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UniProtKB - Q86UK7 (ZN598_HUMAN)

>sp|Q86UK7|ZN598_HUMAN E3 ubiquitin-protein ligase ZNF598 OS=Homo sapiens OX=9606 GN=ZNF598 PE=1 SV=1
MAAAGGAEGRRAALEAAAAAAPERGGGSCVLCCGDLEATALGRCDHPVCYRCSTKMRVLC
EQRYCAVCREELRQVVFGKKLPAFATIPIHQLQHEKKYDIYFADGKVYALYRQLLQHECP
RCPELPPFSLFGDLEQHMRRQHELFCCRLCLQHLQIFTYERKWYSRKDLARHRMQGDPDD
TSHRGHPLCKFCDERYLDNDELLKHLRRDHYFCHFCDSDGAQDYYSDYAYLREHFREKHF
LCEEGRCSTEQFTHAFRTEIDLKAHRTACHSRSRAEARQNRHIDLQFSYAPRHSRRNEGV
VGGEDYEEVDRYSRQGRVARAGTRGAQQSRRGSWRYKREEEDREVAAAVRASVAAQQQEE
ARRSEDQEEGGRPKKEEAAARGPEDPRGPRRSPRTQGEGPGPKETSTNGPVSQEAFSVTG
PAAPGCVGVPGALPPPSPKLKDEDFPSLSASTSSSCSTAATPGPVGLALPYAIPARGRSA
FQEEDFPALVSSVPKPGTAPTSLVSAWNSSSSSKKVAQPPLSAQATGSGQPTRKAGKGSR
GGRKGGPPFTQEEEEDGGPALQELLSTRPTGSVSSTLGLASIQPSKVGKKKKVGSEKPGT
TLPQPPPATCPPGALQAPEAPASRAEGPVAVVVNGHTEGPAPARSAPKEPPGLPRPLGSF
PCPTPQEDFPALGGPCPPRMPPPPGFSAVVLLKGTPPPPPPGLVPPISKPPPGFSGLLPS
PHPACVPSPATTTTTKAPRLLPAPRAYLVPENFRERNLQLIQSIRDFLQSDEARFSEFKS
HSGEFRQGLISAAQYYKSCRDLLGENFQKVFNELLVLLPDTAKQQELLSAHTDFCNREKP
LSTKSKKNKKSAWQATTQQAGLDCRVCPTCQQVLAHGDASSHQALHAARDDDFPSLQAIA
RIIT

Entry version 146 (23 Feb 2022)
Sequence version 1 (01 Jun 2003)
Previous versions | rss

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Protein

E3 ubiquitin-protein ligase ZNF598

Gene

ZNF598

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation (PubMed:28065601, PubMed:28132843).

Required for ribosomes to terminally stall during translation of poly(A) sequences by mediating monoubiquitination of 40S ribosomal protein RPS10/eS10, RPS20/uS10 and RPS3/uS3 (PubMed:28065601, PubMed:28132843).

Stalling precludes synthesis of a long poly-lysine tail and initiates the RQC pathway to degrade the potentially detrimental aberrant nascent polypeptide (PubMed:28065601, PubMed:28132843).

Also acts as a component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931).

3 Publications

Catalytic activityⁱ

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
2 Publications
Manual assertion inferred by curator fromⁱ
- Ref.10
  "Initiation of quality control during poly(A) translation requires site-specific ribosome ubiquitination."
  Juszkiewicz S., Hegde R.S.
  Mol. Cell 65:743-750(2016) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY.
- Ref.11
  "ZNF598 and RACK1 regulate mammalian ribosome-associated quality control function by mediating regulatory 40S ribosomal ubiquitylation."
  Sundaramoorthy E., Leonard M., Mak R., Liao J., Fulzele A., Bennett E.J.
  Mol. Cell 65:751-760(2017) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY, MUTAGENESIS OF CYS-29.
EC:2.3.2.27

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	29 – 69	RING-typePROSITE-ProRule annotationAdd BLAST		41
Zinc fingerⁱ	187 – 210	C2H2-typePROSITE-ProRule annotationAdd BLAST		24

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Transferase
Biological process	Translation regulation, Ubl conjugation pathway
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

PathwayCommonsⁱ	Q86UK7
SignaLinkⁱ	Q86UK7

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: E3 ubiquitin-protein ligase ZNF598Curated (EC:2.3.2.272 Publications) Alternative name(s): Zinc finger protein 598Imported
Gene namesⁱ	Name:ZNF598Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Unplaced

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28079, ZNF598
MIMⁱ	617508, gene
neXtProtⁱ	NX_Q86UK7

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	29	C → A: Abolishes E3 ubiquitin-protein ligase activity, leading to enhanced readthrough on the poly(A)-stall sequences. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	90850
PharmGKBⁱ	PA134944505

Miscellaneous databases

Pharosⁱ	Q86UK7, Tbio

Pharosⁱ

Q86UK7, Tbio

Genetic variation databases

BioMutaⁱ	ZNF598
DMDMⁱ	74727495

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000250568	1 – 904	E3 ubiquitin-protein ligase ZNF598Add BLAST		904

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	306	PhosphotyrosineCombined sources	1
Modified residueⁱ	437	PhosphoserineCombined sources	1
Isoform 2 (identifier: Q86UK7-2)
Modified residueⁱ	428	PhosphoserineCombined sources	1
Isoform 3 (identifier: Q86UK7-3)
Modified residueⁱ	431	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q86UK7
jPOSTⁱ	Q86UK7
MassIVEⁱ	Q86UK7
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q86UK7
PaxDbⁱ	Q86UK7
PeptideAtlas More...PeptideAtlasⁱ	Q86UK7
PRIDEⁱ	Q86UK7
ProteomicsDBⁱ	69826 [Q86UK7-1] 69827 [Q86UK7-2] 69828 [Q86UK7-3] 69829 [Q86UK7-4]

PTM databases

GlyGenⁱ	Q86UK7, 1 site, 1 O-linked glycan (1 site)
iPTMnetⁱ	Q86UK7
PhosphoSitePlusⁱ	Q86UK7
SwissPalmⁱ	Q86UK7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000167962, Expressed in adenohypophysis and 167 other tissues
Genevisibleⁱ	Q86UK7, HS

Interactionⁱ

Subunit structureⁱ

Protein-protein interaction databases

BioGRIDⁱ	124771, 417 interactors
IntActⁱ	Q86UK7, 27 interactors
Molecular INTeraction database More...MINTⁱ	Q86UK7
STRINGⁱ	9606.ENSP00000411409

Miscellaneous databases

RNActⁱ	Q86UK7, protein

RNActⁱ

Q86UK7, protein

Structureⁱ

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	312 – 469	DisorderedSequence analysisAdd BLAST		158
Regionⁱ	490 – 656	DisorderedSequence analysisAdd BLAST		167

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	332 – 347	Basic and acidic residuesSequence analysisAdd BLAST	16
Compositional biasⁱ	359 – 392	Basic and acidic residuesSequence analysisAdd BLAST	34
Compositional biasⁱ	399 – 415	Polar residuesSequence analysisAdd BLAST	17
Compositional biasⁱ	446 – 461	Polar residuesSequence analysisAdd BLAST	16
Compositional biasⁱ	495 – 533	Polar residuesSequence analysisAdd BLAST	39
Compositional biasⁱ	565 – 582	Polar residuesSequence analysisAdd BLAST	18
Compositional biasⁱ	600 – 614	Pro residuesSequence analysisAdd BLAST	15

Sequence similaritiesⁱ

Belongs to the ZNF598 family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	29 – 69	RING-typePROSITE-ProRule annotationAdd BLAST		41
Zinc fingerⁱ	187 – 210	C2H2-typePROSITE-ProRule annotationAdd BLAST		24

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG2231, Eukaryota
HOGENOMⁱ	CLU_015828_0_0_1
InParanoidⁱ	Q86UK7
Database of Orthologous Groups More...OrthoDBⁱ	1003372at2759
PhylomeDBⁱ	Q86UK7
TreeFamⁱ	TF316196

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd16615, RING-HC_ZNF598, 1 hit
InterProⁱ	View protein in InterPro IPR041888, RING-HC_ZNF598/Hel2 IPR044288, ZNF598/Hel2 IPR013087, Znf_C2H2_type IPR001841, Znf_RING
PANTHERⁱ	PTHR22938, PTHR22938, 1 hit
SMARTⁱ	View protein in SMART SM00355, ZnF_C2H2, 5 hits
PROSITEⁱ	View protein in PROSITE PS50089, ZF_RING_2, 1 hit PS00028, ZINC_FINGER_C2H2_1, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q86UK7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAGGAEGR RAALEAAAAA APERGGGSCV LCCGDLEATA LGRCDHPVCY 
        60         70         80         90        100
RCSTKMRVLC EQRYCAVCRE ELRQVVFGKK LPAFATIPIH QLQHEKKYDI 
       110        120        130        140        150
YFADGKVYAL YRQLLQHECP RCPELPPFSL FGDLEQHMRR QHELFCCRLC 
       160        170        180        190        200
LQHLQIFTYE RKWYSRKDLA RHRMQGDPDD TSHRGHPLCK FCDERYLDND 
       210        220        230        240        250
ELLKHLRRDH YFCHFCDSDG AQDYYSDYAY LREHFREKHF LCEEGRCSTE 
       260        270        280        290        300
QFTHAFRTEI DLKAHRTACH SRSRAEARQN RHIDLQFSYA PRHSRRNEGV 
       310        320        330        340        350
VGGEDYEEVD RYSRQGRVAR AGTRGAQQSR RGSWRYKREE EDREVAAAVR 
       360        370        380        390        400
ASVAAQQQEE ARRSEDQEEG GRPKKEEAAA RGPEDPRGPR RSPRTQGEGP 
       410        420        430        440        450
GPKETSTNGP VSQEAFSVTG PAAPGCVGVP GALPPPSPKL KDEDFPSLSA 
       460        470        480        490        500
STSSSCSTAA TPGPVGLALP YAIPARGRSA FQEEDFPALV SSVPKPGTAP 
       510        520        530        540        550
TSLVSAWNSS SSSKKVAQPP LSAQATGSGQ PTRKAGKGSR GGRKGGPPFT 
       560        570        580        590        600
QEEEEDGGPA LQELLSTRPT GSVSSTLGLA SIQPSKVGKK KKVGSEKPGT 
       610        620        630        640        650
TLPQPPPATC PPGALQAPEA PASRAEGPVA VVVNGHTEGP APARSAPKEP 
       660        670        680        690        700
PGLPRPLGSF PCPTPQEDFP ALGGPCPPRM PPPPGFSAVV LLKGTPPPPP 
       710        720        730        740        750
PGLVPPISKP PPGFSGLLPS PHPACVPSPA TTTTTKAPRL LPAPRAYLVP 
       760        770        780        790        800
ENFRERNLQL IQSIRDFLQS DEARFSEFKS HSGEFRQGLI SAAQYYKSCR 
       810        820        830        840        850
DLLGENFQKV FNELLVLLPD TAKQQELLSA HTDFCNREKP LSTKSKKNKK 
       860        870        880        890        900
SAWQATTQQA GLDCRVCPTC QQVLAHGDAS SHQALHAARD DDFPSLQAIA 

RIIT

Length:904

Mass (Da):98,637

Last modified:June 1, 2003 - v1

Checksum:ⁱ492F67EE4E334743

Isoform 2 (identifier: Q86UK7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     335-337: Missing.
     424-429: Missing.
     551-551: Q → QE

« Hide

        10         20         30         40         50
MAAAGGAEGR RAALEAAAAA APERGGGSCV LCCGDLEATA LGRCDHPVCY 
        60         70         80         90        100
RCSTKMRVLC EQRYCAVCRE ELRQVVFGKK LPAFATIPIH QLQHEKKYDI 
       110        120        130        140        150
YFADGKVYAL YRQLLQHECP RCPELPPFSL FGDLEQHMRR QHELFCCRLC 
       160        170        180        190        200
LQHLQIFTYE RKWYSRKDLA RHRMQGDPDD TSHRGHPLCK FCDERYLDND 
       210        220        230        240        250
ELLKHLRRDH YFCHFCDSDG AQDYYSDYAY LREHFREKHF LCEEGRCSTE 
       260        270        280        290        300
QFTHAFRTEI DLKAHRTACH SRSRAEARQN RHIDLQFSYA PRHSRRNEGV 
       310        320        330        340        350
VGGEDYEEVD RYSRQGRVAR AGTRGAQQSR RGSWREEEDR EVAAAVRASV 
       360        370        380        390        400
AAQQQEEARR SEDQEEGGRP KKEEAAARGP EDPRGPRRSP RTQGEGPGPK 
       410        420        430        440        450
ETSTNGPVSQ EAFSVTGPAA PGALPPPSPK LKDEDFPSLS ASTSSSCSTA 
       460        470        480        490        500
ATPGPVGLAL PYAIPARGRS AFQEEDFPAL VSSVPKPGTA PTSLVSAWNS 
       510        520        530        540        550
SSSSKKVAQP PLSAQATGSG QPTRKAGKGS RGGRKGGPPF TQEEEEEDGG 
       560        570        580        590        600
PALQELLSTR PTGSVSSTLG LASIQPSKVG KKKKVGSEKP GTTLPQPPPA 
       610        620        630        640        650
TCPPGALQAP EAPASRAEGP VAVVVNGHTE GPAPARSAPK EPPGLPRPLG 
       660        670        680        690        700
SFPCPTPQED FPALGGPCPP RMPPPPGFSA VVLLKGTPPP PPPGLVPPIS 
       710        720        730        740        750
KPPPGFSGLL PSPHPACVPS PATTTTTKAP RLLPAPRAYL VPENFRERNL 
       760        770        780        790        800
QLIQSIRDFL QSDEARFSEF KSHSGEFRQG LISAAQYYKS CRDLLGENFQ 
       810        820        830        840        850
KVFNELLVLL PDTAKQQELL SAHTDFCNRE KPLSTKSKKN KKSAWQATTQ 
       860        870        880        890 
QAGLDCRVCP TCQQVLAHGD ASSHQALHAA RDDDFPSLQA IARIIT

Show »

Length:896

Mass (Da):97,806

Checksum:ⁱ0524BC8755C1B28D

Isoform 3 (identifier: Q86UK7-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
424-429: Missing.

« Hide

        10         20         30         40         50
MAAAGGAEGR RAALEAAAAA APERGGGSCV LCCGDLEATA LGRCDHPVCY 
        60         70         80         90        100
RCSTKMRVLC EQRYCAVCRE ELRQVVFGKK LPAFATIPIH QLQHEKKYDI 
       110        120        130        140        150
YFADGKVYAL YRQLLQHECP RCPELPPFSL FGDLEQHMRR QHELFCCRLC 
       160        170        180        190        200
LQHLQIFTYE RKWYSRKDLA RHRMQGDPDD TSHRGHPLCK FCDERYLDND 
       210        220        230        240        250
ELLKHLRRDH YFCHFCDSDG AQDYYSDYAY LREHFREKHF LCEEGRCSTE 
       260        270        280        290        300
QFTHAFRTEI DLKAHRTACH SRSRAEARQN RHIDLQFSYA PRHSRRNEGV 
       310        320        330        340        350
VGGEDYEEVD RYSRQGRVAR AGTRGAQQSR RGSWRYKREE EDREVAAAVR 
       360        370        380        390        400
ASVAAQQQEE ARRSEDQEEG GRPKKEEAAA RGPEDPRGPR RSPRTQGEGP 
       410        420        430        440        450
GPKETSTNGP VSQEAFSVTG PAAPGALPPP SPKLKDEDFP SLSASTSSSC 
       460        470        480        490        500
STAATPGPVG LALPYAIPAR GRSAFQEEDF PALVSSVPKP GTAPTSLVSA 
       510        520        530        540        550
WNSSSSSKKV AQPPLSAQAT GSGQPTRKAG KGSRGGRKGG PPFTQEEEED 
       560        570        580        590        600
GGPALQELLS TRPTGSVSST LGLASIQPSK VGKKKKVGSE KPGTTLPQPP 
       610        620        630        640        650
PATCPPGALQ APEAPASRAE GPVAVVVNGH TEGPAPARSA PKEPPGLPRP 
       660        670        680        690        700
LGSFPCPTPQ EDFPALGGPC PPRMPPPPGF SAVVLLKGTP PPPPPGLVPP 
       710        720        730        740        750
ISKPPPGFSG LLPSPHPACV PSPATTTTTK APRLLPAPRA YLVPENFRER 
       760        770        780        790        800
NLQLIQSIRD FLQSDEARFS EFKSHSGEFR QGLISAAQYY KSCRDLLGEN 
       810        820        830        840        850
FQKVFNELLV LLPDTAKQQE LLSAHTDFCN REKPLSTKSK KNKKSAWQAT 
       860        870        880        890 
TQQAGLDCRV CPTCQQVLAH GDASSHQALH AARDDDFPSL QAIARIIT

Show »

Length:898

Mass (Da):98,124

Checksum:ⁱ1C24E53E1A3573CF

Isoform 4 (identifier: Q86UK7-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-397: Missing.
     398-431: EGPGPKETSTNGPVSQEAFSVTGPAAPGCVGVPG → MVGGCGQPQVGAGRAGMEPRGLIAVDQLCFPAPS
     551-551: Q → QE
     738-904: Missing.

« Hide

        10         20         30         40         50
MVGGCGQPQV GAGRAGMEPR GLIAVDQLCF PAPSALPPPS PKLKDEDFPS 
        60         70         80         90        100
LSASTSSSCS TAATPGPVGL ALPYAIPARG RSAFQEEDFP ALVSSVPKPG 
       110        120        130        140        150
TAPTSLVSAW NSSSSSKKVA QPPLSAQATG SGQPTRKAGK GSRGGRKGGP 
       160        170        180        190        200
PFTQEEEEED GGPALQELLS TRPTGSVSST LGLASIQPSK VGKKKKVGSE 
       210        220        230        240        250
KPGTTLPQPP PATCPPGALQ APEAPASRAE GPVAVVVNGH TEGPAPARSA 
       260        270        280        290        300
PKEPPGLPRP LGSFPCPTPQ EDFPALGGPC PPRMPPPPGF SAVVLLKGTP 
       310        320        330        340 
PPPPPGLVPP ISKPPPGFSG LLPSPHPACV PSPATTTTTK A

Show »

Length:341

Mass (Da):34,010

Checksum:ⁱABB2FDC981BB27EC

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H3BPG6	H3BPG6_HUMAN	RING-type E3 ubiquitin transferase RING-type E3 ubiquitin transferase, EC 2.3.2.27	ZNF598	904	Annotation score:
H3BQQ2	H3BQQ2_HUMAN	E3 ubiquitin-protein ligase ZNF598 E3 ubiquitin-protein ligase ZNF598	ZNF598	849	Annotation score:
H3BR87	H3BR87_HUMAN	E3 ubiquitin-protein ligase ZNF598 E3 ubiquitin-protein ligase ZNF598	ZNF598	203	Annotation score:
H3BPF3	H3BPF3_HUMAN	E3 ubiquitin-protein ligase ZNF598 E3 ubiquitin-protein ligase ZNF598	ZNF598	90	Annotation score:

Sequence cautionⁱ

The sequence BAB15777 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_034470	453	S → Y2 PublicationsCorresponds to variant dbSNP:rs11556528Ensembl.	1
Natural variantⁱVAR_059818	608	A → T2 PublicationsCorresponds to variant dbSNP:rs11248905Ensembl.	1
Natural variantⁱVAR_052147	637	T → M2 PublicationsCorresponds to variant dbSNP:rs2286469Ensembl.	1
Natural variantⁱVAR_034471	725	C → S1 PublicationCorresponds to variant dbSNP:rs2286468Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_020660	1 – 397	Missing in isoform 4. 1 PublicationAdd BLAST	397
Alternative sequenceⁱVSP_020661	335 – 337	Missing in isoform 2. 1 Publication	3
Alternative sequenceⁱVSP_020662	398 – 431	EGPGP…VGVPG → MVGGCGQPQVGAGRAGMEPR GLIAVDQLCFPAPS in isoform 4. 1 PublicationAdd BLAST	34
Alternative sequenceⁱVSP_020663	424 – 429	Missing in isoform 2 and isoform 3. 2 Publications	6
Alternative sequenceⁱVSP_020664	551	Q → QE in isoform 2 and isoform 4. 2 Publications	1
Alternative sequenceⁱVSP_020665	738 – 904	Missing in isoform 4. 1 PublicationAdd BLAST	167

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK024487 mRNA Translation: BAB15777.1 Different initiation. BC010990 mRNA Translation: AAH10990.2 BC041015 mRNA Translation: AAH41015.1 BC050477 mRNA Translation: AAH50477.1 AL834428 mRNA Translation: CAD39089.1
NCBI Reference Sequences More...RefSeqⁱ	NP_835461.2, NM_178167.3

Genome annotation databases

GeneIDⁱ	90850
KEGGⁱ	hsa:90850
UCSC genome browser More...UCSCⁱ	uc002cof.3, human [Q86UK7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
Q86UK7	RING-type E3 ubiquitin transferase		HUMAN		904	UniRef90_Q86UK7
E3 ubiquitin-protein ligase ZNF598		HUMAN		849
Isoform 3 of E3 ubiquitin-protein ligase ZNF598		HUMAN		898
+1
Q86UK7-2	RING-type E3 ubiquitin transferase		PAPAN		903	UniRef90_Q86UK7-2
RING-type E3 ubiquitin transferase		MACMU		899
Zinc finger protein 598		Ugandan red Colobus		899
C2H2-type domain-containing protein		RHIRO		848
Zinc finger protein 598, E3 ubiquitin ligase		MACNE		840
+19

Protein	Similar proteins		Species	Score	Length	Source
Q86UK7	E3 ubiquitin-protein ligase ZNF598		MOUSE		908	UniRef50_Q86UK7
RING-type E3 ubiquitin transferase		HUMAN		904
zinc finger protein 598 isoform X2		MICMU		894
LOW QUALITY PROTEIN: zinc finger protein 598		URSMA		920
RING-type E3 ubiquitin transferase		LYNPA		1041
+106
Q86UK7-2	RING-type E3 ubiquitin transferase		PAPAN		903	UniRef50_Q86UK7-2
RING-type E3 ubiquitin transferase		MACMU		899
Zinc finger protein 598		Ugandan red Colobus		899
C2H2-type domain-containing protein		RHIRO		848
Zinc finger protein 598, E3 ubiquitin ligase		MACNE		840
+668

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK024487 mRNA Translation: BAB15777.1 Different initiation. BC010990 mRNA Translation: AAH10990.2 BC041015 mRNA Translation: AAH41015.1 BC050477 mRNA Translation: AAH50477.1 AL834428 mRNA Translation: CAD39089.1
RefSeqⁱ	NP_835461.2, NM_178167.3

3D structure databases

ModBaseⁱ	Search...
SWISS-MODEL-Workspaceⁱ	Submit a new modelling project...

Protein-protein interaction databases

BioGRIDⁱ	124771, 417 interactors
IntActⁱ	Q86UK7, 27 interactors
MINTⁱ	Q86UK7
STRINGⁱ	9606.ENSP00000411409

PTM databases

GlyGenⁱ	Q86UK7, 1 site, 1 O-linked glycan (1 site)
iPTMnetⁱ	Q86UK7
PhosphoSitePlusⁱ	Q86UK7
SwissPalmⁱ	Q86UK7

Genetic variation databases

BioMutaⁱ	ZNF598
DMDMⁱ	74727495

Proteomic databases

EPDⁱ	Q86UK7
jPOSTⁱ	Q86UK7
MassIVEⁱ	Q86UK7
MaxQBⁱ	Q86UK7
PaxDbⁱ	Q86UK7
PeptideAtlasⁱ	Q86UK7
PRIDEⁱ	Q86UK7
ProteomicsDBⁱ	69826 [Q86UK7-1] 69827 [Q86UK7-2] 69828 [Q86UK7-3] 69829 [Q86UK7-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	90850

DNASUⁱ

90850

Genome annotation databases

GeneIDⁱ	90850
KEGGⁱ	hsa:90850
UCSCⁱ	uc002cof.3, human [Q86UK7-1]

Organism-specific databases

CTDⁱ	90850
DisGeNETⁱ	90850
GeneCardsⁱ	ZNF598
HGNCⁱ	HGNC:28079, ZNF598
MIMⁱ	617508, gene
neXtProtⁱ	NX_Q86UK7
PharmGKBⁱ	PA134944505
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2231, Eukaryota
HOGENOMⁱ	CLU_015828_0_0_1
InParanoidⁱ	Q86UK7
OrthoDBⁱ	1003372at2759
PhylomeDBⁱ	Q86UK7
TreeFamⁱ	TF316196

Enzyme and pathway databases

PathwayCommonsⁱ	Q86UK7
SignaLinkⁱ	Q86UK7

Miscellaneous databases

BioGRID-ORCSⁱ	90850, 28 hits in 305 CRISPR screens
ChiTaRSⁱ	ZNF598, human
GenomeRNAiⁱ	90850
Pharosⁱ	Q86UK7, Tbio
Protein Ontology More...PROⁱ	PR:Q86UK7
RNActⁱ	Q86UK7, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000167962, Expressed in adenohypophysis and 167 other tissues
Genevisibleⁱ	Q86UK7, HS

Family and domain databases

CDDⁱ	cd16615, RING-HC_ZNF598, 1 hit
InterProⁱ	View protein in InterPro IPR041888, RING-HC_ZNF598/Hel2 IPR044288, ZNF598/Hel2 IPR013087, Znf_C2H2_type IPR001841, Znf_RING
PANTHERⁱ	PTHR22938, PTHR22938, 1 hit
SMARTⁱ	View protein in SMART SM00355, ZnF_C2H2, 5 hits
PROSITEⁱ	View protein in PROSITE PS50089, ZF_RING_2, 1 hit PS00028, ZINC_FINGER_C2H2_1, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZN598_HUMAN
Accessionⁱ	Q86UK7Primary (citable) accession number: Q86UK7 Secondary accession number(s): Q8IW49 , Q8N3D9, Q96FG3, Q9H7J3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
	Last sequence update:	June 1, 2003
	Last modified:	February 23, 2022
	This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteome

Documents

Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

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UniProtKB - Q86UK7 (ZN598_HUMAN)

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E3 ubiquitin-protein ligase ZNF598

ZNF598

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

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Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ