AKAP14

Functionⁱ

Binds to type II regulatory subunits of protein kinase A and anchors/targets them.

GO - Molecular functionⁱ

protein kinase A regulatory subunit binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12475942

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: A-kinase anchor protein 14 Short name: AKAP-14 Alternative name(s): A-kinase anchor protein 28 kDa Short name: AKAP 28 Protein kinase A-anchoring protein 14 Short name: PRKA14
Gene namesⁱ	Name:AKAP14 Synonyms:AKAP28
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000186471.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24061 AKAP14
MIMⁱ	300462 gene
neXtProtⁱ	NX_Q86UN6

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	43	L → P: Abolishes RII-binding; when associated with P-47. 1 Publication		1
Mutagenesisⁱ	47	V → P: Abolishes RII-binding; when associated with P-43. 1 Publication		1

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000186471
PharmGKBⁱ	PA134914893

Polymorphism and mutation databases

BioMutaⁱ	AKAP14
DMDMⁱ	46395790

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000064521	1 – 197	A-kinase anchor protein 14Add BLAST		197

Proteomic databases

PaxDbⁱ	Q86UN6
PeptideAtlas More...PeptideAtlasⁱ	Q86UN6
PRIDEⁱ	Q86UN6
ProteomicsDBⁱ	69835 69836 [Q86UN6-2] 69837 [Q86UN6-3]

PTM databases

iPTMnetⁱ	Q86UN6
PhosphoSitePlusⁱ	Q86UN6

Expressionⁱ

Tissue specificityⁱ

Present in cilia (at protein level). Expressed in tissues containing axoneme-based organelles (cilia and/or flagella): trachea and testis. Highly expressed in airway cilia.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000186471 Expressed in 83 organ(s), highest expression level in bronchial epithelial cell
CleanExⁱ	HS_AKAP14
Genevisibleⁱ	Q86UN6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA060999

HPAⁱ

HPA060999

Interactionⁱ

Subunit structureⁱ

Binds to type II regulatory subunits (RII).1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
PRKAR2B	P31323	4	EBI-2119626,EBI-2930670

With

Entry

#Exp.

IntAct

Notes

PRKAR2B

P31323

4

EBI-2119626,EBI-2930670

GO - Molecular functionⁱ

protein kinase A regulatory subunit binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12475942

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	127707, 11 interactors
IntActⁱ	Q86UN6, 6 interactors
STRINGⁱ	9606.ENSP00000360485

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q86UN6
SMRⁱ	Q86UN6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	35 – 52	RII-bindingAdd BLAST		18

Phylogenomic databases

eggNOGⁱ	ENOG410IXR2 Eukaryota ENOG4111RMU LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003444
HOGENOMⁱ	HOG000293385
HOVERGENⁱ	HBG050473
InParanoidⁱ	Q86UN6
KEGG Orthology (KO) More...KOⁱ	K16530
OMAⁱ	RWSIPTR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0L2E
PhylomeDBⁱ	Q86UN6
TreeFamⁱ	TF329057

Family and domain databases

InterProⁱ	View protein in InterPro IPR025663 AKAP_28
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF14469 AKAP28, 1 hit

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q86UN6-1) [UniParc]FASTA Add to basket

Also known as: Isoform A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSETQNSTSQ KAMDEDNKAA SQTMPNTQDK NYEDELTQVA LALVEDVINY 
        60         70         80         90        100
AVKIVEEERN PLKNIKWMTH GEFTVEKGLK QIDEYFSKCV SKKCWAHGVE 
       110        120        130        140        150
FVERKDLIHS FLYIYYVHWS ISTADLPVAR ISAGTYFTMK VSKTKPPDAP 
       160        170        180        190 
IVVSYVGDHQ ALVHRPGMVR FRENWQKNLT DAKYSFMESF PFLFNRV

Length:197

Mass (Da):22,815

Last modified:June 1, 2003 - v1

Checksum:ⁱ3A76B9C3036EAEB9

GO

Isoform 2 (identifier: Q86UN6-2) [UniParc]FASTA Add to basket

Also known as: Isoform B

The sequence of this isoform differs from the canonical sequence as follows:
88-147: Missing.

« Hide

        10         20         30         40         50
MSETQNSTSQ KAMDEDNKAA SQTMPNTQDK NYEDELTQVA LALVEDVINY 
        60         70         80         90        100
AVKIVEEERN PLKNIKWMTH GEFTVEKGLK QIDEYFSDAP IVVSYVGDHQ 
       110        120        130 
ALVHRPGMVR FRENWQKNLT DAKYSFMESF PFLFNRV

Show »

Length:137

Mass (Da):15,898

Checksum:ⁱ572CCE6742C45A32

GO

Isoform 3 (identifier: Q86UN6-3) [UniParc]FASTA Add to basket

Also known as: Isoform C

The sequence of this isoform differs from the canonical sequence as follows:
88-89: KC → VS
90-197: Missing.

« Hide

        10         20         30         40         50
MSETQNSTSQ KAMDEDNKAA SQTMPNTQDK NYEDELTQVA LALVEDVINY 
        60         70         80 
AVKIVEEERN PLKNIKWMTH GEFTVEKGLK QIDEYFSVS

Show »

Length:89

Mass (Da):10,187

Checksum:ⁱ2C5E377D247E3277

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Isoform 2 (identifier: Q86UN6-2)
Sequence conflictⁱ	87	S → SP in AAP20826 (PubMed:12475942).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_009909	88 – 147	Missing in isoform 2. 1 PublicationAdd BLAST	60
Alternative sequenceⁱVSP_009910	88 – 89	KC → VS in isoform 3. 1 Publication	2
Alternative sequenceⁱVSP_009911	90 – 197	Missing in isoform 3. 1 PublicationAdd BLAST	108

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF514780 mRNA Translation: AAP20825.1 AF514781 mRNA Translation: AAP20826.1 AF514782 mRNA Translation: AAP20827.1 AC002477 Genomic DNA No translation available. BC066357 mRNA Translation: AAH66357.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14591.1 [Q86UN6-1] CCDS35376.1 [Q86UN6-2] CCDS35377.1 [Q86UN6-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001008534.1, NM_001008534.1 [Q86UN6-2] NP_001008535.1, NM_001008535.1 [Q86UN6-3] NP_848928.1, NM_178813.5 [Q86UN6-1]
UniGeneⁱ	Hs.592245

Genome annotation databases

Ensemblⁱ	ENST00000334356; ENSP00000334680; ENSG00000186471 [Q86UN6-2] ENST00000371422; ENSP00000360476; ENSG00000186471 [Q86UN6-3] ENST00000371425; ENSP00000360479; ENSG00000186471 [Q86UN6-2] ENST00000371431; ENSP00000360485; ENSG00000186471 [Q86UN6-1]
GeneIDⁱ	158798
KEGGⁱ	hsa:158798
UCSC genome browser More...UCSCⁱ	uc004ese.4 human [Q86UN6-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q86UN6	A-kinase anchoring protein 14		GORGO		197	UniRef100_Q86UN6
Q86UN6-2	AKAP14 isoform 1		PONAB		137	UniRef100_A0A2J8WWH0
A-kinase anchoring protein 14		GORGO		137
Q86UN6-3	AKAP14 isoform 4		PONAB		89	UniRef100_A0A2J8WWE9

Protein	Similar proteins		Species	Score	Length	Source
Q86UN6	A-kinase anchoring protein 14		GORGO		197	UniRef90_Q86UN6
A-kinase anchoring protein 14		PANTR		197
Uncharacterized protein		PANPA		197
A-kinase anchor protein 14		MACFA		197
Uncharacterized protein		MACMU		197
+11
Q86UN6-2	Uncharacterized protein		CHLSB		137	UniRef90_A0A0D9S0G5
Uncharacterized protein		MACFA		137
A-kinase anchoring protein 14		PANTR		137
Uncharacterized protein		PANPA		137
AKAP14 isoform 1		PONAB		137
+10
Q86UN6-3	Testis cDNA, clone: QtsA-18795, similar to human A-kinase anchoring protein 28 (AKAP28)		MACFA		89	UniRef90_Q4R687
AKAP14 isoform 4		PONAB		89
AKAP14 isoform 4		PANTR		89

Protein	Similar proteins		Species	Score	Length	Source
Q86UN6	A-kinase anchoring protein 14		GORGO		197	UniRef50_Q86UN6
Uncharacterized protein		MACNE		197
Uncharacterized protein		CERAT		197
A-kinase anchoring protein 14		PANTR		197
Uncharacterized protein		PANPA		197
+18
Q86UN6-2	Uncharacterized protein		CHLSB		137	UniRef50_A0A0D9S0G5
Uncharacterized protein		MACFA		137
AKAP14 isoform 1		PONAB		137
A-kinase anchoring protein 14		GORGO		137
Uncharacterized protein		NOMLE		137
+14
Q86UN6-3	Testis cDNA, clone: QtsA-18795, similar to human A-kinase anchoring protein 28 (AKAP28)		MACFA		89	UniRef50_Q4R687
AKAP14 isoform 4		PANTR		89
AKAP14 isoform 4		PONAB		89
UPI00062AB18F		DASNO		99

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF514780 mRNA Translation: AAP20825.1 AF514781 mRNA Translation: AAP20826.1 AF514782 mRNA Translation: AAP20827.1 AC002477 Genomic DNA No translation available. BC066357 mRNA Translation: AAH66357.1
CCDSⁱ	CCDS14591.1 [Q86UN6-1] CCDS35376.1 [Q86UN6-2] CCDS35377.1 [Q86UN6-3]
RefSeqⁱ	NP_001008534.1, NM_001008534.1 [Q86UN6-2] NP_001008535.1, NM_001008535.1 [Q86UN6-3] NP_848928.1, NM_178813.5 [Q86UN6-1]
UniGeneⁱ	Hs.592245

3D structure databases

ProteinModelPortalⁱ	Q86UN6
SMRⁱ	Q86UN6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	127707, 11 interactors
IntActⁱ	Q86UN6, 6 interactors
STRINGⁱ	9606.ENSP00000360485

PTM databases

iPTMnetⁱ	Q86UN6
PhosphoSitePlusⁱ	Q86UN6

Polymorphism and mutation databases

BioMutaⁱ	AKAP14
DMDMⁱ	46395790

Proteomic databases

PaxDbⁱ	Q86UN6
PeptideAtlasⁱ	Q86UN6
PRIDEⁱ	Q86UN6
ProteomicsDBⁱ	69835 69836 [Q86UN6-2] 69837 [Q86UN6-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	158798
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000334356; ENSP00000334680; ENSG00000186471 [Q86UN6-2] ENST00000371422; ENSP00000360476; ENSG00000186471 [Q86UN6-3] ENST00000371425; ENSP00000360479; ENSG00000186471 [Q86UN6-2] ENST00000371431; ENSP00000360485; ENSG00000186471 [Q86UN6-1]
GeneIDⁱ	158798
KEGGⁱ	hsa:158798
UCSCⁱ	uc004ese.4 human [Q86UN6-1]

Organism-specific databases

CTDⁱ	158798
EuPathDBⁱ	HostDB:ENSG00000186471.12
GeneCardsⁱ	AKAP14
HGNCⁱ	HGNC:24061 AKAP14
HPAⁱ	HPA060999
MIMⁱ	300462 gene
neXtProtⁱ	NX_Q86UN6
OpenTargetsⁱ	ENSG00000186471
PharmGKBⁱ	PA134914893
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IXR2 Eukaryota ENOG4111RMU LUCA
GeneTreeⁱ	ENSGT00390000003444
HOGENOMⁱ	HOG000293385
HOVERGENⁱ	HBG050473
InParanoidⁱ	Q86UN6
KOⁱ	K16530
OMAⁱ	RWSIPTR
OrthoDBⁱ	EOG091G0L2E
PhylomeDBⁱ	Q86UN6
TreeFamⁱ	TF329057

Miscellaneous databases

GenomeRNAiⁱ	158798
Protein Ontology More...PROⁱ	PR:Q86UN6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000186471 Expressed in 83 organ(s), highest expression level in bronchial epithelial cell
CleanExⁱ	HS_AKAP14
Genevisibleⁱ	Q86UN6 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR025663 AKAP_28
Pfamⁱ	View protein in Pfam PF14469 AKAP28, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AKA28_HUMAN
Accessionⁱ	Q86UN6Primary (citable) accession number: Q86UN6 Secondary accession number(s): A6NNZ0, Q86UN4, Q86UN5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
	Last sequence update:	June 1, 2003
	Last modified:	September 12, 2018
	This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q86UN6 (AKA28_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

A-kinase anchor protein 14

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytoskeleton

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ