UniProtKB - Q86UP2 (KTN1_HUMAN)
Protein
Kinectin
Gene
KTN1
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin.
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- kinesin binding Source: InterPro
- RNA binding Source: UniProtKB
GO - Biological processi
- cellular protein metabolic process Source: Reactome
- microtubule-based movement Source: ProtInc
- post-translational protein modification Source: Reactome
- protein transport Source: InterPro
Enzyme and pathway databases
PathwayCommonsi | Q86UP2 |
Reactomei | R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-5625970, RHO GTPases activate KTN1 R-HSA-8957275, Post-translational protein phosphorylation |
SIGNORi | Q86UP2 |
Names & Taxonomyi
Protein namesi | Recommended name: KinectinAlternative name(s): CG-1 antigen Kinesin receptor |
Gene namesi | Name:KTN1 Synonyms:CG1, KIAA0004 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000126777.17 |
HGNCi | HGNC:6467, KTN1 |
MIMi | 600381, gene |
neXtProti | NX_Q86UP2 |
Subcellular locationi
Endoplasmic reticulum
Note: Vesicle membrane protein anchored to the endoplasmic reticulum.
Endoplasmic reticulum
- endoplasmic reticulum Source: HPA
- endoplasmic reticulum lumen Source: Reactome
- endoplasmic reticulum membrane Source: Reactome
- integral component of endoplasmic reticulum membrane Source: InterPro
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
Other locations
- integral component of membrane Source: ProtInc
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 6 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 7 – 29 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 23 | |
Topological domaini | 30 – 1357 | LumenalSequence analysisAdd BLAST | 1328 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 3895 |
OpenTargetsi | ENSG00000126777 |
PharmGKBi | PA30256 |
Miscellaneous databases
Pharosi | Q86UP2, Tbio |
Polymorphism and mutation databases
BioMutai | KTN1 |
DMDMi | 34098465 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000084337 | 1 – 1357 | KinectinAdd BLAST | 1357 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 75 | Phosphoserine; by FAM20CCombined sources1 Publication | 1 | |
Modified residuei | 77 | PhosphoserineCombined sources | 1 | |
Modified residuei | 153 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 156 | PhosphoserineCombined sources | 1 | |
Glycosylationi | 172 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 435 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 772 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 904 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1055 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 1084 | PhosphoserineCombined sources | 1 | |
Glycosylationi | 1088 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1263 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 1313 | PhosphoserineCombined sources | 1 | |
Glycosylationi | 1329 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q86UP2 |
jPOSTi | Q86UP2 |
MassIVEi | Q86UP2 |
MaxQBi | Q86UP2 |
PaxDbi | Q86UP2 |
PeptideAtlasi | Q86UP2 |
PRIDEi | Q86UP2 |
ProteomicsDBi | 69841 [Q86UP2-1] 69842 [Q86UP2-2] 69843 [Q86UP2-3] |
PTM databases
GlyGeni | Q86UP2, 8 sites |
iPTMneti | Q86UP2 |
MetOSitei | Q86UP2 |
PhosphoSitePlusi | Q86UP2 |
SwissPalmi | Q86UP2 |
Expressioni
Tissue specificityi
High levels in peripheral blood lymphocytes, testis and ovary, lower levels in spleen, thymus, prostate, small intestine and colon.
Gene expression databases
Bgeei | ENSG00000126777, Expressed in testis and 254 other tissues |
ExpressionAtlasi | Q86UP2, baseline and differential |
Genevisiblei | Q86UP2, HS |
Organism-specific databases
HPAi | ENSG00000126777, Low tissue specificity |
Interactioni
Subunit structurei
Parallel homodimers formed between the membrane-bound and the cytosolic form, and also between 2 cytosolic forms.
By similarityBinary interactionsi
Hide detailsQ86UP2
With | #Exp. | IntAct |
---|---|---|
BNIP3 [Q12983] | 3 | EBI-359761,EBI-749464 |
CLEC7A [Q9BXN2] | 3 | EBI-359761,EBI-3939278 |
MEOX2 [P50222] | 3 | EBI-359761,EBI-748397 |
SGTA [O43765] | 3 | EBI-359761,EBI-347996 |
SYNE4 [Q8N205] | 3 | EBI-359761,EBI-7131783 |
Isoform 3 [Q86UP2-3]
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- kinesin binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 110092, 114 interactors |
CORUMi | Q86UP2 |
DIPi | DIP-27585N |
IntActi | Q86UP2, 94 interactors |
MINTi | Q86UP2 |
STRINGi | 9606.ENSP00000378725 |
Miscellaneous databases
RNActi | Q86UP2, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 330 – 1356 | Sequence analysisAdd BLAST | 1027 |
Sequence similaritiesi
Belongs to the kinectin family.Curated
Keywords - Domaini
Coiled coil, Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QSIW, Eukaryota |
GeneTreei | ENSGT00940000158237 |
HOGENOMi | CLU_005719_0_0_1 |
InParanoidi | Q86UP2 |
OMAi | GQLMHSE |
PhylomeDBi | Q86UP2 |
TreeFami | TF333579 |
Family and domain databases
InterProi | View protein in InterPro IPR024854, Kinectin IPR007794, Rib_rcpt_KP |
PANTHERi | PTHR18864, PTHR18864, 1 hit |
Pfami | View protein in Pfam PF05104, Rib_recp_KP_reg, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketNote: Additional isoforms seem to exist.
This entry has 4 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q86UP2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEFYESAYFI VLIPSIVITV IFLFFWLFMK ETLYDEVLAK QKREQKLIPT
60 70 80 90 100
KTDKKKAEKK KNKKKEIQNG NLHESDSESV PRDFKLSDAL AVEDDQVAPV
110 120 130 140 150
PLNVVETSSS VRERKKKEKK QKPVLEEQVI KESDASKIPG KKVEPVPVTK
160 170 180 190 200
QPTPPSEAAA SKKKPGQKKS KNGSDDQDKK VETLMVPSKR QEALPLHQET
210 220 230 240 250
KQESGSGKKK ASSKKQKTEN VFVDEPLIHA TTYIPLMDNA DSSPVVDKRE
260 270 280 290 300
VIDLLKPDQV EGIQKSGTKK LKTETDKENA EVKFKDFLLS LKTMMFSEDE
310 320 330 340 350
ALCVVDLLKE KSGVIQDALK KSSKGELTTL IHQLQEKDKL LAAVKEDAAA
360 370 380 390 400
TKDRCKQLTQ EMMTEKERSN VVITRMKDRI GTLEKEHNVF QNKIHVSYQE
410 420 430 440 450
TQQMQMKFQQ VREQMEAEIA HLKQENGILR DAVSNTTNQL ESKQSAELNK
460 470 480 490 500
LRQDYARLVN ELTEKTGKLQ QEEVQKKNAE QAATQLKVQL QEAERRWEEV
510 520 530 540 550
QSYIRKRTAE HEAAQQDLQS KFVAKENEVQ SLHSKLTDTL VSKQQLEQRL
560 570 580 590 600
MQLMESEQKR VNKEESLQMQ VQDILEQNEA LKAQIQQFHS QIAAQTSASV
610 620 630 640 650
LAEELHKVIA EKDKQIKQTE DSLASERDRL TSKEEELKDI QNMNFLLKAE
660 670 680 690 700
VQKLQALANE QAAAAHELEK MQQSVYVKDD KIRLLEEQLQ HEISNKMEEF
710 720 730 740 750
KILNDQNKAL KSEVQKLQTL VSEQPNKDVV EQMEKCIQEK DEKLKTVEEL
760 770 780 790 800
LETGLIQVAT KEEELNAIRT ENSSLTKEVQ DLKAKQNDQV SFASLVEELK
810 820 830 840 850
KVIHEKDGKI KSVEELLEAE LLKVANKEKT VQDLKQEIKA LKEEIGNVQL
860 870 880 890 900
EKAQQLSITS KVQELQNLLK GKEEQMNTMK AVLEEKEKDL ANTGKWLQDL
910 920 930 940 950
QEENESLKAH VQEVAQHNLK EASSASQFEE LEIVLKEKEN ELKRLEAMLK
960 970 980 990 1000
ERESDLSSKT QLLQDVQDEN KLFKSQIEQL KQQNYQQASS FPPHEELLKV
1010 1020 1030 1040 1050
ISEREKEISG LWNELDSLKD AVEHQRKKNN DLREKNWEAM EALASTEKML
1060 1070 1080 1090 1100
QDKVNKTSKE RQQQVEAVEL EAKEVLKKLF PKVSVPSNLS YGEWLHGFEK
1110 1120 1130 1140 1150
KAKECMAGTS GSEEVKVLEH KLKEADEMHT LLQLECEKYK SVLAETEGIL
1160 1170 1180 1190 1200
QKLQRSVEQE ENKWKVKVDE SHKTIKQMQS SFTSSEQELE RLRSENKDIE
1210 1220 1230 1240 1250
NLRREREHLE MELEKAEMER STYVTEVREL KDLLTELQKK LDDSYSEAVR
1260 1270 1280 1290 1300
QNEELNLLKA QLNETLTKLR TEQNERQKVA GDLHKAQQSL ELIQSKIVKA
1310 1320 1330 1340 1350
AGDTTVIENS DVSPETESSE KETMSVSLNQ TVTQLQQLLQ AVNQQLTKEK
EHYQVLE
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3V4L8 | G3V4L8_HUMAN | Kinectin | KTN1 | 75 | Annotation score: | ||
H0YJZ8 | H0YJZ8_HUMAN | Kinectin | KTN1 | 153 | Annotation score: | ||
G3V475 | G3V475_HUMAN | Kinectin | KTN1 | 60 | Annotation score: | ||
G3V5P0 | G3V5P0_HUMAN | Kinectin | KTN1 | 160 | Annotation score: | ||
H0YJP2 | H0YJP2_HUMAN | Kinectin | KTN1 | 138 | Annotation score: | ||
H0YJV5 | H0YJV5_HUMAN | Kinectin | KTN1 | 91 | Annotation score: | ||
G3V4Y7 | G3V4Y7_HUMAN | Kinectin | KTN1 | 595 | Annotation score: | ||
G3V5G2 | G3V5G2_HUMAN | Kinectin | KTN1 | 162 | Annotation score: | ||
B7Z6P3 | B7Z6P3_HUMAN | Kinectin | KTN1 | 334 | Annotation score: | ||
G3V5Q0 | G3V5Q0_HUMAN | Kinectin | KTN1 | 14 | Annotation score: | ||
There is more potential isoformShow all |
Sequence cautioni
The sequence AAH50555 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA02794 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 15 | S → P in BAA02794 (PubMed:7584026).Curated | 1 | |
Sequence conflicti | 210 | Missing in CAA80271 (PubMed:7787243).Curated | 1 | |
Sequence conflicti | 373 | I → M in CAA80271 (PubMed:7787243).Curated | 1 | |
Sequence conflicti | 939 | E → G in CAA80271 (PubMed:7787243).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035931 | 226 | P → R in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_016206 | 282 | V → M. Corresponds to variant dbSNP:rs2274073Ensembl. | 1 | |
Natural variantiVAR_079266 | 1233 | L → M1 PublicationCorresponds to variant dbSNP:rs372815686Ensembl. | 1 | |
Natural variantiVAR_035932 | 1316 | T → P in a breast cancer sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043207 | 832 – 854 | Missing in isoform 3. 1 PublicationAdd BLAST | 23 | |
Alternative sequenceiVSP_007981 | 1031 – 1059 | Missing in isoform 2. 2 PublicationsAdd BLAST | 29 | |
Alternative sequenceiVSP_007982 | 1232 – 1259 | Missing in isoform 2, isoform 3 and isoform 4. 4 PublicationsAdd BLAST | 28 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000395308; ENSP00000378719; ENSG00000126777 [Q86UP2-3] ENST00000395309; ENSP00000378720; ENSG00000126777 [Q86UP2-3] ENST00000395311; ENSP00000378722; ENSG00000126777 [Q86UP2-3] ENST00000395314; ENSP00000378725; ENSG00000126777 [Q86UP2-1] ENST00000413890; ENSP00000394992; ENSG00000126777 [Q86UP2-3] ENST00000438792; ENSP00000391964; ENSG00000126777 [Q86UP2-2] ENST00000459737; ENSP00000432149; ENSG00000126777 [Q86UP2-1] |
GeneIDi | 3895 |
KEGGi | hsa:3895 |
UCSCi | uc001xcb.4, human [Q86UP2-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
SMRi | Q86UP2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 110092, 114 interactors |
CORUMi | Q86UP2 |
DIPi | DIP-27585N |
IntActi | Q86UP2, 94 interactors |
MINTi | Q86UP2 |
STRINGi | 9606.ENSP00000378725 |
PTM databases
GlyGeni | Q86UP2, 8 sites |
iPTMneti | Q86UP2 |
MetOSitei | Q86UP2 |
PhosphoSitePlusi | Q86UP2 |
SwissPalmi | Q86UP2 |
Polymorphism and mutation databases
BioMutai | KTN1 |
DMDMi | 34098465 |
Proteomic databases
EPDi | Q86UP2 |
jPOSTi | Q86UP2 |
MassIVEi | Q86UP2 |
MaxQBi | Q86UP2 |
PaxDbi | Q86UP2 |
PeptideAtlasi | Q86UP2 |
PRIDEi | Q86UP2 |
ProteomicsDBi | 69841 [Q86UP2-1] 69842 [Q86UP2-2] 69843 [Q86UP2-3] |
Protocols and materials databases
Antibodypediai | 127, 175 antibodies |
DNASUi | 3895 |
Genome annotation databases
Organism-specific databases
CTDi | 3895 |
DisGeNETi | 3895 |
EuPathDBi | HostDB:ENSG00000126777.17 |
GeneCardsi | KTN1 |
HGNCi | HGNC:6467, KTN1 |
HPAi | ENSG00000126777, Low tissue specificity |
MIMi | 600381, gene |
neXtProti | NX_Q86UP2 |
OpenTargetsi | ENSG00000126777 |
PharmGKBi | PA30256 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QSIW, Eukaryota |
GeneTreei | ENSGT00940000158237 |
HOGENOMi | CLU_005719_0_0_1 |
InParanoidi | Q86UP2 |
OMAi | GQLMHSE |
PhylomeDBi | Q86UP2 |
TreeFami | TF333579 |
Enzyme and pathway databases
PathwayCommonsi | Q86UP2 |
Reactomei | R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-5625970, RHO GTPases activate KTN1 R-HSA-8957275, Post-translational protein phosphorylation |
SIGNORi | Q86UP2 |
Miscellaneous databases
BioGRID-ORCSi | 3895, 2 hits in 846 CRISPR screens |
ChiTaRSi | KTN1, human |
GeneWikii | KTN1 |
GenomeRNAii | 3895 |
Pharosi | Q86UP2, Tbio |
PROi | PR:Q86UP2 |
RNActi | Q86UP2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000126777, Expressed in testis and 254 other tissues |
ExpressionAtlasi | Q86UP2, baseline and differential |
Genevisiblei | Q86UP2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR024854, Kinectin IPR007794, Rib_rcpt_KP |
PANTHERi | PTHR18864, PTHR18864, 1 hit |
Pfami | View protein in Pfam PF05104, Rib_recp_KP_reg, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KTN1_HUMAN | |
Accessioni | Q86UP2Primary (citable) accession number: Q86UP2 Secondary accession number(s): B4DZ88 Q86W57 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 15, 2003 |
Last sequence update: | June 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 173 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations