UniProtKB - Q86US8 (EST1A_HUMAN)
Telomerase-binding protein EST1A
SMG6
Functioni
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 1251 | Manganese; catalyticCurated | 1 | |
Metal bindingi | 1353 | Manganese; catalyticCurated | 1 | |
Metal bindingi | 1392 | Manganese; catalyticCurated | 1 |
GO - Molecular functioni
- DNA polymerase binding Source: BHF-UCL
- endoribonuclease activity Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- ribonucleoprotein complex binding Source: BHF-UCL
- RNA binding Source: BHF-UCL
- telomerase RNA binding Source: BHF-UCL
- telomeric DNA binding Source: HGNC-UCL
GO - Biological processi
- mRNA export from nucleus Source: HGNC-UCL
- negative regulation of telomere capping Source: BHF-UCL
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: UniProtKB
- regulation of dephosphorylation Source: HGNC-UCL
- regulation of telomerase activity Source: BHF-UCL
- regulation of telomere maintenance Source: BHF-UCL
- regulation of telomere maintenance via telomerase Source: BHF-UCL
Keywordsi
Molecular function | DNA-binding, Endonuclease, Hydrolase, Nuclease |
Biological process | Nonsense-mediated mRNA decay |
Ligand | Manganese, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q86US8 |
Reactomei | R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Names & Taxonomyi
Protein namesi | Recommended name: Telomerase-binding protein EST1A (EC:3.1.-.-)Alternative name(s): EST1-like protein A Ever shorter telomeres 1A Smg-6 homolog Telomerase subunit EST1A hSmg5/7a |
Gene namesi | Name:SMG6 Synonyms:C17orf31, EST1A, KIAA0732 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17809, SMG6 |
MIMi | 610963, gene |
neXtProti | NX_Q86US8 |
VEuPathDBi | HostDB:ENSG00000070366.13 |
Subcellular locationi
Cytosol
- cytosol Source: UniProtKB
Nucleus
- nucleolus Source: BHF-UCL
- nucleus Source: HGNC-UCL
- telomerase holoenzyme complex Source: GO_Central
Other locations
- chromosome, telomeric region Source: UniProtKB-SubCell
- cytoplasm Source: HGNC-UCL
Keywords - Cellular componenti
Chromosome, Cytoplasm, Nucleus, TelomerePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 46 – 52 | RPDLEIY → EPDLEIE: Alters interaction with the EJC. Loss of interaction with the EJC; when associated with 140-E--E-146. 1 Publication | 7 | |
Mutagenesisi | 140 – 146 | KPDLQIY → EPDLQIE: Alters interaction with the EJC. Loss of interaction with the EJC; when associated with 46-E--E-52. 1 Publication | 7 | |
Mutagenesisi | 1251 | D → A: Impaired nonsense-mediated RNA decay. 2 Publications | 1 | |
Mutagenesisi | 1251 | D → N: Loss of endonuclease activity and nonsense-mediated RNA decay; when associated with N-1392. 2 Publications | 1 | |
Mutagenesisi | 1353 | D → A: Abolishes RNase activity. 2 Publications | 1 | |
Mutagenesisi | 1392 | D → A: Impaired nonsense-mediated RNA decay; when associated with A-1251. 2 Publications | 1 | |
Mutagenesisi | 1392 | D → N: Loss of endonuclease activity and nonsense-mediated RNA decay; when associated with N-1251. 2 Publications | 1 |
Organism-specific databases
DisGeNETi | 23293 |
OpenTargetsi | ENSG00000070366 |
PharmGKBi | PA25584 |
Miscellaneous databases
Pharosi | Q86US8, Tbio |
Chemistry databases
DrugBanki | DB05036, Grn163l |
Genetic variation databases
BioMutai | SMG6 |
DMDMi | 91771922 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000087069 | 1 – 1419 | Telomerase-binding protein EST1AAdd BLAST | 1419 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 203 | PhosphoserineCombined sources | 1 | |
Modified residuei | 332 | PhosphoserineBy similarity | 1 | |
Modified residuei | 406 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 433 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 471 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 479 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 484 | PhosphoserineCombined sources | 1 | |
Modified residuei | 831 | PhosphoserineCombined sources | 1 | |
Modified residuei | 870 | PhosphoserineCombined sources | 1 | |
Modified residuei | 874 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
EPDi | Q86US8 |
jPOSTi | Q86US8 |
MassIVEi | Q86US8 |
MaxQBi | Q86US8 |
PaxDbi | Q86US8 |
PeptideAtlasi | Q86US8 |
PRIDEi | Q86US8 |
ProteomicsDBi | 6930 69880 [Q86US8-1] 69881 [Q86US8-2] |
PTM databases
iPTMneti | Q86US8 |
MetOSitei | Q86US8 |
PhosphoSitePlusi | Q86US8 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000070366, Expressed in right ovary and 175 other tissues |
ExpressionAtlasi | Q86US8, baseline and differential |
Genevisiblei | Q86US8, HS |
Organism-specific databases
HPAi | ENSG00000070366, Low tissue specificity |
Interactioni
Subunit structurei
May form homooligomers (PubMed:20930030). Associated component of the telomerase holoenzyme complex (PubMed:19179534).
Interacts with TERT, independently of the telomerase RNA (PubMed:12676087, PubMed:12699629).
Interacts with SMG1, SMG5, SMG7, UPF1, UPF2, UPF3B and the PP2A catalytic subunits (PubMed:12554878, PubMed:19060897, PubMed:20930030).
Also interacts with the exon junction complex (EJC) composed at least of CASC3, EIF4A3, MAGOH and RBM8A; required for the process of nonsense-mediated mRNA decay (PubMed:20930030).
6 PublicationsBinary interactionsi
Hide detailsQ86US8
GO - Molecular functioni
- DNA polymerase binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 116888, 29 interactors |
CORUMi | Q86US8 |
IntActi | Q86US8, 20 interactors |
MINTi | Q86US8 |
STRINGi | 9606.ENSP00000263073 |
Miscellaneous databases
RNActi | Q86US8, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q86US8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q86US8 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1246 – 1397 | PINcAdd BLAST | 152 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 39 – 59 | EJC-binding motif 1; mediates interaction with the EJCAdd BLAST | 21 | |
Regioni | 114 – 503 | Interaction with telomeric DNAAdd BLAST | 390 | |
Regioni | 133 – 153 | EJC-binding motif 2; mediates interaction with the EJCAdd BLAST | 21 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 163 – 193 | Sequence analysisAdd BLAST | 31 | |
Coiled coili | 567 – 625 | Sequence analysisAdd BLAST | 59 | |
Coiled coili | 1197 – 1239 | Sequence analysisAdd BLAST | 43 |
Domaini
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG2162, Eukaryota |
GeneTreei | ENSGT00940000155300 |
HOGENOMi | CLU_004735_0_0_1 |
InParanoidi | Q86US8 |
OMAi | CSPDVWQ |
OrthoDBi | 556396at2759 |
PhylomeDBi | Q86US8 |
TreeFami | TF327119 |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR018834, DNA/RNA-bd_Est1-type IPR019458, EST1 IPR029060, PIN-like_dom_sf IPR002716, PIN_dom IPR011990, TPR-like_helical_dom_sf |
Pfami | View protein in Pfam PF10374, EST1, 1 hit PF10373, EST1_DNA_bind, 1 hit PF13638, PIN_4, 1 hit |
SMARTi | View protein in SMART SM00670, PINc, 1 hit |
SUPFAMi | SSF48452, SSF48452, 1 hit SSF88723, SSF88723, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAEGLERVRI SASELRGILA TLAPQAGSRE NMKELKEARP RKDNRRPDLE
60 70 80 90 100
IYKPGLSRLR NKPKIKEPPG SEEFKDEIVN DRDCSAVENG TQPVKDVCKE
110 120 130 140 150
LNNQEQNGPI DPENNRGQES FPRTAGQEDR SLKIIKRTKK PDLQIYQPGR
160 170 180 190 200
RLQTVSKESA SRVEEEEVLN QVEQLRVEED ECRGNVAKEE VANKPDRAEI
210 220 230 240 250
EKSPGGGRVG AAKGEKGKRM GKGEGVRETH DDPARGRPGS AKRYSRSDKR
260 270 280 290 300
RNRYRTRSTS SAGSNNSAEG AGLTDNGCRR RRQDRTKERP RLKKQVSVSS
310 320 330 340 350
TDSLDEDRID EPDGLGPRRS SERKRHLERN WSGRGEGEQK NSAKEYRGTL
360 370 380 390 400
RVTFDAEAMN KESPMVRSAR DDMDRGKPDK GLSSGGKGSE KQESKNPKQE
410 420 430 440 450
LRGRGRGILI LPAHTTLSVN SAGSPESAPL GPRLLFGSGS KGSRSWGRGG
460 470 480 490 500
TTRRLWDPNN PDQKPALKTQ TPQLHFLDTD DEVSPTSWGD SRQAQASYYK
510 520 530 540 550
FQNSDNPYYY PRTPGPASQY PYTGYNPLQY PVGPTNGVYP GPYYPGYPTP
560 570 580 590 600
SGQYVCSPLP TSTMSPEEVE QHMRNLQQQE LHRLLRVADN QELQLSNLLS
610 620 630 640 650
RDRISPEGLE KMAQLRAELL QLYERCILLD IEFSDNQNVD QILWKNAFYQ
660 670 680 690 700
VIEKFRQLVK DPNVENPEQI RNRLLELLDE GSDFFDSLLQ KLQVTYKFKL
710 720 730 740 750
EDYMDGLAIR SKPLRKTVKY ALISAQRCMI CQGDIARYRE QASDTANYGK
760 770 780 790 800
ARSWYLKAQH IAPKNGRPYN QLALLAVYTR RKLDAVYYYM RSLAASNPIL
810 820 830 840 850
TAKESLMSLF EETKRKAEQM EKKQHEEFDL SPDQWRKGKK STFRHVGDDT
860 870 880 890 900
TRLEIWIHPS HPRSSQGTES GKDSEQENGL GSLSPSDLNK RFILSFLHAH
910 920 930 940 950
GKLFTRIGME TFPAVAEKVL KEFQVLLQHS PSPIGSTRML QLMTINMFAV
960 970 980 990 1000
HNSQLKDCFS EECRSVIQEQ AAALGLAMFS LLVRRCTCLL KESAKAQLSS
1010 1020 1030 1040 1050
PEDQDDQDDI KVSSFVPDLK ELLPSVKVWS DWMLGYPDTW NPPPTSLDLP
1060 1070 1080 1090 1100
SHVAVDVWST LADFCNILTA VNQSEVPLYK DPDDDLTLLI LEEDRLLSGF
1110 1120 1130 1140 1150
VPLLAAPQDP CYVEKTSDKV IAADCKRVTV LKYFLEALCG QEEPLLAFKG
1160 1170 1180 1190 1200
GKYVSVAPVP DTMGKEMGSQ EGTRLEDEEE DVVIEDFEED SEAEGSGGED
1210 1220 1230 1240 1250
DIRELRAKKL ALARKIAEQQ RRQEKIQAVL EDHSQMRQME LEIRPLFLVP
1260 1270 1280 1290 1300
DTNGFIDHLA SLARLLESRK YILVVPLIVI NELDGLAKGQ ETDHRAGGYA
1310 1320 1330 1340 1350
RVVQEKARKS IEFLEQRFES RDSCLRALTS RGNELESIAF RSEDITGQLG
1360 1370 1380 1390 1400
NNDDLILSCC LHYCKDKAKD FMPASKEEPI RLLREVVLLT DDRNLRVKAL
1410
TRNVPVRDIP AFLTWAQVG
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketI3L390 | I3L390_HUMAN | Telomerase-binding protein EST1A | SMG6 | 208 | Annotation score: | ||
I3L355 | I3L355_HUMAN | Telomerase-binding protein EST1A | SMG6 | 123 | Annotation score: | ||
I3L176 | I3L176_HUMAN | Telomerase-binding protein EST1A | SMG6 | 162 | Annotation score: | ||
I3L1W8 | I3L1W8_HUMAN | Telomerase-binding protein EST1A | SMG6 | 164 | Annotation score: | ||
I3L3A9 | I3L3A9_HUMAN | Telomerase-binding protein EST1A | SMG6 | 119 | Annotation score: | ||
I3L421 | I3L421_HUMAN | Telomerase-binding protein EST1A | SMG6 | 163 | Annotation score: | ||
K7ENH7 | K7ENH7_HUMAN | Telomerase-binding protein EST1A | SMG6 | 115 | Annotation score: | ||
K7EKV2 | K7EKV2_HUMAN | Telomerase-binding protein EST1A | SMG6 | 138 | Annotation score: | ||
K7ELM2 | K7ELM2_HUMAN | Telomerase-binding protein EST1A | SMG6 | 124 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_018499 | 291 | R → P1 PublicationCorresponds to variant dbSNP:rs1885986Ensembl. | 1 | |
Natural variantiVAR_018500 | 294 | K → Q. Corresponds to variant dbSNP:rs216195Ensembl. | 1 | |
Natural variantiVAR_018501 | 341 | N → T2 PublicationsCorresponds to variant dbSNP:rs1885987Ensembl. | 1 | |
Natural variantiVAR_050978 | 575 | N → S. Corresponds to variant dbSNP:rs34047637Ensembl. | 1 | |
Natural variantiVAR_018502 | 972 | A → T. Corresponds to variant dbSNP:rs903160Ensembl. | 1 | |
Natural variantiVAR_050979 | 984 | R → C. Corresponds to variant dbSNP:rs35173108Ensembl. | 1 | |
Natural variantiVAR_061648 | 1189 | E → K. Corresponds to variant dbSNP:rs58801957EnsemblClinVar. | 1 | |
Natural variantiVAR_018503 | 1233 | H → R. Corresponds to variant dbSNP:rs2273980Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010360 | 1 – 1089 | Missing in isoform 2. 1 PublicationAdd BLAST | 1089 | |
Alternative sequenceiVSP_047157 | 1 – 908 | Missing in isoform 3. 1 PublicationAdd BLAST | 908 | |
Alternative sequenceiVSP_010361 | 1090 – 1119 | ILEED…KTSDK → MRFRLCHQRGCCPHERENTC TCKMIISSLQ in isoform 2. 1 PublicationAdd BLAST | 30 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY145883 mRNA Translation: AAN46114.1 AB018275 mRNA Translation: BAA34452.2 Different initiation. AL133597 mRNA Translation: CAB63733.1 AY168921 mRNA Translation: AAO17581.1 AK302964 mRNA Translation: BAH13860.1 AC090617 Genomic DNA No translation available. AL450226 Genomic DNA No translation available. CH471108 Genomic DNA Translation: EAW90559.1 BC064916 mRNA Translation: AAH64916.1 Different initiation. |
CCDSi | CCDS11016.1 [Q86US8-1] CCDS58498.1 [Q86US8-3] |
PIRi | T43475 |
RefSeqi | NP_001243756.1, NM_001256827.1 [Q86US8-3] NP_001243757.1, NM_001256828.1 [Q86US8-3] NP_001269255.1, NM_001282326.1 [Q86US8-2] NP_060045.4, NM_017575.4 [Q86US8-1] XP_005256626.1, XM_005256569.3 XP_005256628.1, XM_005256571.4 [Q86US8-3] XP_011522071.1, XM_011523769.2 XP_011522077.1, XM_011523775.2 [Q86US8-3] XP_016879888.1, XM_017024399.1 [Q86US8-3] |
Genome annotation databases
Ensembli | ENST00000263073; ENSP00000263073; ENSG00000070366 [Q86US8-1] ENST00000354901; ENSP00000346977; ENSG00000070366 [Q86US8-3] ENST00000536871; ENSP00000440283; ENSG00000070366 [Q86US8-3] |
GeneIDi | 23293 |
KEGGi | hsa:23293 |
UCSCi | uc002fub.2, human [Q86US8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY145883 mRNA Translation: AAN46114.1 AB018275 mRNA Translation: BAA34452.2 Different initiation. AL133597 mRNA Translation: CAB63733.1 AY168921 mRNA Translation: AAO17581.1 AK302964 mRNA Translation: BAH13860.1 AC090617 Genomic DNA No translation available. AL450226 Genomic DNA No translation available. CH471108 Genomic DNA Translation: EAW90559.1 BC064916 mRNA Translation: AAH64916.1 Different initiation. |
CCDSi | CCDS11016.1 [Q86US8-1] CCDS58498.1 [Q86US8-3] |
PIRi | T43475 |
RefSeqi | NP_001243756.1, NM_001256827.1 [Q86US8-3] NP_001243757.1, NM_001256828.1 [Q86US8-3] NP_001269255.1, NM_001282326.1 [Q86US8-2] NP_060045.4, NM_017575.4 [Q86US8-1] XP_005256626.1, XM_005256569.3 XP_005256628.1, XM_005256571.4 [Q86US8-3] XP_011522071.1, XM_011523769.2 XP_011522077.1, XM_011523775.2 [Q86US8-3] XP_016879888.1, XM_017024399.1 [Q86US8-3] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2DOK | X-ray | 1.80 | A/B | 1239-1419 | [»] | |
2HWW | X-ray | 1.80 | A/B/C | 1239-1419 | [»] | |
2HWX | X-ray | 1.90 | A | 1239-1419 | [»] | |
4UM2 | X-ray | 2.10 | A | 580-1166 | [»] | |
SMRi | Q86US8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116888, 29 interactors |
CORUMi | Q86US8 |
IntActi | Q86US8, 20 interactors |
MINTi | Q86US8 |
STRINGi | 9606.ENSP00000263073 |
Chemistry databases
DrugBanki | DB05036, Grn163l |
PTM databases
iPTMneti | Q86US8 |
MetOSitei | Q86US8 |
PhosphoSitePlusi | Q86US8 |
Genetic variation databases
BioMutai | SMG6 |
DMDMi | 91771922 |
Proteomic databases
EPDi | Q86US8 |
jPOSTi | Q86US8 |
MassIVEi | Q86US8 |
MaxQBi | Q86US8 |
PaxDbi | Q86US8 |
PeptideAtlasi | Q86US8 |
PRIDEi | Q86US8 |
ProteomicsDBi | 6930 69880 [Q86US8-1] 69881 [Q86US8-2] |
Protocols and materials databases
Antibodypediai | 50527, 68 antibodies |
DNASUi | 23293 |
Genome annotation databases
Ensembli | ENST00000263073; ENSP00000263073; ENSG00000070366 [Q86US8-1] ENST00000354901; ENSP00000346977; ENSG00000070366 [Q86US8-3] ENST00000536871; ENSP00000440283; ENSG00000070366 [Q86US8-3] |
GeneIDi | 23293 |
KEGGi | hsa:23293 |
UCSCi | uc002fub.2, human [Q86US8-1] |
Organism-specific databases
CTDi | 23293 |
DisGeNETi | 23293 |
GeneCardsi | SMG6 |
HGNCi | HGNC:17809, SMG6 |
HPAi | ENSG00000070366, Low tissue specificity |
MIMi | 610963, gene |
neXtProti | NX_Q86US8 |
OpenTargetsi | ENSG00000070366 |
PharmGKBi | PA25584 |
VEuPathDBi | HostDB:ENSG00000070366.13 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2162, Eukaryota |
GeneTreei | ENSGT00940000155300 |
HOGENOMi | CLU_004735_0_0_1 |
InParanoidi | Q86US8 |
OMAi | CSPDVWQ |
OrthoDBi | 556396at2759 |
PhylomeDBi | Q86US8 |
TreeFami | TF327119 |
Enzyme and pathway databases
PathwayCommonsi | Q86US8 |
Reactomei | R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Miscellaneous databases
BioGRID-ORCSi | 23293, 626 hits in 890 CRISPR screens |
ChiTaRSi | SMG6, human |
EvolutionaryTracei | Q86US8 |
GeneWikii | SMG6 |
GenomeRNAii | 23293 |
Pharosi | Q86US8, Tbio |
PROi | PR:Q86US8 |
RNActi | Q86US8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000070366, Expressed in right ovary and 175 other tissues |
ExpressionAtlasi | Q86US8, baseline and differential |
Genevisiblei | Q86US8, HS |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR018834, DNA/RNA-bd_Est1-type IPR019458, EST1 IPR029060, PIN-like_dom_sf IPR002716, PIN_dom IPR011990, TPR-like_helical_dom_sf |
Pfami | View protein in Pfam PF10374, EST1, 1 hit PF10373, EST1_DNA_bind, 1 hit PF13638, PIN_4, 1 hit |
SMARTi | View protein in SMART SM00670, PINc, 1 hit |
SUPFAMi | SSF48452, SSF48452, 1 hit SSF88723, SSF88723, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EST1A_HUMAN | |
Accessioni | Q86US8Primary (citable) accession number: Q86US8 Secondary accession number(s): B7Z874 Q9UF60 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 24, 2004 |
Last sequence update: | March 7, 2006 | |
Last modified: | February 10, 2021 | |
This is version 172 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references