Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 133 (11 Dec 2019)
Sequence version 3 (05 Apr 2011)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

ATP-binding cassette sub-family A member 13

Gene

ABCA13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi3875 – 3882ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi4754 – 4761ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6798695 Neutrophil degranulation

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.1.211.18 the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-binding cassette sub-family A member 13
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABCA13
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000179869.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14638 ABCA13

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607807 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86UQ4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei23 – 43HelicalSequence analysisAdd BLAST21
Transmembranei3568 – 3588HelicalSequence analysisAdd BLAST21
Transmembranei3607 – 3627HelicalSequence analysisAdd BLAST21
Transmembranei3648 – 3668HelicalSequence analysisAdd BLAST21
Transmembranei3679 – 3699HelicalSequence analysisAdd BLAST21
Transmembranei3709 – 3729HelicalSequence analysisAdd BLAST21
Transmembranei3752 – 3772HelicalSequence analysisAdd BLAST21
Transmembranei4226 – 4246HelicalSequence analysisAdd BLAST21
Transmembranei4458 – 4478HelicalSequence analysisAdd BLAST21
Transmembranei4504 – 4524HelicalSequence analysisAdd BLAST21
Transmembranei4536 – 4556HelicalSequence analysisAdd BLAST21
Transmembranei4568 – 4588HelicalSequence analysisAdd BLAST21
Transmembranei4607 – 4627HelicalSequence analysisAdd BLAST21
Transmembranei4651 – 4671HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
154664

Open Targets

More...
OpenTargetsi
ENSG00000179869

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134925234

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86UQ4 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ABCA13

Domain mapping of disease mutations (DMDM)

More...
DMDMi
327478592

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002535731 – 5058ATP-binding cassette sub-family A member 13Add BLAST5058

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86UQ4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86UQ4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q86UQ4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86UQ4

PeptideAtlas

More...
PeptideAtlasi
Q86UQ4

PRoteomics IDEntifications database

More...
PRIDEi
Q86UQ4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
69861 [Q86UQ4-1]
69862 [Q86UQ4-2]
69863 [Q86UQ4-3]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q86UQ4

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86UQ4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86UQ4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Significantly expressed in the bone marrow, trachea, testis, thyroid and lung as well as in skin fibroblasts.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000179869 Expressed in 85 organ(s), highest expression level in bronchial epithelial cell

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86UQ4 baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA063601

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127551, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q86UQ4, 3 interactors

Molecular INTeraction database

More...
MINTi
Q86UQ4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000411096

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q86UQ4 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86UQ4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3842 – 4074ABC transporter 1PROSITE-ProRule annotationAdd BLAST233
Domaini4718 – 4956ABC transporter 2PROSITE-ProRule annotationAdd BLAST239

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ABC transporter superfamily.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0059 Eukaryota
COG1131 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161703

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000033760

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86UQ4

KEGG Orthology (KO)

More...
KOi
K05647

Database of Orthologous Groups

More...
OrthoDBi
131191at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86UQ4

TreeFam database of animal gene trees

More...
TreeFami
TF105191

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR026082 ABCA
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR19229 PTHR19229, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86UQ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGHAGCQFKA LLWKNWLCRL RNPVLFLAEF FWPCILFVIL TVLRFQEPPR
60 70 80 90 100
YRDICYLQPR DLPSCGVIPF VQSLLCNTGS RCRNFSYEGS MEHHFRLSRF
110 120 130 140 150
QTAADPKKVN NLAFLKEIQD LAEEIHGMMD KAKNLKRLWV ERSNTPDSSY
160 170 180 190 200
GSSFFTMDLN KTEEVILKLE SLHQQPHIWD FLLLLPRLHT SHDHVEDGMD
210 220 230 240 250
VAVNLLQTIL NSLISLEDLD WLPLNQTFSQ VSELVLNVTI STLTFLQQHG
260 270 280 290 300
VAVTEPVYHL SMQNIVWDPQ KVQYDLKSQF GFDDLHTEQI LNSSAELKEI
310 320 330 340 350
PTDTSLEKMV CSVLSSTSED EAEKWGHVGG CHPKWSEAKN YLVHAVSWLR
360 370 380 390 400
VYQQVFVQWQ QGSLLQKTLT GMGHSLEALR NQFEEESKPW KVVEALHTAL
410 420 430 440 450
LLLNDSLSAD GPKDNHTFPK ILQHLWKLQS LLQNLPQWPA LKRFLQLDGA
460 470 480 490 500
LRNAIAQNLH FVQEVLICLE TSANDFKWFE LNQLKLEKDV FFWELKQMLA
510 520 530 540 550
KNAVCPNGRF SEKEVFLPPG NSSIWGGLQG LLCYCNSSET SVLNKLLGSV
560 570 580 590 600
EDADRILQEV ITWHKNMSVL IPEEYLDWQE LEMQLSEASL SCTRLFLLLG
610 620 630 640 650
ADPSPENDVF SSDCKHQLVS TVIFHTLEKT QFFLEQAYYW KAFKKFIRKT
660 670 680 690 700
CEVAQYVNMQ ESFQNRLLAF PEESPCFEEN MDWKMISDNY FQFLNNLLKS
710 720 730 740 750
PTASISRALN FTKHLLMMEK KLHTLEDEQM NFLLSFVEFF EKLLLPNLFD
760 770 780 790 800
SSIVPSFHSL PSLTEDILNI SSLWTNHLKS LKRDPSATDA QKLLEFGNEV
810 820 830 840 850
IWKMQTLGSH WIRKEPKNLL RFIELILFEI NPKLLELWAY GISKGKRAKL
860 870 880 890 900
ENFFTLLNFS VPENEILSTS FNFSQLFHSD WPKSPAMNID FVRLSEAIIT
910 920 930 940 950
SLHEFGFLEQ EQISEALNTV YAIRNASDLF SALSEPQKQE VDKILTHIHL
960 970 980 990 1000
NVFQDKDSAL LLQIYSSFYR YIYELLNIQS RGSSLTFLTQ ISKHILDIIK
1010 1020 1030 1040 1050
QFNFQNISKA FAFLFKTAEV LGGISNVSYC QQLLSIFNFL ELQAQSFMST
1060 1070 1080 1090 1100
EGQELEVIHT TLTGLKQLLI IDEDFRISLF QYMSQFFNSS VEDLLDNKCL
1110 1120 1130 1140 1150
ISDNKHISSV NYSTSEESSF VFPLAQIFSN LSANVSVFNK FMSIHCTVSW
1160 1170 1180 1190 1200
LQMWTEIWET ISQLFKFDMN VFTSLHHGFT QLLDELEDDV KVSKSCQGIL
1210 1220 1230 1240 1250
PTHNVARLIL NLFKNVTQAN DFHNWEDFLD LRDFLVALGN ALVSVKKLNL
1260 1270 1280 1290 1300
EQVEKSLFTM EAALHQLKTF PFNESTSREF LNSLLEVFIE FSSTSEYIVR
1310 1320 1330 1340 1350
NLDSINDFLS NNLTNYGEKF ENIITELREA IVFLRNVSHD RDLFSCADIF
1360 1370 1380 1390 1400
QNVTECILED GFLYVNTSQR MLRILDTLNS TFSSENTISS LKGCIVWLDV
1410 1420 1430 1440 1450
INHLYLLSNS SFSQGHLQNI LGNFRDIENK MNSILKIVTW VLNIKKPLCS
1460 1470 1480 1490 1500
SNGSHINCVN IYLKDVTDFL NIVLTTVFEK EKKPKFEILL ALLNDSTKQV
1510 1520 1530 1540 1550
RMSINNLTTD FDFASQSNWR YFTELILRPI EMSDEIPNQF QNIWLHLITL
1560 1570 1580 1590 1600
GKEFQKLVKG IYFNILENNS SSKTENLLNI FATSPKEKDV NSVGNSIYHL
1610 1620 1630 1640 1650
ASYLAFSLSH DLQNSPKIII SPEIMKATGL GIQLIRDVFN SLMPVVHHTS
1660 1670 1680 1690 1700
PQNAGYMQAL KKVTSVMRTL KKADIDLLVD QLEQVSVNLM DFFKNISSVG
1710 1720 1730 1740 1750
TGNLVVNLLV GLMEKFADSS HSWNVNHLLQ LSRLFPKDVV DAVIDVYYVL
1760 1770 1780 1790 1800
PHAVRLLQGV PGKNITEGLK DVYSFTLLHG ITISNITKED FAIVIKILLD
1810 1820 1830 1840 1850
TIELVSDKPD IISEALACFP VVWCWNHTNS GFRQNSKIDP CNVHGLMSSS
1860 1870 1880 1890 1900
FYGKVASILD HFHLSPQGED SPCSNESSRM EITRKVVCII HELVDWNSIL
1910 1920 1930 1940 1950
LELSEVFHVN ISLVKTVQKF WHKILPFVPP SINQTRDSIS ELCPSGSIKQ
1960 1970 1980 1990 2000
VALQIIEKLK NVNFTKVTSG ENILDKLSSL NKILNINEDT ETSVQNIISS
2010 2020 2030 2040 2050
NLERTVQLIS EDWSLEKSTH NLLSLFMMLQ NANVTGSSLE ALSSFIEKSE
2060 2070 2080 2090 2100
TPYNFEELWP KFQQIMKDLT QDFRIRHLLS EMNKGIKSIN SMALQKITLQ
2110 2120 2130 2140 2150
FAHFLEILDS PSLKTLEIIE DFLLVTKNWL QEYANEDYSR MIETLFIPVT
2160 2170 2180 2190 2200
NESSTEDIAL LAKAIATFWG SLKNISRAGN FDVAFLTHLL NQEQLTNFSV
2210 2220 2230 2240 2250
VQLLFENILI NLINNLAGNS QEAAWNLNDT DLQIMNFINL ILNHMQSETS
2260 2270 2280 2290 2300
RKTVLSLRSI VDFTEQFLKT FFSLFLKEDS ENKISLLLKY FHKDVIAEMS
2310 2320 2330 2340 2350
FVPKDKILEI LKLDQFLTLM IQDRLMNIFS SLKETIYHLM KSSFILDNGE
2360 2370 2380 2390 2400
FYFDTHQGLK FMQDLFNALL RETSMKNKTE NNIDFFTVVS QLFFHVNKSE
2410 2420 2430 2440 2450
DLFKLNQDLG SALHLVRECS TEMARLLDTI LHSPNKDFYA LYPTLQEVIL
2460 2470 2480 2490 2500
ANLTDLLFFI NNSFPLRNRA TLEITKRLVG AISRASEESH VLKPLLEMSG
2510 2520 2530 2540 2550
TLVMLLNDSA DLRDLATSMD SIVKLLKLVK KVSGKMSTVF KTHFISNTKD
2560 2570 2580 2590 2600
SVKFFDTLYS IMQQSVQNLV KEIATLKKID HFTFEKINDL LVPFLDLAFE
2610 2620 2630 2640 2650
MIGVEPYISS NSDIFSMSPS ILSYMNQSKD FSDILEEIAE FLTSVKMNLE
2660 2670 2680 2690 2700
DMRSLAVAFN NETQTFSMDS VNLREEILGC LVPINNITNQ MDFLYPNPIS
2710 2720 2730 2740 2750
THSGPQDIKW EIIHEVIPFL DKILSQNSTE IGSFLKMVIC LTLEALWKNL
2760 2770 2780 2790 2800
KKDNWNVSNV LMTFTQHPNN LLKTIETVLE ASSGIKSDYE GDLNKSLYFD
2810 2820 2830 2840 2850
TPLSQNITHH QLEKAIHNVL SRIALWRKGL LFNNSEWITS TRTLFQPLFE
2860 2870 2880 2890 2900
IFIKATTGKN VTSEKEERTK KEMIDFPYSF KPFFCLEKYL GGLFVLTKYW
2910 2920 2930 2940 2950
QQIPLTDQSV VEICEVFQQT VKPSEAMEML QKVKMMVVRV LTIVAENPSW
2960 2970 2980 2990 3000
TKDILCATLS CKQNGIRHLI LSAIQGVTLA QDHFQEIEKI WSSPNQLNCE
3010 3020 3030 3040 3050
SLSKNLSSTL ESFKSSLENA TGQDCTSQPR LETVQQHLYM LAKSLEETWS
3060 3070 3080 3090 3100
SGNPIMTFLS NFTVTEDVKI KDLMKNITKL TEELRSSIQI SNETIHSILE
3110 3120 3130 3140 3150
ANISHSKVLF SALTVALSGK CDQEILHLLL TFPKGEKSWI AAEELCSLPG
3160 3170 3180 3190 3200
SKVYSLIVLL SRNLDVRAFI YKTLMPSEAN GLLNSLLDIV SSLSALLAKA
3210 3220 3230 3240 3250
QHVFEYLPEF LHTFKITALL ETLDFQQVSQ NVQARSSAFG SFQFVMKMVC
3260 3270 3280 3290 3300
KDQASFLSDS NMFINLPRVK ELLEDDKEKF NIPEDSTPFC LKLYQEILQL
3310 3320 3330 3340 3350
PNGALVWTFL KPILHGKILY TPNTPEINKV IQKANYTFYI VDKLKTLSET
3360 3370 3380 3390 3400
LLEMSSLFQR SGSGQMFNQL QEALRNKFVR NFVENQLHID VDKLTEKLQT
3410 3420 3430 3440 3450
YGGLLDEMFN HAGAGRFRFL GSILVNLSSC VALNRFQALQ SVDILETKAH
3460 3470 3480 3490 3500
ELLQQNSFLA SIIFSNSLFD KNFRSESVKL PPHVSYTIRT NVLYSVRTDV
3510 3520 3530 3540 3550
VKNPSWKFHP QNLPADGFKY NYVFAPLQDM IERAIILVQT GQEALEPAAQ
3560 3570 3580 3590 3600
TQAAPYPCHT SDLFLNNVGF FFPLIMMLTW MVSVASMVRK LVYEQEIQIE
3610 3620 3630 3640 3650
EYMRMMGVHP VIHFLAWFLE NMAVLTISSA TLAIVLKTSG IFAHSNTFIV
3660 3670 3680 3690 3700
FLFLLDFGMS VVMLSYLLSA FFSQANTAAL CTSLVYMISF LPYIVLLVLH
3710 3720 3730 3740 3750
NQLSFVNQTF LCLLSTTAFG QGVFFITFLE GQETGIQWNN MYQALEQGGM
3760 3770 3780 3790 3800
TFGWVCWMIL FDSSLYFLCG WYLSNLIPGT FGLRKPWYFP FTASYWKSVG
3810 3820 3830 3840 3850
FLVEKRQYFL SSSLFFFNEN FDNKGSSLQN REGELEGSAP GVTLVSVTKE
3860 3870 3880 3890 3900
YEGHKAVVQD LSLTFYRDQI TALLGTNGAG KTTIISMLTG LHPPTSGTII
3910 3920 3930 3940 3950
INGKNLQTDL SRVRMELGVC PQQDILLDNL TVREHLLLFA SIKAPQWTKK
3960 3970 3980 3990 4000
ELHQQVNQTL QDVDLTQHQH KQTRALSGGL KRKLSLGIAF MGMSRTVVLD
4010 4020 4030 4040 4050
EPTSGVDPCS RHSLWDILLK YREGRTIIFT THHLDEAEAL SDRVAVLQHG
4060 4070 4080 4090 4100
RLRCCGPPFC LKEAYGQGLR LTLTRQPSVL EAHDLKDMAC VTSLIKIYIP
4110 4120 4130 4140 4150
QAFLKDSSGS ELTYTIPKDT DKACLKGLFQ ALDENLHQLH LTGYGISDTT
4160 4170 4180 4190 4200
LEEVFLMLLQ DSNKKSHIAL GTESELQNHR PTGHLSGYCG SLARPATVQG
4210 4220 4230 4240 4250
VQLLRAQVAA ILARRLRRTL RAGKSTLADL LLPVLFVALA MGLFMVRPLA
4260 4270 4280 4290 4300
TEYPPLRLTP GHYQRAETYF FSSGGDNLDL TRVLLRKFRD QDLPCADLNP
4310 4320 4330 4340 4350
RQKNSSCWRT DPFSHPEFQD SCGCLKCPNR SASAPYLTNH LGHTLLNLSG
4360 4370 4380 4390 4400
FNMEEYLLAP SEKPRLGGWS FGLKIPSEAG GANGNISKPP TLAKVWYNQK
4410 4420 4430 4440 4450
GFHSLPSYLN HLNNLILWQH LPPTVDWRQY GITLYSHPYG GALLNKDKIL
4460 4470 4480 4490 4500
ESIRQCGVAL CIVLGFSILS ASIGSSVVRD RVIGAKRLQH ISGLGYRMYW
4510 4520 4530 4540 4550
FTNFLYDMLF YLVSVCLCVA VIVAFQLTAF TFRKNLAATA LLLSLFGYAT
4560 4570 4580 4590 4600
LPWMYLMSRI FSSSDVAFIS YVSLNFIFGL CTMLITIMPR LLAIISKAKN
4610 4620 4630 4640 4650
LQNIYDVLKW VFTIFPQFCL GQGLVELCYN QIKYDLTHNF GIDSYVSPFE
4660 4670 4680 4690 4700
MNFLGWIFVQ LASQGTVLLL LRVLLHWDLL RWPRGHSTLQ GTVKSSKDTD
4710 4720 4730 4740 4750
VEKEEKRVFE GRTNGDILVL YNLSKHYRRF FQNIIAVQDI SLGIPKGECF
4760 4770 4780 4790 4800
GLLGVNGAGK STTFKMLNGE VSLTSGHAII RTPMGDAVDL SSAGTAGVLI
4810 4820 4830 4840 4850
GYCPQQDALD ELLTGWEHLY YYCSLRGIPR QCIPEVAGDL IRRLHLEAHA
4860 4870 4880 4890 4900
DKPVATYSGG TKRKLSTALA LVGKPDILLL DEPSSGMDPC SKRYLWQTIM
4910 4920 4930 4940 4950
KEVREGCAAV LTSHSMEECE ALCTRLAIMV NGSFKCLGSP QHIKNRFGDG
4960 4970 4980 4990 5000
YTVKVWLCKE ANQHCTVSDH LKLYFPGIQF KGQHLNLLEY HVPKRWGCLA
5010 5020 5030 5040 5050
DLFKVIENNK TFLNIKHYSI NQTTLEQVFI NFASEQQQTL QSTLDPSTDS

HHTHHLPI
Length:5,058
Mass (Da):576,159
Last modified:April 5, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB7F03D10101551E4
GO
Isoform 2 (identifier: Q86UQ4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     300-317: IPTDTSLEKMVCSVLSST → VHMLDCFSHRWAFPGDWI
     318-5058: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:317
Mass (Da):36,920
Checksum:iF24011161CF5FA8A
GO
Isoform 3 (identifier: Q86UQ4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2298: Missing.

Show »
Length:2,760
Mass (Da):312,248
Checksum:i735554315E7EECAF
GO
Isoform 4 (identifier: Q86UQ4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     4271-4271: F → FS

Show »
Length:5,059
Mass (Da):576,246
Checksum:iAD6C2E6EAD1F0D03
GO
Isoform 5 (identifier: Q86UQ4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2736: Missing.
     4271-4271: F → FS

Show »
Length:2,323
Mass (Da):262,110
Checksum:i5AC6E1C991DAE6F8
GO
Isoform 6 (identifier: Q86UQ4-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2736: Missing.
     4271-4271: F → FS
     4947-5058: FGDGYTVKVW...DSHHTHHLPI → KLNKTN

Show »
Length:2,217
Mass (Da):249,791
Checksum:iD65BFACF1A75A257
GO
Isoform 7 (identifier: Q86UQ4-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2736: Missing.
     4271-4271: F → FS
     4478-4508: Missing.

Show »
Length:2,292
Mass (Da):258,321
Checksum:i80FFF7BE2C761A3F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MT16A0A0A0MT16_HUMAN
ATP-binding cassette sub-family A m...
ABCA13
5,058Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H7B7F5H7B7_HUMAN
ATP-binding cassette sub-family A m...
ABCA13
2,366Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0U5H7C0U5_HUMAN
ATP-binding cassette sub-family A m...
ABCA13
1,192Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4D2H0Y4D2_HUMAN
ATP-binding cassette sub-family A m...
ABCA13
831Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZI9H7BZI9_HUMAN
ATP-binding cassette sub-family A m...
ABCA13
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC03623 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC86492 differs from that shown. Reason: Frameshift.Curated
The sequence BAC86492 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1416H → R in AAP13576 (PubMed:12697998).Curated1
Sequence conflicti2718P → L in AAP13576 (PubMed:12697998).Curated1
Sequence conflicti2831L → R in AAP13576 (PubMed:12697998).Curated1
Sequence conflicti2870K → E in AAP13576 (PubMed:12697998).Curated1
Sequence conflicti3057T → A in AAO59914 (Ref. 5) Curated1
Sequence conflicti4446K → E in AAP13576 (PubMed:12697998).Curated1
Sequence conflicti4446K → E in AAO59914 (Ref. 5) Curated1
Sequence conflicti4584L → P in AAP13576 (PubMed:12697998).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059087506P → L. Corresponds to variant dbSNP:rs1880738Ensembl.1
Natural variantiVAR_059088555R → H. Corresponds to variant dbSNP:rs2361519Ensembl.1
Natural variantiVAR_059089767I → S. Corresponds to variant dbSNP:rs17712293Ensembl.1
Natural variantiVAR_059090799E → K. Corresponds to variant dbSNP:rs17547816Ensembl.1
Natural variantiVAR_0590911434I → V. Corresponds to variant dbSNP:rs17132195Ensembl.1
Natural variantiVAR_0554701508T → I. Corresponds to variant dbSNP:rs6583483Ensembl.1
Natural variantiVAR_0590921540F → L. Corresponds to variant dbSNP:rs17712299Ensembl.1
Natural variantiVAR_0590931889I → K. Corresponds to variant dbSNP:rs17132197Ensembl.1
Natural variantiVAR_0590942033N → D. Corresponds to variant dbSNP:rs17661364Ensembl.1
Natural variantiVAR_0590952154S → L. Corresponds to variant dbSNP:rs17092911Ensembl.1
Natural variantiVAR_0590962178A → E. Corresponds to variant dbSNP:rs1880736Ensembl.1
Natural variantiVAR_0590972212L → S. Corresponds to variant dbSNP:rs17132198Ensembl.1
Natural variantiVAR_0590982436K → R. Corresponds to variant dbSNP:rs17132206Ensembl.1
Natural variantiVAR_0590992537S → A. Corresponds to variant dbSNP:rs17132208Ensembl.1
Natural variantiVAR_0591002674R → W. Corresponds to variant dbSNP:rs2222648Ensembl.1
Natural variantiVAR_0591013142A → V. Corresponds to variant dbSNP:rs3931814Ensembl.1
Natural variantiVAR_0591023851Y → F1 PublicationCorresponds to variant dbSNP:rs17132289Ensembl.1
Natural variantiVAR_0591034277N → D. Corresponds to variant dbSNP:rs4917152Ensembl.1
Natural variantiVAR_0591044302Q → R. Corresponds to variant dbSNP:rs4917153Ensembl.1
Natural variantiVAR_0591054335P → A. Corresponds to variant dbSNP:rs17132370Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0546331 – 2736Missing in isoform 5, isoform 6 and isoform 7. 1 PublicationAdd BLAST2736
Alternative sequenceiVSP_0210681 – 2298Missing in isoform 3. CuratedAdd BLAST2298
Alternative sequenceiVSP_021069300 – 317IPTDT…VLSST → VHMLDCFSHRWAFPGDWI in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_021070318 – 5058Missing in isoform 2. 1 PublicationAdd BLAST4741
Alternative sequenceiVSP_0546344271F → FS in isoform 4, isoform 5, isoform 6 and isoform 7. 2 Publications1
Alternative sequenceiVSP_0546354478 – 4508Missing in isoform 7. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_0546364947 – 5058FGDGY…HHLPI → KLNKTN in isoform 6. 1 PublicationAdd BLAST112

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY204751 mRNA Translation: AAP13576.1
JF913488 mRNA Translation: AFH89038.1
JF913489 mRNA Translation: AFH89039.1
JF913490 mRNA Translation: AFH89040.1
JF913491 mRNA Translation: AFH89041.1
JF913492 mRNA Translation: AFH89042.1
AK091270 mRNA Translation: BAC03623.1 Different initiation.
AK126220 mRNA Translation: BAC86492.1 Sequence problems.
AC073424 Genomic DNA No translation available.
AC073927 Genomic DNA No translation available.
AC091770 Genomic DNA No translation available.
AC095039 Genomic DNA No translation available.
AC232300 Genomic DNA No translation available.
AC232312 Genomic DNA No translation available.
AF501281 mRNA Translation: AAO59914.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47584.1 [Q86UQ4-1]

NCBI Reference Sequences

More...
RefSeqi
NP_689914.3, NM_152701.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000417403; ENSP00000409268; ENSG00000179869 [Q86UQ4-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
154664

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:154664

UCSC genome browser

More...
UCSCi
uc064dot.1 human [Q86UQ4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY204751 mRNA Translation: AAP13576.1
JF913488 mRNA Translation: AFH89038.1
JF913489 mRNA Translation: AFH89039.1
JF913490 mRNA Translation: AFH89040.1
JF913491 mRNA Translation: AFH89041.1
JF913492 mRNA Translation: AFH89042.1
AK091270 mRNA Translation: BAC03623.1 Different initiation.
AK126220 mRNA Translation: BAC86492.1 Sequence problems.
AC073424 Genomic DNA No translation available.
AC073927 Genomic DNA No translation available.
AC091770 Genomic DNA No translation available.
AC095039 Genomic DNA No translation available.
AC232300 Genomic DNA No translation available.
AC232312 Genomic DNA No translation available.
AF501281 mRNA Translation: AAO59914.1
CCDSiCCDS47584.1 [Q86UQ4-1]
RefSeqiNP_689914.3, NM_152701.4

3D structure databases

SMRiQ86UQ4
ModBaseiSearch...

Protein-protein interaction databases

BioGridi127551, 6 interactors
IntActiQ86UQ4, 3 interactors
MINTiQ86UQ4
STRINGi9606.ENSP00000411096

Protein family/group databases

TCDBi3.A.1.211.18 the atp-binding cassette (abc) superfamily

PTM databases

CarbonylDBiQ86UQ4
iPTMnetiQ86UQ4
PhosphoSitePlusiQ86UQ4

Polymorphism and mutation databases

BioMutaiABCA13
DMDMi327478592

Proteomic databases

EPDiQ86UQ4
jPOSTiQ86UQ4
MassIVEiQ86UQ4
PaxDbiQ86UQ4
PeptideAtlasiQ86UQ4
PRIDEiQ86UQ4
ProteomicsDBi69861 [Q86UQ4-1]
69862 [Q86UQ4-2]
69863 [Q86UQ4-3]

Genome annotation databases

EnsembliENST00000417403; ENSP00000409268; ENSG00000179869 [Q86UQ4-2]
GeneIDi154664
KEGGihsa:154664
UCSCiuc064dot.1 human [Q86UQ4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
154664
DisGeNETi154664
EuPathDBiHostDB:ENSG00000179869.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ABCA13
HGNCiHGNC:14638 ABCA13
HPAiHPA063601
MIMi607807 gene
neXtProtiNX_Q86UQ4
OpenTargetsiENSG00000179869
PharmGKBiPA134925234

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0059 Eukaryota
COG1131 LUCA
GeneTreeiENSGT00940000161703
HOGENOMiHOG000033760
InParanoidiQ86UQ4
KOiK05647
OrthoDBi131191at2759
PhylomeDBiQ86UQ4
TreeFamiTF105191

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ABCA13 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ABCA13

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
154664
PharosiQ86UQ4 Tbio

Protein Ontology

More...
PROi
PR:Q86UQ4
RNActiQ86UQ4 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000179869 Expressed in 85 organ(s), highest expression level in bronchial epithelial cell
ExpressionAtlasiQ86UQ4 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR026082 ABCA
IPR027417 P-loop_NTPase
PANTHERiPTHR19229 PTHR19229, 3 hits
PfamiView protein in Pfam
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiABCAD_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86UQ4
Secondary accession number(s): K9LC76
, K9LC79, K9LCX7, K9LDK8, K9LDY4, Q6ZTT7, Q86WI2, Q8N248
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: April 5, 2011
Last modified: December 11, 2019
This is version 133 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again