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UniProtKB - Q86UP3 (ZFHX4_HUMAN)
Protein
Zinc finger homeobox protein 4
Gene
ZFHX4
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in neural and muscle differentiation (By similarity).
May be involved in transcriptional regulation.
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 613 – 636 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 644 – 667 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 699 – 723 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 767 – 789 | C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 917 – 941 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 973 – 995 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1021 – 1045 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 1172 – 1195 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 1201 – 1224 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 1352 – 1374 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1380 – 1403 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 1496 – 1522 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 27 | |
Zinc fingeri | 1548 – 1572 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 1901 – 1924 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 24 | |
DNA bindingi | 2084 – 2143 | Homeobox 1PROSITE-ProRule annotationAdd BLAST | 60 | |
DNA bindingi | 2181 – 2240 | Homeobox 2PROSITE-ProRule annotationAdd BLAST | 60 | |
Zinc fingeri | 2267 – 2291 | C2H2-type 15; degeneratePROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 2448 – 2470 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 23 | |
DNA bindingi | 2560 – 2619 | Homeobox 3PROSITE-ProRule annotationAdd BLAST | 60 | |
Zinc fingeri | 2630 – 2653 | C2H2-type 17PROSITE-ProRule annotationAdd BLAST | 24 | |
DNA bindingi | 2884 – 2943 | Homeobox 4PROSITE-ProRule annotationAdd BLAST | 60 | |
Zinc fingeri | 2962 – 2986 | C2H2-type 18PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 3354 – 3378 | C2H2-type 19; degeneratePROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 3398 – 3422 | C2H2-type 20PROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q86UP3 |
SignaLinki | Q86UP3 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger homeobox protein 4Alternative name(s): Zinc finger homeodomain protein 4 Short name: ZFH-4 |
Gene namesi | Name:ZFHX4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30939, ZFHX4 |
MIMi | 606940, gene |
neXtProti | NX_Q86UP3 |
VEuPathDBi | HostDB:ENSG00000091656 |
Pathology & Biotechi
Involvement in diseasei
A chromosomal aberration involving ZFHX4 is found in one patient with ptosis. Translocation t(1;8)(p34.3;q21.12).1 Publication
Organism-specific databases
DisGeNETi | 79776 |
MalaCardsi | ZFHX4 |
OpenTargetsi | ENSG00000091656 |
Orphaneti | 91411, Congenital ptosis |
PharmGKBi | PA134986366 |
Miscellaneous databases
Pharosi | Q86UP3, Tbio |
Genetic variation databases
BioMutai | ZFHX4 |
DMDMi | 74762449 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000278465 | 1 – 3567 | Zinc finger homeobox protein 4Add BLAST | 3567 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Cross-linki | 1149 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1299 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1324 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1546 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1790 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 2663 | PhosphoserineCombined sources | 1 | |
Cross-linki | 3154 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q86UP3 |
jPOSTi | Q86UP3 |
MassIVEi | Q86UP3 |
MaxQBi | Q86UP3 |
PaxDbi | Q86UP3 |
PeptideAtlasi | Q86UP3 |
PRIDEi | Q86UP3 |
ProteomicsDBi | 32248 69844 [Q86UP3-1] 69845 [Q86UP3-2] 69846 [Q86UP3-3] 69847 [Q86UP3-4] |
PTM databases
GlyGeni | Q86UP3, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q86UP3 |
PhosphoSitePlusi | Q86UP3 |
Expressioni
Tissue specificityi
Expressed in brain, skeletal muscle and liver. Very low expression in stomach.
Gene expression databases
Bgeei | ENSG00000091656, Expressed in calcaneal tendon and 193 other tissues |
ExpressionAtlasi | Q86UP3, baseline and differential |
Genevisiblei | Q86UP3, HS |
Organism-specific databases
HPAi | ENSG00000091656, Tissue enhanced (brain) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 122877, 25 interactors |
IntActi | Q86UP3, 11 interactors |
MINTi | Q86UP3 |
STRINGi | 9606.ENSP00000430497 |
Miscellaneous databases
RNActi | Q86UP3, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 54 | DisorderedSequence analysisAdd BLAST | 54 | |
Regioni | 425 – 480 | DisorderedSequence analysisAdd BLAST | 56 | |
Regioni | 522 – 545 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 565 – 611 | DisorderedSequence analysisAdd BLAST | 47 | |
Regioni | 1098 – 1160 | DisorderedSequence analysisAdd BLAST | 63 | |
Regioni | 1254 – 1324 | DisorderedSequence analysisAdd BLAST | 71 | |
Regioni | 1429 – 1480 | DisorderedSequence analysisAdd BLAST | 52 | |
Regioni | 1761 – 1791 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 1809 – 1858 | DisorderedSequence analysisAdd BLAST | 50 | |
Regioni | 1948 – 2024 | DisorderedSequence analysisAdd BLAST | 77 | |
Regioni | 2289 – 2311 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 2328 – 2431 | DisorderedSequence analysisAdd BLAST | 104 | |
Regioni | 2507 – 2564 | DisorderedSequence analysisAdd BLAST | 58 | |
Regioni | 2764 – 2811 | DisorderedSequence analysisAdd BLAST | 48 | |
Regioni | 2829 – 2885 | DisorderedSequence analysisAdd BLAST | 57 | |
Regioni | 3092 – 3172 | DisorderedSequence analysisAdd BLAST | 81 | |
Regioni | 3281 – 3337 | DisorderedSequence analysisAdd BLAST | 57 | |
Regioni | 3443 – 3462 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 3511 – 3534 | DisorderedSequence analysisAdd BLAST | 24 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 3265 – 3294 | Sequence analysisAdd BLAST | 30 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 26 | Polar residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 34 – 54 | Basic and acidic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 433 – 453 | Basic and acidic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 1098 – 1130 | Basic and acidic residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 1284 – 1321 | Basic and acidic residuesSequence analysisAdd BLAST | 38 | |
Compositional biasi | 1429 – 1454 | Basic and acidic residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 1775 – 1791 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1809 – 1845 | Basic and acidic residuesSequence analysisAdd BLAST | 37 | |
Compositional biasi | 1952 – 1978 | Pro residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 1988 – 2022 | Pro residuesSequence analysisAdd BLAST | 35 | |
Compositional biasi | 2372 – 2397 | Polar residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 2398 – 2414 | Pro residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 2415 – 2431 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 2507 – 2530 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 2533 – 2564 | Basic and acidic residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 2764 – 2788 | Polar residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 2830 – 2855 | Basic and acidic residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 2856 – 2877 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 3092 – 3107 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 3108 – 3127 | Pro residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 3136 – 3172 | Basic and acidic residuesSequence analysisAdd BLAST | 37 | |
Compositional biasi | 3281 – 3312 | Polar residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 3313 – 3337 | Basic and acidic residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 3445 – 3462 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 3511 – 3527 | Polar residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 613 – 636 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 644 – 667 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 699 – 723 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 767 – 789 | C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 917 – 941 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 973 – 995 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1021 – 1045 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 1172 – 1195 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 1201 – 1224 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 1352 – 1374 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1380 – 1403 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 1496 – 1522 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 27 | |
Zinc fingeri | 1548 – 1572 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 1901 – 1924 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 2267 – 2291 | C2H2-type 15; degeneratePROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 2448 – 2470 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 2630 – 2653 | C2H2-type 17PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 2962 – 2986 | C2H2-type 18PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 3354 – 3378 | C2H2-type 19; degeneratePROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 3398 – 3422 | C2H2-type 20PROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Coiled coil, Homeobox, Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1146, Eukaryota |
GeneTreei | ENSGT00940000159542 |
InParanoidi | Q86UP3 |
OMAi | TSPKPDY |
OrthoDBi | 15351at2759 |
PhylomeDBi | Q86UP3 |
TreeFami | TF323288 |
Family and domain databases
CDDi | cd00086, homeodomain, 4 hits |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR003604, Matrin/U1-like-C_Znf_C2H2 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00046, Homeodomain, 4 hits PF00096, zf-C2H2, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 4 hits SM00355, ZnF_C2H2, 23 hits SM00451, ZnF_U1, 7 hits |
SUPFAMi | SSF46689, SSF46689, 4 hits SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 2 hits PS50071, HOMEOBOX_2, 4 hits PS00028, ZINC_FINGER_C2H2_1, 13 hits PS50157, ZINC_FINGER_C2H2_2, 7 hits |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q86UP3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
METCDSPPIS RQENGQSTSK LCGTTQLDNE VPEKVAGMEP DRENSSTDDN
60 70 80 90 100
LKTDERKSEA LLGFSVENAA ATQVTSAKEI PCNECATSFP SLQKYMEHHC
110 120 130 140 150
PNARLPVLKD DNESEISELE DSDVENLTGE IVYQPDGSAY IIEDSKESGQ
160 170 180 190 200
NAQTGANSKL FSTAMFLDSL ASAGEKSDQS ASAPMSFYPQ IINTFHIASS
210 220 230 240 250
LGKPFTADQA FPNTSALAGV GPVLHSFRVY DLRHKREKDY LTSDGSAKNS
260 270 280 290 300
CVSKDVPNNV DLSKFDGCVS DGKRKPVLMC FLCKLSFGYI RSFVTHAVHD
310 320 330 340 350
HRMTLNDEEQ KLLSNKCVSA IIQGIGKDKE PLISFLEPKK STSVYPHFST
360 370 380 390 400
TNLIGPDPTF RGLWSAFHVE NGDSLPAGFA FLKGSASTSS SAEQPLGITQ
410 420 430 440 450
MPKAEVNLGG LSSLVVNTPI TSVSLSHSSS ESSKMSESKD QENNCERPKE
460 470 480 490 500
SNVLHPNGEC PVKSEPTEPG DEDEEDAYSN ELDDEEVLGE LTDSIGNKDF
510 520 530 540 550
PLLNQSISPL SSSVLKFIEK GTSSSSATVS DDTEKKKQTA AVRASGSVAS
560 570 580 590 600
NYGISGKDFA DASASKDSAT AAHPSEIARG DEDSSATPHQ HGFTPSTPGT
610 620 630 640 650
PGPGGDGSPG SGIECPKCDT VLGSSRSLGG HMTMMHSRNS CKTLKCPKCN
660 670 680 690 700
WHYKYQQTLE AHMKEKHPEP GGSCVYCKTG QPHPRLARGE SYTCGYKPFR
710 720 730 740 750
CEVCNYSTTT KGNLSIHMQS DKHLNNVQNL QNGNGEQVFG HSAPAPNTSL
760 770 780 790 800
SGCGTPSPSK PKQKPTWRCE VCDYETNVAR NLRIHMTSEK HMHNMMLLQQ
810 820 830 840 850
NMKQIQHNLH LGLAPAEAEL YQYYLAQNIG LTGMKLENPA DPQLMINPFQ
860 870 880 890 900
LDPATAAALA PGLGELSPYI SDPALKLFQC AVCNKFTSDS LEALSVHVSS
910 920 930 940 950
ERSLPEEEWR AVIGDIYQCK LCNYNTQLKA NFQLHCKTDK HMQKYQLVAH
960 970 980 990 1000
IKEGGKSNEW RLKCIAIGNP VHLKCNACDY YTNSVDKLRL HTTNHRHEAA
1010 1020 1030 1040 1050
LKLYKHLQKQ EGAVNPESCY YYCAVCDYTT KVKLNLVQHV RSVKHQQTEG
1060 1070 1080 1090 1100
LRKLQLHQQG LAPEEDNLSE IFFVKDCPPN ELETASLGAR TCDDDLTEQH
1110 1120 1130 1140 1150
EEAEGAIKPT AVAEDDEKDT SERDNSEGKN SNKDSVSVAG GTQPLLLAKE
1160 1170 1180 1190 1200
EDVATKRSKP TEDNKFCHEQ FYQCPYCNYN SRDQSRIQMH VLSQHSVQPV
1210 1220 1230 1240 1250
ICCPLCQDVL SNKMHLQLHL THLHSVSPDC VEKLLMTVPV PDVMMPNSML
1260 1270 1280 1290 1300
LPAAASEKSE RDTPAAVTAE GSGKYSGESP MDDKSMAGLE DSKANVEVKN
1310 1320 1330 1340 1350
EEQKPTKEPL EVSEWNKNSS KDVKIPDTLQ DQLNEQQKRQ PLSVSDRHVY
1360 1370 1380 1390 1400
KYRCNHCSLA FKTMQKLQIH SQYHAIRAAT MCNLCQRSFR TFQALKKHLE
1410 1420 1430 1440 1450
AGHPELSEAE LQQLYASLPV NGELWAESET MSQDDHGLEQ EMEREYEVDH
1460 1470 1480 1490 1500
EGKASPVGSD SSSIPDDMGS EPKRTLPFRK GPNFTMEKFL DPSRPYKCTV
1510 1520 1530 1540 1550
CKESFTQKNI LLVHYNSVSH LHKLKKVLQE ASSPVPQETN SNTDNKPYKC
1560 1570 1580 1590 1600
SICNVAYSQS STLEIHMRSV LHQTKARAAK LEPSGHVAGG HSIAANVNSP
1610 1620 1630 1640 1650
GQGMLDSMSL AAVNSKDTHL DAKELNKKQT PDLISAQPAH HPPQSPAQIQ
1660 1670 1680 1690 1700
MQLQHELQQQ AAFFQPQFLN PAFLPHFPMT PEALLQFQQP QFLFPFYIPG
1710 1720 1730 1740 1750
TEFSLGPDLG LPGSATFGMP GMTGMAGSLL EDLKQQIQTQ HHVGQTQLQI
1760 1770 1780 1790 1800
LQQQAQQYQA TQPQLQPQKQ QQQPPPPQQQ QQQQASKLLK QEQSNIVSAD
1810 1820 1830 1840 1850
CQIMKDVPSY KEAEDISEKP EKPKQEFISE GEGLKEGKDT KKQKSLEPSI
1860 1870 1880 1890 1900
PPPRIASGAR GNAAKALLEN FGFELVIQYN ENRQKVQKKG KSGEGENTDK
1910 1920 1930 1940 1950
LECGTCGKLF SNVLILKSHQ EHVHGQFFPY AALEKFARQY REAYDKLYPI
1960 1970 1980 1990 2000
SPSSPETPPP PPPPPPLPPA PPQPSSMGPV KIPNTVSTPL QAPPPTPPPP
2010 2020 2030 2040 2050
PPPPPPPPPP PPPPPPSAPP QVQLPVSLDL PLFPSIMMQP VQHPALPPQL
2060 2070 2080 2090 2100
ALQLPQMDAL SADLTQLCQQ QLGLDPNFLR HSQFKRPRTR ITDDQLKILR
2110 2120 2130 2140 2150
AYFDINNSPS EEQIQEMAEK SGLSQKVIKH WFRNTLFKER QRNKDSPYNF
2160 2170 2180 2190 2200
SNPPITVLED IRIDPQPTSL EHYKSDASFS KRSSRTRFTD YQLRVLQDFF
2210 2220 2230 2240 2250
DTNAYPKDDE IEQLSTVLNL PTRVIVVWFQ NARQKARKSY ENQAETKDNE
2260 2270 2280 2290 2300
KRELTNERYI RTSNMQYQCK KCNVVFPRIF DLITHQKKQC YKDEDDDAQD
2310 2320 2330 2340 2350
ESQTEDSMDA TDQVVYKHCT VSGQTDAAKN AAAPAASSGS GTSTPLIPSP
2360 2370 2380 2390 2400
KPEPEKTSPK PEYPAEKPKQ SDPSPPSQGT KPALPLASTS SDPPQASTAQ
2410 2420 2430 2440 2450
PQPQPQPPKQ PQLIGRPPSA SQTPVPSSPL QISMTSLQNS LPPQLLQYQC
2460 2470 2480 2490 2500
DQCTVAFPTL ELWQEHQHMH FLAAQNQFLH SPFLERPMDM PYMIFDPNNP
2510 2520 2530 2540 2550
LMTGQLLGSS LTQMPPQASS SHTTAPTTVA ASLKRKLDDK EDNNCSEKEG
2560 2570 2580 2590 2600
GNSGEDQHRD KRLRTTITPE QLEILYEKYL LDSNPTRKML DHIAREVGLK
2610 2620 2630 2640 2650
KRVVQVWFQN TRARERKGQF RAVGPAQSHK RCPFCRALFK AKSALESHIR
2660 2670 2680 2690 2700
SRHWNEGKQA GYSLPPSPLI STEDGGESPQ KYIYFDYPSL PLTKIDLSSE
2710 2720 2730 2740 2750
NELASTVSTP VSKTAELSPK NLLSPSSFKA ECSEDVENLN APPAEAGYDQ
2760 2770 2780 2790 2800
NKTDFDETSS INTAISDATT GDEGNTEMES TTGSSGDVKP ALSPKEPKTL
2810 2820 2830 2840 2850
DTLPKPATTP TTEVCDDKFL FSLTSPSIHF NDKDGDHDQS FYITDDPDDN
2860 2870 2880 2890 2900
ADRSETSSIA DPSSPNPFGS SNPFKSKSND RPGHKRFRTQ MSNLQLKVLK
2910 2920 2930 2940 2950
ACFSDYRTPT MQECEMLGNE IGLPKRVVQV WFQNARAKEK KFKINIGKPF
2960 2970 2980 2990 3000
MINQGGTEGT KPECTLCGVK YSARLSIRDH IFSKQHISKV RETVGSQLDR
3010 3020 3030 3040 3050
EKDYLAPTTV RQLMAQQELD RIKKASDVLG LTVQQPGMMD SSSLHGISLP
3060 3070 3080 3090 3100
TAYPGLPGLP PVLLPGMNGP SSLPGFPQNS NISAGMLGFP TSATSSPALS
3110 3120 3130 3140 3150
LSSAPTKPLL QTPPPPPPPP PPPPSSSLSG QQTEQQNKES EKKQTKPNKV
3160 3170 3180 3190 3200
KKIKEEELEA TKPEKHPKKE EKISSALSVL GKVVGETHVD PIQLQALQNA
3210 3220 3230 3240 3250
IAGDPASFIG GQFLPYFIPG FASYFTPQLP GTVQGGYFPP VCGMESLFPY
3260 3270 3280 3290 3300
GPTMPQTLAG LSPGALLQQY QQYQQNLQES LQKQQKQQQE QQQKPVQAKT
3310 3320 3330 3340 3350
SKVESDQPQN SNDASETKED KSTATESTKE EPQLESKSAD FSDTYVVPFV
3360 3370 3380 3390 3400
KYEFICRKCQ MMFTDEDAAV NHQKSFCYFG QPLIDPQETV LRVPVSKYQC
3410 3420 3430 3440 3450
LACDVAISGN EALSQHLQSS LHKEKTIKQA MRNAKEHVRL LPHSVCSPNP
3460 3470 3480 3490 3500
NTTSTSQSAA SSNNTYPHLS CFSMKSWPNI LFQASARRAA SPPSSPPSLS
3510 3520 3530 3540 3550
LPSTVTSSLC STSGVQTSLP TESCSDESDS ELSQKLEDLD NSLEVKAKPA
3560
SGLDGNFNSI RMDMFSV
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7EVZ1 | E7EVZ1_HUMAN | Zinc finger homeobox protein 4 | ZFHX4 | 3,590 | Annotation score: | ||
E5RI93 | E5RI93_HUMAN | Zinc finger homeobox protein 4 | ZFHX4 | 1,665 | Annotation score: | ||
A0A494BZV7 | A0A494BZV7_HUMAN | Zinc finger homeobox protein 4 | ZFHX4 | 743 | Annotation score: | ||
E5RGK3 | E5RGK3_HUMAN | Zinc finger homeobox protein 4 | ZFHX4 | 140 | Annotation score: | ||
E5RHS1 | E5RHS1_HUMAN | Zinc finger homeobox protein 4 | ZFHX4 | 155 | Annotation score: | ||
E5RG79 | E5RG79_HUMAN | Zinc finger homeobox protein 4 | ZFHX4 | 155 | Annotation score: | ||
H0YBV0 | H0YBV0_HUMAN | Zinc finger homeobox protein 4 | ZFHX4 | 86 | Annotation score: | ||
H0YC81 | H0YC81_HUMAN | Zinc finger homeobox protein 4 | ZFHX4 | 82 | Annotation score: |
Sequence cautioni
The sequence AK131408 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 32 | P → L in AK131408 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 406 | V → A in AK131408 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 937 | K → E in AK131408 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057375 | 2036 | I → V. Corresponds to variant dbSNP:rs16919452Ensembl. | 1 | |
Natural variantiVAR_057376 | 3033 | V → G. Corresponds to variant dbSNP:rs16939380Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_023298 | 863 | L → LVNNELPPEIRLASGQLMGD DLSLLTA in isoform 2 and isoform 5. 1 Publication | 1 | |
Alternative sequenceiVSP_023299 | 1006 – 1049 | HLQKQ…HQQTE → VSSDIHFRWHRVEKGINSFR AWSTSLQLKEKKREKTSKGR GHSF in isoform 3. 1 PublicationAdd BLAST | 44 | |
Alternative sequenceiVSP_023300 | 1050 – 3567 | Missing in isoform 3. 1 PublicationAdd BLAST | 2518 | |
Alternative sequenceiVSP_023301 | 1100 | H → QLRSTSEEQS in isoform 2 and isoform 5. 1 Publication | 1 | |
Alternative sequenceiVSP_023302 | 1135 | S → SGIITPEKELK in isoform 2 and isoform 5. 1 Publication | 1 | |
Alternative sequenceiVSP_023303 | 2000 – 2016 | Missing in isoform 2. 1 PublicationAdd BLAST | 17 | |
Alternative sequenceiVSP_023304 | 3082 – 3083 | IS → TLTPPG in isoform 2, isoform 4 and isoform 5. 1 Publication | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB083343 mRNA Translation: BAE96598.1 AY260762 mRNA Translation: AAP20225.1 AK131408 mRNA No translation available. AC011716 Genomic DNA No translation available. AC023200 Genomic DNA No translation available. AC087110 Genomic DNA No translation available. CH471068 Genomic DNA Translation: EAW87051.1 |
CCDSi | CCDS47878.2 [Q86UP3-5] |
RefSeqi | NP_078997.4, NM_024721.4 [Q86UP3-5] XP_011515894.1, XM_011517592.2 [Q86UP3-5] XP_011515895.1, XM_011517593.2 [Q86UP3-5] XP_011515896.1, XM_011517594.2 [Q86UP3-5] XP_011515897.1, XM_011517595.2 [Q86UP3-5] |
Genome annotation databases
Ensembli | ENST00000651372; ENSP00000498627; ENSG00000091656 [Q86UP3-5] |
GeneIDi | 79776 |
KEGGi | hsa:79776 |
MANE-Selecti | ENST00000651372.2; ENSP00000498627.1; NM_024721.5; NP_078997.4 [Q86UP3-5] |
UCSCi | uc003yau.3, human [Q86UP3-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB083343 mRNA Translation: BAE96598.1 AY260762 mRNA Translation: AAP20225.1 AK131408 mRNA No translation available. AC011716 Genomic DNA No translation available. AC023200 Genomic DNA No translation available. AC087110 Genomic DNA No translation available. CH471068 Genomic DNA Translation: EAW87051.1 |
CCDSi | CCDS47878.2 [Q86UP3-5] |
RefSeqi | NP_078997.4, NM_024721.4 [Q86UP3-5] XP_011515894.1, XM_011517592.2 [Q86UP3-5] XP_011515895.1, XM_011517593.2 [Q86UP3-5] XP_011515896.1, XM_011517594.2 [Q86UP3-5] XP_011515897.1, XM_011517595.2 [Q86UP3-5] |
3D structure databases
SMRi | Q86UP3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122877, 25 interactors |
IntActi | Q86UP3, 11 interactors |
MINTi | Q86UP3 |
STRINGi | 9606.ENSP00000430497 |
PTM databases
GlyGeni | Q86UP3, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q86UP3 |
PhosphoSitePlusi | Q86UP3 |
Genetic variation databases
BioMutai | ZFHX4 |
DMDMi | 74762449 |
Proteomic databases
EPDi | Q86UP3 |
jPOSTi | Q86UP3 |
MassIVEi | Q86UP3 |
MaxQBi | Q86UP3 |
PaxDbi | Q86UP3 |
PeptideAtlasi | Q86UP3 |
PRIDEi | Q86UP3 |
ProteomicsDBi | 32248 69844 [Q86UP3-1] 69845 [Q86UP3-2] 69846 [Q86UP3-3] 69847 [Q86UP3-4] |
Protocols and materials databases
Antibodypediai | 1757, 65 antibodies from 17 providers |
DNASUi | 79776 |
Genome annotation databases
Ensembli | ENST00000651372; ENSP00000498627; ENSG00000091656 [Q86UP3-5] |
GeneIDi | 79776 |
KEGGi | hsa:79776 |
MANE-Selecti | ENST00000651372.2; ENSP00000498627.1; NM_024721.5; NP_078997.4 [Q86UP3-5] |
UCSCi | uc003yau.3, human [Q86UP3-1] |
Organism-specific databases
CTDi | 79776 |
DisGeNETi | 79776 |
GeneCardsi | ZFHX4 |
HGNCi | HGNC:30939, ZFHX4 |
HPAi | ENSG00000091656, Tissue enhanced (brain) |
MalaCardsi | ZFHX4 |
MIMi | 606940, gene |
neXtProti | NX_Q86UP3 |
OpenTargetsi | ENSG00000091656 |
Orphaneti | 91411, Congenital ptosis |
PharmGKBi | PA134986366 |
VEuPathDBi | HostDB:ENSG00000091656 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1146, Eukaryota |
GeneTreei | ENSGT00940000159542 |
InParanoidi | Q86UP3 |
OMAi | TSPKPDY |
OrthoDBi | 15351at2759 |
PhylomeDBi | Q86UP3 |
TreeFami | TF323288 |
Enzyme and pathway databases
PathwayCommonsi | Q86UP3 |
SignaLinki | Q86UP3 |
Miscellaneous databases
BioGRID-ORCSi | 79776, 9 hits in 1071 CRISPR screens |
ChiTaRSi | ZFHX4, human |
GenomeRNAii | 79776 |
Pharosi | Q86UP3, Tbio |
PROi | PR:Q86UP3 |
RNActi | Q86UP3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000091656, Expressed in calcaneal tendon and 193 other tissues |
ExpressionAtlasi | Q86UP3, baseline and differential |
Genevisiblei | Q86UP3, HS |
Family and domain databases
CDDi | cd00086, homeodomain, 4 hits |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR003604, Matrin/U1-like-C_Znf_C2H2 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00046, Homeodomain, 4 hits PF00096, zf-C2H2, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 4 hits SM00355, ZnF_C2H2, 23 hits SM00451, ZnF_U1, 7 hits |
SUPFAMi | SSF46689, SSF46689, 4 hits SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 2 hits PS50071, HOMEOBOX_2, 4 hits PS00028, ZINC_FINGER_C2H2_1, 13 hits PS50157, ZINC_FINGER_C2H2_2, 7 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZFHX4_HUMAN | |
Accessioni | Q86UP3Primary (citable) accession number: Q86UP3 Secondary accession number(s): G3V138, Q18PS0, Q6ZN20 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 20, 2007 |
Last sequence update: | June 1, 2003 | |
Last modified: | February 23, 2022 | |
This is version 172 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families