHT_NTPase
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF13516, LRR_6, 1 hit
PF05729, NACHT, 1 hit
PROSITEiView protein in PROSITE
PS50837, NACHT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNLRX1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86UT6
Secondary accession number(s): A8K6Q1
, B3KPK2, B3KTA2, Q7RTR3, Q96D51, Q9H724
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: June 1, 2003
Last modified: February 23, 2022
This is version 159 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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