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Entry version 166 (12 Aug 2020)
Sequence version 1 (01 Jun 2003)
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Protein

Zinc finger homeobox protein 4

Gene

ZFHX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri613 – 636C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri644 – 667C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri699 – 723C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri767 – 789C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri917 – 941C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri973 – 995C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1021 – 1045C2H2-type 7PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1172 – 1195C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1201 – 1224C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1352 – 1374C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1380 – 1403C2H2-type 11PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1496 – 1522C2H2-type 12PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri1548 – 1572C2H2-type 13PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1901 – 1924C2H2-type 14PROSITE-ProRule annotationAdd BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi2084 – 2143Homeobox 1PROSITE-ProRule annotationAdd BLAST60
DNA bindingi2181 – 2240Homeobox 2PROSITE-ProRule annotationAdd BLAST60
Zinc fingeri2267 – 2291C2H2-type 15; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri2448 – 2470C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
DNA bindingi2560 – 2619Homeobox 3PROSITE-ProRule annotationAdd BLAST60
Zinc fingeri2630 – 2653C2H2-type 17PROSITE-ProRule annotationAdd BLAST24
DNA bindingi2884 – 2943Homeobox 4PROSITE-ProRule annotationAdd BLAST60
Zinc fingeri2962 – 2986C2H2-type 18PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri3354 – 3378C2H2-type 19; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri3398 – 3422C2H2-type 20PROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q86UP3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger homeobox protein 4
Alternative name(s):
Zinc finger homeodomain protein 4
Short name:
ZFH-4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZFHX4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000091656.15

Human Gene Nomenclature Database

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HGNCi
HGNC:30939, ZFHX4

Online Mendelian Inheritance in Man (OMIM)

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MIMi
606940, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86UP3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving ZFHX4 is found in one patient with ptosis. Translocation t(1;8)(p34.3;q21.12).1 Publication

Organism-specific databases

DisGeNET

More...
DisGeNETi
79776

MalaCards human disease database

More...
MalaCardsi
ZFHX4

Open Targets

More...
OpenTargetsi
ENSG00000091656

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
91411, Congenital ptosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134986366

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q86UP3, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZFHX4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762449

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002784651 – 3567Zinc finger homeobox protein 4Add BLAST3567

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1149Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1299Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1324Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1546Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1790Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei2663PhosphoserineCombined sources1
Cross-linki3154Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86UP3

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q86UP3

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q86UP3

MaxQB - The MaxQuant DataBase

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MaxQBi
Q86UP3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86UP3

PeptideAtlas

More...
PeptideAtlasi
Q86UP3

PRoteomics IDEntifications database

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PRIDEi
Q86UP3

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
32248
69844 [Q86UP3-1]
69845 [Q86UP3-2]
69846 [Q86UP3-3]
69847 [Q86UP3-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q86UP3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q86UP3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, skeletal muscle and liver. Very low expression in stomach.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000091656, Expressed in calcaneal tendon and 192 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q86UP3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q86UP3, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000091656, Tissue enhanced (seminal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
122877, 12 interactors

Protein interaction database and analysis system

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IntActi
Q86UP3, 10 interactors

Molecular INTeraction database

More...
MINTi
Q86UP3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000430497

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q86UP3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q86UP3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili3265 – 3294Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi523 – 526Poly-Ser4
Compositional biasi1644 – 1793Gln-richAdd BLAST150
Compositional biasi1949 – 2048Pro-richAdd BLAST100
Compositional biasi2345 – 2429Pro-richAdd BLAST85
Compositional biasi3050 – 3124Pro-richAdd BLAST75
Compositional biasi3454 – 3533Ser-richAdd BLAST80

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri613 – 636C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri644 – 667C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri699 – 723C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri767 – 789C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri917 – 941C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri973 – 995C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1021 – 1045C2H2-type 7PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1172 – 1195C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1201 – 1224C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1352 – 1374C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1380 – 1403C2H2-type 11PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1496 – 1522C2H2-type 12PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri1548 – 1572C2H2-type 13PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1901 – 1924C2H2-type 14PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri2267 – 2291C2H2-type 15; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri2448 – 2470C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri2630 – 2653C2H2-type 17PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri2962 – 2986C2H2-type 18PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri3354 – 3378C2H2-type 19; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri3398 – 3422C2H2-type 20PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Coiled coil, Homeobox, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1146, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000159542

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q86UP3

KEGG Orthology (KO)

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KOi
K09380

Identification of Orthologs from Complete Genome Data

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OMAi
FMINQGG

Database of Orthologous Groups

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OrthoDBi
15351at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q86UP3

TreeFam database of animal gene trees

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TreeFami
TF323288

Family and domain databases

Conserved Domains Database

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CDDi
cd00086, homeodomain, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR003604, Matrin/U1-like-C_Znf_C2H2
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00046, Homeodomain, 4 hits
PF00096, zf-C2H2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00389, HOX, 4 hits
SM00355, ZnF_C2H2, 23 hits
SM00451, ZnF_U1, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 4 hits
SSF57667, SSF57667, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00027, HOMEOBOX_1, 2 hits
PS50071, HOMEOBOX_2, 4 hits
PS00028, ZINC_FINGER_C2H2_1, 13 hits
PS50157, ZINC_FINGER_C2H2_2, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86UP3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METCDSPPIS RQENGQSTSK LCGTTQLDNE VPEKVAGMEP DRENSSTDDN
60 70 80 90 100
LKTDERKSEA LLGFSVENAA ATQVTSAKEI PCNECATSFP SLQKYMEHHC
110 120 130 140 150
PNARLPVLKD DNESEISELE DSDVENLTGE IVYQPDGSAY IIEDSKESGQ
160 170 180 190 200
NAQTGANSKL FSTAMFLDSL ASAGEKSDQS ASAPMSFYPQ IINTFHIASS
210 220 230 240 250
LGKPFTADQA FPNTSALAGV GPVLHSFRVY DLRHKREKDY LTSDGSAKNS
260 270 280 290 300
CVSKDVPNNV DLSKFDGCVS DGKRKPVLMC FLCKLSFGYI RSFVTHAVHD
310 320 330 340 350
HRMTLNDEEQ KLLSNKCVSA IIQGIGKDKE PLISFLEPKK STSVYPHFST
360 370 380 390 400
TNLIGPDPTF RGLWSAFHVE NGDSLPAGFA FLKGSASTSS SAEQPLGITQ
410 420 430 440 450
MPKAEVNLGG LSSLVVNTPI TSVSLSHSSS ESSKMSESKD QENNCERPKE
460 470 480 490 500
SNVLHPNGEC PVKSEPTEPG DEDEEDAYSN ELDDEEVLGE LTDSIGNKDF
510 520 530 540 550
PLLNQSISPL SSSVLKFIEK GTSSSSATVS DDTEKKKQTA AVRASGSVAS
560 570 580 590 600
NYGISGKDFA DASASKDSAT AAHPSEIARG DEDSSATPHQ HGFTPSTPGT
610 620 630 640 650
PGPGGDGSPG SGIECPKCDT VLGSSRSLGG HMTMMHSRNS CKTLKCPKCN
660 670 680 690 700
WHYKYQQTLE AHMKEKHPEP GGSCVYCKTG QPHPRLARGE SYTCGYKPFR
710 720 730 740 750
CEVCNYSTTT KGNLSIHMQS DKHLNNVQNL QNGNGEQVFG HSAPAPNTSL
760 770 780 790 800
SGCGTPSPSK PKQKPTWRCE VCDYETNVAR NLRIHMTSEK HMHNMMLLQQ
810 820 830 840 850
NMKQIQHNLH LGLAPAEAEL YQYYLAQNIG LTGMKLENPA DPQLMINPFQ
860 870 880 890 900
LDPATAAALA PGLGELSPYI SDPALKLFQC AVCNKFTSDS LEALSVHVSS
910 920 930 940 950
ERSLPEEEWR AVIGDIYQCK LCNYNTQLKA NFQLHCKTDK HMQKYQLVAH
960 970 980 990 1000
IKEGGKSNEW RLKCIAIGNP VHLKCNACDY YTNSVDKLRL HTTNHRHEAA
1010 1020 1030 1040 1050
LKLYKHLQKQ EGAVNPESCY YYCAVCDYTT KVKLNLVQHV RSVKHQQTEG
1060 1070 1080 1090 1100
LRKLQLHQQG LAPEEDNLSE IFFVKDCPPN ELETASLGAR TCDDDLTEQH
1110 1120 1130 1140 1150
EEAEGAIKPT AVAEDDEKDT SERDNSEGKN SNKDSVSVAG GTQPLLLAKE
1160 1170 1180 1190 1200
EDVATKRSKP TEDNKFCHEQ FYQCPYCNYN SRDQSRIQMH VLSQHSVQPV
1210 1220 1230 1240 1250
ICCPLCQDVL SNKMHLQLHL THLHSVSPDC VEKLLMTVPV PDVMMPNSML
1260 1270 1280 1290 1300
LPAAASEKSE RDTPAAVTAE GSGKYSGESP MDDKSMAGLE DSKANVEVKN
1310 1320 1330 1340 1350
EEQKPTKEPL EVSEWNKNSS KDVKIPDTLQ DQLNEQQKRQ PLSVSDRHVY
1360 1370 1380 1390 1400
KYRCNHCSLA FKTMQKLQIH SQYHAIRAAT MCNLCQRSFR TFQALKKHLE
1410 1420 1430 1440 1450
AGHPELSEAE LQQLYASLPV NGELWAESET MSQDDHGLEQ EMEREYEVDH
1460 1470 1480 1490 1500
EGKASPVGSD SSSIPDDMGS EPKRTLPFRK GPNFTMEKFL DPSRPYKCTV
1510 1520 1530 1540 1550
CKESFTQKNI LLVHYNSVSH LHKLKKVLQE ASSPVPQETN SNTDNKPYKC
1560 1570 1580 1590 1600
SICNVAYSQS STLEIHMRSV LHQTKARAAK LEPSGHVAGG HSIAANVNSP
1610 1620 1630 1640 1650
GQGMLDSMSL AAVNSKDTHL DAKELNKKQT PDLISAQPAH HPPQSPAQIQ
1660 1670 1680 1690 1700
MQLQHELQQQ AAFFQPQFLN PAFLPHFPMT PEALLQFQQP QFLFPFYIPG
1710 1720 1730 1740 1750
TEFSLGPDLG LPGSATFGMP GMTGMAGSLL EDLKQQIQTQ HHVGQTQLQI
1760 1770 1780 1790 1800
LQQQAQQYQA TQPQLQPQKQ QQQPPPPQQQ QQQQASKLLK QEQSNIVSAD
1810 1820 1830 1840 1850
CQIMKDVPSY KEAEDISEKP EKPKQEFISE GEGLKEGKDT KKQKSLEPSI
1860 1870 1880 1890 1900
PPPRIASGAR GNAAKALLEN FGFELVIQYN ENRQKVQKKG KSGEGENTDK
1910 1920 1930 1940 1950
LECGTCGKLF SNVLILKSHQ EHVHGQFFPY AALEKFARQY REAYDKLYPI
1960 1970 1980 1990 2000
SPSSPETPPP PPPPPPLPPA PPQPSSMGPV KIPNTVSTPL QAPPPTPPPP
2010 2020 2030 2040 2050
PPPPPPPPPP PPPPPPSAPP QVQLPVSLDL PLFPSIMMQP VQHPALPPQL
2060 2070 2080 2090 2100
ALQLPQMDAL SADLTQLCQQ QLGLDPNFLR HSQFKRPRTR ITDDQLKILR
2110 2120 2130 2140 2150
AYFDINNSPS EEQIQEMAEK SGLSQKVIKH WFRNTLFKER QRNKDSPYNF
2160 2170 2180 2190 2200
SNPPITVLED IRIDPQPTSL EHYKSDASFS KRSSRTRFTD YQLRVLQDFF
2210 2220 2230 2240 2250
DTNAYPKDDE IEQLSTVLNL PTRVIVVWFQ NARQKARKSY ENQAETKDNE
2260 2270 2280 2290 2300
KRELTNERYI RTSNMQYQCK KCNVVFPRIF DLITHQKKQC YKDEDDDAQD
2310 2320 2330 2340 2350
ESQTEDSMDA TDQVVYKHCT VSGQTDAAKN AAAPAASSGS GTSTPLIPSP
2360 2370 2380 2390 2400
KPEPEKTSPK PEYPAEKPKQ SDPSPPSQGT KPALPLASTS SDPPQASTAQ
2410 2420 2430 2440 2450
PQPQPQPPKQ PQLIGRPPSA SQTPVPSSPL QISMTSLQNS LPPQLLQYQC
2460 2470 2480 2490 2500
DQCTVAFPTL ELWQEHQHMH FLAAQNQFLH SPFLERPMDM PYMIFDPNNP
2510 2520 2530 2540 2550
LMTGQLLGSS LTQMPPQASS SHTTAPTTVA ASLKRKLDDK EDNNCSEKEG
2560 2570 2580 2590 2600
GNSGEDQHRD KRLRTTITPE QLEILYEKYL LDSNPTRKML DHIAREVGLK
2610 2620 2630 2640 2650
KRVVQVWFQN TRARERKGQF RAVGPAQSHK RCPFCRALFK AKSALESHIR
2660 2670 2680 2690 2700
SRHWNEGKQA GYSLPPSPLI STEDGGESPQ KYIYFDYPSL PLTKIDLSSE
2710 2720 2730 2740 2750
NELASTVSTP VSKTAELSPK NLLSPSSFKA ECSEDVENLN APPAEAGYDQ
2760 2770 2780 2790 2800
NKTDFDETSS INTAISDATT GDEGNTEMES TTGSSGDVKP ALSPKEPKTL
2810 2820 2830 2840 2850
DTLPKPATTP TTEVCDDKFL FSLTSPSIHF NDKDGDHDQS FYITDDPDDN
2860 2870 2880 2890 2900
ADRSETSSIA DPSSPNPFGS SNPFKSKSND RPGHKRFRTQ MSNLQLKVLK
2910 2920 2930 2940 2950
ACFSDYRTPT MQECEMLGNE IGLPKRVVQV WFQNARAKEK KFKINIGKPF
2960 2970 2980 2990 3000
MINQGGTEGT KPECTLCGVK YSARLSIRDH IFSKQHISKV RETVGSQLDR
3010 3020 3030 3040 3050
EKDYLAPTTV RQLMAQQELD RIKKASDVLG LTVQQPGMMD SSSLHGISLP
3060 3070 3080 3090 3100
TAYPGLPGLP PVLLPGMNGP SSLPGFPQNS NISAGMLGFP TSATSSPALS
3110 3120 3130 3140 3150
LSSAPTKPLL QTPPPPPPPP PPPPSSSLSG QQTEQQNKES EKKQTKPNKV
3160 3170 3180 3190 3200
KKIKEEELEA TKPEKHPKKE EKISSALSVL GKVVGETHVD PIQLQALQNA
3210 3220 3230 3240 3250
IAGDPASFIG GQFLPYFIPG FASYFTPQLP GTVQGGYFPP VCGMESLFPY
3260 3270 3280 3290 3300
GPTMPQTLAG LSPGALLQQY QQYQQNLQES LQKQQKQQQE QQQKPVQAKT
3310 3320 3330 3340 3350
SKVESDQPQN SNDASETKED KSTATESTKE EPQLESKSAD FSDTYVVPFV
3360 3370 3380 3390 3400
KYEFICRKCQ MMFTDEDAAV NHQKSFCYFG QPLIDPQETV LRVPVSKYQC
3410 3420 3430 3440 3450
LACDVAISGN EALSQHLQSS LHKEKTIKQA MRNAKEHVRL LPHSVCSPNP
3460 3470 3480 3490 3500
NTTSTSQSAA SSNNTYPHLS CFSMKSWPNI LFQASARRAA SPPSSPPSLS
3510 3520 3530 3540 3550
LPSTVTSSLC STSGVQTSLP TESCSDESDS ELSQKLEDLD NSLEVKAKPA
3560
SGLDGNFNSI RMDMFSV
Length:3,567
Mass (Da):393,730
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i99DE9E581F477EFB
GO
Isoform 2 (identifier: Q86UP3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     863-863: L → LVNNELPPEIRLASGQLMGDDLSLLTA
     1100-1100: H → QLRSTSEEQS
     1135-1135: S → SGIITPEKELK
     2000-2016: Missing.
     3082-3083: IS → TLTPPG

Show »
Length:3,599
Mass (Da):397,313
Checksum:i42CF89E269BF1E23
GO
Isoform 3 (identifier: Q86UP3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1006-1049: HLQKQEGAVN...VRSVKHQQTE → VSSDIHFRWH...KTSKGRGHSF
     1050-3567: Missing.

Show »
Length:1,049
Mass (Da):114,782
Checksum:i42132524E5905573
GO
Isoform 4 (identifier: Q86UP3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3082-3083: IS → TLTPPG

Show »
Length:3,571
Mass (Da):394,096
Checksum:i69B36792C706F29D
GO
Isoform 5 (identifier: Q86UP3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     863-863: L → LVNNELPPEIRLASGQLMGDDLSLLTA
     1100-1100: H → QLRSTSEEQS
     1135-1135: S → SGIITPEKELK
     3082-3083: IS → TLTPPG

Show »
Length:3,616
Mass (Da):398,964
Checksum:i8FFA9FD9E8F1F38A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EVZ1E7EVZ1_HUMAN
Zinc finger homeobox protein 4
ZFHX4
3,590Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RI93E5RI93_HUMAN
Zinc finger homeobox protein 4
ZFHX4
1,665Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494BZV7A0A494BZV7_HUMAN
Zinc finger homeobox protein 4
ZFHX4
743Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGK3E5RGK3_HUMAN
Zinc finger homeobox protein 4
ZFHX4
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHS1E5RHS1_HUMAN
Zinc finger homeobox protein 4
ZFHX4
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RG79E5RG79_HUMAN
Zinc finger homeobox protein 4
ZFHX4
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YC81H0YC81_HUMAN
Zinc finger homeobox protein 4
ZFHX4
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBV0H0YBV0_HUMAN
Zinc finger homeobox protein 4
ZFHX4
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AK131408 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti32P → L in AK131408 (PubMed:14702039).Curated1
Sequence conflicti406V → A in AK131408 (PubMed:14702039).Curated1
Sequence conflicti937K → E in AK131408 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0573752036I → V. Corresponds to variant dbSNP:rs16919452Ensembl.1
Natural variantiVAR_0573763033V → G. Corresponds to variant dbSNP:rs16939380Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_023298863L → LVNNELPPEIRLASGQLMGD DLSLLTA in isoform 2 and isoform 5. 1 Publication1
Alternative sequenceiVSP_0232991006 – 1049HLQKQ…HQQTE → VSSDIHFRWHRVEKGINSFR AWSTSLQLKEKKREKTSKGR GHSF in isoform 3. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_0233001050 – 3567Missing in isoform 3. 1 PublicationAdd BLAST2518
Alternative sequenceiVSP_0233011100H → QLRSTSEEQS in isoform 2 and isoform 5. 1 Publication1
Alternative sequenceiVSP_0233021135S → SGIITPEKELK in isoform 2 and isoform 5. 1 Publication1
Alternative sequenceiVSP_0233032000 – 2016Missing in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_0233043082 – 3083IS → TLTPPG in isoform 2, isoform 4 and isoform 5. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB083343 mRNA Translation: BAE96598.1
AY260762 mRNA Translation: AAP20225.1
AK131408 mRNA No translation available.
AC011716 Genomic DNA No translation available.
AC023200 Genomic DNA No translation available.
AC087110 Genomic DNA No translation available.
CH471068 Genomic DNA Translation: EAW87051.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47878.2 [Q86UP3-5]

NCBI Reference Sequences

More...
RefSeqi
NP_078997.4, NM_024721.4 [Q86UP3-5]
XP_011515894.1, XM_011517592.2 [Q86UP3-5]
XP_011515895.1, XM_011517593.2 [Q86UP3-5]
XP_011515896.1, XM_011517594.2 [Q86UP3-5]
XP_011515897.1, XM_011517595.2 [Q86UP3-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000651372; ENSP00000498627; ENSG00000091656 [Q86UP3-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79776

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79776

UCSC genome browser

More...
UCSCi
uc003yau.3, human [Q86UP3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB083343 mRNA Translation: BAE96598.1
AY260762 mRNA Translation: AAP20225.1
AK131408 mRNA No translation available.
AC011716 Genomic DNA No translation available.
AC023200 Genomic DNA No translation available.
AC087110 Genomic DNA No translation available.
CH471068 Genomic DNA Translation: EAW87051.1
CCDSiCCDS47878.2 [Q86UP3-5]
RefSeqiNP_078997.4, NM_024721.4 [Q86UP3-5]
XP_011515894.1, XM_011517592.2 [Q86UP3-5]
XP_011515895.1, XM_011517593.2 [Q86UP3-5]
XP_011515896.1, XM_011517594.2 [Q86UP3-5]
XP_011515897.1, XM_011517595.2 [Q86UP3-5]

3D structure databases

SMRiQ86UP3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122877, 12 interactors
IntActiQ86UP3, 10 interactors
MINTiQ86UP3
STRINGi9606.ENSP00000430497

PTM databases

iPTMnetiQ86UP3
PhosphoSitePlusiQ86UP3

Polymorphism and mutation databases

BioMutaiZFHX4
DMDMi74762449

Proteomic databases

EPDiQ86UP3
jPOSTiQ86UP3
MassIVEiQ86UP3
MaxQBiQ86UP3
PaxDbiQ86UP3
PeptideAtlasiQ86UP3
PRIDEiQ86UP3
ProteomicsDBi32248
69844 [Q86UP3-1]
69845 [Q86UP3-2]
69846 [Q86UP3-3]
69847 [Q86UP3-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1757, 60 antibodies

Genome annotation databases

EnsembliENST00000651372; ENSP00000498627; ENSG00000091656 [Q86UP3-5]
GeneIDi79776
KEGGihsa:79776
UCSCiuc003yau.3, human [Q86UP3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79776
DisGeNETi79776
EuPathDBiHostDB:ENSG00000091656.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZFHX4
HGNCiHGNC:30939, ZFHX4
HPAiENSG00000091656, Tissue enhanced (seminal)
MalaCardsiZFHX4
MIMi606940, gene
neXtProtiNX_Q86UP3
OpenTargetsiENSG00000091656
Orphaneti91411, Congenital ptosis
PharmGKBiPA134986366

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1146, Eukaryota
GeneTreeiENSGT00940000159542
InParanoidiQ86UP3
KOiK09380
OMAiFMINQGG
OrthoDBi15351at2759
PhylomeDBiQ86UP3
TreeFamiTF323288

Enzyme and pathway databases

PathwayCommonsiQ86UP3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
79776, 6 hits in 895 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZFHX4, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
79776
PharosiQ86UP3, Tbio

Protein Ontology

More...
PROi
PR:Q86UP3
RNActiQ86UP3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000091656, Expressed in calcaneal tendon and 192 other tissues
ExpressionAtlasiQ86UP3, baseline and differential
GenevisibleiQ86UP3, HS

Family and domain databases

CDDicd00086, homeodomain, 4 hits
InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR003604, Matrin/U1-like-C_Znf_C2H2
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00046, Homeodomain, 4 hits
PF00096, zf-C2H2, 1 hit
SMARTiView protein in SMART
SM00389, HOX, 4 hits
SM00355, ZnF_C2H2, 23 hits
SM00451, ZnF_U1, 7 hits
SUPFAMiSSF46689, SSF46689, 4 hits
SSF57667, SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS00027, HOMEOBOX_1, 2 hits
PS50071, HOMEOBOX_2, 4 hits
PS00028, ZINC_FINGER_C2H2_1, 13 hits
PS50157, ZINC_FINGER_C2H2_2, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZFHX4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86UP3
Secondary accession number(s): G3V138, Q18PS0, Q6ZN20
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: June 1, 2003
Last modified: August 12, 2020
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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