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Entry version 146 (16 Oct 2019)
Sequence version 2 (21 Dec 2004)
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Protein

Protein LYRIC

Gene

MTDH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.4 Publications

Miscellaneous

Knockdown significantly reduces the adhesion of cancer cells to lung microvascular endothelial cells and the reciprocal effect is observed following overexpression.

Caution

Was originally thought to be a type II membrane protein but this is inconsistent with the results of multiple phosphorylation studies because this topology would locate the phosphorylation sites in the lumen or extracellularly rather than in the cytoplasm.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein LYRIC
Alternative name(s):
3D3/LYRIC
Astrocyte elevated gene-1 protein
Short name:
AEG-1
Lysine-rich CEACAM1 co-isolated protein
Metadherin
Metastasis adhesion protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MTDH
Synonyms:AEG1, LYRIC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29608 MTDH

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610323 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86UE4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 48LumenalSequence analysisAdd BLAST48
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Topological domaini70 – 582CytoplasmicSequence analysisAdd BLAST513

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus, Tight junction

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
92140

Open Targets

More...
OpenTargetsi
ENSG00000147649

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671307

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86UE4

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MTDH

Domain mapping of disease mutations (DMDM)

More...
DMDMi
56749088

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000845331 – 582Protein LYRICAdd BLAST582

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei143PhosphothreonineCombined sources1
Modified residuei180PhosphoserineCombined sources1
Modified residuei216PhosphoserineCombined sources1
Modified residuei251PhosphoserineCombined sources1
Modified residuei264N6-acetyllysineBy similarity1
Modified residuei298PhosphoserineCombined sources1
Modified residuei306PhosphoserineCombined sources1
Modified residuei308PhosphoserineCombined sources1
Modified residuei311PhosphoserineCombined sources1
Modified residuei323PhosphoserineCombined sources1
Modified residuei339PhosphoserineCombined sources1
Modified residuei344PhosphoserineCombined sources1
Modified residuei369PhosphoserineCombined sources1
Modified residuei415PhosphoserineCombined sources1
Modified residuei426PhosphoserineCombined sources1
Modified residuei457PhosphoserineBy similarity1
Modified residuei458PhosphothreonineCombined sources1
Modified residuei478PhosphoserineCombined sources1
Modified residuei494PhosphoserineCombined sources1
Modified residuei496PhosphoserineCombined sources1
Modified residuei568PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86UE4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86UE4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q86UE4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86UE4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86UE4

PeptideAtlas

More...
PeptideAtlasi
Q86UE4

PRoteomics IDEntifications database

More...
PRIDEi
Q86UE4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
69809

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q86UE4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86UE4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86UE4

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q86UE4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with highest levels in muscle-dominating organs such as skeletal muscle, heart, tongue and small intestine and in endocrine glands such as thyroid and adrenal gland. Overexpressed in various cancers including breast, brain, prostate, melanoma and glioblastoma multiforme.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By TNF (at protein level). By HIV-1 infection of primary fetal astrocytes.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000147649 Expressed in 248 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86UE4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86UE4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB068204
CAB068205
HPA010932
HPA015104

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with BCCIP, CREBBP/CBP and RELA/p65.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124913, 50 interactors

Protein interaction database and analysis system

More...
IntActi
Q86UE4, 33 interactors

Molecular INTeraction database

More...
MINTi
Q86UE4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000338235

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86UE4

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 71Activation of NF-kappa-BAdd BLAST71
Regioni72 – 169Interaction with BCCIP1 PublicationAdd BLAST98
Regioni101 – 205Interaction with RELA1 PublicationAdd BLAST105
Regioni381 – 443Lung-homing for mammary tumorsBy similarityAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi59 – 67Poly-Leu9
Compositional biasi441 – 451Poly-LysAdd BLAST11
Compositional biasi573 – 577Poly-Lys5

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIV9 Eukaryota
ENOG410YF4D LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154181

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113417

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86UE4

Identification of Orthologs from Complete Genome Data

More...
OMAi
NYEEPPV

Database of Orthologous Groups

More...
OrthoDBi
1432988at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86UE4

TreeFam database of animal gene trees

More...
TreeFami
TF331350

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031402 LYRIC

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15686 LYRIC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q86UE4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAARSWQDEL AQQAEEGSAR LREMLSVGLG FLRTELGLDL GLEPKRYPGW
60 70 80 90 100
VILVGTGALG LLLLFLLGYG WAAACAGARK KRRSPPRKRE EAAAVPAAAP
110 120 130 140 150
DDLALLKNLR SEEQKKKNRK KLSEKPKPNG RTVEVAEGEA VRTPQSVTAK
160 170 180 190 200
QPPEIDKKNE KSKKNKKKSK SDAKAVQNSS RHDGKEVDEG AWETKISHRE
210 220 230 240 250
KRQQRKRDKV LTDSGSLDST IPGIENTITV TTEQLTTASF PVGSKKNKGD
260 270 280 290 300
SHLNVQVSNF KSGKGDSTLQ VSSGLNENLT VNGGGWNEKS VKLSSQISAG
310 320 330 340 350
EEKWNSVSPA SAGKRKTEPS AWSQDTGDAN TNGKDWGRSW SDRSIFSGIG
360 370 380 390 400
STAEPVSQST TSDYQWDVSR NQPYIDDEWS GLNGLSSADP NSDWNAPAEE
410 420 430 440 450
WGNWVDEERA SLLKSQEPIP DDQKVSDDDK EKGEGALPTG KSKKKKKKKK
460 470 480 490 500
KQGEDNSTAQ DTEELEKEIR EDLPVNTSKT RPKQEKAFSL KTISTSDPAE
510 520 530 540 550
VLVKNSQPIK TLPPATSTEP SVILSKSDSD KSSSQVPPIL QETDKSKSNT
560 570 580
KQNSVPPSQT KSETSWESPK QIKKKKKARR ET
Length:582
Mass (Da):63,837
Last modified:December 21, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2460D6218FD3A4C4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RJU9E5RJU9_HUMAN
Protein LYRIC
MTDH
526Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBJ8H0YBJ8_HUMAN
Protein LYRIC
MTDH
188Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YB56H0YB56_HUMAN
Protein LYRIC
MTDH
224Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBE0H0YBE0_HUMAN
Protein LYRIC
MTDH
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti78A → S in AAH09324 (PubMed:15489334).Curated1
Sequence conflicti78A → S in AAH45642 (PubMed:15489334).Curated1
Sequence conflicti145Q → H in AAX84832 (Ref. 4) Curated1
Sequence conflicti543T → A in AAX84832 (Ref. 4) Curated1
Sequence conflicti581E → D in AAX84832 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054661317T → A1 PublicationCorresponds to variant dbSNP:rs17854374Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF501310 mRNA Translation: AAP30791.1
AY082966 mRNA Translation: AAL92861.1
AF411226 mRNA Translation: AAO65771.1
AY974040 mRNA Translation: AAX84832.1
BC009324 mRNA Translation: AAH09324.1
BC014977 mRNA Translation: AAH14977.1
BC045642 mRNA Translation: AAH45642.1
AK000745 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6274.1

NCBI Reference Sequences

More...
RefSeqi
NP_848927.2, NM_178812.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000336273; ENSP00000338235; ENSG00000147649

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
92140

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:92140

UCSC genome browser

More...
UCSCi
uc003yhz.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF501310 mRNA Translation: AAP30791.1
AY082966 mRNA Translation: AAL92861.1
AF411226 mRNA Translation: AAO65771.1
AY974040 mRNA Translation: AAX84832.1
BC009324 mRNA Translation: AAH09324.1
BC014977 mRNA Translation: AAH14977.1
BC045642 mRNA Translation: AAH45642.1
AK000745 mRNA No translation available.
CCDSiCCDS6274.1
RefSeqiNP_848927.2, NM_178812.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4QMGX-ray2.70F/G/H/I/J386-407[»]
SMRiQ86UE4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi124913, 50 interactors
IntActiQ86UE4, 33 interactors
MINTiQ86UE4
STRINGi9606.ENSP00000338235

PTM databases

iPTMnetiQ86UE4
PhosphoSitePlusiQ86UE4
SwissPalmiQ86UE4

Polymorphism and mutation databases

BioMutaiMTDH
DMDMi56749088

Proteomic databases

EPDiQ86UE4
jPOSTiQ86UE4
MassIVEiQ86UE4
MaxQBiQ86UE4
PaxDbiQ86UE4
PeptideAtlasiQ86UE4
PRIDEiQ86UE4
ProteomicsDBi69809
TopDownProteomicsiQ86UE4

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
92140

Genome annotation databases

EnsembliENST00000336273; ENSP00000338235; ENSG00000147649
GeneIDi92140
KEGGihsa:92140
UCSCiuc003yhz.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
92140
DisGeNETi92140

GeneCards: human genes, protein and diseases

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GeneCardsi
MTDH
HGNCiHGNC:29608 MTDH
HPAiCAB068204
CAB068205
HPA010932
HPA015104
MIMi610323 gene
neXtProtiNX_Q86UE4
OpenTargetsiENSG00000147649
PharmGKBiPA142671307

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IIV9 Eukaryota
ENOG410YF4D LUCA
GeneTreeiENSGT00940000154181
HOGENOMiHOG000113417
InParanoidiQ86UE4
OMAiNYEEPPV
OrthoDBi1432988at2759
PhylomeDBiQ86UE4
TreeFamiTF331350

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MTDH human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MTDH

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
92140
PharosiQ86UE4

Protein Ontology

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PROi
PR:Q86UE4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000147649 Expressed in 248 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ86UE4 baseline and differential
GenevisibleiQ86UE4 HS

Family and domain databases

InterProiView protein in InterPro
IPR031402 LYRIC
PfamiView protein in Pfam
PF15686 LYRIC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLYRIC_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86UE4
Secondary accession number(s): Q05DH2
, Q52QU9, Q6PK07, Q8TCX3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 21, 2004
Last modified: October 16, 2019
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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