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Protein

Kinectin

Gene

KTN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-5625970 RHO GTPases activate KTN1
R-HSA-8957275 Post-translational protein phosphorylation
SIGNORiQ86UP2

Names & Taxonomyi

Protein namesi
Recommended name:
Kinectin
Alternative name(s):
CG-1 antigen
Kinesin receptor
Gene namesi
Name:KTN1
Synonyms:CG1, KIAA0004
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000126777.17
HGNCiHGNC:6467 KTN1
MIMi600381 gene
neXtProtiNX_Q86UP2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicSequence analysis6
Transmembranei7 – 29Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
Topological domaini30 – 1357LumenalSequence analysisAdd BLAST1328

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3895
OpenTargetsiENSG00000126777
PharmGKBiPA30256

Polymorphism and mutation databases

BioMutaiKTN1
DMDMi34098465

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000843371 – 1357KinectinAdd BLAST1357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei75Phosphoserine; by FAM20CCombined sources1 Publication1
Modified residuei77PhosphoserineCombined sources1
Modified residuei153PhosphothreonineCombined sources1
Modified residuei156PhosphoserineCombined sources1
Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi435N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi772N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi904N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1055N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1084PhosphoserineCombined sources1
Glycosylationi1088N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1263N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1313PhosphoserineCombined sources1
Glycosylationi1329N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ86UP2
MaxQBiQ86UP2
PaxDbiQ86UP2
PeptideAtlasiQ86UP2
PRIDEiQ86UP2
ProteomicsDBi69841
69842 [Q86UP2-2]
69843 [Q86UP2-3]

PTM databases

iPTMnetiQ86UP2
PhosphoSitePlusiQ86UP2
SwissPalmiQ86UP2

Expressioni

Tissue specificityi

High levels in peripheral blood lymphocytes, testis and ovary, lower levels in spleen, thymus, prostate, small intestine and colon.

Gene expression databases

BgeeiENSG00000126777 Expressed in 244 organ(s), highest expression level in testis
CleanExiHS_KTN1
ExpressionAtlasiQ86UP2 baseline and differential
GenevisibleiQ86UP2 HS

Organism-specific databases

HPAiCAB015331
HPA003178
HPA017876

Interactioni

Subunit structurei

Parallel homodimers formed between the membrane-bound and the cytosolic form, and also between 2 cytosolic forms.By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110092, 62 interactors
CORUMiQ86UP2
DIPiDIP-27585N
IntActiQ86UP2, 52 interactors
MINTiQ86UP2
STRINGi9606.ENSP00000378720

Structurei

3D structure databases

ProteinModelPortaliQ86UP2
SMRiQ86UP2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili330 – 1356Sequence analysisAdd BLAST1027

Sequence similaritiesi

Belongs to the kinectin family.Curated

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIAW Eukaryota
ENOG410YAE3 LUCA
GeneTreeiENSGT00530000063895
HOGENOMiHOG000113267
HOVERGENiHBG007851
InParanoidiQ86UP2
KOiK17975
OMAiTIKQMQL
OrthoDBiEOG091G12OH
PhylomeDBiQ86UP2
TreeFamiTF333579

Family and domain databases

InterProiView protein in InterPro
IPR024854 Kinectin
PANTHERiPTHR18864 PTHR18864, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 4 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86UP2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEFYESAYFI VLIPSIVITV IFLFFWLFMK ETLYDEVLAK QKREQKLIPT
60 70 80 90 100
KTDKKKAEKK KNKKKEIQNG NLHESDSESV PRDFKLSDAL AVEDDQVAPV
110 120 130 140 150
PLNVVETSSS VRERKKKEKK QKPVLEEQVI KESDASKIPG KKVEPVPVTK
160 170 180 190 200
QPTPPSEAAA SKKKPGQKKS KNGSDDQDKK VETLMVPSKR QEALPLHQET
210 220 230 240 250
KQESGSGKKK ASSKKQKTEN VFVDEPLIHA TTYIPLMDNA DSSPVVDKRE
260 270 280 290 300
VIDLLKPDQV EGIQKSGTKK LKTETDKENA EVKFKDFLLS LKTMMFSEDE
310 320 330 340 350
ALCVVDLLKE KSGVIQDALK KSSKGELTTL IHQLQEKDKL LAAVKEDAAA
360 370 380 390 400
TKDRCKQLTQ EMMTEKERSN VVITRMKDRI GTLEKEHNVF QNKIHVSYQE
410 420 430 440 450
TQQMQMKFQQ VREQMEAEIA HLKQENGILR DAVSNTTNQL ESKQSAELNK
460 470 480 490 500
LRQDYARLVN ELTEKTGKLQ QEEVQKKNAE QAATQLKVQL QEAERRWEEV
510 520 530 540 550
QSYIRKRTAE HEAAQQDLQS KFVAKENEVQ SLHSKLTDTL VSKQQLEQRL
560 570 580 590 600
MQLMESEQKR VNKEESLQMQ VQDILEQNEA LKAQIQQFHS QIAAQTSASV
610 620 630 640 650
LAEELHKVIA EKDKQIKQTE DSLASERDRL TSKEEELKDI QNMNFLLKAE
660 670 680 690 700
VQKLQALANE QAAAAHELEK MQQSVYVKDD KIRLLEEQLQ HEISNKMEEF
710 720 730 740 750
KILNDQNKAL KSEVQKLQTL VSEQPNKDVV EQMEKCIQEK DEKLKTVEEL
760 770 780 790 800
LETGLIQVAT KEEELNAIRT ENSSLTKEVQ DLKAKQNDQV SFASLVEELK
810 820 830 840 850
KVIHEKDGKI KSVEELLEAE LLKVANKEKT VQDLKQEIKA LKEEIGNVQL
860 870 880 890 900
EKAQQLSITS KVQELQNLLK GKEEQMNTMK AVLEEKEKDL ANTGKWLQDL
910 920 930 940 950
QEENESLKAH VQEVAQHNLK EASSASQFEE LEIVLKEKEN ELKRLEAMLK
960 970 980 990 1000
ERESDLSSKT QLLQDVQDEN KLFKSQIEQL KQQNYQQASS FPPHEELLKV
1010 1020 1030 1040 1050
ISEREKEISG LWNELDSLKD AVEHQRKKNN DLREKNWEAM EALASTEKML
1060 1070 1080 1090 1100
QDKVNKTSKE RQQQVEAVEL EAKEVLKKLF PKVSVPSNLS YGEWLHGFEK
1110 1120 1130 1140 1150
KAKECMAGTS GSEEVKVLEH KLKEADEMHT LLQLECEKYK SVLAETEGIL
1160 1170 1180 1190 1200
QKLQRSVEQE ENKWKVKVDE SHKTIKQMQS SFTSSEQELE RLRSENKDIE
1210 1220 1230 1240 1250
NLRREREHLE MELEKAEMER STYVTEVREL KDLLTELQKK LDDSYSEAVR
1260 1270 1280 1290 1300
QNEELNLLKA QLNETLTKLR TEQNERQKVA GDLHKAQQSL ELIQSKIVKA
1310 1320 1330 1340 1350
AGDTTVIENS DVSPETESSE KETMSVSLNQ TVTQLQQLLQ AVNQQLTKEK

EHYQVLE
Length:1,357
Mass (Da):156,275
Last modified:June 1, 2003 - v1
Checksum:i971FCDF8AA8FC88E
GO
Isoform 2 (identifier: Q86UP2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1031-1059: Missing.
     1232-1259: Missing.

Show »
Length:1,300
Mass (Da):149,611
Checksum:i5AE4CEBC926D079E
GO
Isoform 3 (identifier: Q86UP2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     832-854: Missing.
     1232-1259: Missing.

Show »
Length:1,306
Mass (Da):150,353
Checksum:iB972F3DD3C7B6960
GO
Isoform 4 (identifier: Q86UP2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1232-1259: Missing.

Show »
Length:1,329
Mass (Da):152,988
Checksum:i591E551B1658AB77
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V4L8G3V4L8_HUMAN
Kinectin
KTN1
75Annotation score:
G3V475G3V475_HUMAN
Kinectin
KTN1
60Annotation score:
H0YJV5H0YJV5_HUMAN
Kinectin
KTN1
91Annotation score:
B7Z6P3B7Z6P3_HUMAN
cDNA FLJ55573, highly similar to Ki...
KTN1
334Annotation score:
G3V5P0G3V5P0_HUMAN
Kinectin
KTN1
160Annotation score:
G3V4Y7G3V4Y7_HUMAN
Kinectin
KTN1
595Annotation score:
H0YJZ8H0YJZ8_HUMAN
Kinectin
KTN1
153Annotation score:
H0YJP2H0YJP2_HUMAN
Kinectin
KTN1
138Annotation score:
G3V5G2G3V5G2_HUMAN
Kinectin
KTN1
162Annotation score:
G3V5Q0G3V5Q0_HUMAN
Kinectin
KTN1
14Annotation score:
There is more potential isoformShow all

Sequence cautioni

The sequence AAH50555 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA02794 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15S → P in BAA02794 (PubMed:7584026).Curated1
Sequence conflicti210Missing in CAA80271 (PubMed:7787243).Curated1
Sequence conflicti373I → M in CAA80271 (PubMed:7787243).Curated1
Sequence conflicti939E → G in CAA80271 (PubMed:7787243).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035931226P → R in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_016206282V → M. Corresponds to variant dbSNP:rs2274073Ensembl.1
Natural variantiVAR_0792661233L → M1 PublicationCorresponds to variant dbSNP:rs372815686Ensembl.1
Natural variantiVAR_0359321316T → P in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043207832 – 854Missing in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_0079811031 – 1059Missing in isoform 2. 2 PublicationsAdd BLAST29
Alternative sequenceiVSP_0079821232 – 1259Missing in isoform 2, isoform 3 and isoform 4. 4 PublicationsAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22551 mRNA Translation: CAA80271.1
L25616 mRNA Translation: AAB65853.1
AY264265 mRNA Translation: AAP20418.1
D13629 mRNA Translation: BAA02794.2 Different initiation.
AK302797 mRNA Translation: BAG64000.1
AL138499 Genomic DNA No translation available.
AL355773 Genomic DNA No translation available.
BC050555 mRNA Translation: AAH50555.1 Sequence problems.
BC112337 mRNA Translation: AAI12338.1
BC117132 mRNA Translation: AAI17133.1
BC143720 mRNA Translation: AAI43721.1
AY536375 mRNA Translation: AAT66048.1
CCDSiCCDS41957.1 [Q86UP2-1]
CCDS41958.1 [Q86UP2-2]
CCDS41959.1 [Q86UP2-3]
PIRiI53799
S32763
RefSeqiNP_001072989.1, NM_001079521.1 [Q86UP2-1]
NP_001072990.1, NM_001079522.1 [Q86UP2-3]
NP_001257943.1, NM_001271014.1 [Q86UP2-4]
NP_004977.2, NM_004986.3 [Q86UP2-2]
XP_006720201.1, XM_006720138.2 [Q86UP2-1]
XP_006720202.1, XM_006720139.2 [Q86UP2-4]
XP_011535053.1, XM_011536751.2 [Q86UP2-1]
XP_011535055.1, XM_011536753.1 [Q86UP2-3]
XP_016876767.1, XM_017021278.1 [Q86UP2-1]
XP_016876771.1, XM_017021282.1 [Q86UP2-2]
XP_016876772.1, XM_017021283.1 [Q86UP2-2]
UniGeneiHs.509414
Hs.687012

Genome annotation databases

EnsembliENST00000395308; ENSP00000378719; ENSG00000126777 [Q86UP2-3]
ENST00000395309; ENSP00000378720; ENSG00000126777 [Q86UP2-3]
ENST00000395311; ENSP00000378722; ENSG00000126777 [Q86UP2-3]
ENST00000395314; ENSP00000378725; ENSG00000126777 [Q86UP2-1]
ENST00000413890; ENSP00000394992; ENSG00000126777 [Q86UP2-3]
ENST00000438792; ENSP00000391964; ENSG00000126777 [Q86UP2-2]
ENST00000459737; ENSP00000432149; ENSG00000126777 [Q86UP2-1]
GeneIDi3895
KEGGihsa:3895
UCSCiuc001xcb.4 human [Q86UP2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22551 mRNA Translation: CAA80271.1
L25616 mRNA Translation: AAB65853.1
AY264265 mRNA Translation: AAP20418.1
D13629 mRNA Translation: BAA02794.2 Different initiation.
AK302797 mRNA Translation: BAG64000.1
AL138499 Genomic DNA No translation available.
AL355773 Genomic DNA No translation available.
BC050555 mRNA Translation: AAH50555.1 Sequence problems.
BC112337 mRNA Translation: AAI12338.1
BC117132 mRNA Translation: AAI17133.1
BC143720 mRNA Translation: AAI43721.1
AY536375 mRNA Translation: AAT66048.1
CCDSiCCDS41957.1 [Q86UP2-1]
CCDS41958.1 [Q86UP2-2]
CCDS41959.1 [Q86UP2-3]
PIRiI53799
S32763
RefSeqiNP_001072989.1, NM_001079521.1 [Q86UP2-1]
NP_001072990.1, NM_001079522.1 [Q86UP2-3]
NP_001257943.1, NM_001271014.1 [Q86UP2-4]
NP_004977.2, NM_004986.3 [Q86UP2-2]
XP_006720201.1, XM_006720138.2 [Q86UP2-1]
XP_006720202.1, XM_006720139.2 [Q86UP2-4]
XP_011535053.1, XM_011536751.2 [Q86UP2-1]
XP_011535055.1, XM_011536753.1 [Q86UP2-3]
XP_016876767.1, XM_017021278.1 [Q86UP2-1]
XP_016876771.1, XM_017021282.1 [Q86UP2-2]
XP_016876772.1, XM_017021283.1 [Q86UP2-2]
UniGeneiHs.509414
Hs.687012

3D structure databases

ProteinModelPortaliQ86UP2
SMRiQ86UP2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110092, 62 interactors
CORUMiQ86UP2
DIPiDIP-27585N
IntActiQ86UP2, 52 interactors
MINTiQ86UP2
STRINGi9606.ENSP00000378720

PTM databases

iPTMnetiQ86UP2
PhosphoSitePlusiQ86UP2
SwissPalmiQ86UP2

Polymorphism and mutation databases

BioMutaiKTN1
DMDMi34098465

Proteomic databases

EPDiQ86UP2
MaxQBiQ86UP2
PaxDbiQ86UP2
PeptideAtlasiQ86UP2
PRIDEiQ86UP2
ProteomicsDBi69841
69842 [Q86UP2-2]
69843 [Q86UP2-3]

Protocols and materials databases

DNASUi3895
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395308; ENSP00000378719; ENSG00000126777 [Q86UP2-3]
ENST00000395309; ENSP00000378720; ENSG00000126777 [Q86UP2-3]
ENST00000395311; ENSP00000378722; ENSG00000126777 [Q86UP2-3]
ENST00000395314; ENSP00000378725; ENSG00000126777 [Q86UP2-1]
ENST00000413890; ENSP00000394992; ENSG00000126777 [Q86UP2-3]
ENST00000438792; ENSP00000391964; ENSG00000126777 [Q86UP2-2]
ENST00000459737; ENSP00000432149; ENSG00000126777 [Q86UP2-1]
GeneIDi3895
KEGGihsa:3895
UCSCiuc001xcb.4 human [Q86UP2-1]

Organism-specific databases

CTDi3895
DisGeNETi3895
EuPathDBiHostDB:ENSG00000126777.17
GeneCardsiKTN1
HGNCiHGNC:6467 KTN1
HPAiCAB015331
HPA003178
HPA017876
MIMi600381 gene
neXtProtiNX_Q86UP2
OpenTargetsiENSG00000126777
PharmGKBiPA30256
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIAW Eukaryota
ENOG410YAE3 LUCA
GeneTreeiENSGT00530000063895
HOGENOMiHOG000113267
HOVERGENiHBG007851
InParanoidiQ86UP2
KOiK17975
OMAiTIKQMQL
OrthoDBiEOG091G12OH
PhylomeDBiQ86UP2
TreeFamiTF333579

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-5625970 RHO GTPases activate KTN1
R-HSA-8957275 Post-translational protein phosphorylation
SIGNORiQ86UP2

Miscellaneous databases

ChiTaRSiKTN1 human
GeneWikiiKTN1
GenomeRNAii3895
PROiPR:Q86UP2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126777 Expressed in 244 organ(s), highest expression level in testis
CleanExiHS_KTN1
ExpressionAtlasiQ86UP2 baseline and differential
GenevisibleiQ86UP2 HS

Family and domain databases

InterProiView protein in InterPro
IPR024854 Kinectin
PANTHERiPTHR18864 PTHR18864, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKTN1_HUMAN
AccessioniPrimary (citable) accession number: Q86UP2
Secondary accession number(s): B4DZ88
, Q13999, Q14707, Q15387, Q17RZ5, Q5GGW3, Q86W57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: June 1, 2003
Last modified: November 7, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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