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Protein

Tetraspanin-33

Gene

TSPAN33

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26686862). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (PubMed:26686862).By similarity1 Publication

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

GO - Biological processi

  • cell surface receptor signaling pathway Source: GO_Central
  • protein localization to plasma membrane Source: UniProtKB
  • protein maturation Source: UniProtKB

Protein family/group databases

TCDBi8.A.40.1.11 the tetraspanin (tetraspanin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-33
Short name:
Tspan-33
Alternative name(s):
Penumbra
Short name:
hPen
Proerythroblast new membrane
Gene namesi
Name:TSPAN33
Synonyms:PEN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000158457.5
HGNCiHGNC:28743 TSPAN33
MIMi610120 gene
neXtProtiNX_Q86UF1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24CytoplasmicSequence analysisAdd BLAST24
Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Topological domaini46 – 64ExtracellularSequence analysisAdd BLAST19
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Topological domaini86 – 96CytoplasmicSequence analysisAdd BLAST11
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Topological domaini118 – 235ExtracellularSequence analysisAdd BLAST118
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 283CytoplasmicSequence analysisAdd BLAST27

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi340348
OpenTargetsiENSG00000158457
PharmGKBiPA142670690

Polymorphism and mutation databases

BioMutaiTSPAN33
DMDMi74727485

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002829221 – 283Tetraspanin-33Add BLAST283

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ86UF1
MaxQBiQ86UF1
PaxDbiQ86UF1
PeptideAtlasiQ86UF1
PRIDEiQ86UF1
ProteomicsDBi69814

PTM databases

iPTMnetiQ86UF1
PhosphoSitePlusiQ86UF1
SwissPalmiQ86UF1

Expressioni

Tissue specificityi

Predominantly expressed in erythroblasts.1 Publication

Gene expression databases

BgeeiENSG00000158457 Expressed in 196 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_TSPAN33
GenevisibleiQ86UF1 HS

Organism-specific databases

HPAiHPA020357

Interactioni

Subunit structurei

Homodimer; disulfide-linked (PubMed:17158226). Interacts with ADAM10 (PubMed:26686862).2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi131040, 6 interactors
IntActiQ86UF1, 21 interactors
STRINGi9606.ENSP00000289407

Structurei

3D structure databases

ProteinModelPortaliQ86UF1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137851
HOGENOMiHOG000230652
HOVERGENiHBG108605
InParanoidiQ86UF1
KOiK17346
OMAiYRYQGAG
OrthoDBiEOG091G0CHZ
PhylomeDBiQ86UF1
TreeFamiTF313002

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit

Sequencei

Sequence statusi: Complete.

Q86UF1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARRPRAPAA SGEEFSFVSP LVKYLLFFFN MLFWVISMVM VAVGVYARLM
60 70 80 90 100
KHAEAALACL AVDPAILLIV VGVLMFLLTF CGCIGSLREN ICLLQTFSLC
110 120 130 140 150
LTAVFLLQLA AGILGFVFSD KARGKVSEII NNAIVHYRDD LDLQNLIDFG
160 170 180 190 200
QKKFSCCGGI SYKDWSQNMY FNCSEDNPSR ERCSVPYSCC LPTPDQAVIN
210 220 230 240 250
TMCGQGMQAF DYLEASKVIY TNGCIDKLVN WIHSNLFLLG GVALGLAIPQ
260 270 280
LVGILLSQIL VNQIKDQIKL QLYNQQHRAD PWY
Length:283
Mass (Da):31,538
Last modified:June 1, 2003 - v1
Checksum:iA551E9F2EF04FABC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC044244 mRNA Translation: AAH44244.1
AY236849 mRNA Translation: AAO91940.1
AF276891 mRNA Translation: AAQ14314.1
CCDSiCCDS5810.1
RefSeqiNP_848657.1, NM_178562.4
UniGeneiHs.27267

Genome annotation databases

EnsembliENST00000486685; ENSP00000483872; ENSG00000158457
GeneIDi340348
KEGGihsa:340348
UCSCiuc033ahb.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC044244 mRNA Translation: AAH44244.1
AY236849 mRNA Translation: AAO91940.1
AF276891 mRNA Translation: AAQ14314.1
CCDSiCCDS5810.1
RefSeqiNP_848657.1, NM_178562.4
UniGeneiHs.27267

3D structure databases

ProteinModelPortaliQ86UF1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131040, 6 interactors
IntActiQ86UF1, 21 interactors
STRINGi9606.ENSP00000289407

Protein family/group databases

TCDBi8.A.40.1.11 the tetraspanin (tetraspanin) family

PTM databases

iPTMnetiQ86UF1
PhosphoSitePlusiQ86UF1
SwissPalmiQ86UF1

Polymorphism and mutation databases

BioMutaiTSPAN33
DMDMi74727485

Proteomic databases

EPDiQ86UF1
MaxQBiQ86UF1
PaxDbiQ86UF1
PeptideAtlasiQ86UF1
PRIDEiQ86UF1
ProteomicsDBi69814

Protocols and materials databases

DNASUi340348
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000486685; ENSP00000483872; ENSG00000158457
GeneIDi340348
KEGGihsa:340348
UCSCiuc033ahb.2 human

Organism-specific databases

CTDi340348
DisGeNETi340348
EuPathDBiHostDB:ENSG00000158457.5
GeneCardsiTSPAN33
HGNCiHGNC:28743 TSPAN33
HPAiHPA020357
MIMi610120 gene
neXtProtiNX_Q86UF1
OpenTargetsiENSG00000158457
PharmGKBiPA142670690
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137851
HOGENOMiHOG000230652
HOVERGENiHBG108605
InParanoidiQ86UF1
KOiK17346
OMAiYRYQGAG
OrthoDBiEOG091G0CHZ
PhylomeDBiQ86UF1
TreeFamiTF313002

Miscellaneous databases

GenomeRNAii340348
PROiPR:Q86UF1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158457 Expressed in 196 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_TSPAN33
GenevisibleiQ86UF1 HS

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTSN33_HUMAN
AccessioniPrimary (citable) accession number: Q86UF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: June 1, 2003
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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