UniProtKB - Q86UT6 (NLRX1_HUMAN)
NLR family member X1
NLRX1
Functioni
Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010).
Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12 (PubMed:22749352).
Regulates also MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis (PubMed:27393910).
Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313).
4 PublicationsRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 166 – 173 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
GO - Biological processi
- innate immune response Source: UniProtKB-KW
- intracellular signal transduction Source: GO_Central
- negative regulation of I-kappaB kinase/NF-kappaB signaling Source: GO_Central
- negative regulation of inflammatory response Source: Ensembl
- negative regulation of innate immune response Source: Ensembl
- negative regulation of interferon-beta production Source: Ensembl
- negative regulation of interleukin-6 production Source: Ensembl
- negative regulation of RIG-I signaling pathway Source: Ensembl
Keywordsi
Biological process | Host-virus interaction, Immunity, Innate immunity |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q86UT6 |
Reactomei | R-HSA-168928, DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-936440, Negative regulators of DDX58/IFIH1 signaling |
SignaLinki | Q86UT6 |
SIGNORi | Q86UT6 |
Names & Taxonomyi
Protein namesi | Recommended name: NLR family member X1Alternative name(s): Caterpiller protein 11.3 Short name: CLR11.3 Nucleotide-binding oligomerization domain protein 26 Nucleotide-binding oligomerization domain protein 5 Nucleotide-binding oligomerization domain protein 9 |
Gene namesi | Name:NLRX1 Synonyms:NOD26, NOD5, NOD9 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29890, NLRX1 |
MIMi | 611947, gene |
neXtProti | NX_Q86UT6 |
VEuPathDBi | HostDB:ENSG00000160703 |
Subcellular locationi
Mitochondrion
- Mitochondrion outer membrane 3 Publications
Mitochondrion
- mitochondrial outer membrane Source: Reactome
- mitochondrion Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- cell junction Source: HPA
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion outer membranePathology & Biotechi
Organism-specific databases
DisGeNETi | 79671 |
OpenTargetsi | ENSG00000160703 |
PharmGKBi | PA162398052 |
Miscellaneous databases
Pharosi | Q86UT6, Tbio |
Genetic variation databases
BioMutai | NLRX1 |
DMDMi | 74759406 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 86 | MitochondrionAdd BLAST | 86 | |
ChainiPRO_0000296190 | 87 – 975 | NLR family member X1Add BLAST | 889 |
Proteomic databases
EPDi | Q86UT6 |
jPOSTi | Q86UT6 |
MassIVEi | Q86UT6 |
MaxQBi | Q86UT6 |
PaxDbi | Q86UT6 |
PeptideAtlasi | Q86UT6 |
PRIDEi | Q86UT6 |
ProteomicsDBi | 69887 [Q86UT6-1] 69888 [Q86UT6-2] |
PTM databases
iPTMneti | Q86UT6 |
PhosphoSitePlusi | Q86UT6 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000160703, Expressed in lower esophagus mucosa and 217 other tissues |
ExpressionAtlasi | Q86UT6, baseline and differential |
Genevisiblei | Q86UT6, HS |
Organism-specific databases
HPAi | ENSG00000160703, Tissue enhanced (esophagus) |
Interactioni
Subunit structurei
(Microbial infection) Interacts with influenza A virus protein PB1-F2.
1 PublicationBinary interactionsi
Q86UT6
With | #Exp. | IntAct |
---|---|---|
TUFM [P49411] | 2 | EBI-3893071,EBI-359097 |
Sarm1 [Q6PDS3] from Mus musculus. | 2 | EBI-3893071,EBI-6117196 |
Isoform 1 [Q86UT6-1]
With | #Exp. | IntAct |
---|---|---|
MAVS - isoform 1 [Q7Z434-1] | 3 | EBI-15680006,EBI-15577799 |
Protein-protein interaction databases
BioGRIDi | 122796, 63 interactors |
DIPi | DIP-60637N |
IntActi | Q86UT6, 29 interactors |
STRINGi | 9606.ENSP00000387334 |
Miscellaneous databases
RNActi | Q86UT6, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q86UT6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 160 – 483 | NACHTPROSITE-ProRule annotationAdd BLAST | 324 | |
Domaini | 667 – 694 | LRRNTAdd BLAST | 28 | |
Repeati | 695 – 718 | LRR 11 PublicationAdd BLAST | 24 | |
Repeati | 724 – 747 | LRR 21 PublicationAdd BLAST | 24 | |
Repeati | 749 – 777 | LRR 31 PublicationAdd BLAST | 29 | |
Repeati | 778 – 801 | LRR 41 PublicationAdd BLAST | 24 | |
Repeati | 811 – 834 | LRR 51 PublicationAdd BLAST | 24 | |
Repeati | 835 – 857 | LRR 61 PublicationAdd BLAST | 23 | |
Repeati | 858 – 877 | LRR 71 PublicationAdd BLAST | 20 | |
Repeati | 878 – 899 | LRR 81 PublicationAdd BLAST | 22 | |
Domaini | 906 – 970 | LRRCTAdd BLAST | 65 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 75 – 556 | Required for interaction with MAVS1 PublicationAdd BLAST | 482 | |
Regioni | 556 – 974 | Required for the repression of MAVS-induced interferon signalingAdd BLAST | 419 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Leucine-rich repeat, Repeat, Transit peptidePhylogenomic databases
eggNOGi | KOG4308, Eukaryota |
GeneTreei | ENSGT00940000159493 |
HOGENOMi | CLU_016769_0_0_1 |
InParanoidi | Q86UT6 |
OMAi | NQPDCGC |
OrthoDBi | 114368at2759 |
PhylomeDBi | Q86UT6 |
TreeFami | TF331068 |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR032675, LRR_dom_sf IPR007111, NACHT_NTPase IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF13516, LRR_6, 1 hit PF05729, NACHT, 1 hit |
PROSITEi | View protein in PROSITE PS50837, NACHT, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRWGHHLPRA SWGSGFRRAL QRPDDRIPFL IHWSWPLQGE RPFGPPRAFI
60 70 80 90 100
RHHGSSVDSA PPPGRHGRLF PSASATEAIQ RHRRNLAEWF SRLPREERQF
110 120 130 140 150
GPTFALDTVH VDPVIRESTP DELLRPPAEL ALEHQPPQAG LPPLALSQLF
160 170 180 190 200
NPDACGRRVQ TVVLYGTVGT GKSTLVRKMV LDWCYGRLPA FELLIPFSCE
210 220 230 240 250
DLSSLGPAPA SLCQLVAQRY TPLKEVLPLM AAAGSHLLFV LHGLEHLNLD
260 270 280 290 300
FRLAGTGLCS DPEEPQEPAA IIVNLLRKYM LPQASILVTT RPSAIGRIPS
310 320 330 340 350
KYVGRYGEIC GFSDTNLQKL YFQLRLNQPY CGYAVGGSGV SATPAQRDHL
360 370 380 390 400
VQMLSRNLEG HHQIAAACFL PSYCWLVCAT LHFLHAPTPA GQTLTSIYTS
410 420 430 440 450
FLRLNFSGET LDSTDPSNLS LMAYAARTMG KLAYEGVSSR KTYFSEEDVC
460 470 480 490 500
GCLEAGIRTE EEFQLLHIFR RDALRFFLAP CVEPGRAGTF VFTVPAMQEY
510 520 530 540 550
LAALYIVLGL RKTTLQKVGK EVAELVGRVG EDVSLVLGIM AKLLPLRALP
560 570 580 590 600
LLFNLIKVVP RVFGRMVGKS REAVAQAMVL EMFREEDYYN DDVLDQMGAS
610 620 630 640 650
ILGVEGPRRH PDEPPEDEVF ELFPMFMGGL LSAHNRAVLA QLGCPIKNLD
660 670 680 690 700
ALENAQAIKK KLGKLGRQVL PPSELLDHLF FHYEFQNQRF SAEVLSSLRQ
710 720 730 740 750
LNLAGVRMTP VKCTVVAAVL GSGRHALDEV NLASCQLDPA GLRTLLPVFL
760 770 780 790 800
RARKLGLQLN SLGPEACKDL RDLLLHDQCQ ITTLRLSNNP LTAAGVAVLM
810 820 830 840 850
EGLAGNTSVT HLSLLHTGLG DEGLELLAAQ LDRNRQLQEL NVAYNGAGDT
860 870 880 890 900
AALALARAAR EHPSLELLHL YFNELSSEGR QVLRDLGGAA EGGARVVVSL
910 920 930 940 950
TEGTAVSEYW SVILSEVQRN LNSWDRARVQ RHLELLLRDL EDSRGATLNP
960 970
WRKAQLLRVE GEVRALLEQL GSSGS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J0R6 | C9J0R6_HUMAN | NLR family member X1 | NLRX1 | 151 | Annotation score: | ||
C9JLK8 | C9JLK8_HUMAN | NLR family member X1 | NLRX1 | 127 | Annotation score: | ||
C9JQE9 | C9JQE9_HUMAN | NLR family member X1 | NLRX1 | 137 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 325 | R → C in BAG53014 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 575 | A → T in BAG51714 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034614 | 63 | P → S2 PublicationsCorresponds to variant dbSNP:rs643423Ensembl. | 1 | |
Natural variantiVAR_034615 | 125 | R → L. Corresponds to variant dbSNP:rs3809045Ensembl. | 1 | |
Natural variantiVAR_034616 | 793 | A → E3 PublicationsCorresponds to variant dbSNP:rs4245191Ensembl. | 1 | |
Natural variantiVAR_034617 | 843 | A → S. Corresponds to variant dbSNP:rs35500631Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027158 | 869 – 921 | HLYFN…VQRNL → QGVAIQMCWKLPLLPYAHLW TPRMPSHWCFLLILMPPLPQ WYDGLVAPRGRCT in isoform 2. 1 PublicationAdd BLAST | 53 | |
Alternative sequenceiVSP_027159 | 922 – 975 | Missing in isoform 2. 1 PublicationAdd BLAST | 54 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY245437 mRNA Translation: AAP31240.1 BK001111 mRNA Translation: DAA01244.1 EF452237 mRNA Translation: ABO40480.1 AB094095 mRNA Translation: BAC76049.1 AK025131 mRNA Translation: BAB15075.1 Different initiation. AK056454 mRNA Translation: BAG51714.1 Sequence problems. AK095247 mRNA Translation: BAG53014.1 AK291716 mRNA Translation: BAF84405.1 BC013199 mRNA Translation: AAH13199.3 BC110890 mRNA Translation: AAI10891.1 |
CCDSi | CCDS8416.1 [Q86UT6-1] |
RefSeqi | NP_001269072.1, NM_001282143.1 [Q86UT6-1] NP_001269073.1, NM_001282144.1 [Q86UT6-1] NP_001269287.1, NM_001282358.1 [Q86UT6-1] NP_078894.2, NM_024618.3 [Q86UT6-1] XP_005271726.1, XM_005271669.1 [Q86UT6-1] XP_006718967.1, XM_006718904.1 [Q86UT6-2] XP_011541282.1, XM_011542980.1 [Q86UT6-1] |
Genome annotation databases
Ensembli | ENST00000292199; ENSP00000292199; ENSG00000160703 ENST00000409109; ENSP00000387334; ENSG00000160703 ENST00000409265; ENSP00000386858; ENSG00000160703 ENST00000409991; ENSP00000386851; ENSG00000160703 ENST00000525863; ENSP00000433442; ENSG00000160703 [Q86UT6-2] |
GeneIDi | 79671 |
KEGGi | hsa:79671 |
MANE-Selecti | ENST00000409109.6; ENSP00000387334.1; NM_001282144.2; NP_001269073.1 |
UCSCi | uc001pvu.5, human [Q86UT6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY245437 mRNA Translation: AAP31240.1 BK001111 mRNA Translation: DAA01244.1 EF452237 mRNA Translation: ABO40480.1 AB094095 mRNA Translation: BAC76049.1 AK025131 mRNA Translation: BAB15075.1 Different initiation. AK056454 mRNA Translation: BAG51714.1 Sequence problems. AK095247 mRNA Translation: BAG53014.1 AK291716 mRNA Translation: BAF84405.1 BC013199 mRNA Translation: AAH13199.3 BC110890 mRNA Translation: AAI10891.1 |
CCDSi | CCDS8416.1 [Q86UT6-1] |
RefSeqi | NP_001269072.1, NM_001282143.1 [Q86UT6-1] NP_001269073.1, NM_001282144.1 [Q86UT6-1] NP_001269287.1, NM_001282358.1 [Q86UT6-1] NP_078894.2, NM_024618.3 [Q86UT6-1] XP_005271726.1, XM_005271669.1 [Q86UT6-1] XP_006718967.1, XM_006718904.1 [Q86UT6-2] XP_011541282.1, XM_011542980.1 [Q86UT6-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3UN9 | X-ray | 2.65 | A/B/C | 629-975 | [»] | |
SMRi | Q86UT6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 122796, 63 interactors |
DIPi | DIP-60637N |
IntActi | Q86UT6, 29 interactors |
STRINGi | 9606.ENSP00000387334 |
PTM databases
iPTMneti | Q86UT6 |
PhosphoSitePlusi | Q86UT6 |
Genetic variation databases
BioMutai | NLRX1 |
DMDMi | 74759406 |
Proteomic databases
EPDi | Q86UT6 |
jPOSTi | Q86UT6 |
MassIVEi | Q86UT6 |
MaxQBi | Q86UT6 |
PaxDbi | Q86UT6 |
PeptideAtlasi | Q86UT6 |
PRIDEi | Q86UT6 |
ProteomicsDBi | 69887 [Q86UT6-1] 69888 [Q86UT6-2] |
Protocols and materials databases
Antibodypediai | 45879, 234 antibodies from 36 providers |
DNASUi | 79671 |
Genome annotation databases
Ensembli | ENST00000292199; ENSP00000292199; ENSG00000160703 ENST00000409109; ENSP00000387334; ENSG00000160703 ENST00000409265; ENSP00000386858; ENSG00000160703 ENST00000409991; ENSP00000386851; ENSG00000160703 ENST00000525863; ENSP00000433442; ENSG00000160703 [Q86UT6-2] |
GeneIDi | 79671 |
KEGGi | hsa:79671 |
MANE-Selecti | ENST00000409109.6; ENSP00000387334.1; NM_001282144.2; NP_001269073.1 |
UCSCi | uc001pvu.5, human [Q86UT6-1] |
Organism-specific databases
CTDi | 79671 |
DisGeNETi | 79671 |
GeneCardsi | NLRX1 |
HGNCi | HGNC:29890, NLRX1 |
HPAi | ENSG00000160703, Tissue enhanced (esophagus) |
MIMi | 611947, gene |
neXtProti | NX_Q86UT6 |
OpenTargetsi | ENSG00000160703 |
PharmGKBi | PA162398052 |
VEuPathDBi | HostDB:ENSG00000160703 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4308, Eukaryota |
GeneTreei | ENSGT00940000159493 |
HOGENOMi | CLU_016769_0_0_1 |
InParanoidi | Q86UT6 |
OMAi | NQPDCGC |
OrthoDBi | 114368at2759 |
PhylomeDBi | Q86UT6 |
TreeFami | TF331068 |
Enzyme and pathway databases
PathwayCommonsi | Q86UT6 |
Reactomei | R-HSA-168928, DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-936440, Negative regulators of DDX58/IFIH1 signaling |
SignaLinki | Q86UT6 |
SIGNORi | Q86UT6 |
Miscellaneous databases
BioGRID-ORCSi | 79671, 6 hits in 1045 CRISPR screens |
ChiTaRSi | NLRX1, human |
GeneWikii | NLRX1 |
GenomeRNAii | 79671 |
Pharosi | Q86UT6, Tbio |
PROi | PR:Q86UT6 |
RNActi | Q86UT6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000160703, Expressed in lower esophagus mucosa and 217 other tissues |
ExpressionAtlasi | Q86UT6, baseline and differential |
Genevisiblei | Q86UT6, HS |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR032675, LRR_dom_sf IPR007111, NACHT_NTPase IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF13516, LRR_6, 1 hit PF05729, NACHT, 1 hit |
PROSITEi | View protein in PROSITE PS50837, NACHT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NLRX1_HUMAN | |
Accessioni | Q86UT6Primary (citable) accession number: Q86UT6 Secondary accession number(s): A8K6Q1 Q9H724 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 24, 2007 |
Last sequence update: | June 1, 2003 | |
Last modified: | February 23, 2022 | |
This is version 159 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families