UniProtKB - Q86UN6 (AKA28_HUMAN)
Protein
A-kinase anchor protein 14
Gene
AKAP14
Organism
Homo sapiens (Human)
Status
Functioni
Binds to type II regulatory subunits of protein kinase A and anchors/targets them.
GO - Molecular functioni
- protein kinase A regulatory subunit binding Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q86UN6 |
Names & Taxonomyi
Protein namesi | Recommended name: A-kinase anchor protein 14Short name: AKAP-14 Alternative name(s): A-kinase anchor protein 28 kDa Short name: AKAP 28 Protein kinase A-anchoring protein 14 Short name: PRKA14 |
Gene namesi | Name:AKAP14 Synonyms:AKAP28 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000186471.12 |
HGNCi | HGNC:24061, AKAP14 |
MIMi | 300462, gene |
neXtProti | NX_Q86UN6 |
Subcellular locationi
Other locations
- Cytoplasm Curated
Cytoskeleton
- axoneme Source: UniProtKB
Other locations
- cAMP-dependent protein kinase complex Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 43 | L → P: Abolishes RII-binding; when associated with P-47. 1 Publication | 1 | |
Mutagenesisi | 47 | V → P: Abolishes RII-binding; when associated with P-43. 1 Publication | 1 |
Organism-specific databases
OpenTargetsi | ENSG00000186471 |
PharmGKBi | PA134914893 |
Miscellaneous databases
Pharosi | Q86UN6, Tbio |
Polymorphism and mutation databases
BioMutai | AKAP14 |
DMDMi | 46395790 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000064521 | 1 – 197 | A-kinase anchor protein 14Add BLAST | 197 |
Proteomic databases
MassIVEi | Q86UN6 |
PaxDbi | Q86UN6 |
PeptideAtlasi | Q86UN6 |
PRIDEi | Q86UN6 |
ProteomicsDBi | 1648 69835 [Q86UN6-1] 69836 [Q86UN6-2] 69837 [Q86UN6-3] |
PTM databases
iPTMneti | Q86UN6 |
PhosphoSitePlusi | Q86UN6 |
Expressioni
Tissue specificityi
Present in cilia (at protein level). Expressed in tissues containing axoneme-based organelles (cilia and/or flagella): trachea and testis. Highly expressed in airway cilia.1 Publication
Gene expression databases
Bgeei | ENSG00000186471, Expressed in bronchial epithelial cell and 110 other tissues |
Genevisiblei | Q86UN6, HS |
Organism-specific databases
HPAi | ENSG00000186471, Tissue enhanced (brain, fallopian tube, testis) |
Interactioni
Subunit structurei
Binds to type II regulatory subunits (RII).
1 PublicationBinary interactionsi
Hide detailsQ86UN6
GO - Molecular functioni
- protein kinase A regulatory subunit binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 127707, 16 interactors |
IntActi | Q86UN6, 15 interactors |
STRINGi | 9606.ENSP00000360485 |
Miscellaneous databases
RNActi | Q86UN6, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 35 – 52 | RII-bindingAdd BLAST | 18 |
Phylogenomic databases
eggNOGi | ENOG502S0CR, Eukaryota |
GeneTreei | ENSGT00390000003444 |
HOGENOMi | CLU_116552_0_0_1 |
InParanoidi | Q86UN6 |
OMAi | YHYRARF |
OrthoDBi | 1552956at2759 |
PhylomeDBi | Q86UN6 |
TreeFami | TF329057 |
Family and domain databases
InterProi | View protein in InterPro IPR025663, AKAP_28 |
Pfami | View protein in Pfam PF14469, AKAP28, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q86UN6-1) [UniParc]FASTAAdd to basket
Also known as: Isoform A
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSETQNSTSQ KAMDEDNKAA SQTMPNTQDK NYEDELTQVA LALVEDVINY
60 70 80 90 100
AVKIVEEERN PLKNIKWMTH GEFTVEKGLK QIDEYFSKCV SKKCWAHGVE
110 120 130 140 150
FVERKDLIHS FLYIYYVHWS ISTADLPVAR ISAGTYFTMK VSKTKPPDAP
160 170 180 190
IVVSYVGDHQ ALVHRPGMVR FRENWQKNLT DAKYSFMESF PFLFNRV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Isoform 2 (identifier: Q86UN6-2) | |||||
Sequence conflicti | 87 | S → SP in AAP20826 (PubMed:12475942).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_009909 | 88 – 147 | Missing in isoform 2. 1 PublicationAdd BLAST | 60 | |
Alternative sequenceiVSP_009910 | 88 – 89 | KC → VS in isoform 3. 1 Publication | 2 | |
Alternative sequenceiVSP_009911 | 90 – 197 | Missing in isoform 3. 1 PublicationAdd BLAST | 108 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF514780 mRNA Translation: AAP20825.1 AF514781 mRNA Translation: AAP20826.1 AF514782 mRNA Translation: AAP20827.1 AC002477 Genomic DNA No translation available. BC066357 mRNA Translation: AAH66357.1 |
CCDSi | CCDS14591.1 [Q86UN6-1] CCDS35376.1 [Q86UN6-2] CCDS35377.1 [Q86UN6-3] |
RefSeqi | NP_001008534.1, NM_001008534.1 [Q86UN6-2] NP_001008535.1, NM_001008535.1 [Q86UN6-3] NP_848928.1, NM_178813.5 [Q86UN6-1] |
Genome annotation databases
Ensembli | ENST00000334356; ENSP00000334680; ENSG00000186471 [Q86UN6-2] ENST00000371422; ENSP00000360476; ENSG00000186471 [Q86UN6-3] ENST00000371425; ENSP00000360479; ENSG00000186471 [Q86UN6-2] ENST00000371431; ENSP00000360485; ENSG00000186471 [Q86UN6-1] |
GeneIDi | 158798 |
KEGGi | hsa:158798 |
UCSCi | uc004ese.4, human [Q86UN6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF514780 mRNA Translation: AAP20825.1 AF514781 mRNA Translation: AAP20826.1 AF514782 mRNA Translation: AAP20827.1 AC002477 Genomic DNA No translation available. BC066357 mRNA Translation: AAH66357.1 |
CCDSi | CCDS14591.1 [Q86UN6-1] CCDS35376.1 [Q86UN6-2] CCDS35377.1 [Q86UN6-3] |
RefSeqi | NP_001008534.1, NM_001008534.1 [Q86UN6-2] NP_001008535.1, NM_001008535.1 [Q86UN6-3] NP_848928.1, NM_178813.5 [Q86UN6-1] |
3D structure databases
SMRi | Q86UN6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127707, 16 interactors |
IntActi | Q86UN6, 15 interactors |
STRINGi | 9606.ENSP00000360485 |
PTM databases
iPTMneti | Q86UN6 |
PhosphoSitePlusi | Q86UN6 |
Polymorphism and mutation databases
BioMutai | AKAP14 |
DMDMi | 46395790 |
Proteomic databases
MassIVEi | Q86UN6 |
PaxDbi | Q86UN6 |
PeptideAtlasi | Q86UN6 |
PRIDEi | Q86UN6 |
ProteomicsDBi | 1648 69835 [Q86UN6-1] 69836 [Q86UN6-2] 69837 [Q86UN6-3] |
Protocols and materials databases
Antibodypediai | 44608, 93 antibodies |
DNASUi | 158798 |
Genome annotation databases
Ensembli | ENST00000334356; ENSP00000334680; ENSG00000186471 [Q86UN6-2] ENST00000371422; ENSP00000360476; ENSG00000186471 [Q86UN6-3] ENST00000371425; ENSP00000360479; ENSG00000186471 [Q86UN6-2] ENST00000371431; ENSP00000360485; ENSG00000186471 [Q86UN6-1] |
GeneIDi | 158798 |
KEGGi | hsa:158798 |
UCSCi | uc004ese.4, human [Q86UN6-1] |
Organism-specific databases
CTDi | 158798 |
EuPathDBi | HostDB:ENSG00000186471.12 |
GeneCardsi | AKAP14 |
HGNCi | HGNC:24061, AKAP14 |
HPAi | ENSG00000186471, Tissue enhanced (brain, fallopian tube, testis) |
MIMi | 300462, gene |
neXtProti | NX_Q86UN6 |
OpenTargetsi | ENSG00000186471 |
PharmGKBi | PA134914893 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S0CR, Eukaryota |
GeneTreei | ENSGT00390000003444 |
HOGENOMi | CLU_116552_0_0_1 |
InParanoidi | Q86UN6 |
OMAi | YHYRARF |
OrthoDBi | 1552956at2759 |
PhylomeDBi | Q86UN6 |
TreeFami | TF329057 |
Enzyme and pathway databases
PathwayCommonsi | Q86UN6 |
Miscellaneous databases
BioGRID-ORCSi | 158798, 2 hits in 472 CRISPR screens |
ChiTaRSi | AKAP14, human |
GenomeRNAii | 158798 |
Pharosi | Q86UN6, Tbio |
PROi | PR:Q86UN6 |
RNActi | Q86UN6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000186471, Expressed in bronchial epithelial cell and 110 other tissues |
Genevisiblei | Q86UN6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR025663, AKAP_28 |
Pfami | View protein in Pfam PF14469, AKAP28, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AKA28_HUMAN | |
Accessioni | Q86UN6Primary (citable) accession number: Q86UN6 Secondary accession number(s): A6NNZ0, Q86UN4, Q86UN5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 13, 2004 |
Last sequence update: | June 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM