UniProtKB - Q86UN2 (R4RL1_HUMAN)
Protein
Reticulon-4 receptor-like 1
Gene
RTN4RL1
Organism
Homo sapiens (Human)
Status
Functioni
Cell surface receptor. Plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG. Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans. Binds heparin (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200).By similarity1 Publication
GO - Molecular functioni
- chondroitin sulfate binding Source: UniProtKB
- heparin binding Source: UniProtKB
- signaling receptor activity Source: UniProtKB
GO - Biological processi
- axon regeneration Source: UniProtKB
- corpus callosum development Source: Ensembl
- negative regulation of axon regeneration Source: UniProtKB
- negative regulation of neuron projection development Source: UniProtKB
Keywordsi
Molecular function | Receptor |
Enzyme and pathway databases
PathwayCommonsi | Q86UN2 |
Reactomei | R-HSA-163125, Post-translational modification: synthesis of GPI-anchored proteins |
Names & Taxonomyi
Protein namesi | Recommended name: Reticulon-4 receptor-like 1Alternative name(s): Nogo receptor-like 2 Nogo-66 receptor homolog 21 Publication Nogo-66 receptor-related protein 3 Short name: NgR3 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21329, RTN4RL1 |
MIMi | 610461, gene |
neXtProti | NX_Q86UN2 |
VEuPathDBi | HostDB:ENSG00000185924.6 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; GPI-anchor 1 Publication
Other locations
- Membrane raft 1 Publication
- Perikaryon By similarity
- Cell projection By similarity
Note: Localized to the surface of neurons, including axons.By similarity
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Plasma Membrane
- anchored component of plasma membrane Source: UniProtKB
- external side of plasma membrane Source: Ensembl
- plasma membrane Source: Reactome
Other locations
- cell projection Source: UniProtKB-SubCell
- cell surface Source: DFLAT
- extracellular matrix Source: GO_Central
- membrane raft Source: UniProtKB-SubCell
- perikaryon Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, Cell projection, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 146760 |
OpenTargetsi | ENSG00000185924 |
PharmGKBi | PA134973992 |
Miscellaneous databases
Pharosi | Q86UN2, Tbio |
Genetic variation databases
BioMutai | RTN4RL1 |
DMDMi | 74714017 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_0000046042 | 25 – 420 | Reticulon-4 receptor-like 1Add BLAST | 396 | |
PropeptideiPRO_0000046043 | 421 – 441 | Removed in mature formSequence analysisAdd BLAST | 21 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 420 | GPI-anchor amidated serineSequence analysis | 1 |
Keywords - PTMi
Glycoprotein, GPI-anchor, LipoproteinProteomic databases
MassIVEi | Q86UN2 |
PaxDbi | Q86UN2 |
PeptideAtlasi | Q86UN2 |
PRIDEi | Q86UN2 |
ProteomicsDBi | 69833 |
PTM databases
GlyGeni | Q86UN2, 1 site |
iPTMneti | Q86UN2 |
PhosphoSitePlusi | Q86UN2 |
Expressioni
Tissue specificityi
Predominantly expressed in brain. Expressed at lower levels in kidney, lung, mammary gland, placenta, salivary gland, skeletal muscle and spleen.2 Publications
Gene expression databases
Bgeei | ENSG00000185924, Expressed in cortical plate and 132 other tissues |
Genevisiblei | Q86UN2, HS |
Organism-specific databases
HPAi | ENSG00000185924, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Identified in a complex that contains RTN4R, RTN4RL1 and NGFR; the interaction depends on the presence of chondroitin sulfate proteoglycans. Does not interact with MAG, OMG and RTN4.
By similarityBinary interactionsi
Hide detailsQ86UN2
Protein-protein interaction databases
BioGRIDi | 127008, 10 interactors |
IntActi | Q86UN2, 5 interactors |
STRINGi | 9606.ENSP00000330631 |
Miscellaneous databases
RNActi | Q86UN2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 54 | LRRNTAdd BLAST | 30 | |
Repeati | 55 – 76 | LRR 1Add BLAST | 22 | |
Repeati | 77 – 98 | LRR 2Add BLAST | 22 | |
Repeati | 101 – 123 | LRR 3Add BLAST | 23 | |
Repeati | 126 – 147 | LRR 4Add BLAST | 22 | |
Repeati | 150 – 171 | LRR 5Add BLAST | 22 | |
Repeati | 174 – 195 | LRR 6Add BLAST | 22 | |
Repeati | 198 – 219 | LRR 7Add BLAST | 22 | |
Repeati | 222 – 243 | LRR 8Add BLAST | 22 | |
Domaini | 255 – 306 | LRRCTAdd BLAST | 52 |
Sequence similaritiesi
Belongs to the Nogo receptor family.Curated
Keywords - Domaini
Leucine-rich repeat, Repeat, SignalPhylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000157112 |
HOGENOMi | CLU_000288_18_6_1 |
InParanoidi | Q86UN2 |
OMAi | NGNAWDC |
OrthoDBi | 826997at2759 |
PhylomeDBi | Q86UN2 |
TreeFami | TF330080 |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf |
Pfami | View protein in Pfam PF13855, LRR_8, 2 hits |
SMARTi | View protein in SMART SM00369, LRR_TYP, 7 hits SM00082, LRRCT, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 6 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q86UN2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLRKGCCVEL LLLLVAAELP LGGGCPRDCV CYPAPMTVSC QAHNFAAIPE
60 70 80 90 100
GIPVDSERVF LQNNRIGLLQ PGHFSPAMVT LWIYSNNITY IHPSTFEGFV
110 120 130 140 150
HLEELDLGDN RQLRTLAPET FQGLVKLHAL YLYKCGLSAL PAGVFGGLHS
160 170 180 190 200
LQYLYLQDNH IEYLQDDIFV DLVNLSHLFL HGNKLWSLGP GTFRGLVNLD
210 220 230 240 250
RLLLHENQLQ WVHHKAFHDL RRLTTLFLFN NSLSELQGEC LAPLGALEFL
260 270 280 290 300
RLNGNPWDCG CRARSLWEWL QRFRGSSSAV PCVSPGLRHG QDLKLLRAED
310 320 330 340 350
FRNCTGPASP HQIKSHTLTT TDRAARKEHH SPHGPTRSKG HPHGPRPGHR
360 370 380 390 400
KPGKNCTNPR NRNQISKAGA GKQAPELPDY APDYQHKFSF DIMPTARPKR
410 420 430 440
KGKCARRTPI RAPSGVQQAS SASSLGASLL AWTLGLAVTL R
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 22 | G → S in CAD39071 (PubMed:17974005).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY250219 mRNA Translation: AAP82836.1 AF532859 mRNA Translation: AAP21836.1 CH471108 Genomic DNA Translation: EAW90570.1 BC128608 mRNA Translation: AAI28609.1 AL834409 mRNA Translation: CAD39071.1 BK001305 mRNA Translation: DAA01388.1 |
CCDSi | CCDS45569.1 |
RefSeqi | NP_848663.1, NM_178568.3 |
Genome annotation databases
Ensembli | ENST00000331238; ENSP00000330631; ENSG00000185924 |
GeneIDi | 146760 |
KEGGi | hsa:146760 |
UCSCi | uc002ftp.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY250219 mRNA Translation: AAP82836.1 AF532859 mRNA Translation: AAP21836.1 CH471108 Genomic DNA Translation: EAW90570.1 BC128608 mRNA Translation: AAI28609.1 AL834409 mRNA Translation: CAD39071.1 BK001305 mRNA Translation: DAA01388.1 |
CCDSi | CCDS45569.1 |
RefSeqi | NP_848663.1, NM_178568.3 |
3D structure databases
SMRi | Q86UN2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127008, 10 interactors |
IntActi | Q86UN2, 5 interactors |
STRINGi | 9606.ENSP00000330631 |
PTM databases
GlyGeni | Q86UN2, 1 site |
iPTMneti | Q86UN2 |
PhosphoSitePlusi | Q86UN2 |
Genetic variation databases
BioMutai | RTN4RL1 |
DMDMi | 74714017 |
Proteomic databases
MassIVEi | Q86UN2 |
PaxDbi | Q86UN2 |
PeptideAtlasi | Q86UN2 |
PRIDEi | Q86UN2 |
ProteomicsDBi | 69833 |
Protocols and materials databases
Antibodypediai | 50502, 144 antibodies |
Genome annotation databases
Ensembli | ENST00000331238; ENSP00000330631; ENSG00000185924 |
GeneIDi | 146760 |
KEGGi | hsa:146760 |
UCSCi | uc002ftp.4, human |
Organism-specific databases
CTDi | 146760 |
DisGeNETi | 146760 |
GeneCardsi | RTN4RL1 |
HGNCi | HGNC:21329, RTN4RL1 |
HPAi | ENSG00000185924, Tissue enhanced (brain) |
MIMi | 610461, gene |
neXtProti | NX_Q86UN2 |
OpenTargetsi | ENSG00000185924 |
PharmGKBi | PA134973992 |
VEuPathDBi | HostDB:ENSG00000185924.6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000157112 |
HOGENOMi | CLU_000288_18_6_1 |
InParanoidi | Q86UN2 |
OMAi | NGNAWDC |
OrthoDBi | 826997at2759 |
PhylomeDBi | Q86UN2 |
TreeFami | TF330080 |
Enzyme and pathway databases
PathwayCommonsi | Q86UN2 |
Reactomei | R-HSA-163125, Post-translational modification: synthesis of GPI-anchored proteins |
Miscellaneous databases
BioGRID-ORCSi | 146760, 8 hits in 985 CRISPR screens |
ChiTaRSi | RTN4RL1, human |
GenomeRNAii | 146760 |
Pharosi | Q86UN2, Tbio |
PROi | PR:Q86UN2 |
RNActi | Q86UN2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000185924, Expressed in cortical plate and 132 other tissues |
Genevisiblei | Q86UN2, HS |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf |
Pfami | View protein in Pfam PF13855, LRR_8, 2 hits |
SMARTi | View protein in SMART SM00369, LRR_TYP, 7 hits SM00082, LRRCT, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 6 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | R4RL1_HUMAN | |
Accessioni | Q86UN2Primary (citable) accession number: Q86UN2 Secondary accession number(s): A1A5E3, Q8ND46 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 7, 2006 |
Last sequence update: | June 1, 2003 | |
Last modified: | April 7, 2021 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families