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Entry version 102 (13 Feb 2019)
Sequence version 2 (22 Sep 2009)
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Protein

cTAGE family member 6

Gene

CTAGE6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • lipoprotein transporter activity Source: GO_Central

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
cTAGE family member 6
Short name:
Protein cTAGE-6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CTAGE6
Synonyms:CTAGE6P
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000271321.1

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28644 CTAGE6

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86UF2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei39 – 59HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165617921

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CTAGE6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
259016213

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003841491 – 777cTAGE family member 6Add BLAST777

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86UF2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86UF2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86UF2

PeptideAtlas

More...
PeptideAtlasi
Q86UF2

PRoteomics IDEntifications database

More...
PRIDEi
Q86UF2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
69815

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86UF2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86UF2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000271321 Expressed in 33 organ(s), highest expression level in right testis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86UF2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA000387
HPA000922

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
131033, 3 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q86UF2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q86UF2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili118 – 269Sequence analysisAdd BLAST152
Coiled coili339 – 498Sequence analysisAdd BLAST160

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi691 – 775Pro-richAdd BLAST85

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cTAGE family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153207

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112043

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051216

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86UF2

Database of Orthologous Groups

More...
OrthoDBi
135910at2759

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q86UF2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEPGATPQP YLGLVLEELR RVVAALPESM RPDENPYGFP SELVVCAAVI
60 70 80 90 100
GFFVVLLFLW RSFRSVRSRL YVGREQKLGA TLSGLIEEKC KLLEKFSLIQ
110 120 130 140 150
KEYEGYEVES SLEDASFEKA AAEEARSLEA TCEKLNRSNS ELEDEILCLE
160 170 180 190 200
KDLKEEKSKH SQQDELMADI SKSIQSLEDE SKSLKSQIAE AKIICKTFKM
210 220 230 240 250
SEERRAIAIK DALNENSQLQ TSHKQLFQQE AEVWKGEVSE LNKQKITFED
260 270 280 290 300
SKVHAEQVLN DKENHIKTLT GHLPMMKDQA AVLEEDTTDD DNLELEVNSQ
310 320 330 340 350
WENGANLDDP LKGALKKLIH AAKLNVSLKS LEGERNHIII QLSEVDKTKE
360 370 380 390 400
ELTEHIKNLQ TQQESLQSEN IYFESENQKL QQKLKIMTEF YQEDEMKLYR
410 420 430 440 450
KLTVEENYRI EEEEKLSKVE EKLSRATEQL ETYRKLAKDL EEELERTVHF
460 470 480 490 500
YQKQVISYEK RGHDNWLAAR TAERNLSDLR KENAHNKQKL TETELKFELL
510 520 530 540 550
EKDPNALDVS NTAFGREHAP NGPAPLGQRS SETRAFLSPQ TLLEDPLGLS
560 570 580 590 600
PVLPEGGGRG PRGPGNPLDH QITNERGEPS CDRLTDPHRA PSDTGSLSSP
610 620 630 640 650
VEQDCKMMFP PPGQSYPDSA LPPQREDRFY SNSERLSGSA EPRSFKMTSL
660 670 680 690 700
DKMDGSMPSE MESSRNDAKD DLGNLNVPDS SLPAENEATG PGFIPPPLAP
710 720 730 740 750
VRGPLFPVDT RGPFMRRGPP FPPPPPGTMF GASRGYFPPR DFPGPPHAPF
760 770
AMRNIYPPRG LPPYFHPRPG FYPNPAF
Length:777
Mass (Da):87,900
Last modified:September 22, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCD26899AC51E30C0
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BC043153 differs from that shown. Reason: Frameshift at position 63.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti237E → Q in AAI01324 (PubMed:15489334).Curated1
Sequence conflicti237E → Q in AAI01325 (PubMed:15489334).Curated1
Sequence conflicti296E → K in AAI01324 (PubMed:15489334).Curated1
Sequence conflicti311L → P in AAI01324 (PubMed:15489334).Curated1
Sequence conflicti348T → S in AAI01325 (PubMed:15489334).Curated1
Sequence conflicti364E → A in AAI01325 (PubMed:15489334).Curated1
Sequence conflicti412E → G in BC043153 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC106862 mRNA No translation available.
BC043153 mRNA No translation available.
BC101323 mRNA Translation: AAI01324.1
BC101324 mRNA Translation: AAI01325.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS64790.1

NCBI Reference Sequences

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RefSeqi
NP_848656.2, NM_178561.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.676333

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000470691; ENSP00000474388; ENSG00000271321
ENST00000643756; ENSP00000493497; ENSG00000285123

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
340307

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:340307

UCSC genome browser

More...
UCSCi
uc003wdk.5 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC106862 mRNA No translation available.
BC043153 mRNA No translation available.
BC101323 mRNA Translation: AAI01324.1
BC101324 mRNA Translation: AAI01325.1
CCDSiCCDS64790.1
RefSeqiNP_848656.2, NM_178561.4
UniGeneiHs.676333

3D structure databases

ProteinModelPortaliQ86UF2
SMRiQ86UF2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131033, 3 interactors

PTM databases

iPTMnetiQ86UF2
PhosphoSitePlusiQ86UF2

Polymorphism and mutation databases

BioMutaiCTAGE6
DMDMi259016213

Proteomic databases

EPDiQ86UF2
jPOSTiQ86UF2
MaxQBiQ86UF2
PeptideAtlasiQ86UF2
PRIDEiQ86UF2
ProteomicsDBi69815

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000470691; ENSP00000474388; ENSG00000271321
ENST00000643756; ENSP00000493497; ENSG00000285123
GeneIDi340307
KEGGihsa:340307
UCSCiuc003wdk.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
340307
EuPathDBiHostDB:ENSG00000271321.1

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CTAGE6
HGNCiHGNC:28644 CTAGE6
HPAiHPA000387
HPA000922
neXtProtiNX_Q86UF2
PharmGKBiPA165617921

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000153207
HOGENOMiHOG000112043
HOVERGENiHBG051216
InParanoidiQ86UF2
OrthoDBi135910at2759

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
340307

Protein Ontology

More...
PROi
PR:Q86UF2

Gene expression databases

BgeeiENSG00000271321 Expressed in 33 organ(s), highest expression level in right testis
GenevisibleiQ86UF2 HS

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCTGE6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86UF2
Secondary accession number(s): A4FU29, Q3ZCM5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: September 22, 2009
Last modified: February 13, 2019
This is version 102 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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