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UniProtKB - Q86UP2 (KTN1_HUMAN)

Entry version 174 (10 Feb 2021)
Sequence version 1 (01 Jun 2003)
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Protein

Kinectin

Gene

KTN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q86UP2

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-5625970, RHO GTPases activate KTN1
R-HSA-8957275, Post-translational protein phosphorylation

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q86UP2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kinectin
Alternative name(s):
CG-1 antigen
Kinesin receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KTN1
Synonyms:CG1, KIAA0004
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6467, KTN1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600381, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q86UP2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000126777.17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 6CytoplasmicSequence analysis6
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 29Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
Topological domaini30 – 1357LumenalSequence analysisAdd BLAST1328

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		3895

Open Targets

More...OpenTargetsi		ENSG00000126777

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30256

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q86UP2, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KTN1

Domain mapping of disease mutations (DMDM)

More...DMDMi		34098465

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000843371 – 1357KinectinAdd BLAST1357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei75Phosphoserine; by FAM20CCombined sources1 Publication1
Modified residuei77PhosphoserineCombined sources1
Modified residuei153PhosphothreonineCombined sources1
Modified residuei156PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi435N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi772N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi904N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1055N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1084PhosphoserineCombined sources1
Glycosylationi1088N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1263N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1313PhosphoserineCombined sources1
Glycosylationi1329N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q86UP2

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q86UP2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q86UP2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q86UP2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q86UP2

PeptideAtlas

More...PeptideAtlasi		Q86UP2

PRoteomics IDEntifications database

More...PRIDEi		Q86UP2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		69841 [Q86UP2-1]
69842 [Q86UP2-2]
69843 [Q86UP2-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q86UP2, 8 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q86UP2

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q86UP2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q86UP2

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q86UP2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

High levels in peripheral blood lymphocytes, testis and ovary, lower levels in spleen, thymus, prostate, small intestine and colon.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000126777, Expressed in testis and 254 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q86UP2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q86UP2, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000126777, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Parallel homodimers formed between the membrane-bound and the cytosolic form, and also between 2 cytosolic forms.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110092, 140 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q86UP2

Database of interacting proteins

More...DIPi		DIP-27585N

Protein interaction database and analysis system

More...IntActi		Q86UP2, 96 interactors

Molecular INTeraction database

More...MINTi		Q86UP2

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000378725

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q86UP2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q86UP2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili330 – 1356Sequence analysisAdd BLAST1027

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the kinectin family.Curated

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QSIW, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158237

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005719_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q86UP2

Identification of Orthologs from Complete Genome Data

More...OMAi		GQLMHSE

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q86UP2

TreeFam database of animal gene trees

More...TreeFami		TF333579

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR024854, Kinectin
IPR007794, Rib_rcpt_KP

The PANTHER Classification System

More...PANTHERi		PTHR18864, PTHR18864, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05104, Rib_recp_KP_reg, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 4 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86UP2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEFYESAYFI VLIPSIVITV IFLFFWLFMK ETLYDEVLAK QKREQKLIPT 
        60         70         80         90        100
KTDKKKAEKK KNKKKEIQNG NLHESDSESV PRDFKLSDAL AVEDDQVAPV 
       110        120        130        140        150
PLNVVETSSS VRERKKKEKK QKPVLEEQVI KESDASKIPG KKVEPVPVTK 
       160        170        180        190        200
QPTPPSEAAA SKKKPGQKKS KNGSDDQDKK VETLMVPSKR QEALPLHQET 
       210        220        230        240        250
KQESGSGKKK ASSKKQKTEN VFVDEPLIHA TTYIPLMDNA DSSPVVDKRE 
       260        270        280        290        300
VIDLLKPDQV EGIQKSGTKK LKTETDKENA EVKFKDFLLS LKTMMFSEDE 
       310        320        330        340        350
ALCVVDLLKE KSGVIQDALK KSSKGELTTL IHQLQEKDKL LAAVKEDAAA 
       360        370        380        390        400
TKDRCKQLTQ EMMTEKERSN VVITRMKDRI GTLEKEHNVF QNKIHVSYQE 
       410        420        430        440        450
TQQMQMKFQQ VREQMEAEIA HLKQENGILR DAVSNTTNQL ESKQSAELNK 
       460        470        480        490        500
LRQDYARLVN ELTEKTGKLQ QEEVQKKNAE QAATQLKVQL QEAERRWEEV 
       510        520        530        540        550
QSYIRKRTAE HEAAQQDLQS KFVAKENEVQ SLHSKLTDTL VSKQQLEQRL 
       560        570        580        590        600
MQLMESEQKR VNKEESLQMQ VQDILEQNEA LKAQIQQFHS QIAAQTSASV 
       610        620        630        640        650
LAEELHKVIA EKDKQIKQTE DSLASERDRL TSKEEELKDI QNMNFLLKAE 
       660        670        680        690        700
VQKLQALANE QAAAAHELEK MQQSVYVKDD KIRLLEEQLQ HEISNKMEEF 
       710        720        730        740        750
KILNDQNKAL KSEVQKLQTL VSEQPNKDVV EQMEKCIQEK DEKLKTVEEL 
       760        770        780        790        800
LETGLIQVAT KEEELNAIRT ENSSLTKEVQ DLKAKQNDQV SFASLVEELK 
       810        820        830        840        850
KVIHEKDGKI KSVEELLEAE LLKVANKEKT VQDLKQEIKA LKEEIGNVQL 
       860        870        880        890        900
EKAQQLSITS KVQELQNLLK GKEEQMNTMK AVLEEKEKDL ANTGKWLQDL 
       910        920        930        940        950
QEENESLKAH VQEVAQHNLK EASSASQFEE LEIVLKEKEN ELKRLEAMLK 
       960        970        980        990       1000
ERESDLSSKT QLLQDVQDEN KLFKSQIEQL KQQNYQQASS FPPHEELLKV 
      1010       1020       1030       1040       1050
ISEREKEISG LWNELDSLKD AVEHQRKKNN DLREKNWEAM EALASTEKML 
      1060       1070       1080       1090       1100
QDKVNKTSKE RQQQVEAVEL EAKEVLKKLF PKVSVPSNLS YGEWLHGFEK 
      1110       1120       1130       1140       1150
KAKECMAGTS GSEEVKVLEH KLKEADEMHT LLQLECEKYK SVLAETEGIL 
      1160       1170       1180       1190       1200
QKLQRSVEQE ENKWKVKVDE SHKTIKQMQS SFTSSEQELE RLRSENKDIE 
      1210       1220       1230       1240       1250
NLRREREHLE MELEKAEMER STYVTEVREL KDLLTELQKK LDDSYSEAVR 
      1260       1270       1280       1290       1300
QNEELNLLKA QLNETLTKLR TEQNERQKVA GDLHKAQQSL ELIQSKIVKA 
      1310       1320       1330       1340       1350
AGDTTVIENS DVSPETESSE KETMSVSLNQ TVTQLQQLLQ AVNQQLTKEK 

EHYQVLE
Length:1,357
Mass (Da):156,275
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i971FCDF8AA8FC88E
GO
Isoform 2 (identifier: Q86UP2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1031-1059: Missing.
     1232-1259: Missing.

Show »
Length:1,300
Mass (Da):149,611
Checksum:i5AE4CEBC926D079E
GO
Isoform 3 (identifier: Q86UP2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     832-854: Missing.
     1232-1259: Missing.

Show »
Length:1,306
Mass (Da):150,353
Checksum:iB972F3DD3C7B6960
GO
Isoform 4 (identifier: Q86UP2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1232-1259: Missing.

Show »
Length:1,329
Mass (Da):152,988
Checksum:i591E551B1658AB77
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V4L8G3V4L8_HUMAN
Kinectin
KTN1
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJZ8H0YJZ8_HUMAN
Kinectin
KTN1
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V475G3V475_HUMAN
Kinectin
KTN1
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5P0G3V5P0_HUMAN
Kinectin
KTN1
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJP2H0YJP2_HUMAN
Kinectin
KTN1
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJV5H0YJV5_HUMAN
Kinectin
KTN1
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V4Y7G3V4Y7_HUMAN
Kinectin
KTN1
595Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7Z6P3B7Z6P3_HUMAN
Kinectin
KTN1
334Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5G2G3V5G2_HUMAN
Kinectin
KTN1
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5Q0G3V5Q0_HUMAN
Kinectin
KTN1
14Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH50555 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA02794 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti15S → P in BAA02794 (PubMed:7584026).Curated1
Sequence conflicti210Missing in CAA80271 (PubMed:7787243).Curated1
Sequence conflicti373I → M in CAA80271 (PubMed:7787243).Curated1
Sequence conflicti939E → G in CAA80271 (PubMed:7787243).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035931226P → R in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_016206282V → M. Corresponds to variant dbSNP:rs2274073Ensembl.1
Natural variantiVAR_0792661233L → M1 PublicationCorresponds to variant dbSNP:rs372815686Ensembl.1
Natural variantiVAR_0359321316T → P in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_043207832 – 854Missing in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_0079811031 – 1059Missing in isoform 2. 2 PublicationsAdd BLAST29
Alternative sequenceiVSP_0079821232 – 1259Missing in isoform 2, isoform 3 and isoform 4. 4 PublicationsAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z22551 mRNA Translation: CAA80271.1
L25616 mRNA Translation: AAB65853.1
AY264265 mRNA Translation: AAP20418.1
D13629 mRNA Translation: BAA02794.2 Different initiation.
AK302797 mRNA Translation: BAG64000.1
AL138499 Genomic DNA No translation available.
AL355773 Genomic DNA No translation available.
BC050555 mRNA Translation: AAH50555.1 Sequence problems.
BC112337 mRNA Translation: AAI12338.1
BC117132 mRNA Translation: AAI17133.1
BC143720 mRNA Translation: AAI43721.1
AY536375 mRNA Translation: AAT66048.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41957.1 [Q86UP2-1]
CCDS41958.1 [Q86UP2-2]
CCDS41959.1 [Q86UP2-3]

Protein sequence database of the Protein Information Resource

More...PIRi		I53799
S32763

NCBI Reference Sequences

More...RefSeqi		NP_001072989.1, NM_001079521.1 [Q86UP2-1]
NP_001072990.1, NM_001079522.1 [Q86UP2-3]
NP_001257943.1, NM_001271014.1 [Q86UP2-4]
NP_004977.2, NM_004986.3 [Q86UP2-2]
XP_006720201.1, XM_006720138.2 [Q86UP2-1]
XP_006720202.1, XM_006720139.2 [Q86UP2-4]
XP_011535053.1, XM_011536751.2 [Q86UP2-1]
XP_011535055.1, XM_011536753.1 [Q86UP2-3]
XP_016876767.1, XM_017021278.1 [Q86UP2-1]
XP_016876771.1, XM_017021282.1 [Q86UP2-2]
XP_016876772.1, XM_017021283.1 [Q86UP2-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000395308; ENSP00000378719; ENSG00000126777 [Q86UP2-3]
ENST00000395309; ENSP00000378720; ENSG00000126777 [Q86UP2-3]
ENST00000395311; ENSP00000378722; ENSG00000126777 [Q86UP2-3]
ENST00000395314; ENSP00000378725; ENSG00000126777 [Q86UP2-1]
ENST00000413890; ENSP00000394992; ENSG00000126777 [Q86UP2-3]
ENST00000438792; ENSP00000391964; ENSG00000126777 [Q86UP2-2]
ENST00000459737; ENSP00000432149; ENSG00000126777 [Q86UP2-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3895

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3895

UCSC genome browser

More...UCSCi		uc001xcb.4, human [Q86UP2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22551 mRNA Translation: CAA80271.1
L25616 mRNA Translation: AAB65853.1
AY264265 mRNA Translation: AAP20418.1
D13629 mRNA Translation: BAA02794.2 Different initiation.
AK302797 mRNA Translation: BAG64000.1
AL138499 Genomic DNA No translation available.
AL355773 Genomic DNA No translation available.
BC050555 mRNA Translation: AAH50555.1 Sequence problems.
BC112337 mRNA Translation: AAI12338.1
BC117132 mRNA Translation: AAI17133.1
BC143720 mRNA Translation: AAI43721.1
AY536375 mRNA Translation: AAT66048.1
CCDSiCCDS41957.1 [Q86UP2-1]
CCDS41958.1 [Q86UP2-2]
CCDS41959.1 [Q86UP2-3]
PIRiI53799
S32763
RefSeqiNP_001072989.1, NM_001079521.1 [Q86UP2-1]
NP_001072990.1, NM_001079522.1 [Q86UP2-3]
NP_001257943.1, NM_001271014.1 [Q86UP2-4]
NP_004977.2, NM_004986.3 [Q86UP2-2]
XP_006720201.1, XM_006720138.2 [Q86UP2-1]
XP_006720202.1, XM_006720139.2 [Q86UP2-4]
XP_011535053.1, XM_011536751.2 [Q86UP2-1]
XP_011535055.1, XM_011536753.1 [Q86UP2-3]
XP_016876767.1, XM_017021278.1 [Q86UP2-1]
XP_016876771.1, XM_017021282.1 [Q86UP2-2]
XP_016876772.1, XM_017021283.1 [Q86UP2-2]

3D structure databases

SMRiQ86UP2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi110092, 140 interactors
CORUMiQ86UP2
DIPiDIP-27585N
IntActiQ86UP2, 96 interactors
MINTiQ86UP2
STRINGi9606.ENSP00000378725

PTM databases

GlyGeniQ86UP2, 8 sites
iPTMnetiQ86UP2
MetOSiteiQ86UP2
PhosphoSitePlusiQ86UP2
SwissPalmiQ86UP2

Genetic variation databases

BioMutaiKTN1
DMDMi34098465

Proteomic databases

EPDiQ86UP2
jPOSTiQ86UP2
MassIVEiQ86UP2
MaxQBiQ86UP2
PaxDbiQ86UP2
PeptideAtlasiQ86UP2
PRIDEiQ86UP2
ProteomicsDBi69841 [Q86UP2-1]
69842 [Q86UP2-2]
69843 [Q86UP2-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		127, 175 antibodies

The DNASU plasmid repository

More...DNASUi		3895

Genome annotation databases

EnsembliENST00000395308; ENSP00000378719; ENSG00000126777 [Q86UP2-3]
ENST00000395309; ENSP00000378720; ENSG00000126777 [Q86UP2-3]
ENST00000395311; ENSP00000378722; ENSG00000126777 [Q86UP2-3]
ENST00000395314; ENSP00000378725; ENSG00000126777 [Q86UP2-1]
ENST00000413890; ENSP00000394992; ENSG00000126777 [Q86UP2-3]
ENST00000438792; ENSP00000391964; ENSG00000126777 [Q86UP2-2]
ENST00000459737; ENSP00000432149; ENSG00000126777 [Q86UP2-1]
GeneIDi3895
KEGGihsa:3895
UCSCiuc001xcb.4, human [Q86UP2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3895
DisGeNETi3895

GeneCards: human genes, protein and diseases

More...GeneCardsi		KTN1
HGNCiHGNC:6467, KTN1
HPAiENSG00000126777, Low tissue specificity
MIMi600381, gene
neXtProtiNX_Q86UP2
OpenTargetsiENSG00000126777
PharmGKBiPA30256
VEuPathDBiHostDB:ENSG00000126777.17

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QSIW, Eukaryota
GeneTreeiENSGT00940000158237
HOGENOMiCLU_005719_0_0_1
InParanoidiQ86UP2
OMAiGQLMHSE
PhylomeDBiQ86UP2
TreeFamiTF333579

Enzyme and pathway databases

PathwayCommonsiQ86UP2
ReactomeiR-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-5625970, RHO GTPases activate KTN1
R-HSA-8957275, Post-translational protein phosphorylation
SIGNORiQ86UP2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3895, 4 hits in 878 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		KTN1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		KTN1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3895
PharosiQ86UP2, Tbio

Protein Ontology

More...PROi		PR:Q86UP2
RNActiQ86UP2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000126777, Expressed in testis and 254 other tissues
ExpressionAtlasiQ86UP2, baseline and differential
GenevisibleiQ86UP2, HS

Family and domain databases

InterProiView protein in InterPro
IPR024854, Kinectin
IPR007794, Rib_rcpt_KP
PANTHERiPTHR18864, PTHR18864, 1 hit
PfamiView protein in Pfam
PF05104, Rib_recp_KP_reg, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKTN1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86UP2
Secondary accession number(s): B4DZ88
, Q13999, Q14707, Q15387, Q17RZ5, Q5GGW3, Q86W57
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: June 1, 2003
Last modified: February 10, 2021
This is version 174 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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