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UniProtKB - Q86UP2 (KTN1_HUMAN)

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Protein

Kinectin

Gene

KTN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin.

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-5625970 RHO GTPases activate KTN1
R-HSA-8957275 Post-translational protein phosphorylation
SIGNORiQ86UP2

Names & Taxonomyi

Protein namesi
Recommended name:
Kinectin
Alternative name(s):
CG-1 antigen
Kinesin receptor
Gene namesi
Name:KTN1
Synonyms:CG1, KIAA0004
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000126777.17
HGNCiHGNC:6467 KTN1
MIMi600381 gene
neXtProtiNX_Q86UP2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicSequence analysis6
Transmembranei7 – 29Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
Topological domaini30 – 1357LumenalSequence analysisAdd BLAST1328

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3895
OpenTargetsiENSG00000126777
PharmGKBiPA30256

Polymorphism and mutation databases

BioMutaiKTN1
DMDMi34098465

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000843371 – 1357KinectinAdd BLAST1357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei75Phosphoserine; by FAM20CCombined sources1 Publication1
Modified residuei77PhosphoserineCombined sources1
Modified residuei153PhosphothreonineCombined sources1
Modified residuei156PhosphoserineCombined sources1
Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi435N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi772N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi904N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1055N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1084PhosphoserineCombined sources1
Glycosylationi1088N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1263N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1313PhosphoserineCombined sources1
Glycosylationi1329N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ86UP2
MaxQBiQ86UP2
PaxDbiQ86UP2
PeptideAtlasiQ86UP2
PRIDEiQ86UP2
ProteomicsDBi69841
69842 [Q86UP2-2]
69843 [Q86UP2-3]

PTM databases

iPTMnetiQ86UP2
PhosphoSitePlusiQ86UP2
SwissPalmiQ86UP2

Expressioni

Tissue specificityi

High levels in peripheral blood lymphocytes, testis and ovary, lower levels in spleen, thymus, prostate, small intestine and colon.

Gene expression databases

BgeeiENSG00000126777
CleanExiHS_KTN1
ExpressionAtlasiQ86UP2 baseline and differential
GenevisibleiQ86UP2 HS

Organism-specific databases

HPAiCAB015331
HPA003178
HPA017876

Interactioni

Subunit structurei

Parallel homodimers formed between the membrane-bound and the cytosolic form, and also between 2 cytosolic forms.By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi110092, 62 interactors
CORUMiQ86UP2
DIPiDIP-27585N
IntActiQ86UP2, 52 interactors
MINTiQ86UP2
STRINGi9606.ENSP00000378720

Structurei

3D structure databases

ProteinModelPortaliQ86UP2
SMRiQ86UP2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili330 – 1356Sequence analysisAdd BLAST1027

Sequence similaritiesi

Belongs to the kinectin family.Curated

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIAW Eukaryota
ENOG410YAE3 LUCA
GeneTreeiENSGT00530000063895
HOGENOMiHOG000113267
HOVERGENiHBG007851
InParanoidiQ86UP2
KOiK17975
OMAiKEHNVFQ
OrthoDBiEOG091G12OH
PhylomeDBiQ86UP2
TreeFamiTF333579

Family and domain databases

InterProiView protein in InterPro
IPR024854 Kinectin
PANTHERiPTHR18864 PTHR18864, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q86UP2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEFYESAYFI VLIPSIVITV IFLFFWLFMK ETLYDEVLAK QKREQKLIPT 
        60         70         80         90        100
KTDKKKAEKK KNKKKEIQNG NLHESDSESV PRDFKLSDAL AVEDDQVAPV 
       110        120        130        140        150
PLNVVETSSS VRERKKKEKK QKPVLEEQVI KESDASKIPG KKVEPVPVTK 
       160        170        180        190        200
QPTPPSEAAA SKKKPGQKKS KNGSDDQDKK VETLMVPSKR QEALPLHQET 
       210        220        230        240        250
KQESGSGKKK ASSKKQKTEN VFVDEPLIHA TTYIPLMDNA DSSPVVDKRE 
       260        270        280        290        300
VIDLLKPDQV EGIQKSGTKK LKTETDKENA EVKFKDFLLS LKTMMFSEDE 
       310        320        330        340        350
ALCVVDLLKE KSGVIQDALK KSSKGELTTL IHQLQEKDKL LAAVKEDAAA 
       360        370        380        390        400
TKDRCKQLTQ EMMTEKERSN VVITRMKDRI GTLEKEHNVF QNKIHVSYQE 
       410        420        430        440        450
TQQMQMKFQQ VREQMEAEIA HLKQENGILR DAVSNTTNQL ESKQSAELNK 
       460        470        480        490        500
LRQDYARLVN ELTEKTGKLQ QEEVQKKNAE QAATQLKVQL QEAERRWEEV 
       510        520        530        540        550
QSYIRKRTAE HEAAQQDLQS KFVAKENEVQ SLHSKLTDTL VSKQQLEQRL 
       560        570        580        590        600
MQLMESEQKR VNKEESLQMQ VQDILEQNEA LKAQIQQFHS QIAAQTSASV 
       610        620        630        640        650
LAEELHKVIA EKDKQIKQTE DSLASERDRL TSKEEELKDI QNMNFLLKAE 
       660        670        680        690        700
VQKLQALANE QAAAAHELEK MQQSVYVKDD KIRLLEEQLQ HEISNKMEEF 
       710        720        730        740        750
KILNDQNKAL KSEVQKLQTL VSEQPNKDVV EQMEKCIQEK DEKLKTVEEL 
       760        770        780        790        800
LETGLIQVAT KEEELNAIRT ENSSLTKEVQ DLKAKQNDQV SFASLVEELK 
       810        820        830        840        850
KVIHEKDGKI KSVEELLEAE LLKVANKEKT VQDLKQEIKA LKEEIGNVQL 
       860        870        880        890        900
EKAQQLSITS KVQELQNLLK GKEEQMNTMK AVLEEKEKDL ANTGKWLQDL 
       910        920        930        940        950
QEENESLKAH VQEVAQHNLK EASSASQFEE LEIVLKEKEN ELKRLEAMLK 
       960        970        980        990       1000
ERESDLSSKT QLLQDVQDEN KLFKSQIEQL KQQNYQQASS FPPHEELLKV 
      1010       1020       1030       1040       1050
ISEREKEISG LWNELDSLKD AVEHQRKKNN DLREKNWEAM EALASTEKML 
      1060       1070       1080       1090       1100
QDKVNKTSKE RQQQVEAVEL EAKEVLKKLF PKVSVPSNLS YGEWLHGFEK 
      1110       1120       1130       1140       1150
KAKECMAGTS GSEEVKVLEH KLKEADEMHT LLQLECEKYK SVLAETEGIL 
      1160       1170       1180       1190       1200
QKLQRSVEQE ENKWKVKVDE SHKTIKQMQS SFTSSEQELE RLRSENKDIE 
      1210       1220       1230       1240       1250
NLRREREHLE MELEKAEMER STYVTEVREL KDLLTELQKK LDDSYSEAVR 
      1260       1270       1280       1290       1300
QNEELNLLKA QLNETLTKLR TEQNERQKVA GDLHKAQQSL ELIQSKIVKA 
      1310       1320       1330       1340       1350
AGDTTVIENS DVSPETESSE KETMSVSLNQ TVTQLQQLLQ AVNQQLTKEK 

EHYQVLE
Length:1,357
Mass (Da):156,275
Last modified:June 1, 2003 - v1
Checksum:i971FCDF8AA8FC88E
GO
Isoform 2 (identifier: Q86UP2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1031-1059: Missing.
     1232-1259: Missing.

Show »
Length:1,300
Mass (Da):149,611
Checksum:i5AE4CEBC926D079E
GO
Isoform 3 (identifier: Q86UP2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     832-854: Missing.
     1232-1259: Missing.

Show »
Length:1,306
Mass (Da):150,353
Checksum:iB972F3DD3C7B6960
GO
Isoform 4 (identifier: Q86UP2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1232-1259: Missing.

Show »
Length:1,329
Mass (Da):152,988
Checksum:i591E551B1658AB77
GO

Sequence cautioni

The sequence AAH50555 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA02794 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15S → P in BAA02794 (PubMed:7584026).Curated1
Sequence conflicti210Missing in CAA80271 (PubMed:7787243).Curated1
Sequence conflicti373I → M in CAA80271 (PubMed:7787243).Curated1
Sequence conflicti939E → G in CAA80271 (PubMed:7787243).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035931226P → R in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_016206282V → M. Corresponds to variant dbSNP:rs2274073Ensembl.1
Natural variantiVAR_0792661233L → M1 PublicationCorresponds to variant dbSNP:rs372815686Ensembl.1
Natural variantiVAR_0359321316T → P in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043207832 – 854Missing in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_0079811031 – 1059Missing in isoform 2. 2 PublicationsAdd BLAST29
Alternative sequenceiVSP_0079821232 – 1259Missing in isoform 2, isoform 3 and isoform 4. 4 PublicationsAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22551 mRNA Translation: CAA80271.1
L25616 mRNA Translation: AAB65853.1
AY264265 mRNA Translation: AAP20418.1
D13629 mRNA Translation: BAA02794.2 Different initiation.
AK302797 mRNA Translation: BAG64000.1
AL138499 Genomic DNA No translation available.
AL355773 Genomic DNA No translation available.
BC050555 mRNA Translation: AAH50555.1 Sequence problems.
BC112337 mRNA Translation: AAI12338.1
BC117132 mRNA Translation: AAI17133.1
BC143720 mRNA Translation: AAI43721.1
AY536375 mRNA Translation: AAT66048.1
CCDSiCCDS41957.1 [Q86UP2-1]
CCDS41958.1 [Q86UP2-2]
CCDS41959.1 [Q86UP2-3]
PIRiI53799
S32763
RefSeqiNP_001072989.1, NM_001079521.1 [Q86UP2-1]
NP_001072990.1, NM_001079522.1 [Q86UP2-3]
NP_001257943.1, NM_001271014.1 [Q86UP2-4]
NP_004977.2, NM_004986.3 [Q86UP2-2]
XP_006720201.1, XM_006720138.2 [Q86UP2-1]
XP_006720202.1, XM_006720139.2 [Q86UP2-4]
XP_011535053.1, XM_011536751.2 [Q86UP2-1]
XP_011535055.1, XM_011536753.1 [Q86UP2-3]
XP_016876767.1, XM_017021278.1 [Q86UP2-1]
XP_016876771.1, XM_017021282.1 [Q86UP2-2]
XP_016876772.1, XM_017021283.1 [Q86UP2-2]
UniGeneiHs.509414
Hs.687012

Genome annotation databases

EnsembliENST00000395308; ENSP00000378719; ENSG00000126777 [Q86UP2-3]
ENST00000395309; ENSP00000378720; ENSG00000126777 [Q86UP2-3]
ENST00000395311; ENSP00000378722; ENSG00000126777 [Q86UP2-3]
ENST00000395314; ENSP00000378725; ENSG00000126777 [Q86UP2-1]
ENST00000413890; ENSP00000394992; ENSG00000126777 [Q86UP2-3]
ENST00000438792; ENSP00000391964; ENSG00000126777 [Q86UP2-2]
ENST00000459737; ENSP00000432149; ENSG00000126777 [Q86UP2-1]
GeneIDi3895
KEGGihsa:3895
UCSCiuc001xcb.4 human [Q86UP2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKTN1_HUMAN
AccessioniPrimary (citable) accession number: Q86UP2
Secondary accession number(s): B4DZ88
, Q13999, Q14707, Q15387, Q17RZ5, Q5GGW3, Q86W57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: June 1, 2003
Last modified: July 18, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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