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Protein

Cadherin-24

Gene

CDH24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-24 mediate strong cell-cell adhesion.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • alpha-catenin binding Source: UniProtKB
  • beta-catenin binding Source: UniProtKB
  • cadherin binding Source: GO_Central
  • calcium ion binding Source: MGI
  • cytoskeletal protein binding Source: GO_Central
  • delta-catenin binding Source: UniProtKB
  • protein homodimerization activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-418990 Adherens junctions interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cadherin-24
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDH24
Synonyms:CDH11L
ORF Names:UNQ2834/PRO34009
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000139880.19

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14265 CDH24

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86UP0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini45 – 641ExtracellularSequence analysisAdd BLAST597
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei642 – 662HelicalSequence analysisAdd BLAST21
Topological domaini663 – 819CytoplasmicSequence analysisAdd BLAST157

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000139880

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26297

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CDH24

Domain mapping of disease mutations (DMDM)

More...
DMDMi
38257450

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000000382721 – 44Sequence analysisAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000382845 – 819Cadherin-24Add BLAST775

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi446N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi548N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi563N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86UP0

PeptideAtlas

More...
PeptideAtlasi
Q86UP0

PRoteomics IDEntifications database

More...
PRIDEi
Q86UP0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
69838
69839 [Q86UP0-2]
69840 [Q86UP0-3]

2D gel databases

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
Q86UP0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86UP0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86UP0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000139880 Expressed in 132 organ(s), highest expression level in cerebellar hemisphere

CleanEx database of gene expression profiles

More...
CleanExi
HS_CDH24

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86UP0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86UP0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA065233

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with alpha-, beta- and delta-catenins.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122158, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q86UP0, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000267383

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q86UP0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86UP0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini46 – 150Cadherin 1PROSITE-ProRule annotationAdd BLAST105
Domaini151 – 259Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini260 – 374Cadherin 3PROSITE-ProRule annotationAdd BLAST115
Domaini375 – 517Cadherin 4PROSITE-ProRule annotationAdd BLAST143
Domaini517 – 630Cadherin 5PROSITE-ProRule annotationAdd BLAST114

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3594 Eukaryota
ENOG410XQHI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159567

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231252

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG005217

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86UP0

KEGG Orthology (KO)

More...
KOi
K06814

Identification of Orthologs from Complete Genome Data

More...
OMAi
EARAWHN

Database of Orthologous Groups

More...
OrthoDBi
EOG091G02RV

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86UP0

TreeFam database of animal gene trees

More...
TreeFami
TF329887

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.900.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039808 Cadherin
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR24027 PTHR24027, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028 Cadherin, 4 hits
PF01049 Cadherin_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313 SSF49313, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00232 CADHERIN_1, 2 hits
PS50268 CADHERIN_2, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86UP0-1) [UniParc]FASTAAdd to basket
Also known as: Long form

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWGLVRLLLA WLGGWGCMGR LAAPARAWAG SREHPGPALL RTRRSWVWNQ
60 70 80 90 100
FFVIEEYAGP EPVLIGKLHS DVDRGEGRTK YLLTGEGAGT VFVIDEATGN
110 120 130 140 150
IHVTKSLDRE EKAQYVLLAQ AVDRASNRPL EPPSEFIIKV QDINDNPPIF
160 170 180 190 200
PLGPYHATVP EMSNVGTSVI QVTAHDADDP SYGNSAKLVY TVLDGLPFFS
210 220 230 240 250
VDPQTGVVRT AIPNMDRETQ EEFLVVIQAK DMGGHMGGLS GSTTVTVTLS
260 270 280 290 300
DVNDNPPKFP QSLYQFSVVE TAGPGTLVGR LRAQDPDLGD NALMAYSILD
310 320 330 340 350
GEGSEAFSIS TDLQGRDGLL TVRKPLDFES QRSYSFRVEA TNTLIDPAYL
360 370 380 390 400
RRGPFKDVAS VRVAVQDAPE PPAFTQAAYH LTVPENKAPG TLVGQISAAD
410 420 430 440 450
LDSPASPIRY SILPHSDPER CFSIQPEEGT IHTAAPLDRE ARAWHNLTVL
460 470 480 490 500
ATELGWSWGP ERGWVPLLVA EWSAPAAPPQ RSPVGSAVGI PQDSSAQASR
510 520 530 540 550
VQVAIQTLDE NDNAPQLAEP YDTFVCDSAA PGQLIQVIRA LDRDEVGNSS
560 570 580 590 600
HVSFQGPLGP DANFTVQDNR DGSASLLLPS RPAPPRHAPY LVPIELWDWG
610 620 630 640 650
QPALSSTATV TVSVCRCQPD GSVASCWPEA HLSAAGLSTG ALLAIITCVG
660 670 680 690 700
ALLALVVLFV ALRRQKQEAL MVLEEEDVRE NIITYDDEGG GEEDTEAFDI
710 720 730 740 750
TALQNPDGAA PPAPGPPARR DVLPRARVSR QPRPPGPADV AQLLALRLRE
760 770 780 790 800
ADEDPGVPPY DSVQVYGYEG RGSSCGSLSS LGSGSEAGGA PGPAEPLDDW
810
GPLFRTLAEL YGAKEPPAP
Length:819
Mass (Da):87,752
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9083034F18BA7E4A
GO
Isoform 2 (identifier: Q86UP0-2) [UniParc]FASTAAdd to basket
Also known as: Short form

The sequence of this isoform differs from the canonical sequence as follows:
     455-492: Missing.

Show »
Length:781
Mass (Da):83,776
Checksum:iEE1730E67347CF76
GO
Isoform 3 (identifier: Q86UP0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-427: Missing.
     428-492: EGTIHTAAPL...PVGSAVGIPQ → MNIVCTWYCS...WRVCFGVLPS

Note: No experimental confirmation available.
Show »
Length:392
Mass (Da):41,746
Checksum:i7E4C2075B1DD0710
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WTR7A0A087WTR7_HUMAN
Cadherin-24
CDH24
314Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0087181 – 427Missing in isoform 3. 1 PublicationAdd BLAST427
Alternative sequenceiVSP_008719428 – 492EGTIH…VGIPQ → MNIVCTWYCSIHSATLFSTC TLHAYFMCFLCMLYASCGIH AHAPHMLRVNCVVCVWRVCF GVLPS in isoform 3. 1 PublicationAdd BLAST65
Alternative sequenceiVSP_008717455 – 492Missing in isoform 2. 2 PublicationsAdd BLAST38

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY260900 mRNA Translation: AAP20590.1
AY260901 mRNA Translation: AAP20591.1
AY358199 mRNA Translation: AAQ88566.1
AL137477 mRNA Translation: CAB70758.1
CH471078 Genomic DNA Translation: EAW66190.1
CH471078 Genomic DNA Translation: EAW66192.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9585.1 [Q86UP0-1]
CCDS9586.1 [Q86UP0-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
T46418

NCBI Reference Sequences

More...
RefSeqi
NP_071923.2, NM_022478.3 [Q86UP0-1]
NP_659422.2, NM_144985.3 [Q86UP0-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.155912

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000267383; ENSP00000267383; ENSG00000139880 [Q86UP0-1]
ENST00000397359; ENSP00000380517; ENSG00000139880 [Q86UP0-1]
ENST00000487137; ENSP00000434821; ENSG00000139880 [Q86UP0-2]
ENST00000554034; ENSP00000452493; ENSG00000139880 [Q86UP0-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
64403

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:64403

UCSC genome browser

More...
UCSCi
uc001wil.4 human [Q86UP0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY260900 mRNA Translation: AAP20590.1
AY260901 mRNA Translation: AAP20591.1
AY358199 mRNA Translation: AAQ88566.1
AL137477 mRNA Translation: CAB70758.1
CH471078 Genomic DNA Translation: EAW66190.1
CH471078 Genomic DNA Translation: EAW66192.1
CCDSiCCDS9585.1 [Q86UP0-1]
CCDS9586.1 [Q86UP0-2]
PIRiT46418
RefSeqiNP_071923.2, NM_022478.3 [Q86UP0-1]
NP_659422.2, NM_144985.3 [Q86UP0-2]
UniGeneiHs.155912

3D structure databases

ProteinModelPortaliQ86UP0
SMRiQ86UP0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122158, 4 interactors
IntActiQ86UP0, 1 interactor
STRINGi9606.ENSP00000267383

PTM databases

iPTMnetiQ86UP0
PhosphoSitePlusiQ86UP0

Polymorphism and mutation databases

BioMutaiCDH24
DMDMi38257450

2D gel databases

UCD-2DPAGEiQ86UP0

Proteomic databases

PaxDbiQ86UP0
PeptideAtlasiQ86UP0
PRIDEiQ86UP0
ProteomicsDBi69838
69839 [Q86UP0-2]
69840 [Q86UP0-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
64403
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267383; ENSP00000267383; ENSG00000139880 [Q86UP0-1]
ENST00000397359; ENSP00000380517; ENSG00000139880 [Q86UP0-1]
ENST00000487137; ENSP00000434821; ENSG00000139880 [Q86UP0-2]
ENST00000554034; ENSP00000452493; ENSG00000139880 [Q86UP0-2]
GeneIDi64403
KEGGihsa:64403
UCSCiuc001wil.4 human [Q86UP0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
64403
EuPathDBiHostDB:ENSG00000139880.19

GeneCards: human genes, protein and diseases

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GeneCardsi
CDH24
HGNCiHGNC:14265 CDH24
HPAiHPA065233
neXtProtiNX_Q86UP0
OpenTargetsiENSG00000139880
PharmGKBiPA26297

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00940000159567
HOGENOMiHOG000231252
HOVERGENiHBG005217
InParanoidiQ86UP0
KOiK06814
OMAiEARAWHN
OrthoDBiEOG091G02RV
PhylomeDBiQ86UP0
TreeFamiTF329887

Enzyme and pathway databases

ReactomeiR-HSA-418990 Adherens junctions interactions

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
64403

Protein Ontology

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PROi
PR:Q86UP0

Gene expression databases

BgeeiENSG00000139880 Expressed in 132 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_CDH24
ExpressionAtlasiQ86UP0 baseline and differential
GenevisibleiQ86UP0 HS

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR039808 Cadherin
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
PANTHERiPTHR24027 PTHR24027, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 4 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 4 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 2 hits
PS50268 CADHERIN_2, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAD24_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86UP0
Secondary accession number(s): D3DS44, Q86UP1, Q9NT84
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: June 1, 2003
Last modified: December 5, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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