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Protein

A-kinase anchor protein 14

Gene

AKAP14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to type II regulatory subunits of protein kinase A and anchors/targets them.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein kinase A regulatory subunit binding Source: UniProtKB

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
A-kinase anchor protein 14
Short name:
AKAP-14
Alternative name(s):
A-kinase anchor protein 28 kDa
Short name:
AKAP 28
Protein kinase A-anchoring protein 14
Short name:
PRKA14
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AKAP14
Synonyms:AKAP28
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000186471.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24061 AKAP14

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300462 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86UN6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi43L → P: Abolishes RII-binding; when associated with P-47. 1 Publication1
Mutagenesisi47V → P: Abolishes RII-binding; when associated with P-43. 1 Publication1

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000186471

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134914893

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AKAP14

Domain mapping of disease mutations (DMDM)

More...
DMDMi
46395790

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000645211 – 197A-kinase anchor protein 14Add BLAST197

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86UN6

PeptideAtlas

More...
PeptideAtlasi
Q86UN6

PRoteomics IDEntifications database

More...
PRIDEi
Q86UN6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
69835
69836 [Q86UN6-2]
69837 [Q86UN6-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86UN6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86UN6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Present in cilia (at protein level). Expressed in tissues containing axoneme-based organelles (cilia and/or flagella): trachea and testis. Highly expressed in airway cilia.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000186471 Expressed in 83 organ(s), highest expression level in bronchial epithelial cell

CleanEx database of gene expression profiles

More...
CleanExi
HS_AKAP14

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86UN6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA060999

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to type II regulatory subunits (RII).1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
PRKAR2BP313234EBI-2119626,EBI-2930670

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
127707, 12 interactors

Protein interaction database and analysis system

More...
IntActi
Q86UN6, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000360485

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q86UN6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q86UN6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni35 – 52RII-bindingAdd BLAST18

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IXR2 Eukaryota
ENOG4111RMU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003444

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293385

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG050473

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q86UN6

KEGG Orthology (KO)

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KOi
K16530

Identification of Orthologs from Complete Genome Data

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OMAi
IKWITHG

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0L2E

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86UN6

TreeFam database of animal gene trees

More...
TreeFami
TF329057

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR025663 AKAP_28

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14469 AKAP28, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q86UN6-1) [UniParc]FASTAAdd to basket
Also known as: Isoform A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSETQNSTSQ KAMDEDNKAA SQTMPNTQDK NYEDELTQVA LALVEDVINY
60 70 80 90 100
AVKIVEEERN PLKNIKWMTH GEFTVEKGLK QIDEYFSKCV SKKCWAHGVE
110 120 130 140 150
FVERKDLIHS FLYIYYVHWS ISTADLPVAR ISAGTYFTMK VSKTKPPDAP
160 170 180 190
IVVSYVGDHQ ALVHRPGMVR FRENWQKNLT DAKYSFMESF PFLFNRV
Length:197
Mass (Da):22,815
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3A76B9C3036EAEB9
GO
Isoform 2 (identifier: Q86UN6-2) [UniParc]FASTAAdd to basket
Also known as: Isoform B

The sequence of this isoform differs from the canonical sequence as follows:
     88-147: Missing.

Show »
Length:137
Mass (Da):15,898
Checksum:i572CCE6742C45A32
GO
Isoform 3 (identifier: Q86UN6-3) [UniParc]FASTAAdd to basket
Also known as: Isoform C

The sequence of this isoform differs from the canonical sequence as follows:
     88-89: KC → VS
     90-197: Missing.

Show »
Length:89
Mass (Da):10,187
Checksum:i2C5E377D247E3277
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 2 (identifier: Q86UN6-2)
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti87S → SP in AAP20826 (PubMed:12475942).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00990988 – 147Missing in isoform 2. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_00991088 – 89KC → VS in isoform 3. 1 Publication2
Alternative sequenceiVSP_00991190 – 197Missing in isoform 3. 1 PublicationAdd BLAST108

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF514780 mRNA Translation: AAP20825.1
AF514781 mRNA Translation: AAP20826.1
AF514782 mRNA Translation: AAP20827.1
AC002477 Genomic DNA No translation available.
BC066357 mRNA Translation: AAH66357.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14591.1 [Q86UN6-1]
CCDS35376.1 [Q86UN6-2]
CCDS35377.1 [Q86UN6-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001008534.1, NM_001008534.1 [Q86UN6-2]
NP_001008535.1, NM_001008535.1 [Q86UN6-3]
NP_848928.1, NM_178813.5 [Q86UN6-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.592245

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000334356; ENSP00000334680; ENSG00000186471 [Q86UN6-2]
ENST00000371422; ENSP00000360476; ENSG00000186471 [Q86UN6-3]
ENST00000371425; ENSP00000360479; ENSG00000186471 [Q86UN6-2]
ENST00000371431; ENSP00000360485; ENSG00000186471 [Q86UN6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
158798

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:158798

UCSC genome browser

More...
UCSCi
uc004ese.4 human [Q86UN6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF514780 mRNA Translation: AAP20825.1
AF514781 mRNA Translation: AAP20826.1
AF514782 mRNA Translation: AAP20827.1
AC002477 Genomic DNA No translation available.
BC066357 mRNA Translation: AAH66357.1
CCDSiCCDS14591.1 [Q86UN6-1]
CCDS35376.1 [Q86UN6-2]
CCDS35377.1 [Q86UN6-3]
RefSeqiNP_001008534.1, NM_001008534.1 [Q86UN6-2]
NP_001008535.1, NM_001008535.1 [Q86UN6-3]
NP_848928.1, NM_178813.5 [Q86UN6-1]
UniGeneiHs.592245

3D structure databases

ProteinModelPortaliQ86UN6
SMRiQ86UN6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127707, 12 interactors
IntActiQ86UN6, 6 interactors
STRINGi9606.ENSP00000360485

PTM databases

iPTMnetiQ86UN6
PhosphoSitePlusiQ86UN6

Polymorphism and mutation databases

BioMutaiAKAP14
DMDMi46395790

Proteomic databases

PaxDbiQ86UN6
PeptideAtlasiQ86UN6
PRIDEiQ86UN6
ProteomicsDBi69835
69836 [Q86UN6-2]
69837 [Q86UN6-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
158798
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334356; ENSP00000334680; ENSG00000186471 [Q86UN6-2]
ENST00000371422; ENSP00000360476; ENSG00000186471 [Q86UN6-3]
ENST00000371425; ENSP00000360479; ENSG00000186471 [Q86UN6-2]
ENST00000371431; ENSP00000360485; ENSG00000186471 [Q86UN6-1]
GeneIDi158798
KEGGihsa:158798
UCSCiuc004ese.4 human [Q86UN6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
158798
EuPathDBiHostDB:ENSG00000186471.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
AKAP14
HGNCiHGNC:24061 AKAP14
HPAiHPA060999
MIMi300462 gene
neXtProtiNX_Q86UN6
OpenTargetsiENSG00000186471
PharmGKBiPA134914893

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IXR2 Eukaryota
ENOG4111RMU LUCA
GeneTreeiENSGT00390000003444
HOGENOMiHOG000293385
HOVERGENiHBG050473
InParanoidiQ86UN6
KOiK16530
OMAiIKWITHG
OrthoDBiEOG091G0L2E
PhylomeDBiQ86UN6
TreeFamiTF329057

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
158798

Protein Ontology

More...
PROi
PR:Q86UN6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000186471 Expressed in 83 organ(s), highest expression level in bronchial epithelial cell
CleanExiHS_AKAP14
GenevisibleiQ86UN6 HS

Family and domain databases

InterProiView protein in InterPro
IPR025663 AKAP_28
PfamiView protein in Pfam
PF14469 AKAP28, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAKA28_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86UN6
Secondary accession number(s): A6NNZ0, Q86UN4, Q86UN5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2003
Last modified: December 5, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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