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Protein

A-kinase anchor protein 14

Gene

AKAP14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to type II regulatory subunits of protein kinase A and anchors/targets them.

GO - Molecular functioni

  • protein kinase A regulatory subunit binding Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
A-kinase anchor protein 14
Short name:
AKAP-14
Alternative name(s):
A-kinase anchor protein 28 kDa
Short name:
AKAP 28
Protein kinase A-anchoring protein 14
Short name:
PRKA14
Gene namesi
Name:AKAP14
Synonyms:AKAP28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000186471.12
HGNCiHGNC:24061 AKAP14
MIMi300462 gene
neXtProtiNX_Q86UN6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi43L → P: Abolishes RII-binding; when associated with P-47. 1 Publication1
Mutagenesisi47V → P: Abolishes RII-binding; when associated with P-43. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000186471
PharmGKBiPA134914893

Polymorphism and mutation databases

BioMutaiAKAP14
DMDMi46395790

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000645211 – 197A-kinase anchor protein 14Add BLAST197

Proteomic databases

PaxDbiQ86UN6
PeptideAtlasiQ86UN6
PRIDEiQ86UN6
ProteomicsDBi69835
69836 [Q86UN6-2]
69837 [Q86UN6-3]

PTM databases

iPTMnetiQ86UN6
PhosphoSitePlusiQ86UN6

Expressioni

Tissue specificityi

Present in cilia (at protein level). Expressed in tissues containing axoneme-based organelles (cilia and/or flagella): trachea and testis. Highly expressed in airway cilia.1 Publication

Gene expression databases

BgeeiENSG00000186471 Expressed in 83 organ(s), highest expression level in bronchial epithelial cell
CleanExiHS_AKAP14
GenevisibleiQ86UN6 HS

Organism-specific databases

HPAiHPA060999

Interactioni

Subunit structurei

Binds to type II regulatory subunits (RII).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PRKAR2BP313234EBI-2119626,EBI-2930670

GO - Molecular functioni

Protein-protein interaction databases

BioGridi127707, 11 interactors
IntActiQ86UN6, 6 interactors
STRINGi9606.ENSP00000360485

Structurei

3D structure databases

ProteinModelPortaliQ86UN6
SMRiQ86UN6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni35 – 52RII-bindingAdd BLAST18

Phylogenomic databases

eggNOGiENOG410IXR2 Eukaryota
ENOG4111RMU LUCA
GeneTreeiENSGT00390000003444
HOGENOMiHOG000293385
HOVERGENiHBG050473
InParanoidiQ86UN6
KOiK16530
OMAiRWSIPTR
OrthoDBiEOG091G0L2E
PhylomeDBiQ86UN6
TreeFamiTF329057

Family and domain databases

InterProiView protein in InterPro
IPR025663 AKAP_28
PfamiView protein in Pfam
PF14469 AKAP28, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q86UN6-1) [UniParc]FASTAAdd to basket
Also known as: Isoform A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSETQNSTSQ KAMDEDNKAA SQTMPNTQDK NYEDELTQVA LALVEDVINY
60 70 80 90 100
AVKIVEEERN PLKNIKWMTH GEFTVEKGLK QIDEYFSKCV SKKCWAHGVE
110 120 130 140 150
FVERKDLIHS FLYIYYVHWS ISTADLPVAR ISAGTYFTMK VSKTKPPDAP
160 170 180 190
IVVSYVGDHQ ALVHRPGMVR FRENWQKNLT DAKYSFMESF PFLFNRV
Length:197
Mass (Da):22,815
Last modified:June 1, 2003 - v1
Checksum:i3A76B9C3036EAEB9
GO
Isoform 2 (identifier: Q86UN6-2) [UniParc]FASTAAdd to basket
Also known as: Isoform B

The sequence of this isoform differs from the canonical sequence as follows:
     88-147: Missing.

Show »
Length:137
Mass (Da):15,898
Checksum:i572CCE6742C45A32
GO
Isoform 3 (identifier: Q86UN6-3) [UniParc]FASTAAdd to basket
Also known as: Isoform C

The sequence of this isoform differs from the canonical sequence as follows:
     88-89: KC → VS
     90-197: Missing.

Show »
Length:89
Mass (Da):10,187
Checksum:i2C5E377D247E3277
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 2 (identifier: Q86UN6-2)
Sequence conflicti87S → SP in AAP20826 (PubMed:12475942).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00990988 – 147Missing in isoform 2. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_00991088 – 89KC → VS in isoform 3. 1 Publication2
Alternative sequenceiVSP_00991190 – 197Missing in isoform 3. 1 PublicationAdd BLAST108

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF514780 mRNA Translation: AAP20825.1
AF514781 mRNA Translation: AAP20826.1
AF514782 mRNA Translation: AAP20827.1
AC002477 Genomic DNA No translation available.
BC066357 mRNA Translation: AAH66357.1
CCDSiCCDS14591.1 [Q86UN6-1]
CCDS35376.1 [Q86UN6-2]
CCDS35377.1 [Q86UN6-3]
RefSeqiNP_001008534.1, NM_001008534.1 [Q86UN6-2]
NP_001008535.1, NM_001008535.1 [Q86UN6-3]
NP_848928.1, NM_178813.5 [Q86UN6-1]
UniGeneiHs.592245

Genome annotation databases

EnsembliENST00000334356; ENSP00000334680; ENSG00000186471 [Q86UN6-2]
ENST00000371422; ENSP00000360476; ENSG00000186471 [Q86UN6-3]
ENST00000371425; ENSP00000360479; ENSG00000186471 [Q86UN6-2]
ENST00000371431; ENSP00000360485; ENSG00000186471 [Q86UN6-1]
GeneIDi158798
KEGGihsa:158798
UCSCiuc004ese.4 human [Q86UN6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF514780 mRNA Translation: AAP20825.1
AF514781 mRNA Translation: AAP20826.1
AF514782 mRNA Translation: AAP20827.1
AC002477 Genomic DNA No translation available.
BC066357 mRNA Translation: AAH66357.1
CCDSiCCDS14591.1 [Q86UN6-1]
CCDS35376.1 [Q86UN6-2]
CCDS35377.1 [Q86UN6-3]
RefSeqiNP_001008534.1, NM_001008534.1 [Q86UN6-2]
NP_001008535.1, NM_001008535.1 [Q86UN6-3]
NP_848928.1, NM_178813.5 [Q86UN6-1]
UniGeneiHs.592245

3D structure databases

ProteinModelPortaliQ86UN6
SMRiQ86UN6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127707, 11 interactors
IntActiQ86UN6, 6 interactors
STRINGi9606.ENSP00000360485

PTM databases

iPTMnetiQ86UN6
PhosphoSitePlusiQ86UN6

Polymorphism and mutation databases

BioMutaiAKAP14
DMDMi46395790

Proteomic databases

PaxDbiQ86UN6
PeptideAtlasiQ86UN6
PRIDEiQ86UN6
ProteomicsDBi69835
69836 [Q86UN6-2]
69837 [Q86UN6-3]

Protocols and materials databases

DNASUi158798
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334356; ENSP00000334680; ENSG00000186471 [Q86UN6-2]
ENST00000371422; ENSP00000360476; ENSG00000186471 [Q86UN6-3]
ENST00000371425; ENSP00000360479; ENSG00000186471 [Q86UN6-2]
ENST00000371431; ENSP00000360485; ENSG00000186471 [Q86UN6-1]
GeneIDi158798
KEGGihsa:158798
UCSCiuc004ese.4 human [Q86UN6-1]

Organism-specific databases

CTDi158798
EuPathDBiHostDB:ENSG00000186471.12
GeneCardsiAKAP14
HGNCiHGNC:24061 AKAP14
HPAiHPA060999
MIMi300462 gene
neXtProtiNX_Q86UN6
OpenTargetsiENSG00000186471
PharmGKBiPA134914893
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXR2 Eukaryota
ENOG4111RMU LUCA
GeneTreeiENSGT00390000003444
HOGENOMiHOG000293385
HOVERGENiHBG050473
InParanoidiQ86UN6
KOiK16530
OMAiRWSIPTR
OrthoDBiEOG091G0L2E
PhylomeDBiQ86UN6
TreeFamiTF329057

Miscellaneous databases

GenomeRNAii158798
PROiPR:Q86UN6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186471 Expressed in 83 organ(s), highest expression level in bronchial epithelial cell
CleanExiHS_AKAP14
GenevisibleiQ86UN6 HS

Family and domain databases

InterProiView protein in InterPro
IPR025663 AKAP_28
PfamiView protein in Pfam
PF14469 AKAP28, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAKA28_HUMAN
AccessioniPrimary (citable) accession number: Q86UN6
Secondary accession number(s): A6NNZ0, Q86UN4, Q86UN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2003
Last modified: September 12, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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