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Protein

Solute carrier organic anion transporter family member 6A1

Gene

SLCO6A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.60.1.17 the organo anion transporter (oat) family

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 6A1
Alternative name(s):
Cancer/testis antigen 48
Short name:
CT48
Gonad-specific transporter
Short name:
GST
Organic anion-transporting polypeptide 6A1
Organic anion-transporting polypeptide I
Short name:
OATP-I
Solute carrier family 21 member 19
Gene namesi
Name:SLCO6A1
Synonyms:OATP6A1, SLC21A19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000205359.9
HGNCiHGNC:23613 SLCO6A1
MIMi613365 gene
neXtProtiNX_Q86UG4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 106CytoplasmicSequence analysisAdd BLAST106
Transmembranei107 – 126Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini127 – 145ExtracellularSequence analysisAdd BLAST19
Transmembranei146 – 166Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini167 – 171CytoplasmicSequence analysis5
Transmembranei172 – 196Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini197 – 223ExtracellularSequence analysisAdd BLAST27
Transmembranei224 – 254Helical; Name=4Sequence analysisAdd BLAST31
Topological domaini255 – 274CytoplasmicSequence analysisAdd BLAST20
Transmembranei275 – 295Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini296 – 311ExtracellularSequence analysisAdd BLAST16
Transmembranei312 – 336Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini337 – 378CytoplasmicSequence analysisAdd BLAST42
Transmembranei379 – 400Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini401 – 420ExtracellularSequence analysisAdd BLAST20
Transmembranei421 – 444Helical; Name=8Sequence analysisAdd BLAST24
Topological domaini445 – 448CytoplasmicSequence analysis4
Transmembranei449 – 472Helical; Name=9Sequence analysisAdd BLAST24
Topological domaini473 – 581ExtracellularSequence analysisAdd BLAST109
Transmembranei582 – 604Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini605 – 613CytoplasmicSequence analysis9
Transmembranei614 – 639Helical; Name=11Sequence analysisAdd BLAST26
Topological domaini640 – 673ExtracellularSequence analysisAdd BLAST34
Transmembranei674 – 691Helical; Name=12Sequence analysisAdd BLAST18
Topological domaini692 – 719CytoplasmicSequence analysisAdd BLAST28

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi133482
OpenTargetsiENSG00000205359
PharmGKBiPA134949852

Polymorphism and mutation databases

BioMutaiSLCO6A1
DMDMi160185610

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003076421 – 719Solute carrier organic anion transporter family member 6A1Add BLAST719

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi300N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi497N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi502 ↔ 528PROSITE-ProRule annotation
Disulfide bondi506 ↔ 517PROSITE-ProRule annotation
Disulfide bondi508 ↔ 532PROSITE-ProRule annotation
Glycosylationi546N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi661N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ86UG4
PeptideAtlasiQ86UG4
PRIDEiQ86UG4
ProteomicsDBi69818
69819 [Q86UG4-2]
69820 [Q86UG4-3]

PTM databases

iPTMnetiQ86UG4
PhosphoSitePlusiQ86UG4

Expressioni

Tissue specificityi

Strongly expressed in testis. Weakly expressed in spleen, brain, fetal brain and placenta. Detected in lung tumors.2 Publications

Gene expression databases

BgeeiENSG00000205359 Expressed in 39 organ(s), highest expression level in testis
CleanExiHS_SLCO6A1
ExpressionAtlasiQ86UG4 baseline and differential
GenevisibleiQ86UG4 HS

Organism-specific databases

HPAiHPA054126

Interactioni

Protein-protein interaction databases

BioGridi126359, 13 interactors
STRINGi9606.ENSP00000369135

Structurei

3D structure databases

ProteinModelPortaliQ86UG4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini496 – 551Kazal-likePROSITE-ProRule annotationAdd BLAST56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi89 – 118Cys-richAdd BLAST30

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626 Eukaryota
ENOG410XRSF LUCA
GeneTreeiENSGT00760000119014
HOGENOMiHOG000231270
HOVERGENiHBG100565
InParanoidiQ86UG4
KOiK14357
OMAiSCKALMR
OrthoDBiEOG091G02FX
PhylomeDBiQ86UG4
TreeFamiTF317540

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004156 OATP
PANTHERiPTHR11388 PTHR11388, 1 hit
PfamiView protein in Pfam
PF07648 Kazal_2, 1 hit
PF03137 OATP, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF103473 SSF103473, 3 hits
TIGRFAMsiTIGR00805 oat, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86UG4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFVGVARHSG SQDEVSRGVE PLEAARAQPA KDRRAKGTPK SSKPGKKHRY
60 70 80 90 100
LRLLPEALIR FGGFRKRKKA KSSVSKKPGE VDDSLEQPCG LGCLVSTCCE
110 120 130 140 150
CCNNIRCFMI FYCILLICQG VVFGLIDVSI GDFQKEYQLK TIEKLALEKS
160 170 180 190 200
YDISSGLVAI FIAFYGDRKK VIWFVASSFL IGLGSLLCAF PSINEENKQS
210 220 230 240 250
KVGIEDICEE IKVVSGCQSS GISFQSKYLS FFILGQTVQG IAGMPLYILG
260 270 280 290 300
ITFIDENVAT HSAGIYLGIA ECTSMIGYAL GYVLGAPLVK VPENTTSATN
310 320 330 340 350
TTVNNGSPEW LWTWWINFLF AAVVAWCTLI PLSCFPNNMP GSTRIKARKR
360 370 380 390 400
KQLHFFDSRL KDLKLGTNIK DLCAALWILM KNPVLICLAL SKATEYLVII
410 420 430 440 450
GASEFLPIYL ENQFILTPTV ATTLAGLVLI PGGALGQLLG GVIVSTLEMS
460 470 480 490 500
CKALMRFIMV TSVISLILLV FIIFVRCNPV QFAGINEDYD GTGKLGNLTA
510 520 530 540 550
PCNEKCRCSS SIYSSICGRD DIEYFSPCFA GCTYSKAQNQ KKMYYNCSCI
560 570 580 590 600
KEGLITADAE GDFIDARPGK CDAKCYKLPL FIAFIFSTLI FSGFSGVPIV
610 620 630 640 650
LAMTRVVPDK LRSLALGVSY VILRIFGTIP GPSIFKMSGE TSCILRDVNK
660 670 680 690 700
CGHTGRCWIY NKTKMAFLLV GICFLCKLCT IIFTTIAFFI YKRRLNENTD
710
FPDVTVKNPK VKKKEETDL
Length:719
Mass (Da):79,232
Last modified:October 23, 2007 - v2
Checksum:i56EFD346A8F0569B
GO
Isoform 2 (identifier: Q86UG4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     206-267: Missing.

Note: No experimental confirmation available.
Show »
Length:657
Mass (Da):72,576
Checksum:i9F9946EB3C04FAAC
GO
Isoform 3 (identifier: Q86UG4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     206-267: Missing.
     301-491: Missing.

Note: No experimental confirmation available.
Show »
Length:466
Mass (Da):51,398
Checksum:iF8E2638DFECD13E4
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J020C9J020_HUMAN
Solute carrier organic anion transp...
SLCO6A1
466Annotation score:
H0Y8R6H0Y8R6_HUMAN
Solute carrier organic anion transp...
SLCO6A1
25Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23E → D in BAD18590 (PubMed:14702039).Curated1
Sequence conflicti77 – 79KPG → NRE in AAP33048 (Ref. 1) Curated3
Sequence conflicti300N → K in BAD18590 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03662227A → V. Corresponds to variant dbSNP:rs13190449Ensembl.1
Natural variantiVAR_036623381K → R. Corresponds to variant dbSNP:rs17150488Ensembl.1
Natural variantiVAR_053680527P → A. Corresponds to variant dbSNP:rs10073333Ensembl.1
Natural variantiVAR_036624654T → R1 PublicationCorresponds to variant dbSNP:rs10055840Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_028753206 – 267Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST62
Alternative sequenceiVSP_028754301 – 491Missing in isoform 3. 1 PublicationAdd BLAST191

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY273897 mRNA Translation: AAP33048.1
AF505657 mRNA Translation: AAP30851.1
AK131445 mRNA Translation: BAD18590.1
AC094108 Genomic DNA No translation available.
CH471086 Genomic DNA Translation: EAW49095.1
BC034976 mRNA Translation: AAH34976.1
CCDSiCCDS34206.1 [Q86UG4-1]
CCDS75282.1 [Q86UG4-2]
CCDS78042.1 [Q86UG4-3]
RefSeqiNP_001275931.1, NM_001289002.1 [Q86UG4-1]
NP_001275933.1, NM_001289004.1 [Q86UG4-2]
NP_001294943.1, NM_001308014.1
NP_775759.3, NM_173488.4 [Q86UG4-1]
XP_005271931.1, XM_005271874.3 [Q86UG4-1]
UniGeneiHs.388874

Genome annotation databases

EnsembliENST00000379807; ENSP00000369135; ENSG00000205359 [Q86UG4-1]
ENST00000389019; ENSP00000373671; ENSG00000205359 [Q86UG4-2]
ENST00000506729; ENSP00000421339; ENSG00000205359 [Q86UG4-1]
GeneIDi133482
KEGGihsa:133482
UCSCiuc003knn.5 human [Q86UG4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY273897 mRNA Translation: AAP33048.1
AF505657 mRNA Translation: AAP30851.1
AK131445 mRNA Translation: BAD18590.1
AC094108 Genomic DNA No translation available.
CH471086 Genomic DNA Translation: EAW49095.1
BC034976 mRNA Translation: AAH34976.1
CCDSiCCDS34206.1 [Q86UG4-1]
CCDS75282.1 [Q86UG4-2]
CCDS78042.1 [Q86UG4-3]
RefSeqiNP_001275931.1, NM_001289002.1 [Q86UG4-1]
NP_001275933.1, NM_001289004.1 [Q86UG4-2]
NP_001294943.1, NM_001308014.1
NP_775759.3, NM_173488.4 [Q86UG4-1]
XP_005271931.1, XM_005271874.3 [Q86UG4-1]
UniGeneiHs.388874

3D structure databases

ProteinModelPortaliQ86UG4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126359, 13 interactors
STRINGi9606.ENSP00000369135

Protein family/group databases

TCDBi2.A.60.1.17 the organo anion transporter (oat) family

PTM databases

iPTMnetiQ86UG4
PhosphoSitePlusiQ86UG4

Polymorphism and mutation databases

BioMutaiSLCO6A1
DMDMi160185610

Proteomic databases

PaxDbiQ86UG4
PeptideAtlasiQ86UG4
PRIDEiQ86UG4
ProteomicsDBi69818
69819 [Q86UG4-2]
69820 [Q86UG4-3]

Protocols and materials databases

DNASUi133482
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379807; ENSP00000369135; ENSG00000205359 [Q86UG4-1]
ENST00000389019; ENSP00000373671; ENSG00000205359 [Q86UG4-2]
ENST00000506729; ENSP00000421339; ENSG00000205359 [Q86UG4-1]
GeneIDi133482
KEGGihsa:133482
UCSCiuc003knn.5 human [Q86UG4-1]

Organism-specific databases

CTDi133482
DisGeNETi133482
EuPathDBiHostDB:ENSG00000205359.9
GeneCardsiSLCO6A1
H-InvDBiHIX0024807
HGNCiHGNC:23613 SLCO6A1
HPAiHPA054126
MIMi613365 gene
neXtProtiNX_Q86UG4
OpenTargetsiENSG00000205359
PharmGKBiPA134949852
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3626 Eukaryota
ENOG410XRSF LUCA
GeneTreeiENSGT00760000119014
HOGENOMiHOG000231270
HOVERGENiHBG100565
InParanoidiQ86UG4
KOiK14357
OMAiSCKALMR
OrthoDBiEOG091G02FX
PhylomeDBiQ86UG4
TreeFamiTF317540

Miscellaneous databases

ChiTaRSiSLCO6A1 human
GenomeRNAii133482
PROiPR:Q86UG4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000205359 Expressed in 39 organ(s), highest expression level in testis
CleanExiHS_SLCO6A1
ExpressionAtlasiQ86UG4 baseline and differential
GenevisibleiQ86UG4 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004156 OATP
PANTHERiPTHR11388 PTHR11388, 1 hit
PfamiView protein in Pfam
PF07648 Kazal_2, 1 hit
PF03137 OATP, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF103473 SSF103473, 3 hits
TIGRFAMsiTIGR00805 oat, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSO6A1_HUMAN
AccessioniPrimary (citable) accession number: Q86UG4
Secondary accession number(s): A6NHC1
, Q6ZMY5, Q86UV2, Q8IYU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: September 12, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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