TSPAN33

Functionⁱ

Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26686862). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (PubMed:26686862).By similarity1 Publication

GO - Molecular functionⁱ

enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 23091066

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell surface receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein localization to plasma membrane
Source: UniProtKB
Inferred from direct assayⁱ
- 23091066
protein maturation
Source: UniProtKB
Inferred from direct assayⁱ
- 23091066

View the complete GO annotation on QuickGO ...

Protein family/group databases

TCDBⁱ	8.A.40.1.11 the tetraspanin (tetraspanin) family

TCDBⁱ

8.A.40.1.11 the tetraspanin (tetraspanin) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tetraspanin-33 Short name: Tspan-33 Alternative name(s): Penumbra Short name: hPen Proerythroblast new membrane
Gene namesⁱ	Name:TSPAN33 Synonyms:PEN
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000158457.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28743 TSPAN33
MIMⁱ	610120 gene
neXtProtⁱ	NX_Q86UF1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 24	CytoplasmicSequence analysisAdd BLAST	24
Transmembraneⁱ	25 – 45	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	46 – 64	ExtracellularSequence analysisAdd BLAST	19
Transmembraneⁱ	65 – 85	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	86 – 96	CytoplasmicSequence analysisAdd BLAST	11
Transmembraneⁱ	97 – 117	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	118 – 235	ExtracellularSequence analysisAdd BLAST	118
Transmembraneⁱ	236 – 256	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	257 – 283	CytoplasmicSequence analysisAdd BLAST	27

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	340348
Open Targets More...OpenTargetsⁱ	ENSG00000158457
PharmGKBⁱ	PA142670690

Polymorphism and mutation databases

BioMutaⁱ	TSPAN33
DMDMⁱ	74727485

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000282922	1 – 283	Tetraspanin-33Add BLAST		283

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	172	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	Q86UF1
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q86UF1
PaxDbⁱ	Q86UF1
PeptideAtlas More...PeptideAtlasⁱ	Q86UF1
PRIDEⁱ	Q86UF1
ProteomicsDBⁱ	69814

PTM databases

iPTMnetⁱ	Q86UF1
PhosphoSitePlusⁱ	Q86UF1
SwissPalmⁱ	Q86UF1

Expressionⁱ

Tissue specificityⁱ

Predominantly expressed in erythroblasts.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000158457 Expressed in 196 organ(s), highest expression level in adult mammalian kidney
CleanExⁱ	HS_TSPAN33
Genevisibleⁱ	Q86UF1 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA020357

HPAⁱ

HPA020357

Interactionⁱ

Subunit structureⁱ

Homodimer; disulfide-linked (PubMed:17158226). Interacts with ADAM10 (PubMed:26686862).2 Publications

GO - Molecular functionⁱ

enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 23091066

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	131040, 6 interactors
IntActⁱ	Q86UF1, 21 interactors
STRINGⁱ	9606.ENSP00000289407

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q86UF1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3882 Eukaryota ENOG4111IRY LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00880000137851
HOGENOMⁱ	HOG000230652
HOVERGENⁱ	HBG108605
InParanoidⁱ	Q86UF1
KEGG Orthology (KO) More...KOⁱ	K17346
OMAⁱ	YRYQGAG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CHZ
PhylomeDBⁱ	Q86UF1
TreeFamⁱ	TF313002

Family and domain databases

Gene3Dⁱ	1.10.1450.10, 1 hit
InterProⁱ	View protein in InterPro IPR000301 Tetraspanin IPR018499 Tetraspanin/Peripherin IPR008952 Tetraspanin_EC2_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00335 Tetraspannin, 1 hit
PIRSFⁱ	PIRSF002419 Tetraspanin, 1 hit
PRINTSⁱ	PR00259 TMFOUR
SUPFAMⁱ	SSF48652 SSF48652, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q86UF1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MARRPRAPAA SGEEFSFVSP LVKYLLFFFN MLFWVISMVM VAVGVYARLM 
        60         70         80         90        100
KHAEAALACL AVDPAILLIV VGVLMFLLTF CGCIGSLREN ICLLQTFSLC 
       110        120        130        140        150
LTAVFLLQLA AGILGFVFSD KARGKVSEII NNAIVHYRDD LDLQNLIDFG 
       160        170        180        190        200
QKKFSCCGGI SYKDWSQNMY FNCSEDNPSR ERCSVPYSCC LPTPDQAVIN 
       210        220        230        240        250
TMCGQGMQAF DYLEASKVIY TNGCIDKLVN WIHSNLFLLG GVALGLAIPQ 
       260        270        280 
LVGILLSQIL VNQIKDQIKL QLYNQQHRAD PWY

Length:283

Mass (Da):31,538

Last modified:June 1, 2003 - v1

Checksum:ⁱA551E9F2EF04FABC

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC044244 mRNA Translation: AAH44244.1 AY236849 mRNA Translation: AAO91940.1 AF276891 mRNA Translation: AAQ14314.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5810.1
NCBI Reference Sequences More...RefSeqⁱ	NP_848657.1, NM_178562.4
UniGeneⁱ	Hs.27267

Genome annotation databases

Ensemblⁱ	ENST00000486685; ENSP00000483872; ENSG00000158457
GeneIDⁱ	340348
KEGGⁱ	hsa:340348
UCSC genome browser More...UCSCⁱ	uc033ahb.2 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q86UF1	Tetraspanin		PANTR		283	UniRef100_Q86UF1
Tetraspanin		NOMLE		283
Tetraspanin		PANPA		260
UPI00027443DB		PANPA		253

Protein	Similar proteins		Species	Score	Length	Source
Q86UF1	Tetraspanin-33		MOUSE		283	UniRef90_Q8R3S2
Tetraspanin-33		BOVIN		283
Tetraspanin		ERIEU		286
Tetraspanin		PANTR		283
Tetraspanin		NOMLE		283
+139

Protein	Similar proteins		Species	Score	Length	Source
Q86UF1	Tetraspanin-33		MOUSE		283	UniRef50_Q8R3S2
Tetraspanin-33		BOVIN		283
Tetraspanin		ERIEU		286
Tetraspanin		PONAB		283
Tetraspanin		MYODS		283
+177

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC044244 mRNA Translation: AAH44244.1 AY236849 mRNA Translation: AAO91940.1 AF276891 mRNA Translation: AAQ14314.1
CCDSⁱ	CCDS5810.1
RefSeqⁱ	NP_848657.1, NM_178562.4
UniGeneⁱ	Hs.27267

3D structure databases

ProteinModelPortalⁱ	Q86UF1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	131040, 6 interactors
IntActⁱ	Q86UF1, 21 interactors
STRINGⁱ	9606.ENSP00000289407

Protein family/group databases

TCDBⁱ	8.A.40.1.11 the tetraspanin (tetraspanin) family

TCDBⁱ

8.A.40.1.11 the tetraspanin (tetraspanin) family

PTM databases

iPTMnetⁱ	Q86UF1
PhosphoSitePlusⁱ	Q86UF1
SwissPalmⁱ	Q86UF1

Polymorphism and mutation databases

BioMutaⁱ	TSPAN33
DMDMⁱ	74727485

Proteomic databases

EPDⁱ	Q86UF1
MaxQBⁱ	Q86UF1
PaxDbⁱ	Q86UF1
PeptideAtlasⁱ	Q86UF1
PRIDEⁱ	Q86UF1
ProteomicsDBⁱ	69814

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	340348
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000486685; ENSP00000483872; ENSG00000158457
GeneIDⁱ	340348
KEGGⁱ	hsa:340348
UCSCⁱ	uc033ahb.2 human

Organism-specific databases

CTDⁱ	340348
DisGeNETⁱ	340348
EuPathDBⁱ	HostDB:ENSG00000158457.5
GeneCardsⁱ	TSPAN33
HGNCⁱ	HGNC:28743 TSPAN33
HPAⁱ	HPA020357
MIMⁱ	610120 gene
neXtProtⁱ	NX_Q86UF1
OpenTargetsⁱ	ENSG00000158457
PharmGKBⁱ	PA142670690
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3882 Eukaryota ENOG4111IRY LUCA
GeneTreeⁱ	ENSGT00880000137851
HOGENOMⁱ	HOG000230652
HOVERGENⁱ	HBG108605
InParanoidⁱ	Q86UF1
KOⁱ	K17346
OMAⁱ	YRYQGAG
OrthoDBⁱ	EOG091G0CHZ
PhylomeDBⁱ	Q86UF1
TreeFamⁱ	TF313002

Miscellaneous databases

GenomeRNAiⁱ	340348
Protein Ontology More...PROⁱ	PR:Q86UF1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000158457 Expressed in 196 organ(s), highest expression level in adult mammalian kidney
CleanExⁱ	HS_TSPAN33
Genevisibleⁱ	Q86UF1 HS

Family and domain databases

Gene3Dⁱ	1.10.1450.10, 1 hit
InterProⁱ	View protein in InterPro IPR000301 Tetraspanin IPR018499 Tetraspanin/Peripherin IPR008952 Tetraspanin_EC2_sf
Pfamⁱ	View protein in Pfam PF00335 Tetraspannin, 1 hit
PIRSFⁱ	PIRSF002419 Tetraspanin, 1 hit
PRINTSⁱ	PR00259 TMFOUR
SUPFAMⁱ	SSF48652 SSF48652, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TSN33_HUMAN
Accessionⁱ	Q86UF1Primary (citable) accession number: Q86UF1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
	Last sequence update:	June 1, 2003
	Last modified:	November 7, 2018
	This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q86UF1 (TSN33_HUMAN)

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Tetraspanin-33

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ