Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 146 (02 Dec 2020)
Sequence version 1 (01 Jun 2003)
Previous versions | rss
Add a publicationFeedback
Protein

CUB and zona pellucida-like domain-containing protein 1

Gene

CUZD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in these processes. May also play a role in the uterus during late pregnancy and/or in trypsin activation in pancreatic acinar cells.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion, Cell cycle, Cell division

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q86UP6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CUB and zona pellucida-like domain-containing protein 1
Short name:
CUB and ZP domain-containing protein 1
Alternative name(s):
Transmembrane protein UO-44
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CUZD1Imported
ORF Names:UNQ224/PRO257
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
HostDB:ENSG00000138161.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17937, CUZD1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616644, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86UP6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini25 – 568ExtracellularSequence analysisAdd BLAST544
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei569 – 589HelicalSequence analysisAdd BLAST21
Topological domaini590 – 607CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
50624

Open Targets

More...
OpenTargetsi
ENSG00000138161

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134903546

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86UP6, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CUZD1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74750426

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000023333125 – 607CUB and zona pellucida-like domain-containing protein 1Sequence analysisAdd BLAST583

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi17 ↔ 58PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi67N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi85 ↔ 107PROSITE-ProRule annotation
Disulfide bondi154 ↔ 180PROSITE-ProRule annotation
Disulfide bondi207 ↔ 229PROSITE-ProRule annotation
Glycosylationi394N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi419N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi442 ↔ 498PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86UP6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q86UP6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86UP6

PeptideAtlas

More...
PeptideAtlasi
Q86UP6

PRoteomics IDEntifications database

More...
PRIDEi
Q86UP6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
69848 [Q86UP6-1]
69849 [Q86UP6-2]
69850 [Q86UP6-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q86UP6, 5 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86UP6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86UP6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in pancreas and epithelium of ovary. Expressed at higher levels in ovarian tumors than in normal tissue.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000138161, Expressed in body of pancreas and 110 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86UP6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86UP6, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000138161, Tissue enriched (pancreas)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q86UP6, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000357900

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q86UP6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86UP6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini25 – 146CUB 1PROSITE-ProRule annotationAdd BLAST122
Domaini154 – 265CUB 2PROSITE-ProRule annotationAdd BLAST112
Domaini276 – 519ZPPROSITE-ProRule annotationAdd BLAST244

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RSDM, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154525

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_024908_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86UP6

Identification of Orthologs from Complete Genome Data

More...
OMAi
CEMEYNS

Database of Orthologous Groups

More...
OrthoDBi
776870at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86UP6

TreeFam database of animal gene trees

More...
TreeFami
TF351216

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00041, CUB, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.290, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000859, CUB_dom
IPR035914, Sperma_CUB_dom_sf
IPR001507, ZP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00431, CUB, 2 hits
PF00100, Zona_pellucida, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00023, ZPELLUCIDA

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00042, CUB, 2 hits
SM00241, ZP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49854, SSF49854, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01180, CUB, 2 hits
PS51034, ZP_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q86UP6-1) [UniParc]FASTAAdd to basket
Also known as: UO-44D1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELVRRLMPL TLLILSCLAE LTMAEAEGNA SCTVSLGGAN MAETHKAMIL
60 70 80 90 100
QLNPSENCTW TIERPENKSI RIIFSYVQLD PDGSCESENI KVFDGTSSNG
110 120 130 140 150
PLLGQVCSKN DYVPVFESSS STLTFQIVTD SARIQRTVFV FYYFFSPNIS
160 170 180 190 200
IPNCGGYLDT LEGSFTSPNY PKPHPELAYC VWHIQVEKDY KIKLNFKEIF
210 220 230 240 250
LEIDKQCKFD FLAIYDGPST NSGLIGQVCG RVTPTFESSS NSLTVVLSTD
260 270 280 290 300
YANSYRGFSA SYTSIYAENI NTTSLTCSSD RMRVIISKSY LEAFNSNGNN
310 320 330 340 350
LQLKDPTCRP KLSNVVEFSV PLNGCGTIRK VEDQSITYTN IITFSASSTS
360 370 380 390 400
EVITRQKQLQ IIVKCEMGHN STVEIIYITE DDVIQSQNAL GKYNTSMALF
410 420 430 440 450
ESNSFEKTIL ESPYYVDLNQ TLFVQVSLHT SDPNLVVFLD TCRASPTSDF
460 470 480 490 500
ASPTYDLIKS GCSRDETCKV YPLFGHYGRF QFNAFKFLRS MSSVYLQCKV
510 520 530 540 550
LICDSSDHQS RCNQGCVSRS KRDISSYKWK TDSIIGPIRL KRDRSASGNS
560 570 580 590 600
GFQHETHAEE TPNQPFNSVH LFSFMVLALN VVTVATITVR HFVNQRADYK

YQKLQNY
Length:607
Mass (Da):68,153
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i098A365612251C5E
GO
Isoform 21 Publication (identifier: Q86UP6-2) [UniParc]FASTAAdd to basket
Also known as: UO-44B1 Publication, UO-44C1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-281: Missing.

Show »
Length:326
Mass (Da):36,978
Checksum:iAE3B82BB66C99920
GO
Isoform 31 Publication (identifier: Q86UP6-3) [UniParc]FASTAAdd to basket
Also known as: UO-44A1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-366: Missing.

Show »
Length:241
Mass (Da):27,486
Checksum:iBE6169197516A767
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MRA6A0A0A0MRA6_HUMAN
CUB and zona pellucida-like domain-...
CUZD1
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MRL2A0A0A0MRL2_HUMAN
CUB and zona pellucida-like domain-...
CUZD1
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG23215 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti235T → P in CAD98079 (PubMed:17974005).Curated1
Sequence conflicti331V → A in CAD98079 (PubMed:17974005).Curated1
Sequence conflicti494 – 495VY → AC in AAG23215 (PubMed:15184879).Curated2
Sequence conflicti560E → G in CAD98080 (PubMed:17974005).Curated1
Sequence conflicti583T → I in CAD98080 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061992156G → S. Corresponds to variant dbSNP:rs35120257Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0520181 – 366Missing in isoform 3. 1 PublicationAdd BLAST366
Alternative sequenceiVSP_0520191 – 281Missing in isoform 2. 2 PublicationsAdd BLAST281

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY260047 mRNA Translation: AAP15458.1
AY260048 mRNA Translation: AAP15459.1
AY260049 mRNA Translation: AAP15460.1
AY260050 mRNA Translation: AAP15461.1
AF305835 mRNA Translation: AAG23215.1 Frameshift.
AY358556 mRNA Translation: AAQ88920.1
AK289445 mRNA Translation: BAF82134.1
AL359747 Genomic DNA Translation: CAH70003.1
AL359747 Genomic DNA Translation: CAH70004.1
AL359747, AC073585 Genomic DNA Translation: CAH70006.1
CH471066 Genomic DNA Translation: EAW49302.1
CH471066 Genomic DNA Translation: EAW49303.1
CH471066 Genomic DNA Translation: EAW49304.1
CH471066 Genomic DNA Translation: EAW49305.1
BC136755 mRNA Translation: AAI36756.1
BX538283 mRNA Translation: CAD98079.2
BX538284 mRNA Translation: CAD98080.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7631.1 [Q86UP6-1]

NCBI Reference Sequences

More...
RefSeqi
NP_071317.2, NM_022034.5 [Q86UP6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000392790; ENSP00000376540; ENSG00000138161 [Q86UP6-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
50624

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:50624

UCSC genome browser

More...
UCSCi
uc001lgs.4, human [Q86UP6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY260047 mRNA Translation: AAP15458.1
AY260048 mRNA Translation: AAP15459.1
AY260049 mRNA Translation: AAP15460.1
AY260050 mRNA Translation: AAP15461.1
AF305835 mRNA Translation: AAG23215.1 Frameshift.
AY358556 mRNA Translation: AAQ88920.1
AK289445 mRNA Translation: BAF82134.1
AL359747 Genomic DNA Translation: CAH70003.1
AL359747 Genomic DNA Translation: CAH70004.1
AL359747, AC073585 Genomic DNA Translation: CAH70006.1
CH471066 Genomic DNA Translation: EAW49302.1
CH471066 Genomic DNA Translation: EAW49303.1
CH471066 Genomic DNA Translation: EAW49304.1
CH471066 Genomic DNA Translation: EAW49305.1
BC136755 mRNA Translation: AAI36756.1
BX538283 mRNA Translation: CAD98079.2
BX538284 mRNA Translation: CAD98080.2
CCDSiCCDS7631.1 [Q86UP6-1]
RefSeqiNP_071317.2, NM_022034.5 [Q86UP6-1]

3D structure databases

SMRiQ86UP6
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ86UP6, 1 interactor
STRINGi9606.ENSP00000357900

PTM databases

GlyGeniQ86UP6, 5 sites
iPTMnetiQ86UP6
PhosphoSitePlusiQ86UP6

Polymorphism and mutation databases

BioMutaiCUZD1
DMDMi74750426

Proteomic databases

EPDiQ86UP6
MassIVEiQ86UP6
PaxDbiQ86UP6
PeptideAtlasiQ86UP6
PRIDEiQ86UP6
ProteomicsDBi69848 [Q86UP6-1]
69849 [Q86UP6-2]
69850 [Q86UP6-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
62632, 146 antibodies

Genome annotation databases

EnsembliENST00000392790; ENSP00000376540; ENSG00000138161 [Q86UP6-1]
GeneIDi50624
KEGGihsa:50624
UCSCiuc001lgs.4, human [Q86UP6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
50624
DisGeNETi50624
EuPathDBiHostDB:ENSG00000138161.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CUZD1
HGNCiHGNC:17937, CUZD1
HPAiENSG00000138161, Tissue enriched (pancreas)
MIMi616644, gene
neXtProtiNX_Q86UP6
OpenTargetsiENSG00000138161
PharmGKBiPA134903546

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502RSDM, Eukaryota
GeneTreeiENSGT00940000154525
HOGENOMiCLU_024908_1_0_1
InParanoidiQ86UP6
OMAiCEMEYNS
OrthoDBi776870at2759
PhylomeDBiQ86UP6
TreeFamiTF351216

Enzyme and pathway databases

PathwayCommonsiQ86UP6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
50624, 2 hits in 843 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CUZD1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
50624
PharosiQ86UP6, Tbio

Protein Ontology

More...
PROi
PR:Q86UP6
RNActiQ86UP6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000138161, Expressed in body of pancreas and 110 other tissues
ExpressionAtlasiQ86UP6, baseline and differential
GenevisibleiQ86UP6, HS

Family and domain databases

CDDicd00041, CUB, 2 hits
Gene3Di2.60.120.290, 2 hits
InterProiView protein in InterPro
IPR000859, CUB_dom
IPR035914, Sperma_CUB_dom_sf
IPR001507, ZP_dom
PfamiView protein in Pfam
PF00431, CUB, 2 hits
PF00100, Zona_pellucida, 1 hit
PRINTSiPR00023, ZPELLUCIDA
SMARTiView protein in SMART
SM00042, CUB, 2 hits
SM00241, ZP, 1 hit
SUPFAMiSSF49854, SSF49854, 2 hits
PROSITEiView protein in PROSITE
PS01180, CUB, 2 hits
PS51034, ZP_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCUZD1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86UP6
Secondary accession number(s): A8K080
, B2RN93, D3DRE5, Q7Z660, Q7Z661, Q86SG1, Q86UP5, Q9HAR7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: June 1, 2003
Last modified: December 2, 2020
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again