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UniProtKB - Q86UP3 (ZFHX4_HUMAN)

Entry version 172 (23 Feb 2022)
Sequence version 1 (01 Jun 2003)
Previous versions | rss
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Protein

Zinc finger homeobox protein 4

Gene

ZFHX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in neural and muscle differentiation (By similarity).

May be involved in transcriptional regulation.

By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri613 – 636C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri644 – 667C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri699 – 723C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri767 – 789C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri917 – 941C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri973 – 995C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1021 – 1045C2H2-type 7PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1172 – 1195C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1201 – 1224C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1352 – 1374C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1380 – 1403C2H2-type 11PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1496 – 1522C2H2-type 12PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri1548 – 1572C2H2-type 13PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1901 – 1924C2H2-type 14PROSITE-ProRule annotationAdd BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi2084 – 2143Homeobox 1PROSITE-ProRule annotationAdd BLAST60
DNA bindingi2181 – 2240Homeobox 2PROSITE-ProRule annotationAdd BLAST60
Zinc fingeri2267 – 2291C2H2-type 15; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri2448 – 2470C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
DNA bindingi2560 – 2619Homeobox 3PROSITE-ProRule annotationAdd BLAST60
Zinc fingeri2630 – 2653C2H2-type 17PROSITE-ProRule annotationAdd BLAST24
DNA bindingi2884 – 2943Homeobox 4PROSITE-ProRule annotationAdd BLAST60
Zinc fingeri2962 – 2986C2H2-type 18PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri3354 – 3378C2H2-type 19; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri3398 – 3422C2H2-type 20PROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q86UP3

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q86UP3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger homeobox protein 4
Alternative name(s):
Zinc finger homeodomain protein 4
Short name:
ZFH-4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZFHX4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:30939, ZFHX4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606940, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q86UP3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000091656

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving ZFHX4 is found in one patient with ptosis. Translocation t(1;8)(p34.3;q21.12).1 Publication

Organism-specific databases

DisGeNET

More...DisGeNETi		79776

MalaCards human disease database

More...MalaCardsi		ZFHX4

Open Targets

More...OpenTargetsi		ENSG00000091656

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		91411, Congenital ptosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134986366

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q86UP3, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZFHX4

Domain mapping of disease mutations (DMDM)

More...DMDMi		74762449

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002784651 – 3567Zinc finger homeobox protein 4Add BLAST3567

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1149Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1299Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1324Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1546Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1790Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei2663PhosphoserineCombined sources1
Cross-linki3154Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q86UP3

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q86UP3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q86UP3

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q86UP3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q86UP3

PeptideAtlas

More...PeptideAtlasi		Q86UP3

PRoteomics IDEntifications database

More...PRIDEi		Q86UP3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		32248
69844 [Q86UP3-1]
69845 [Q86UP3-2]
69846 [Q86UP3-3]
69847 [Q86UP3-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q86UP3, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q86UP3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q86UP3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, skeletal muscle and liver. Very low expression in stomach.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000091656, Expressed in calcaneal tendon and 193 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q86UP3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q86UP3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000091656, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122877, 25 interactors

Protein interaction database and analysis system

More...IntActi		Q86UP3, 11 interactors

Molecular INTeraction database

More...MINTi		Q86UP3

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000430497

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q86UP3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q86UP3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 54DisorderedSequence analysisAdd BLAST54
Regioni425 – 480DisorderedSequence analysisAdd BLAST56
Regioni522 – 545DisorderedSequence analysisAdd BLAST24
Regioni565 – 611DisorderedSequence analysisAdd BLAST47
Regioni1098 – 1160DisorderedSequence analysisAdd BLAST63
Regioni1254 – 1324DisorderedSequence analysisAdd BLAST71
Regioni1429 – 1480DisorderedSequence analysisAdd BLAST52
Regioni1761 – 1791DisorderedSequence analysisAdd BLAST31
Regioni1809 – 1858DisorderedSequence analysisAdd BLAST50
Regioni1948 – 2024DisorderedSequence analysisAdd BLAST77
Regioni2289 – 2311DisorderedSequence analysisAdd BLAST23
Regioni2328 – 2431DisorderedSequence analysisAdd BLAST104
Regioni2507 – 2564DisorderedSequence analysisAdd BLAST58
Regioni2764 – 2811DisorderedSequence analysisAdd BLAST48
Regioni2829 – 2885DisorderedSequence analysisAdd BLAST57
Regioni3092 – 3172DisorderedSequence analysisAdd BLAST81
Regioni3281 – 3337DisorderedSequence analysisAdd BLAST57
Regioni3443 – 3462DisorderedSequence analysisAdd BLAST20
Regioni3511 – 3534DisorderedSequence analysisAdd BLAST24

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili3265 – 3294Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 26Polar residuesSequence analysisAdd BLAST26
Compositional biasi34 – 54Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi433 – 453Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi1098 – 1130Basic and acidic residuesSequence analysisAdd BLAST33
Compositional biasi1284 – 1321Basic and acidic residuesSequence analysisAdd BLAST38
Compositional biasi1429 – 1454Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi1775 – 1791Polar residuesSequence analysisAdd BLAST17
Compositional biasi1809 – 1845Basic and acidic residuesSequence analysisAdd BLAST37
Compositional biasi1952 – 1978Pro residuesSequence analysisAdd BLAST27
Compositional biasi1988 – 2022Pro residuesSequence analysisAdd BLAST35
Compositional biasi2372 – 2397Polar residuesSequence analysisAdd BLAST26
Compositional biasi2398 – 2414Pro residuesSequence analysisAdd BLAST17
Compositional biasi2415 – 2431Polar residuesSequence analysisAdd BLAST17
Compositional biasi2507 – 2530Polar residuesSequence analysisAdd BLAST24
Compositional biasi2533 – 2564Basic and acidic residuesSequence analysisAdd BLAST32
Compositional biasi2764 – 2788Polar residuesSequence analysisAdd BLAST25
Compositional biasi2830 – 2855Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi2856 – 2877Polar residuesSequence analysisAdd BLAST22
Compositional biasi3092 – 3107Polar residuesSequence analysisAdd BLAST16
Compositional biasi3108 – 3127Pro residuesSequence analysisAdd BLAST20
Compositional biasi3136 – 3172Basic and acidic residuesSequence analysisAdd BLAST37
Compositional biasi3281 – 3312Polar residuesSequence analysisAdd BLAST32
Compositional biasi3313 – 3337Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi3445 – 3462Polar residuesSequence analysisAdd BLAST18
Compositional biasi3511 – 3527Polar residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri613 – 636C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri644 – 667C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri699 – 723C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri767 – 789C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri917 – 941C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri973 – 995C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1021 – 1045C2H2-type 7PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1172 – 1195C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1201 – 1224C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1352 – 1374C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1380 – 1403C2H2-type 11PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1496 – 1522C2H2-type 12PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri1548 – 1572C2H2-type 13PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1901 – 1924C2H2-type 14PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri2267 – 2291C2H2-type 15; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri2448 – 2470C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri2630 – 2653C2H2-type 17PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri2962 – 2986C2H2-type 18PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri3354 – 3378C2H2-type 19; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri3398 – 3422C2H2-type 20PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Coiled coil, Homeobox, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1146, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159542

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q86UP3

Identification of Orthologs from Complete Genome Data

More...OMAi		TSPKPDY

Database of Orthologous Groups

More...OrthoDBi		15351at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q86UP3

TreeFam database of animal gene trees

More...TreeFami		TF323288

Family and domain databases

Conserved Domains Database

More...CDDi		cd00086, homeodomain, 4 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR003604, Matrin/U1-like-C_Znf_C2H2
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00046, Homeodomain, 4 hits
PF00096, zf-C2H2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00389, HOX, 4 hits
SM00355, ZnF_C2H2, 23 hits
SM00451, ZnF_U1, 7 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46689, SSF46689, 4 hits
SSF57667, SSF57667, 6 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00027, HOMEOBOX_1, 2 hits
PS50071, HOMEOBOX_2, 4 hits
PS00028, ZINC_FINGER_C2H2_1, 13 hits
PS50157, ZINC_FINGER_C2H2_2, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86UP3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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METCDSPPIS RQENGQSTSK LCGTTQLDNE VPEKVAGMEP DRENSSTDDN 
        60         70         80         90        100
LKTDERKSEA LLGFSVENAA ATQVTSAKEI PCNECATSFP SLQKYMEHHC 
       110        120        130        140        150
PNARLPVLKD DNESEISELE DSDVENLTGE IVYQPDGSAY IIEDSKESGQ 
       160        170        180        190        200
NAQTGANSKL FSTAMFLDSL ASAGEKSDQS ASAPMSFYPQ IINTFHIASS 
       210        220        230        240        250
LGKPFTADQA FPNTSALAGV GPVLHSFRVY DLRHKREKDY LTSDGSAKNS 
       260        270        280        290        300
CVSKDVPNNV DLSKFDGCVS DGKRKPVLMC FLCKLSFGYI RSFVTHAVHD 
       310        320        330        340        350
HRMTLNDEEQ KLLSNKCVSA IIQGIGKDKE PLISFLEPKK STSVYPHFST 
       360        370        380        390        400
TNLIGPDPTF RGLWSAFHVE NGDSLPAGFA FLKGSASTSS SAEQPLGITQ 
       410        420        430        440        450
MPKAEVNLGG LSSLVVNTPI TSVSLSHSSS ESSKMSESKD QENNCERPKE 
       460        470        480        490        500
SNVLHPNGEC PVKSEPTEPG DEDEEDAYSN ELDDEEVLGE LTDSIGNKDF 
       510        520        530        540        550
PLLNQSISPL SSSVLKFIEK GTSSSSATVS DDTEKKKQTA AVRASGSVAS 
       560        570        580        590        600
NYGISGKDFA DASASKDSAT AAHPSEIARG DEDSSATPHQ HGFTPSTPGT 
       610        620        630        640        650
PGPGGDGSPG SGIECPKCDT VLGSSRSLGG HMTMMHSRNS CKTLKCPKCN 
       660        670        680        690        700
WHYKYQQTLE AHMKEKHPEP GGSCVYCKTG QPHPRLARGE SYTCGYKPFR 
       710        720        730        740        750
CEVCNYSTTT KGNLSIHMQS DKHLNNVQNL QNGNGEQVFG HSAPAPNTSL 
       760        770        780        790        800
SGCGTPSPSK PKQKPTWRCE VCDYETNVAR NLRIHMTSEK HMHNMMLLQQ 
       810        820        830        840        850
NMKQIQHNLH LGLAPAEAEL YQYYLAQNIG LTGMKLENPA DPQLMINPFQ 
       860        870        880        890        900
LDPATAAALA PGLGELSPYI SDPALKLFQC AVCNKFTSDS LEALSVHVSS 
       910        920        930        940        950
ERSLPEEEWR AVIGDIYQCK LCNYNTQLKA NFQLHCKTDK HMQKYQLVAH 
       960        970        980        990       1000
IKEGGKSNEW RLKCIAIGNP VHLKCNACDY YTNSVDKLRL HTTNHRHEAA 
      1010       1020       1030       1040       1050
LKLYKHLQKQ EGAVNPESCY YYCAVCDYTT KVKLNLVQHV RSVKHQQTEG 
      1060       1070       1080       1090       1100
LRKLQLHQQG LAPEEDNLSE IFFVKDCPPN ELETASLGAR TCDDDLTEQH 
      1110       1120       1130       1140       1150
EEAEGAIKPT AVAEDDEKDT SERDNSEGKN SNKDSVSVAG GTQPLLLAKE 
      1160       1170       1180       1190       1200
EDVATKRSKP TEDNKFCHEQ FYQCPYCNYN SRDQSRIQMH VLSQHSVQPV 
      1210       1220       1230       1240       1250
ICCPLCQDVL SNKMHLQLHL THLHSVSPDC VEKLLMTVPV PDVMMPNSML 
      1260       1270       1280       1290       1300
LPAAASEKSE RDTPAAVTAE GSGKYSGESP MDDKSMAGLE DSKANVEVKN 
      1310       1320       1330       1340       1350
EEQKPTKEPL EVSEWNKNSS KDVKIPDTLQ DQLNEQQKRQ PLSVSDRHVY 
      1360       1370       1380       1390       1400
KYRCNHCSLA FKTMQKLQIH SQYHAIRAAT MCNLCQRSFR TFQALKKHLE 
      1410       1420       1430       1440       1450
AGHPELSEAE LQQLYASLPV NGELWAESET MSQDDHGLEQ EMEREYEVDH 
      1460       1470       1480       1490       1500
EGKASPVGSD SSSIPDDMGS EPKRTLPFRK GPNFTMEKFL DPSRPYKCTV 
      1510       1520       1530       1540       1550
CKESFTQKNI LLVHYNSVSH LHKLKKVLQE ASSPVPQETN SNTDNKPYKC 
      1560       1570       1580       1590       1600
SICNVAYSQS STLEIHMRSV LHQTKARAAK LEPSGHVAGG HSIAANVNSP 
      1610       1620       1630       1640       1650
GQGMLDSMSL AAVNSKDTHL DAKELNKKQT PDLISAQPAH HPPQSPAQIQ 
      1660       1670       1680       1690       1700
MQLQHELQQQ AAFFQPQFLN PAFLPHFPMT PEALLQFQQP QFLFPFYIPG 
      1710       1720       1730       1740       1750
TEFSLGPDLG LPGSATFGMP GMTGMAGSLL EDLKQQIQTQ HHVGQTQLQI 
      1760       1770       1780       1790       1800
LQQQAQQYQA TQPQLQPQKQ QQQPPPPQQQ QQQQASKLLK QEQSNIVSAD 
      1810       1820       1830       1840       1850
CQIMKDVPSY KEAEDISEKP EKPKQEFISE GEGLKEGKDT KKQKSLEPSI 
      1860       1870       1880       1890       1900
PPPRIASGAR GNAAKALLEN FGFELVIQYN ENRQKVQKKG KSGEGENTDK 
      1910       1920       1930       1940       1950
LECGTCGKLF SNVLILKSHQ EHVHGQFFPY AALEKFARQY REAYDKLYPI 
      1960       1970       1980       1990       2000
SPSSPETPPP PPPPPPLPPA PPQPSSMGPV KIPNTVSTPL QAPPPTPPPP 
      2010       2020       2030       2040       2050
PPPPPPPPPP PPPPPPSAPP QVQLPVSLDL PLFPSIMMQP VQHPALPPQL 
      2060       2070       2080       2090       2100
ALQLPQMDAL SADLTQLCQQ QLGLDPNFLR HSQFKRPRTR ITDDQLKILR 
      2110       2120       2130       2140       2150
AYFDINNSPS EEQIQEMAEK SGLSQKVIKH WFRNTLFKER QRNKDSPYNF 
      2160       2170       2180       2190       2200
SNPPITVLED IRIDPQPTSL EHYKSDASFS KRSSRTRFTD YQLRVLQDFF 
      2210       2220       2230       2240       2250
DTNAYPKDDE IEQLSTVLNL PTRVIVVWFQ NARQKARKSY ENQAETKDNE 
      2260       2270       2280       2290       2300
KRELTNERYI RTSNMQYQCK KCNVVFPRIF DLITHQKKQC YKDEDDDAQD 
      2310       2320       2330       2340       2350
ESQTEDSMDA TDQVVYKHCT VSGQTDAAKN AAAPAASSGS GTSTPLIPSP 
      2360       2370       2380       2390       2400
KPEPEKTSPK PEYPAEKPKQ SDPSPPSQGT KPALPLASTS SDPPQASTAQ 
      2410       2420       2430       2440       2450
PQPQPQPPKQ PQLIGRPPSA SQTPVPSSPL QISMTSLQNS LPPQLLQYQC 
      2460       2470       2480       2490       2500
DQCTVAFPTL ELWQEHQHMH FLAAQNQFLH SPFLERPMDM PYMIFDPNNP 
      2510       2520       2530       2540       2550
LMTGQLLGSS LTQMPPQASS SHTTAPTTVA ASLKRKLDDK EDNNCSEKEG 
      2560       2570       2580       2590       2600
GNSGEDQHRD KRLRTTITPE QLEILYEKYL LDSNPTRKML DHIAREVGLK 
      2610       2620       2630       2640       2650
KRVVQVWFQN TRARERKGQF RAVGPAQSHK RCPFCRALFK AKSALESHIR 
      2660       2670       2680       2690       2700
SRHWNEGKQA GYSLPPSPLI STEDGGESPQ KYIYFDYPSL PLTKIDLSSE 
      2710       2720       2730       2740       2750
NELASTVSTP VSKTAELSPK NLLSPSSFKA ECSEDVENLN APPAEAGYDQ 
      2760       2770       2780       2790       2800
NKTDFDETSS INTAISDATT GDEGNTEMES TTGSSGDVKP ALSPKEPKTL 
      2810       2820       2830       2840       2850
DTLPKPATTP TTEVCDDKFL FSLTSPSIHF NDKDGDHDQS FYITDDPDDN 
      2860       2870       2880       2890       2900
ADRSETSSIA DPSSPNPFGS SNPFKSKSND RPGHKRFRTQ MSNLQLKVLK 
      2910       2920       2930       2940       2950
ACFSDYRTPT MQECEMLGNE IGLPKRVVQV WFQNARAKEK KFKINIGKPF 
      2960       2970       2980       2990       3000
MINQGGTEGT KPECTLCGVK YSARLSIRDH IFSKQHISKV RETVGSQLDR 
      3010       3020       3030       3040       3050
EKDYLAPTTV RQLMAQQELD RIKKASDVLG LTVQQPGMMD SSSLHGISLP 
      3060       3070       3080       3090       3100
TAYPGLPGLP PVLLPGMNGP SSLPGFPQNS NISAGMLGFP TSATSSPALS 
      3110       3120       3130       3140       3150
LSSAPTKPLL QTPPPPPPPP PPPPSSSLSG QQTEQQNKES EKKQTKPNKV 
      3160       3170       3180       3190       3200
KKIKEEELEA TKPEKHPKKE EKISSALSVL GKVVGETHVD PIQLQALQNA 
      3210       3220       3230       3240       3250
IAGDPASFIG GQFLPYFIPG FASYFTPQLP GTVQGGYFPP VCGMESLFPY 
      3260       3270       3280       3290       3300
GPTMPQTLAG LSPGALLQQY QQYQQNLQES LQKQQKQQQE QQQKPVQAKT 
      3310       3320       3330       3340       3350
SKVESDQPQN SNDASETKED KSTATESTKE EPQLESKSAD FSDTYVVPFV 
      3360       3370       3380       3390       3400
KYEFICRKCQ MMFTDEDAAV NHQKSFCYFG QPLIDPQETV LRVPVSKYQC 
      3410       3420       3430       3440       3450
LACDVAISGN EALSQHLQSS LHKEKTIKQA MRNAKEHVRL LPHSVCSPNP 
      3460       3470       3480       3490       3500
NTTSTSQSAA SSNNTYPHLS CFSMKSWPNI LFQASARRAA SPPSSPPSLS 
      3510       3520       3530       3540       3550
LPSTVTSSLC STSGVQTSLP TESCSDESDS ELSQKLEDLD NSLEVKAKPA 
      3560 
SGLDGNFNSI RMDMFSV
Length:3,567
Mass (Da):393,730
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i99DE9E581F477EFB
GO
Isoform 2 (identifier: Q86UP3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     863-863: L → LVNNELPPEIRLASGQLMGDDLSLLTA
     1100-1100: H → QLRSTSEEQS
     1135-1135: S → SGIITPEKELK
     2000-2016: Missing.
     3082-3083: IS → TLTPPG

Show »
Length:3,599
Mass (Da):397,313
Checksum:i42CF89E269BF1E23
GO
Isoform 3 (identifier: Q86UP3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1006-1049: HLQKQEGAVN...VRSVKHQQTE → VSSDIHFRWH...KTSKGRGHSF
     1050-3567: Missing.

Show »
Length:1,049
Mass (Da):114,782
Checksum:i42132524E5905573
GO
Isoform 4 (identifier: Q86UP3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3082-3083: IS → TLTPPG

Show »
Length:3,571
Mass (Da):394,096
Checksum:i69B36792C706F29D
GO
Isoform 5 (identifier: Q86UP3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     863-863: L → LVNNELPPEIRLASGQLMGDDLSLLTA
     1100-1100: H → QLRSTSEEQS
     1135-1135: S → SGIITPEKELK
     3082-3083: IS → TLTPPG

Show »
Length:3,616
Mass (Da):398,964
Checksum:i8FFA9FD9E8F1F38A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EVZ1E7EVZ1_HUMAN
Zinc finger homeobox protein 4
ZFHX4
3,590Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RI93E5RI93_HUMAN
Zinc finger homeobox protein 4
ZFHX4
1,665Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494BZV7A0A494BZV7_HUMAN
Zinc finger homeobox protein 4
ZFHX4
743Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGK3E5RGK3_HUMAN
Zinc finger homeobox protein 4
ZFHX4
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHS1E5RHS1_HUMAN
Zinc finger homeobox protein 4
ZFHX4
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RG79E5RG79_HUMAN
Zinc finger homeobox protein 4
ZFHX4
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBV0H0YBV0_HUMAN
Zinc finger homeobox protein 4
ZFHX4
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YC81H0YC81_HUMAN
Zinc finger homeobox protein 4
ZFHX4
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AK131408 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti32P → L in AK131408 (PubMed:14702039).Curated1
Sequence conflicti406V → A in AK131408 (PubMed:14702039).Curated1
Sequence conflicti937K → E in AK131408 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0573752036I → V. Corresponds to variant dbSNP:rs16919452Ensembl.1
Natural variantiVAR_0573763033V → G. Corresponds to variant dbSNP:rs16939380Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_023298863L → LVNNELPPEIRLASGQLMGD DLSLLTA in isoform 2 and isoform 5. 1 Publication1
Alternative sequenceiVSP_0232991006 – 1049HLQKQ…HQQTE → VSSDIHFRWHRVEKGINSFR AWSTSLQLKEKKREKTSKGR GHSF in isoform 3. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_0233001050 – 3567Missing in isoform 3. 1 PublicationAdd BLAST2518
Alternative sequenceiVSP_0233011100H → QLRSTSEEQS in isoform 2 and isoform 5. 1 Publication1
Alternative sequenceiVSP_0233021135S → SGIITPEKELK in isoform 2 and isoform 5. 1 Publication1
Alternative sequenceiVSP_0233032000 – 2016Missing in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_0233043082 – 3083IS → TLTPPG in isoform 2, isoform 4 and isoform 5. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB083343 mRNA Translation: BAE96598.1
AY260762 mRNA Translation: AAP20225.1
AK131408 mRNA No translation available.
AC011716 Genomic DNA No translation available.
AC023200 Genomic DNA No translation available.
AC087110 Genomic DNA No translation available.
CH471068 Genomic DNA Translation: EAW87051.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS47878.2 [Q86UP3-5]

NCBI Reference Sequences

More...RefSeqi		NP_078997.4, NM_024721.4 [Q86UP3-5]
XP_011515894.1, XM_011517592.2 [Q86UP3-5]
XP_011515895.1, XM_011517593.2 [Q86UP3-5]
XP_011515896.1, XM_011517594.2 [Q86UP3-5]
XP_011515897.1, XM_011517595.2 [Q86UP3-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000651372; ENSP00000498627; ENSG00000091656 [Q86UP3-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		79776

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:79776

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000651372.2; ENSP00000498627.1; NM_024721.5; NP_078997.4 [Q86UP3-5]

UCSC genome browser

More...UCSCi		uc003yau.3, human [Q86UP3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB083343 mRNA Translation: BAE96598.1
AY260762 mRNA Translation: AAP20225.1
AK131408 mRNA No translation available.
AC011716 Genomic DNA No translation available.
AC023200 Genomic DNA No translation available.
AC087110 Genomic DNA No translation available.
CH471068 Genomic DNA Translation: EAW87051.1
CCDSiCCDS47878.2 [Q86UP3-5]
RefSeqiNP_078997.4, NM_024721.4 [Q86UP3-5]
XP_011515894.1, XM_011517592.2 [Q86UP3-5]
XP_011515895.1, XM_011517593.2 [Q86UP3-5]
XP_011515896.1, XM_011517594.2 [Q86UP3-5]
XP_011515897.1, XM_011517595.2 [Q86UP3-5]

3D structure databases

SMRiQ86UP3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122877, 25 interactors
IntActiQ86UP3, 11 interactors
MINTiQ86UP3
STRINGi9606.ENSP00000430497

PTM databases

GlyGeniQ86UP3, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ86UP3
PhosphoSitePlusiQ86UP3

Genetic variation databases

BioMutaiZFHX4
DMDMi74762449

Proteomic databases

EPDiQ86UP3
jPOSTiQ86UP3
MassIVEiQ86UP3
MaxQBiQ86UP3
PaxDbiQ86UP3
PeptideAtlasiQ86UP3
PRIDEiQ86UP3
ProteomicsDBi32248
69844 [Q86UP3-1]
69845 [Q86UP3-2]
69846 [Q86UP3-3]
69847 [Q86UP3-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1757, 65 antibodies from 17 providers

The DNASU plasmid repository

More...DNASUi		79776

Genome annotation databases

EnsembliENST00000651372; ENSP00000498627; ENSG00000091656 [Q86UP3-5]
GeneIDi79776
KEGGihsa:79776
MANE-SelectiENST00000651372.2; ENSP00000498627.1; NM_024721.5; NP_078997.4 [Q86UP3-5]
UCSCiuc003yau.3, human [Q86UP3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79776
DisGeNETi79776

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZFHX4
HGNCiHGNC:30939, ZFHX4
HPAiENSG00000091656, Tissue enhanced (brain)
MalaCardsiZFHX4
MIMi606940, gene
neXtProtiNX_Q86UP3
OpenTargetsiENSG00000091656
Orphaneti91411, Congenital ptosis
PharmGKBiPA134986366
VEuPathDBiHostDB:ENSG00000091656

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1146, Eukaryota
GeneTreeiENSGT00940000159542
InParanoidiQ86UP3
OMAiTSPKPDY
OrthoDBi15351at2759
PhylomeDBiQ86UP3
TreeFamiTF323288

Enzyme and pathway databases

PathwayCommonsiQ86UP3
SignaLinkiQ86UP3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		79776, 9 hits in 1071 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZFHX4, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		79776
PharosiQ86UP3, Tbio

Protein Ontology

More...PROi		PR:Q86UP3
RNActiQ86UP3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000091656, Expressed in calcaneal tendon and 193 other tissues
ExpressionAtlasiQ86UP3, baseline and differential
GenevisibleiQ86UP3, HS

Family and domain databases

CDDicd00086, homeodomain, 4 hits
InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR003604, Matrin/U1-like-C_Znf_C2H2
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00046, Homeodomain, 4 hits
PF00096, zf-C2H2, 1 hit
SMARTiView protein in SMART
SM00389, HOX, 4 hits
SM00355, ZnF_C2H2, 23 hits
SM00451, ZnF_U1, 7 hits
SUPFAMiSSF46689, SSF46689, 4 hits
SSF57667, SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS00027, HOMEOBOX_1, 2 hits
PS50071, HOMEOBOX_2, 4 hits
PS00028, ZINC_FINGER_C2H2_1, 13 hits
PS50157, ZINC_FINGER_C2H2_2, 7 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZFHX4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86UP3
Secondary accession number(s): G3V138, Q18PS0, Q6ZN20
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: June 1, 2003
Last modified: February 23, 2022
This is version 172 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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