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Entry version 155 (07 Apr 2021)
Sequence version 1 (01 Jun 2003)
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Protein

NADPH oxidase activator 1

Gene

NOXA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.8 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q86UR1

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-5668599, RHO GTPases Activate NADPH Oxidases
R-HSA-9673324, WNT5:FZD7-mediated leishmania damping

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q86UR1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NADPH oxidase activator 1
Short name:
NOX activator 1
Alternative name(s):
Antigen NY-CO-31
NCF2-like protein
P67phox-like factor
p51-nox
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NOXA1
Synonyms:P51NOX
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:10668, NOXA1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
611255, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q86UR1

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSG00000188747.8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi34P → A: Partial loss of function. 1 Publication1
Mutagenesisi37P → A: Partial loss of function. 1 Publication1
Mutagenesisi68D → A: Loss of function and loss of interaction with RAC1. 1 Publication1
Mutagenesisi103R → E: Loss of function and loss of interaction with RAC1. Loss of localization to membranes. 3 Publications1
Mutagenesisi172S → A: Loss of phosphorylation. Loss of interaction with YHAWZ; when associated with A-461. 1 Publication1
Mutagenesisi172S → E: Constitutively interacts with YWHAZ; when associated with E-461. 1 Publication1
Mutagenesisi205V → A: Unable to activate NOX2. 1 Publication1
Mutagenesisi436W → R: Loss of interaction with NOXO1 and NCF1. Loss of localization to membranes. Partial loss of function. 3 Publications1
Mutagenesisi461S → A: Loss of phosphorylation. Loss of interaction with YHAWZ; when associated with A-172. 1 Publication1
Mutagenesisi461S → E: Constitutively interacts with YWHAZ; when associated with E-172. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
10811

Open Targets

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OpenTargetsi
ENSG00000188747

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA35598

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q86UR1, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
NOXA1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74759404

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003146091 – 476NADPH oxidase activator 1Add BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei172Phosphoserine; by PKA1 Publication1
Modified residuei461Phosphoserine; by PKA1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Interaction with YWHAZ depends on phosphorylation by PKA.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q86UR1

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q86UR1

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q86UR1

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q86UR1

PeptideAtlas

More...
PeptideAtlasi
Q86UR1

PRoteomics IDEntifications database

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PRIDEi
Q86UR1

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
69867 [Q86UR1-1]
69868 [Q86UR1-2]
69869 [Q86UR1-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86UR1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86UR1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Detected in pancreas, liver, kidney, spleen, prostate, small intestine and colon.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in fetal kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000188747, Expressed in cerebellar vermis and 194 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q86UR1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000188747, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

NOX1, NOXA1, NOXO1, RAC1 and CYBA forms a functional multimeric complex supporting ROS production. Interaction with YWHAZ prevents the interaction of NOXA1 with NOXO1 and RAC1 and its targeting to membranes, hence reducing its ability to activate NOX1.

Interacts (via N-terminus) with SH3PXD2A and SH3PXD2B; the interaction is direct.

7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q86UR1
With#Exp.IntAct
NOXO1 - isoform 3 [Q8NFA2-3]5EBI-949814,EBI-20557410
RIMBP3 [Q9UFD9]4EBI-949814,EBI-10182375
NOXA1 - isoform 2 [Q86UR1-2]
With#Exp.IntAct
ANKRD55 [Q3KP44]3EBI-12025760,EBI-14493093
C19orf54 - isoform 3 [Q5BKX5-3]5EBI-12025760,EBI-11976299
CEP70 [Q8NHQ1]3EBI-12025760,EBI-739624
CFP [P27918]3EBI-12025760,EBI-9038570
CRYBA1 [P05813]3EBI-12025760,EBI-7043337
CTDSP1 [Q9GZU7]3EBI-12025760,EBI-751587
CYSRT1 [A8MQ03]3EBI-12025760,EBI-3867333
DCLRE1B [Q9H816]3EBI-12025760,EBI-3508943
DDAH2 [O95865]3EBI-12025760,EBI-749139
DUSP4 [Q13115]3EBI-12025760,EBI-6591081
GATAD2B [Q8WXI9]3EBI-12025760,EBI-923440
IL16 - isoform 2 [Q14005-2]6EBI-12025760,EBI-17178971
KCTD15 - isoform 2 [Q96SI1-2]3EBI-12025760,EBI-12382297
KRTAP15-1 [Q3LI76]3EBI-12025760,EBI-11992140
KRTAP19-4 [Q3LI73]3EBI-12025760,EBI-12958461
KRTAP19-7 [Q3SYF9]3EBI-12025760,EBI-10241353
KRTAP8-1 [Q8IUC2]3EBI-12025760,EBI-10261141
LASP1 - isoform 2 [Q14847-2]3EBI-12025760,EBI-9088686
LMO2 - isoform 3 [P25791-3]3EBI-12025760,EBI-11959475
METTL27 [Q8N6F8]3EBI-12025760,EBI-8487781
MORN3 [Q6PF18]3EBI-12025760,EBI-9675802
MYLIP [Q8WY64]5EBI-12025760,EBI-6952711
NAA10 [P41227]6EBI-12025760,EBI-747693
NADSYN1 [Q6IA69]3EBI-12025760,EBI-748610
NDUFAB1 [O14561]3EBI-12025760,EBI-1246261
itself3EBI-12025760,EBI-12025760
PFDN5 [Q99471]3EBI-12025760,EBI-357275
PLA2G10 [O15496]3EBI-12025760,EBI-726466
QARS1 [P47897]3EBI-12025760,EBI-347462
REL - isoform 2 [Q04864-2]3EBI-12025760,EBI-10829018
RIMBP3 [Q9UFD9]3EBI-12025760,EBI-10182375
SMRP1 [Q8NCR6]3EBI-12025760,EBI-10269322
SMUG1 - isoform 2 [Q53HV7-2]4EBI-12025760,EBI-12275818
TCF19 [Q9Y242]3EBI-12025760,EBI-7413767
TCF4 - isoform SEF2-1D [P15884-3]3EBI-12025760,EBI-13636688
TGS1 [Q96RS0]3EBI-12025760,EBI-949244
TRAF2 [Q12933]3EBI-12025760,EBI-355744
TRIM23 [P36406]3EBI-12025760,EBI-740098
UBAP2 [Q5T6F2]3EBI-12025760,EBI-2514383
WDR83 [Q9BRX9]3EBI-12025760,EBI-7705033
ZC2HC1C - isoform 2 [Q53FD0-2]3EBI-12025760,EBI-14104088
ZNF474 [Q6S9Z5]3EBI-12025760,EBI-17269964
ZNF620 [Q6ZNG0]3EBI-12025760,EBI-4395669

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
116025, 58 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q86UR1

Protein interaction database and analysis system

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IntActi
Q86UR1, 50 interactors

Molecular INTeraction database

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MINTi
Q86UR1

STRING: functional protein association networks

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STRINGi
9606.ENSP00000342848

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q86UR1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q86UR1

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati7 – 38TPR 1Add BLAST32
Repeati39 – 71TPR 2Add BLAST33
Repeati73 – 105TPR 3Add BLAST33
Repeati122 – 155TPR 4Add BLAST34
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini315 – 395PB1PROSITE-ProRule annotationAdd BLAST81
Domaini399 – 458SH3PROSITE-ProRule annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 224Mediates interaction with RAC1Add BLAST224

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SH3 domain mediates interaction with NOXO1 and NCF1 and has autoregulatory function.
The TPR repeats mediate interaction with RAC1.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NCF2/NOXA1 family.Curated

Keywords - Domaini

Repeat, SH3 domain, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4225, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00530000063843

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_041290_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q86UR1

Identification of Orthologs from Complete Genome Data

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OMAi
DWHRGVQ

Database of Orthologous Groups

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OrthoDBi
431898at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q86UR1

TreeFam database of animal gene trees

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TreeFami
TF329087

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR034899, NOXA1
IPR000270, PB1_dom
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat

The PANTHER Classification System

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PANTHERi
PTHR15175:SF4, PTHR15175:SF4, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00564, PB1, 1 hit
PF00018, SH3_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00666, PB1, 1 hit
SM00326, SH3, 1 hit
SM00028, TPR, 3 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48452, SSF48452, 1 hit
SSF50044, SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51745, PB1, 1 hit
PS50002, SH3, 1 hit
PS50293, TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q86UR1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASLGDLVRA WHLGAQAVDR GDWARALHLF SGVPAPPARL CFNAGCVHLL
60 70 80 90 100
AGDPEAALRA FDQAVTKDTC MAVGFFQRGV ANFQLARFQE ALSDFWLALE
110 120 130 140 150
QLRGHAAIDY TQLGLRFKLQ AWEVLHNVAS AQCQLGLWTE AASSLREAMS
160 170 180 190 200
KWPEGSLNGL DSALDQVQRR GSLPPRQVPR GEVFRPHRWH LKHLEPVDFL
210 220 230 240 250
GKAKVVASAI PDDQGWGVRP QQPQGPGANH DARSLIMDSP RAGTHQGPLD
260 270 280 290 300
AETEVGADRC TSTAYQEQRP QVEQVGKQAP LSPGLPAMGG PGPGPCEDPA
310 320 330 340 350
GAGGAGAGGS EPLVTVTVQC AFTVALRARR GADLSSLRAL LGQALPHQAQ
360 370 380 390 400
LGQLSYLAPG EDGHWVPIPE EESLQRAWQD AAACPRGLQL QCRGAGGRPV
410 420 430 440 450
LYQVVAQHSY SAQGPEDLGF RQGDTVDVLC EVDQAWLEGH CDGRIGIFPK
460 470
CFVVPAGPRM SGAPGRLPRS QQGDQP
Length:476
Mass (Da):50,933
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i64DFBF64C59722AD
GO
Isoform 2 (identifier: Q86UR1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     431-431: E → EEPDVPLA

Note: Mostly inactive for NOX1 activation. Does not interact with NOXO1.Curated
Show »
Length:483
Mass (Da):51,655
Checksum:i3C3B2AC24286D2D2
GO
Isoform 3 (identifier: Q86UR1-3) [UniParc]FASTAAdd to basket
Also known as: NOXA1inhib

The sequence of this isoform differs from the canonical sequence as follows:
     168-223: Missing.
     431-431: E → EEPDVPLA

Note: Inactive for NOX1 activation.Curated
Show »
Length:427
Mass (Da):45,245
Checksum:i122CD814C315AA08
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAY16126 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti51A → T in AAY16126 (PubMed:17602954).Curated1
Sequence conflicti56A → T in AAY16127 (PubMed:17602954).Curated1
Sequence conflicti73V → L in AAY16127 (PubMed:17602954).Curated1
Sequence conflicti142A → T in AAY16127 (PubMed:17602954).Curated1
Sequence conflicti261T → A in AAY16126 (PubMed:17602954).Curated1
Sequence conflicti277K → E in AAY16126 (PubMed:17602954).Curated1
Sequence conflicti278Q → V in AAC18046 (PubMed:9610721).Curated1
Sequence conflicti320C → R in AAY16127 (PubMed:17602954).Curated1
Sequence conflicti329R → G in AAC18046 (PubMed:9610721).Curated1
Sequence conflicti345 – 346LP → FL in AAC18046 (PubMed:9610721).Curated2
Sequence conflicti354L → F in AAC18046 (PubMed:9610721).Curated1
Sequence conflicti409S → R in AAC18046 (PubMed:9610721).Curated1
Sequence conflicti441C → R in AAI10841 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037985274 – 476Missing Found in a truncated form isolated from Caco-2 cells treated with butyrate. Add BLAST203
Natural variantiVAR_037986286P → L1 PublicationCorresponds to variant dbSNP:rs34155071Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_030335168 – 223Missing in isoform 3. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_030336431E → EEPDVPLA in isoform 2 and isoform 3. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY255769 mRNA Translation: AAP13480.1
AB095031 mRNA Translation: BAC76710.1
AY927790 mRNA Translation: AAY16126.1 Frameshift.
AY927791 mRNA Translation: AAY16127.1
BX322799 Genomic DNA No translation available.
BC041594 mRNA Translation: AAH41594.1
BC110840 mRNA Translation: AAI10841.1
AF039697 mRNA Translation: AAC18046.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS59157.1 [Q86UR1-3]
CCDS7042.1 [Q86UR1-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001242996.1, NM_001256067.1 [Q86UR1-1]
NP_001242997.1, NM_001256068.1 [Q86UR1-3]
NP_006638.1, NM_006647.1 [Q86UR1-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000341349; ENSP00000342848; ENSG00000188747 [Q86UR1-2]
ENST00000392815; ENSP00000376562; ENSG00000188747 [Q86UR1-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10811

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10811

UCSC genome browser

More...
UCSCi
uc004cmu.4, human [Q86UR1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY255769 mRNA Translation: AAP13480.1
AB095031 mRNA Translation: BAC76710.1
AY927790 mRNA Translation: AAY16126.1 Frameshift.
AY927791 mRNA Translation: AAY16127.1
BX322799 Genomic DNA No translation available.
BC041594 mRNA Translation: AAH41594.1
BC110840 mRNA Translation: AAI10841.1
AF039697 mRNA Translation: AAC18046.1
CCDSiCCDS59157.1 [Q86UR1-3]
CCDS7042.1 [Q86UR1-2]
RefSeqiNP_001242996.1, NM_001256067.1 [Q86UR1-1]
NP_001242997.1, NM_001256068.1 [Q86UR1-3]
NP_006638.1, NM_006647.1 [Q86UR1-2]

3D structure databases

SMRiQ86UR1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116025, 58 interactors
ELMiQ86UR1
IntActiQ86UR1, 50 interactors
MINTiQ86UR1
STRINGi9606.ENSP00000342848

PTM databases

iPTMnetiQ86UR1
PhosphoSitePlusiQ86UR1

Genetic variation databases

BioMutaiNOXA1
DMDMi74759404

Proteomic databases

EPDiQ86UR1
jPOSTiQ86UR1
MassIVEiQ86UR1
PaxDbiQ86UR1
PeptideAtlasiQ86UR1
PRIDEiQ86UR1
ProteomicsDBi69867 [Q86UR1-1]
69868 [Q86UR1-2]
69869 [Q86UR1-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
32446, 137 antibodies

Genome annotation databases

EnsembliENST00000341349; ENSP00000342848; ENSG00000188747 [Q86UR1-2]
ENST00000392815; ENSP00000376562; ENSG00000188747 [Q86UR1-3]
GeneIDi10811
KEGGihsa:10811
UCSCiuc004cmu.4, human [Q86UR1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10811
DisGeNETi10811

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NOXA1
HGNCiHGNC:10668, NOXA1
HPAiENSG00000188747, Low tissue specificity
MIMi611255, gene
neXtProtiNX_Q86UR1
OpenTargetsiENSG00000188747
PharmGKBiPA35598
VEuPathDBiHostDB:ENSG00000188747.8

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4225, Eukaryota
GeneTreeiENSGT00530000063843
HOGENOMiCLU_041290_1_0_1
InParanoidiQ86UR1
OMAiDWHRGVQ
OrthoDBi431898at2759
PhylomeDBiQ86UR1
TreeFamiTF329087

Enzyme and pathway databases

PathwayCommonsiQ86UR1
ReactomeiR-HSA-5668599, RHO GTPases Activate NADPH Oxidases
R-HSA-9673324, WNT5:FZD7-mediated leishmania damping
SIGNORiQ86UR1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
10811, 7 hits in 984 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
NOXA1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10811
PharosiQ86UR1, Tbio

Protein Ontology

More...
PROi
PR:Q86UR1
RNActiQ86UR1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000188747, Expressed in cerebellar vermis and 194 other tissues
GenevisibleiQ86UR1, HS

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR034899, NOXA1
IPR000270, PB1_dom
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
PANTHERiPTHR15175:SF4, PTHR15175:SF4, 1 hit
PfamiView protein in Pfam
PF00564, PB1, 1 hit
PF00018, SH3_1, 1 hit
SMARTiView protein in SMART
SM00666, PB1, 1 hit
SM00326, SH3, 1 hit
SM00028, TPR, 3 hits
SUPFAMiSSF48452, SSF48452, 1 hit
SSF50044, SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51745, PB1, 1 hit
PS50002, SH3, 1 hit
PS50293, TPR_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNOXA1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86UR1
Secondary accession number(s): O60533
, Q29VU9, Q29VV0, Q2TAM1, Q8IUS3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2003
Last modified: April 7, 2021
This is version 155 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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