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Entry version 184 (02 Dec 2020)
Sequence version 1 (01 Jun 2003)
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Protein

Regulating synaptic membrane exocytosis protein 1

Gene

RIMS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri110 – 170FYVE-typePROSITE-ProRule annotationAdd BLAST61

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation, Exocytosis, Neurotransmitter transport, Sensory transduction, Transport, Vision
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q86UR5

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-181429, Serotonin Neurotransmitter Release Cycle
R-HSA-181430, Norepinephrine Neurotransmitter Release Cycle
R-HSA-210500, Glutamate Neurotransmitter Release Cycle
R-HSA-212676, Dopamine Neurotransmitter Release Cycle
R-HSA-264642, Acetylcholine Neurotransmitter Release Cycle
R-HSA-888590, GABA synthesis, release, reuptake and degradation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q86UR5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Regulating synaptic membrane exocytosis protein 1
Alternative name(s):
Rab-3-interacting molecule 1
Short name:
RIM 1
Rab-3-interacting protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RIMS1
Synonyms:KIAA0340, RAB3IP2, RIM1
ORF Names:Nbla00761
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

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EuPathDBi
HostDB:ENSG00000079841.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17282, RIMS1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606629, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86UR5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cone-rod dystrophy 7 (CORD7)1 Publication
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionAn inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa, due to cone photoreceptors degenerating at a higher rate than rod photoreceptors.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_016804820R → H in CORD7. 1 PublicationCorresponds to variant dbSNP:rs121918302EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi796 – 797RR → AA: Abolishes interaction with SYT1 and CACNA1B. 1 Publication2
Mutagenesisi1591 – 1592KK → AA: Abolishes interaction with SYT1 and CACNA1B. 1 Publication2

Keywords - Diseasei

Cone-rod dystrophy, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
22999

MalaCards human disease database

More...
MalaCardsi
RIMS1
MIMi603649, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000079841

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
1872, Cone rod dystrophy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38220

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86UR5, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RIMS1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
34395763

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001901981 – 1692Regulating synaptic membrane exocytosis protein 1Add BLAST1692

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei500PhosphoserineBy similarity1
Modified residuei578PhosphoserineBy similarity1
Modified residuei728PhosphoserineBy similarity1
Modified residuei731PhosphoserineBy similarity1
Modified residuei881PhosphoserineBy similarity1
Modified residuei977PhosphoserineBy similarity1
Modified residuei1031PhosphoserineBy similarity1
Modified residuei1252PhosphoserineBy similarity1
Modified residuei1254PhosphothreonineBy similarity1
Modified residuei1256PhosphoserineBy similarity1
Modified residuei1308PhosphoserineBy similarity1
Modified residuei1310PhosphoserineBy similarity1
Modified residuei1311PhosphoserineBy similarity1
Modified residuei1339PhosphoserineBy similarity1
Modified residuei1340PhosphoserineBy similarity1
Modified residuei1342PhosphoserineBy similarity1
Modified residuei1416PhosphoserineBy similarity1
Modified residuei1677PhosphoserineCombined sources1
Modified residuei1680PhosphoserineCombined sources1
Modified residuei1683PhosphoserineCombined sources1
Modified residuei1692PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by BRSK1.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86UR5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86UR5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q86UR5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86UR5

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q86UR5

PeptideAtlas

More...
PeptideAtlasi
Q86UR5

PRoteomics IDEntifications database

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PRIDEi
Q86UR5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
19415
19549
20026
20521
69870 [Q86UR5-1]
69871 [Q86UR5-2]
69872 [Q86UR5-3]
69873 [Q86UR5-4]
69874 [Q86UR5-5]
69875 [Q86UR5-6]
69876 [Q86UR5-7]
69877 [Q86UR5-8]
69878 [Q86UR5-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86UR5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86UR5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in melanocytes (PubMed:23999003). Detected in brain and retina (PubMed:23999003).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000079841, Expressed in corpus callosum and 144 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86UR5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86UR5, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000079841, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds RAB3A, RAB3B and RAB3D that have been activated by GTP-binding.

Interacts with RAB3C, RAB10, RAB26 AND RAB37. Binds UNC13A.

Interacts with TSPOAP1 and RIMBP2.

Interacts with PPFIA3 and PPFIA4.

Interacts with ERC1 (By similarity). Binds SNAP25, SYT1 and CACNA1B. Interaction with SYT1 is enhanced by calcium ions. Interaction with SNAP25 is weaker in the presence of calcium ions.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
116646, 17 interactors

Protein interaction database and analysis system

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IntActi
Q86UR5, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000428417

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q86UR5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11692
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q86UR5

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q86UR5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 182RabBDPROSITE-ProRule annotationAdd BLAST161
Domaini605 – 691PDZPROSITE-ProRule annotationAdd BLAST87
Domaini742 – 865C2 1PROSITE-ProRule annotationAdd BLAST124
Domaini1538 – 1656C2 2PROSITE-ProRule annotationAdd BLAST119

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1336 – 1402Ser-richAdd BLAST67

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri110 – 170FYVE-typePROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2060, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155134

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001061_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86UR5

Identification of Orthologs from Complete Genome Data

More...
OMAi
NRGRWSP

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86UR5

TreeFam database of animal gene trees

More...
TreeFami
TF321703

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.10, 1 hit
2.60.40.150, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR041282, FYVE_2
IPR001478, PDZ
IPR036034, PDZ_sf
IPR010911, Rab_BD
IPR039032, Rim-like
IPR030630, RIM1
IPR017455, Znf_FYVE-rel
IPR011011, Znf_FYVE_PHD

The PANTHER Classification System

More...
PANTHERi
PTHR12157, PTHR12157, 1 hit
PTHR12157:SF19, PTHR12157:SF19, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168, C2, 2 hits
PF02318, FYVE_2, 1 hit
PF00595, PDZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239, C2, 2 hits
SM00228, PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156, SSF50156, 1 hit
SSF57903, SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004, C2, 2 hits
PS50106, PDZ, 1 hit
PS50916, RABBD, 1 hit
PS50178, ZF_FYVE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (13+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 13 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 13 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86UR5-1) [UniParc]FASTAAdd to basket
Also known as: RIM1 alpha

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSAVGPRGP RPPTVPPPMQ ELPDLSHLTE EERNIIMAVM DRQKEEEEKE
60 70 80 90 100
EAMLKCVVRD MAKPAACKTP RNAENQPHQP SPRLHQQFES YKEQVRKIGE
110 120 130 140 150
EARRYQGEHK DDAPTCGICH KTKFADGCGH LCSYCRTKFC ARCGGRVSLR
160 170 180 190 200
SNNEDKVVMW VCNLCRKQQE ILTKSGAWFF GSGPQQTSQD GTLSDTATGA
210 220 230 240 250
GSEVPREKKA RLQERSRSQT PLSTAAASSQ DAAPPSAPPD RSKGAEPSQQ
260 270 280 290 300
ALGPEQKQAS SRSRSEPPRE RKKTPGLSEQ NGKGALKSER KRVPKTSAQP
310 320 330 340 350
VEGAVEERER KERRESRRLE KGRSQDYPDT PEKRDEGKAA DEEKQRKEED
360 370 380 390 400
YQTRYRSDPN LARYPVKPPP EEQQMRMHAR VSRARHERRH SDVALPRTEA
410 420 430 440 450
GAALPEGKAG KRAPAAARAS PPDSPRAYSA ERTAETRAPG AKQLTNHSPP
460 470 480 490 500
APRHGPVPAE APELKAQEPL RKQSRLDPSS AVLMRKAKRE KVETMLRNDS
510 520 530 540 550
LSSDQSESVR PSPPKPHRSK RGGKKRQMSV SSSEEEGVST PEYTSCEDVE
560 570 580 590 600
LESESVSEKG DLDYYWLDPA TWHSRETSPI SSHPVTWQPS KEGDRLIGRV
610 620 630 640 650
ILNKRTTMPK DSGALLGLKV VGGKMTDLGR LGAFITKVKK GSLADVVGHL
660 670 680 690 700
RAGDEVLEWN GKPLPGATNE EVYNIILESK SEPQVEIIVS RPIGDIPRIP
710 720 730 740 750
ESSHPPLESS SSSFESQKME RPSISVISPT SPGALKDAPQ VLPGQLSVKL
760 770 780 790 800
WYDKVGHQLI VNVLQATDLP ARVDGRPRNP YVKMYFLPDR SDKSKRRTKT
810 820 830 840 850
VKKILEPKWN QTFVYSHVHR RDFRERMLEI TVWDQPRVQE EESEFLGEIL
860 870 880 890 900
IELETALLDD EPHWYKLQTH DESSLPLPQP SPFMPRRHIH GESSSKKLQR
910 920 930 940 950
SQRISDSDIS DYEVDDGIGV VPPVGYRSSA RESKSTTLTV PEQQRTTHHR
960 970 980 990 1000
SRSVSPHRGN DQGKPRSRLP NVPLQRSLDE IHPTRRSRSP TRHHDASRSP
1010 1020 1030 1040 1050
VDHRTRDVDS QYLSEQDSEL LMLPRAKRGR SAECLHTTRH LVRHYKTLPP
1060 1070 1080 1090 1100
KMPLLQSSSH WNIYSSILPA HTKTKSVTRQ DISLHHECFN STVLRFTDEI
1110 1120 1130 1140 1150
LVSELQPFLD RARSASTNCL RPDTSLHSPE RERGRWSPSL DRRRPPSPRI
1160 1170 1180 1190 1200
QIQHASPEND RHSRKSERSS IQKQTRKGTA SDAERVLPTC LSRRGHAAPR
1210 1220 1230 1240 1250
ATDQPVIRGK HPARSRSSEH SSIRTLCSMH HLVPGGSAPP SPLLTRMHRQ
1260 1270 1280 1290 1300
RSPTQSPPAD TSFSSRRGRQ LPQVPVRSGS IEQASLVVEE RTRQMKMKVH
1310 1320 1330 1340 1350
RFKQTTGSGS SQELDREQYS KYNIHKDQYR SCDNVSAKSS DSDVSDVSAI
1360 1370 1380 1390 1400
SRTSSASRLS STSFMSEQSE RPRGRISSFT PKMQGRRMGT SGRSIMKSTS
1410 1420 1430 1440 1450
VSGEMYTLEH NDGSQSDTAV GTVGAGGKKR RSSLSAKVVA IVSRRSRSTS
1460 1470 1480 1490 1500
QLSQTESGHK KLKSTIQRST ETGMAAEMRK MVRQPSREST DGSINSYSSE
1510 1520 1530 1540 1550
GNLIFPGVRL GADSQFSDFL DGLGPAQLVG RQTLATPAMG DIQIGMEDKK
1560 1570 1580 1590 1600
GQLEVEVIRA RSLTQKPGSK STPAPYVKVY LLENGACIAK KKTRIARKTL
1610 1620 1630 1640 1650
DPLYQQSLVF DESPQGKVLQ VIVWGDYGRM DHKCFMGVAQ ILLEELDLSS
1660 1670 1680 1690
MVIGWYKLFP PSSLVDPTLT PLTRRASQSS LESSTGPPCI RS
Length:1,692
Mass (Da):189,073
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0A96642DC832C15E
GO
Isoform 2 (identifier: Q86UR5-2) [UniParc]FASTAAdd to basket
Also known as: RIM short form

The sequence of this isoform differs from the canonical sequence as follows:
     1040-1692: Missing.

Note: May be due to intron retention.Curated
Show »
Length:1,039
Mass (Da):116,704
Checksum:iEF56FBC20E5A629E
GO
Isoform 3 (identifier: Q86UR5-3) [UniParc]FASTAAdd to basket
Also known as: RIM long form, Rab3 interacting protein variant 2

The sequence of this isoform differs from the canonical sequence as follows:
     1039-1102: Missing.
     1133-1245: Missing.
     1540-1573: Missing.

Show »
Length:1,481
Mass (Da):165,360
Checksum:iF34E4B8FAF1D35FD
GO
Isoform 4 (identifier: Q86UR5-4) [UniParc]FASTAAdd to basket
Also known as: Rab3 interacting protein variant 1

The sequence of this isoform differs from the canonical sequence as follows:
     1065-1102: Missing.
     1133-1245: Missing.

Show »
Length:1,541
Mass (Da):172,224
Checksum:i98A7006DC8206CB3
GO
Isoform 5 (identifier: Q86UR5-5) [UniParc]FASTAAdd to basket
Also known as: Rab3 interacting protein variant 3

The sequence of this isoform differs from the canonical sequence as follows:
     924-924: Missing.
     1038-1244: Missing.
     1377-1385: Missing.

Show »
Length:1,475
Mass (Da):164,580
Checksum:i8192B1AF38A1661B
GO
Isoform 6 (identifier: Q86UR5-6) [UniParc]FASTAAdd to basket
Also known as: Rab3 interacting protein variant 4

The sequence of this isoform differs from the canonical sequence as follows:
     1039-1102: Missing.
     1161-1245: Missing.
     1284-1455: Missing.

Show »
Length:1,371
Mass (Da):153,500
Checksum:i815C71ECFEF6D8C5
GO
Isoform 7 (identifier: Q86UR5-7) [UniParc]FASTAAdd to basket
Also known as: Rab3 interacting protein variant 5

The sequence of this isoform differs from the canonical sequence as follows:
     924-924: Missing.
     1039-1102: Missing.
     1133-1245: Missing.
     1284-1455: Missing.

Show »
Length:1,342
Mass (Da):150,109
Checksum:i87E88E425651F382
GO
Isoform 8 (identifier: Q86UR5-8) [UniParc]FASTAAdd to basket
Also known as: Rab3 interacting protein variant 6

The sequence of this isoform differs from the canonical sequence as follows:
     924-924: Missing.
     1018-1245: Missing.
     1284-1455: Missing.

Show »
Length:1,291
Mass (Da):144,361
Checksum:i8D52C8AD83A640AD
GO
Isoform 9 (identifier: Q86UR5-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MSSAVGPRGPRPPTVPPP → MFAGFLQFLLLHTLHSGT
     19-559: Missing.
     1039-1102: Missing.
     1133-1160: Missing.
     1185-1245: Missing.
     1284-1455: Missing.

Show »
Length:826
Mass (Da):92,731
Checksum:iC20C62181371B83B
GO
Isoform 10 (identifier: Q86UR5-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-607: Missing.
     1039-1102: Missing.
     1133-1160: Missing.
     1185-1245: Missing.
     1284-1455: Missing.

Show »
Length:760
Mass (Da):85,152
Checksum:i1BC5B3BB0B105D6B
GO
Isoform 11 (identifier: Q86UR5-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1473: Missing.

Show »
Length:219
Mass (Da):24,013
Checksum:i9906E3592B6D9848
GO
Isoform 12 (identifier: Q86UR5-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-559: MSSAVGPRGP...ELESESVSEK → MCAPGIHVSSEGWEEVRSVDSEEGTIEARRAVA
     924-924: Missing.
     1039-1102: Missing.
     1133-1160: Missing.
     1185-1245: Missing.

Show »
Length:1,012
Mass (Da):112,988
Checksum:iA6F0E2D8AFE8B426
GO
Isoform 13 (identifier: Q86UR5-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-559: MSSAVGPRGP...ELESESVSEK → MCAPGIHVSSEGWEEVRSVDSEEGTIEARRAVA
     1039-1102: Missing.
     1133-1245: Missing.
     1284-1455: Missing.

Show »
Length:817
Mass (Da):91,530
Checksum:i97107E7A7F961EC8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YBU6H0YBU6_HUMAN
Regulating synaptic membrane exocyt...
RIMS1
1,038Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGM0E5RGM0_HUMAN
Regulating synaptic membrane exocyt...
RIMS1
753Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBE7H0YBE7_HUMAN
Regulating synaptic membrane exocyt...
RIMS1
610Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DFV1A0A0C4DFV1_HUMAN
Regulating synaptic membrane exocyt...
RIMS1
740Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA20798 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI39600 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI42135 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti157V → Y in CAI16961 (PubMed:14574404).Curated1
Sequence conflicti484 – 494Missing in BAB87121 (Ref. 2) CuratedAdd BLAST11
Sequence conflicti484 – 494Missing in BAB87242 (Ref. 2) CuratedAdd BLAST11
Sequence conflicti484 – 494Missing in BAA20798 (PubMed:9205841).CuratedAdd BLAST11
Sequence conflicti484 – 494Missing in AAI51854 (PubMed:15489334).CuratedAdd BLAST11
Sequence conflicti484 – 494Missing in AAI52436 (PubMed:15489334).CuratedAdd BLAST11
Sequence conflicti1272P → S in BAH11945 (PubMed:14702039).Curated1
Sequence conflicti1606Q → R in BAH11906 (PubMed:14702039).Curated1
Sequence conflicti1609V → A in BAH13358 (PubMed:14702039).Curated1
Sequence conflicti1662S → P in AK309185 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016804820R → H in CORD7. 1 PublicationCorresponds to variant dbSNP:rs121918302EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0454851 – 1473Missing in isoform 11. 1 PublicationAdd BLAST1473
Alternative sequenceiVSP_0454861 – 607Missing in isoform 10. 1 PublicationAdd BLAST607
Alternative sequenceiVSP_0467961 – 559MSSAV…SVSEK → MCAPGIHVSSEGWEEVRSVD SEEGTIEARRAVA in isoform 12 and isoform 13. 1 PublicationAdd BLAST559
Alternative sequenceiVSP_0431771 – 18MSSAV…TVPPP → MFAGFLQFLLLHTLHSGT in isoform 9. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_04317819 – 559Missing in isoform 9. 1 PublicationAdd BLAST541
Alternative sequenceiVSP_008161924Missing in isoform 5, isoform 7, isoform 8 and isoform 12. 2 Publications1
Alternative sequenceiVSP_0081621018 – 1245Missing in isoform 8. 1 PublicationAdd BLAST228
Alternative sequenceiVSP_0081631038 – 1244Missing in isoform 5. 1 PublicationAdd BLAST207
Alternative sequenceiVSP_0081641039 – 1102Missing in isoform 3, isoform 6, isoform 7, isoform 9, isoform 10, isoform 12 and isoform 13. 3 PublicationsAdd BLAST64
Alternative sequenceiVSP_0081651040 – 1692Missing in isoform 2. 3 PublicationsAdd BLAST653
Alternative sequenceiVSP_0081661065 – 1102Missing in isoform 4. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_0081671133 – 1245Missing in isoform 3, isoform 4, isoform 7 and isoform 13. 3 PublicationsAdd BLAST113
Alternative sequenceiVSP_0431791133 – 1160Missing in isoform 9, isoform 10 and isoform 12. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_0081681161 – 1245Missing in isoform 6. 1 PublicationAdd BLAST85
Alternative sequenceiVSP_0431801185 – 1245Missing in isoform 9, isoform 10 and isoform 12. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_0081691284 – 1455Missing in isoform 6, isoform 7, isoform 8, isoform 9, isoform 10 and isoform 13. 2 PublicationsAdd BLAST172
Alternative sequenceiVSP_0081701377 – 1385Missing in isoform 5. 1 Publication9
Alternative sequenceiVSP_0081711540 – 1573Missing in isoform 3. 2 PublicationsAdd BLAST34

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY190519 mRNA Translation: AAO38848.1
AB045726 mRNA Translation: BAB87121.1
AB051866 mRNA Translation: BAB87242.1
AB002338 mRNA Translation: BAA20798.1 Different initiation.
AK296303 mRNA Translation: BAH12309.1
AK294868 mRNA Translation: BAH11906.1
AK295001 mRNA Translation: BAH11945.1
AK300853 mRNA Translation: BAH13358.1
AK309185 mRNA No translation available.
AL160405 Genomic DNA No translation available.
AL590011 AL445256 Genomic DNA Translation: CAI16961.1
AL034373 AL590011 Genomic DNA Translation: CAI20558.1
AL390056 AL590011 Genomic DNA Translation: CAI21554.1
AL445256 AL590011 Genomic DNA Translation: CAI39598.1
AL445256, AL035633 Genomic DNA Translation: CAI39600.1 Sequence problems.
AL445256, AL035633 Genomic DNA Translation: CAI39604.1
AL035633, AL445256 Genomic DNA Translation: CAI42135.1 Sequence problems.
AL035633, AL445256 Genomic DNA Translation: CAI42139.1
BC151853 mRNA Translation: AAI51854.1
BC152435 mRNA Translation: AAI52436.1
AF263305 mRNA Translation: AAG23162.1
AF263306 mRNA Translation: AAG23163.1
AF263307 mRNA Translation: AAG23164.1
AF263308 mRNA Translation: AAG23165.1
AF263309 mRNA Translation: AAG23166.1
AF263310 mRNA Translation: AAG23167.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47449.1 [Q86UR5-1]
CCDS55029.1 [Q86UR5-13]
CCDS55030.1 [Q86UR5-12]
CCDS55031.1 [Q86UR5-9]
CCDS55032.1 [Q86UR5-10]
CCDS55033.1 [Q86UR5-11]

NCBI Reference Sequences

More...
RefSeqi
NP_001161879.1, NM_001168407.1 [Q86UR5-12]
NP_001161880.1, NM_001168408.1 [Q86UR5-13]
NP_001161881.1, NM_001168409.1 [Q86UR5-10]
NP_001161882.1, NM_001168410.1 [Q86UR5-9]
NP_001161883.1, NM_001168411.1 [Q86UR5-11]
NP_055804.2, NM_014989.5 [Q86UR5-1]
XP_011533917.2, XM_011535615.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000264839; ENSP00000264839; ENSG00000079841 [Q86UR5-4]
ENST00000401910; ENSP00000385649; ENSG00000079841 [Q86UR5-12]
ENST00000414192; ENSP00000402273; ENSG00000079841 [Q86UR5-11]
ENST00000425662; ENSP00000411235; ENSG00000079841 [Q86UR5-10]
ENST00000491071; ENSP00000430101; ENSG00000079841 [Q86UR5-3]
ENST00000517827; ENSP00000428367; ENSG00000079841 [Q86UR5-9]
ENST00000517960; ENSP00000429959; ENSG00000079841 [Q86UR5-5]
ENST00000518273; ENSP00000430408; ENSG00000079841 [Q86UR5-6]
ENST00000520567; ENSP00000430502; ENSG00000079841 [Q86UR5-7]
ENST00000521978; ENSP00000428417; ENSG00000079841 [Q86UR5-1]
ENST00000522291; ENSP00000430932; ENSG00000079841 [Q86UR5-8]
ENST00000523963; ENSP00000428328; ENSG00000079841 [Q86UR5-13]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
22999

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:22999

UCSC genome browser

More...
UCSCi
uc003pga.5, human [Q86UR5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY190519 mRNA Translation: AAO38848.1
AB045726 mRNA Translation: BAB87121.1
AB051866 mRNA Translation: BAB87242.1
AB002338 mRNA Translation: BAA20798.1 Different initiation.
AK296303 mRNA Translation: BAH12309.1
AK294868 mRNA Translation: BAH11906.1
AK295001 mRNA Translation: BAH11945.1
AK300853 mRNA Translation: BAH13358.1
AK309185 mRNA No translation available.
AL160405 Genomic DNA No translation available.
AL590011 AL445256 Genomic DNA Translation: CAI16961.1
AL034373 AL590011 Genomic DNA Translation: CAI20558.1
AL390056 AL590011 Genomic DNA Translation: CAI21554.1
AL445256 AL590011 Genomic DNA Translation: CAI39598.1
AL445256, AL035633 Genomic DNA Translation: CAI39600.1 Sequence problems.
AL445256, AL035633 Genomic DNA Translation: CAI39604.1
AL035633, AL445256 Genomic DNA Translation: CAI42135.1 Sequence problems.
AL035633, AL445256 Genomic DNA Translation: CAI42139.1
BC151853 mRNA Translation: AAI51854.1
BC152435 mRNA Translation: AAI52436.1
AF263305 mRNA Translation: AAG23162.1
AF263306 mRNA Translation: AAG23163.1
AF263307 mRNA Translation: AAG23164.1
AF263308 mRNA Translation: AAG23165.1
AF263309 mRNA Translation: AAG23166.1
AF263310 mRNA Translation: AAG23167.1
CCDSiCCDS47449.1 [Q86UR5-1]
CCDS55029.1 [Q86UR5-13]
CCDS55030.1 [Q86UR5-12]
CCDS55031.1 [Q86UR5-9]
CCDS55032.1 [Q86UR5-10]
CCDS55033.1 [Q86UR5-11]
RefSeqiNP_001161879.1, NM_001168407.1 [Q86UR5-12]
NP_001161880.1, NM_001168408.1 [Q86UR5-13]
NP_001161881.1, NM_001168409.1 [Q86UR5-10]
NP_001161882.1, NM_001168410.1 [Q86UR5-9]
NP_001161883.1, NM_001168411.1 [Q86UR5-11]
NP_055804.2, NM_014989.5 [Q86UR5-1]
XP_011533917.2, XM_011535615.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CSSNMR-A585-692[»]
SMRiQ86UR5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116646, 17 interactors
IntActiQ86UR5, 6 interactors
STRINGi9606.ENSP00000428417

PTM databases

iPTMnetiQ86UR5
PhosphoSitePlusiQ86UR5

Polymorphism and mutation databases

BioMutaiRIMS1
DMDMi34395763

Proteomic databases

EPDiQ86UR5
jPOSTiQ86UR5
MassIVEiQ86UR5
MaxQBiQ86UR5
PaxDbiQ86UR5
PeptideAtlasiQ86UR5
PRIDEiQ86UR5
ProteomicsDBi19415
19549
20026
20521
69870 [Q86UR5-1]
69871 [Q86UR5-2]
69872 [Q86UR5-3]
69873 [Q86UR5-4]
69874 [Q86UR5-5]
69875 [Q86UR5-6]
69876 [Q86UR5-7]
69877 [Q86UR5-8]
69878 [Q86UR5-9]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
49157, 15 antibodies

Genome annotation databases

EnsembliENST00000264839; ENSP00000264839; ENSG00000079841 [Q86UR5-4]
ENST00000401910; ENSP00000385649; ENSG00000079841 [Q86UR5-12]
ENST00000414192; ENSP00000402273; ENSG00000079841 [Q86UR5-11]
ENST00000425662; ENSP00000411235; ENSG00000079841 [Q86UR5-10]
ENST00000491071; ENSP00000430101; ENSG00000079841 [Q86UR5-3]
ENST00000517827; ENSP00000428367; ENSG00000079841 [Q86UR5-9]
ENST00000517960; ENSP00000429959; ENSG00000079841 [Q86UR5-5]
ENST00000518273; ENSP00000430408; ENSG00000079841 [Q86UR5-6]
ENST00000520567; ENSP00000430502; ENSG00000079841 [Q86UR5-7]
ENST00000521978; ENSP00000428417; ENSG00000079841 [Q86UR5-1]
ENST00000522291; ENSP00000430932; ENSG00000079841 [Q86UR5-8]
ENST00000523963; ENSP00000428328; ENSG00000079841 [Q86UR5-13]
GeneIDi22999
KEGGihsa:22999
UCSCiuc003pga.5, human [Q86UR5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22999
DisGeNETi22999
EuPathDBiHostDB:ENSG00000079841.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RIMS1
HGNCiHGNC:17282, RIMS1
HPAiENSG00000079841, Tissue enriched (brain)
MalaCardsiRIMS1
MIMi603649, phenotype
606629, gene
neXtProtiNX_Q86UR5
OpenTargetsiENSG00000079841
Orphaneti1872, Cone rod dystrophy
PharmGKBiPA38220

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2060, Eukaryota
GeneTreeiENSGT00940000155134
HOGENOMiCLU_001061_1_0_1
InParanoidiQ86UR5
OMAiNRGRWSP
PhylomeDBiQ86UR5
TreeFamiTF321703

Enzyme and pathway databases

PathwayCommonsiQ86UR5
ReactomeiR-HSA-181429, Serotonin Neurotransmitter Release Cycle
R-HSA-181430, Norepinephrine Neurotransmitter Release Cycle
R-HSA-210500, Glutamate Neurotransmitter Release Cycle
R-HSA-212676, Dopamine Neurotransmitter Release Cycle
R-HSA-264642, Acetylcholine Neurotransmitter Release Cycle
R-HSA-888590, GABA synthesis, release, reuptake and degradation
SIGNORiQ86UR5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
22999, 4 hits in 848 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RIMS1, human
EvolutionaryTraceiQ86UR5

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
RIMS1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
22999
PharosiQ86UR5, Tbio

Protein Ontology

More...
PROi
PR:Q86UR5
RNActiQ86UR5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000079841, Expressed in corpus callosum and 144 other tissues
ExpressionAtlasiQ86UR5, baseline and differential
GenevisibleiQ86UR5, HS

Family and domain databases

Gene3Di2.30.42.10, 1 hit
2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR041282, FYVE_2
IPR001478, PDZ
IPR036034, PDZ_sf
IPR010911, Rab_BD
IPR039032, Rim-like
IPR030630, RIM1
IPR017455, Znf_FYVE-rel
IPR011011, Znf_FYVE_PHD
PANTHERiPTHR12157, PTHR12157, 1 hit
PTHR12157:SF19, PTHR12157:SF19, 1 hit
PfamiView protein in Pfam
PF00168, C2, 2 hits
PF02318, FYVE_2, 1 hit
PF00595, PDZ, 1 hit
SMARTiView protein in SMART
SM00239, C2, 2 hits
SM00228, PDZ, 1 hit
SUPFAMiSSF50156, SSF50156, 1 hit
SSF57903, SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 2 hits
PS50106, PDZ, 1 hit
PS50916, RABBD, 1 hit
PS50178, ZF_FYVE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRIMS1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86UR5
Secondary accession number(s): A7MBN6
, B7Z2M0, B7Z2Q9, B7Z3S3, B7Z6S2, E7EX08, E9PCB7, E9PCZ1, E9PF48, E9PHF5, E9PHR1, O15048, Q5JY21, Q5JY25, Q5SZK1, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: June 1, 2003
Last modified: December 2, 2020
This is version 184 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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