UniProtKB - Q86UL8 (MAGI2_HUMAN)
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
MAGI2
Functioni
GO - Molecular functioni
- beta-1 adrenergic receptor binding Source: UniProtKB
- phosphatase binding Source: UniProtKB
- signaling receptor complex adaptor activity Source: UniProtKB
- SMAD binding Source: UniProtKB
- type II activin receptor binding Source: UniProtKB
GO - Biological processi
- cellular response to nerve growth factor stimulus Source: UniProtKB
- glomerular visceral epithelial cell development Source: UniProtKB
- mitotic cell cycle arrest Source: UniProtKB
- negative regulation of activin receptor signaling pathway Source: UniProtKB
- negative regulation of cell migration Source: UniProtKB
- negative regulation of cell population proliferation Source: UniProtKB
- negative regulation of protein kinase B signaling Source: UniProtKB
- nerve growth factor signaling pathway Source: UniProtKB
- neuroligin clustering involved in postsynaptic membrane assembly Source: Ensembl
- planar cell polarity pathway involved in axis elongation Source: UniProtKB
- positive regulation of neuron projection development Source: UniProtKB
- positive regulation of phosphoprotein phosphatase activity Source: UniProtKB
- positive regulation of receptor internalization Source: UniProtKB
- positive regulation of synaptic vesicle clustering Source: Ensembl
- receptor clustering Source: UniProtKB
- signal transduction Source: GO_Central
- SMAD protein signal transduction Source: UniProtKB
Keywordsi
Biological process | Neurogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q86UL8 |
Reactomei | R-HSA-373753, Nephrin family interactions |
SignaLinki | Q86UL8 |
Protein family/group databases
TCDBi | 8.A.24.1.6, the ezrin/radixin/moesin-binding phosphoprotein 50 (ebp50) family |
Names & Taxonomyi
Protein namesi | Recommended name: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2Alternative name(s): Atrophin-1-interacting protein 1 Short name: AIP-1 Atrophin-1-interacting protein A Membrane-associated guanylate kinase inverted 2 Short name: MAGI-2 |
Gene namesi | Name:MAGI2 Synonyms:ACVRINP1, AIP1, KIAA0705 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18957, MAGI2 |
MIMi | 606382, gene |
neXtProti | NX_Q86UL8 |
VEuPathDBi | HostDB:ENSG00000187391.18 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Peripheral membrane protein By similarity
Endosome
- Late endosome By similarity
Other locations
- Cytoplasm By similarity
- synaptosome By similarity
Note: Localized diffusely in the cytoplasm before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Membrane-associated in synaptosomes (By similarity).By similarity
Endosome
- late endosome Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- bicellular tight junction Source: UniProtKB
- cell-cell junction Source: GO_Central
- cytoplasm Source: UniProtKB
- dendrite Source: UniProtKB
- perinuclear region of cytoplasm Source: UniProtKB
- postsynaptic density Source: UniProtKB
- protein-containing complex Source: UniProtKB
- slit diaphragm Source: UniProtKB
- synapse Source: UniProtKB
Keywords - Cellular componenti
Cell junction, Cell membrane, Cytoplasm, Endosome, Membrane, Synapse, SynaptosomePathology & Biotechi
Involvement in diseasei
Nephrotic syndrome 15 (NPHS15)1 Publication
Organism-specific databases
DisGeNETi | 9863 |
MalaCardsi | MAGI2 |
MIMi | 617609, phenotype |
OpenTargetsi | ENSG00000187391 |
Orphaneti | 656, Genetic steroid-resistant nephrotic syndrome |
PharmGKBi | PA142671484 |
Miscellaneous databases
Pharosi | Q86UL8, Tbio |
Genetic variation databases
BioMutai | MAGI2 |
DMDMi | 88909269 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000094586 | 1 – 1455 | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2Add BLAST | 1455 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 362 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 686 | PhosphoserineBy similarity | 1 | |
Modified residuei | 827 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 884 | PhosphoserineBy similarity | 1 | |
Modified residuei | 885 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1014 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q86UL8 |
MassIVEi | Q86UL8 |
MaxQBi | Q86UL8 |
PaxDbi | Q86UL8 |
PeptideAtlasi | Q86UL8 |
PRIDEi | Q86UL8 |
ProteomicsDBi | 69831 [Q86UL8-1] 69832 [Q86UL8-2] |
PTM databases
iPTMneti | Q86UL8 |
PhosphoSitePlusi | Q86UL8 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000187391, Expressed in metanephric glomerulus and 222 other tissues |
ExpressionAtlasi | Q86UL8, baseline and differential |
Genevisiblei | Q86UL8, HS |
Organism-specific databases
HPAi | ENSG00000187391, Tissue enhanced (brain, parathyroid gland) |
Interactioni
Subunit structurei
Interacts (via its WW domains) with DRPLA (PubMed:9647693).
Interacts (via its second PDZ domain) with PTEN (via unphosphorylated C-terminus); this interaction diminishes the degradation rate of PTEN (PubMed:10760291, PubMed:11707428).
Interacts (via guanylate kinase domain) with DLGAP1 (By similarity).
Interacts (via the PDZ domains) with GRIN2A, GRID2 and NLGN1 (By similarity).
Interacts with CTNND2, CTNNB1, MAGUIN-1, ACVR2A, SMAD2 and SMAD3 (By similarity).
Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 (By similarity). May interact with HTR2A (By similarity).
Interacts with IGSF9, RAPGEF2 and HTR4 (By similarity).
Identified in a complex with ACTN4, CASK, IQGAP1, NPHS1, SPTAN1 and SPTBN1 (By similarity).
Found in a complex, at least composed of KIDINS220, MAGI2, NTRK1 and RAPGEF2; the complex is mainly formed at late endosomes in a NGF-dependent manner (By similarity).
Interacts with RAPGEF2; the interaction occurs before or after nerve growth factor (NGF) stimulation (By similarity).
Interacts (via PDZ domain) with KIDINS220 (via C-terminal domain) (By similarity).
Interacts with DDN (PubMed:16464232).
Interacts with DLL1 (By similarity).
Found in a complex with IGSF9B and NLGN2; the interaction with IGSF9B is mediated via the PDZ 5 and PDZ 6 domains, while the interaction with NLGN2 is mediated via the WW1, WW2 and PDZ2 domains (PubMed:23751499).
By similarity5 PublicationsBinary interactionsi
Hide detailsQ86UL8
With | #Exp. | IntAct |
---|---|---|
ADRB1 [P08588] | 3 | EBI-311035,EBI-991009 |
Isoform 2 [Q86UL8-2]
GO - Molecular functioni
- beta-1 adrenergic receptor binding Source: UniProtKB
- phosphatase binding Source: UniProtKB
- SMAD binding Source: UniProtKB
- type II activin receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 115197, 22 interactors |
CORUMi | Q86UL8 |
IntActi | Q86UL8, 18 interactors |
MINTi | Q86UL8 |
STRINGi | 9606.ENSP00000346151 |
Miscellaneous databases
RNActi | Q86UL8, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q86UL8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q86UL8 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 17 – 101 | PDZ 1PROSITE-ProRule annotationAdd BLAST | 85 | |
Domaini | 109 – 283 | Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST | 175 | |
Domaini | 302 – 335 | WW 1PROSITE-ProRule annotationAdd BLAST | 34 | |
Domaini | 348 – 381 | WW 2PROSITE-ProRule annotationAdd BLAST | 34 | |
Domaini | 426 – 510 | PDZ 2PROSITE-ProRule annotationAdd BLAST | 85 | |
Domaini | 605 – 683 | PDZ 3PROSITE-ProRule annotationAdd BLAST | 79 | |
Domaini | 778 – 860 | PDZ 4PROSITE-ProRule annotationAdd BLAST | 83 | |
Domaini | 920 – 1010 | PDZ 5PROSITE-ProRule annotationAdd BLAST | 91 | |
Domaini | 1147 – 1229 | PDZ 6PROSITE-ProRule annotationAdd BLAST | 83 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 302 – 381 | Interaction with DDN1 PublicationAdd BLAST | 80 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1015 – 1118 | Pro-richAdd BLAST | 104 | |
Compositional biasi | 1340 – 1430 | Ala-richAdd BLAST | 91 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3209, Eukaryota |
GeneTreei | ENSGT00940000155057 |
InParanoidi | Q86UL8 |
OMAi | RNGRMRX |
OrthoDBi | 284488at2759 |
PhylomeDBi | Q86UL8 |
TreeFami | TF316816 |
Family and domain databases
CDDi | cd00201, WW, 2 hits |
Gene3Di | 2.30.42.10, 6 hits |
InterProi | View protein in InterPro IPR008145, GK/Ca_channel_bsu IPR008144, Guanylate_kin-like_dom IPR020590, Guanylate_kinase_CS IPR030036, MAGI2 IPR027417, P-loop_NTPase IPR001478, PDZ IPR036034, PDZ_sf IPR001202, WW_dom IPR036020, WW_dom_sf |
PANTHERi | PTHR10316:SF27, PTHR10316:SF27, 1 hit |
Pfami | View protein in Pfam PF00625, Guanylate_kin, 1 hit PF00595, PDZ, 6 hits PF00397, WW, 1 hit |
SMARTi | View protein in SMART SM00072, GuKc, 1 hit SM00228, PDZ, 6 hits SM00456, WW, 2 hits |
SUPFAMi | SSF50156, SSF50156, 6 hits SSF51045, SSF51045, 2 hits SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00856, GUANYLATE_KINASE_1, 1 hit PS50052, GUANYLATE_KINASE_2, 1 hit PS50106, PDZ, 6 hits PS01159, WW_DOMAIN_1, 2 hits PS50020, WW_DOMAIN_2, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 19 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSKSLKKKSH WTSKVHESVI GRNPEGQLGF ELKGGAENGQ FPYLGEVKPG
60 70 80 90 100
KVAYESGSKL VSEELLLEVN ETPVAGLTIR DVLAVIKHCK DPLRLKCVKQ
110 120 130 140 150
GGIVDKDLRH YLNLRFQKGS VDHELQQIIR DNLYLRTVPC TTRPHKEGEV
160 170 180 190 200
PGVDYIFITV EDFMELEKSG ALLESGTYED NYYGTPKPPA EPAPLLLNVT
210 220 230 240 250
DQILPGATPS AEGKRKRNKS VSNMEKASIE PPEEEEEERP VVNGNGVVVT
260 270 280 290 300
PESSEHEDKS AGASGEMPSQ PYPAPVYSQP EELKEQMDDT KPTKPEDNEE
310 320 330 340 350
PDPLPDNWEM AYTEKGEVYF IDHNTKTTSW LDPRLAKKAK PPEECKENEL
360 370 380 390 400
PYGWEKIDDP IYGTYYVDHI NRRTQFENPV LEAKRKLQQH NMPHTELGTK
410 420 430 440 450
PLQAPGFREK PLFTRDASQL KGTFLSTTLK KSNMGFGFTI IGGDEPDEFL
460 470 480 490 500
QVKSVIPDGP AAQDGKMETG DVIVYINEVC VLGHTHADVV KLFQSVPIGQ
510 520 530 540 550
SVNLVLCRGY PLPFDPEDPA NSMVPPLAIM ERPPPVMVNG RHNYETYLEY
560 570 580 590 600
ISRTSQSVPD ITDRPPHSLH SMPTDGQLDG TYPPPVHDDN VSMASSGATQ
610 620 630 640 650
AELMTLTIVK GAQGFGFTIA DSPTGQRVKQ ILDIQGCPGL CEGDLIVEIN
660 670 680 690 700
QQNVQNLSHT EVVDILKDCP IGSETSLIIH RGGFFSPWKT PKPIMDRWEN
710 720 730 740 750
QGSPQTSLSA PAIPQNLPFP PALHRSSFPD STEAFDPRKP DPYELYEKSR
760 770 780 790 800
AIYESRQQVP PRTSFRMDSS GPDYKELDVH LRRMESGFGF RILGGDEPGQ
810 820 830 840 850
PILIGAVIAM GSADRDGRLH PGDELVYVDG IPVAGKTHRY VIDLMHHAAR
860 870 880 890 900
NGQVNLTVRR KVLCGGEPCP ENGRSPGSVS THHSSPRSDY ATYTNSNHAA
910 920 930 940 950
PSSNASPPEG FASHSLQTSD VVIHRKENEG FGFVIISSLN RPESGSTITV
960 970 980 990 1000
PHKIGRIIDG SPADRCAKLK VGDRILAVNG QSIINMPHAD IVKLIKDAGL
1010 1020 1030 1040 1050
SVTLRIIPQE ELNSPTSAPS SEKQSPMAQQ SPLAQQSPLA QPSPATPNSP
1060 1070 1080 1090 1100
IAQPAPPQPL QLQGHENSYR SEVKARQDVK PDIRQPPFTD YRQPPLDYRQ
1110 1120 1130 1140 1150
PPGGDYQQPP PLDYRQPPLL DYRQHSPDTR QYPLSDYRQP QDFDYFTVDM
1160 1170 1180 1190 1200
EKGAKGFGFS IRGGREYKMD LYVLRLAEDG PAIRNGRMRV GDQIIEINGE
1210 1220 1230 1240 1250
STRDMTHARA IELIKSGGRR VRLLLKRGTG QVPEYDEPAP WSSPAAAAPG
1260 1270 1280 1290 1300
LPEVGVSLDD GLAPFSPSHP APPSDPSHQI SPGPTWDIKR EHDVRKPKEL
1310 1320 1330 1340 1350
SACGQKKQRL GEQRERSASP QRAARPRLEE APGGQGRPEA GRPASEARAP
1360 1370 1380 1390 1400
GLAAADAADA ARAGGKEAPR AAAGSELCRR EGPGAAPAFA GPGGGGSGAL
1410 1420 1430 1440 1450
EAEGRAGARA GPRPGPRPPG GAPARKAAVA PGPWKVPGSD KLPSVLKPGA
SAASR
Computationally mapped potential isoform sequencesi
There are 19 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7EWI0 | E7EWI0_HUMAN | Membrane-associated guanylate kinas... | MAGI2 | 1,283 | Annotation score: | ||
A0A0D9SGI1 | A0A0D9SGI1_HUMAN | Membrane-associated guanylate kinas... | MAGI2 | 1,317 | Annotation score: | ||
A0A0E3D6M1 | A0A0E3D6M1_HUMAN | Membrane-associated guanylate kinas... | MAGI2 | 1,303 | Annotation score: | ||
A0A1B0GTC0 | A0A1B0GTC0_HUMAN | Membrane-associated guanylate kinas... | MAGI2 | 1,206 | Annotation score: | ||
A0A0D9SGF8 | A0A0D9SGF8_HUMAN | Membrane associated guanylate kinas... | MAGI2 hCG_40263 | 1,106 | Annotation score: | ||
A0A0D9SET0 | A0A0D9SET0_HUMAN | Membrane-associated guanylate kinas... | MAGI2 | 555 | Annotation score: | ||
A0A0D9SEY4 | A0A0D9SEY4_HUMAN | Membrane-associated guanylate kinas... | MAGI2 | 1,120 | Annotation score: | ||
A0A0D9SEZ7 | A0A0D9SEZ7_HUMAN | Membrane-associated guanylate kinas... | MAGI2 | 238 | Annotation score: | ||
A0A0D9SGF2 | A0A0D9SGF2_HUMAN | Membrane-associated guanylate kinas... | MAGI2 | 495 | Annotation score: | ||
A0A0D9SF86 | A0A0D9SF86_HUMAN | Membrane-associated guanylate kinas... | MAGI2 | 183 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1234 | E → Q in AAC05370 (PubMed:9647693).Curated | 1 | |
Sequence conflicti | 1250 | G → C in AAC05370 (PubMed:9647693).Curated | 1 | |
Sequence conflicti | 1291 | E → K in AAC05370 (PubMed:9647693).Curated | 1 | |
Sequence conflicti | 1383 | P → L in AAC05370 (PubMed:9647693).Curated | 1 | |
Sequence conflicti | 1389 – 1394 | FAGPGG → SADPAD in AAC05370 (PubMed:9647693).Curated | 6 | |
Sequence conflicti | 1401 | E → A in AAC05370 (PubMed:9647693).Curated | 1 | |
Sequence conflicti | 1411 | G → A in AAC05370 (PubMed:9647693).Curated | 1 | |
Sequence conflicti | 1414 – 1415 | PG → SV in AAC05370 (PubMed:9647693).Curated | 2 | |
Sequence conflicti | 1420 | G → A in AAC05370 (PubMed:9647693).Curated | 1 | |
Sequence conflicti | 1423 | P → A in AAC05370 (PubMed:9647693).Curated | 1 | |
Sequence conflicti | 1426 | K → R in AAC05370 (PubMed:9647693).Curated | 1 | |
Sequence conflicti | 1429 | V → G in AAC05370 (PubMed:9647693).Curated | 1 | |
Sequence conflicti | 1437 | P → R in AAC05370 (PubMed:9647693).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_008435 | 757 – 771 | QQVPP…MDSSG → R in isoform 2. 2 PublicationsAdd BLAST | 15 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF038563 mRNA Translation: AAC05370.1 AB014605 mRNA Translation: BAA31680.2 Different initiation. AC004808 Genomic DNA Translation: AAC23438.1 AC004945 Genomic DNA Translation: AAC61488.1 AC004990 Genomic DNA Translation: AAC79151.1 AC005246 Genomic DNA Translation: AAC25530.1 AC006043 Genomic DNA Translation: AAD15413.2 AC006324 Genomic DNA Translation: AAF66080.1 AC007237 Genomic DNA Translation: AAP21886.1 AC073200 Genomic DNA Translation: AAP22360.1 CH236949 Genomic DNA Translation: EAL24194.1 BC150277 mRNA Translation: AAI50278.1 |
CCDSi | CCDS5594.1 [Q86UL8-1] CCDS75623.1 [Q86UL8-2] |
RefSeqi | NP_001288057.1, NM_001301128.1 [Q86UL8-2] NP_036433.2, NM_012301.3 [Q86UL8-1] |
Genome annotation databases
Ensembli | ENST00000354212; ENSP00000346151; ENSG00000187391 [Q86UL8-1] ENST00000419488; ENSP00000405766; ENSG00000187391 [Q86UL8-2] |
GeneIDi | 9863 |
KEGGi | hsa:9863 |
UCSCi | uc003ugx.3, human [Q86UL8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF038563 mRNA Translation: AAC05370.1 AB014605 mRNA Translation: BAA31680.2 Different initiation. AC004808 Genomic DNA Translation: AAC23438.1 AC004945 Genomic DNA Translation: AAC61488.1 AC004990 Genomic DNA Translation: AAC79151.1 AC005246 Genomic DNA Translation: AAC25530.1 AC006043 Genomic DNA Translation: AAD15413.2 AC006324 Genomic DNA Translation: AAF66080.1 AC007237 Genomic DNA Translation: AAP21886.1 AC073200 Genomic DNA Translation: AAP22360.1 CH236949 Genomic DNA Translation: EAL24194.1 BC150277 mRNA Translation: AAI50278.1 |
CCDSi | CCDS5594.1 [Q86UL8-1] CCDS75623.1 [Q86UL8-2] |
RefSeqi | NP_001288057.1, NM_001301128.1 [Q86UL8-2] NP_036433.2, NM_012301.3 [Q86UL8-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1UEP | NMR | - | A | 774-863 | [»] | |
1UEQ | NMR | - | A | 412-522 | [»] | |
1UEW | NMR | - | A | 915-1015 | [»] | |
1UJV | NMR | - | A | 600-682 | [»] | |
1WFV | NMR | - | A | 1141-1230 | [»] | |
SMRi | Q86UL8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115197, 22 interactors |
CORUMi | Q86UL8 |
IntActi | Q86UL8, 18 interactors |
MINTi | Q86UL8 |
STRINGi | 9606.ENSP00000346151 |
Protein family/group databases
TCDBi | 8.A.24.1.6, the ezrin/radixin/moesin-binding phosphoprotein 50 (ebp50) family |
PTM databases
iPTMneti | Q86UL8 |
PhosphoSitePlusi | Q86UL8 |
Genetic variation databases
BioMutai | MAGI2 |
DMDMi | 88909269 |
Proteomic databases
jPOSTi | Q86UL8 |
MassIVEi | Q86UL8 |
MaxQBi | Q86UL8 |
PaxDbi | Q86UL8 |
PeptideAtlasi | Q86UL8 |
PRIDEi | Q86UL8 |
ProteomicsDBi | 69831 [Q86UL8-1] 69832 [Q86UL8-2] |
Protocols and materials databases
Antibodypediai | 2880, 230 antibodies |
Genome annotation databases
Ensembli | ENST00000354212; ENSP00000346151; ENSG00000187391 [Q86UL8-1] ENST00000419488; ENSP00000405766; ENSG00000187391 [Q86UL8-2] |
GeneIDi | 9863 |
KEGGi | hsa:9863 |
UCSCi | uc003ugx.3, human [Q86UL8-1] |
Organism-specific databases
CTDi | 9863 |
DisGeNETi | 9863 |
GeneCardsi | MAGI2 |
HGNCi | HGNC:18957, MAGI2 |
HPAi | ENSG00000187391, Tissue enhanced (brain, parathyroid gland) |
MalaCardsi | MAGI2 |
MIMi | 606382, gene 617609, phenotype |
neXtProti | NX_Q86UL8 |
OpenTargetsi | ENSG00000187391 |
Orphaneti | 656, Genetic steroid-resistant nephrotic syndrome |
PharmGKBi | PA142671484 |
VEuPathDBi | HostDB:ENSG00000187391.18 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3209, Eukaryota |
GeneTreei | ENSGT00940000155057 |
InParanoidi | Q86UL8 |
OMAi | RNGRMRX |
OrthoDBi | 284488at2759 |
PhylomeDBi | Q86UL8 |
TreeFami | TF316816 |
Enzyme and pathway databases
PathwayCommonsi | Q86UL8 |
Reactomei | R-HSA-373753, Nephrin family interactions |
SignaLinki | Q86UL8 |
Miscellaneous databases
BioGRID-ORCSi | 9863, 4 hits in 874 CRISPR screens |
ChiTaRSi | MAGI2, human |
EvolutionaryTracei | Q86UL8 |
GeneWikii | MAGI2 |
GenomeRNAii | 9863 |
Pharosi | Q86UL8, Tbio |
PROi | PR:Q86UL8 |
RNActi | Q86UL8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000187391, Expressed in metanephric glomerulus and 222 other tissues |
ExpressionAtlasi | Q86UL8, baseline and differential |
Genevisiblei | Q86UL8, HS |
Family and domain databases
CDDi | cd00201, WW, 2 hits |
Gene3Di | 2.30.42.10, 6 hits |
InterProi | View protein in InterPro IPR008145, GK/Ca_channel_bsu IPR008144, Guanylate_kin-like_dom IPR020590, Guanylate_kinase_CS IPR030036, MAGI2 IPR027417, P-loop_NTPase IPR001478, PDZ IPR036034, PDZ_sf IPR001202, WW_dom IPR036020, WW_dom_sf |
PANTHERi | PTHR10316:SF27, PTHR10316:SF27, 1 hit |
Pfami | View protein in Pfam PF00625, Guanylate_kin, 1 hit PF00595, PDZ, 6 hits PF00397, WW, 1 hit |
SMARTi | View protein in SMART SM00072, GuKc, 1 hit SM00228, PDZ, 6 hits SM00456, WW, 2 hits |
SUPFAMi | SSF50156, SSF50156, 6 hits SSF51045, SSF51045, 2 hits SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00856, GUANYLATE_KINASE_1, 1 hit PS50052, GUANYLATE_KINASE_2, 1 hit PS50106, PDZ, 6 hits PS01159, WW_DOMAIN_1, 2 hits PS50020, WW_DOMAIN_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MAGI2_HUMAN | |
Accessioni | Q86UL8Primary (citable) accession number: Q86UL8 Secondary accession number(s): A4D1C1 Q9UDU1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2003 |
Last sequence update: | February 7, 2006 | |
Last modified: | February 10, 2021 | |
This is version 180 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families