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Entry version 141 (10 Feb 2021)
Sequence version 2 (30 Aug 2005)
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Protein

Sodium/hydrogen exchanger 9B2

Gene

SLC9B2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Na+/H+ antiporter that extrudes Na+ or Li+ in exchange for external protons across the membrane (PubMed:18000046, PubMed:28154142, PubMed:22948142, PubMed:18508966). Contributes to the regulation of intracellular pH, sodium homeostasis, and cell volume. Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta-cells (By similarity). Involved in sperm motility and fertility (By similarity). It is controversial whether SLC9B2 plays a role in osteoclast differentiation or not (By similarity).By similarity4 Publications

Miscellaneous

Inhibited by phloretin but not by the classical SLC9A-inhibitor amiloride (PubMed:18000046).1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=33 mM for Na+1 Publication
  2. KM=67 mM for Li+1 Publication

    pH dependencei

    Optimum pH is 8.5.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei278Important for cation transport1 Publication1
    Sitei279Important for cation transport1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Biological processAntiport, Hydrogen ion transport, Ion transport, Sodium transport, Transport
    LigandSodium

    Enzyme and pathway databases

    Pathway Commons web resource for biological pathway data

    More...
    PathwayCommonsi
    Q86UD5

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-2672351, Stimuli-sensing channels

    Protein family/group databases

    Transport Classification Database

    More...
    TCDBi
    2.A.36.2.2, the monovalent cation:proton antiporter-1 (cpa1) family

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Sodium/hydrogen exchanger 9B2
    Alternative name(s):
    Na(+)/H(+) exchanger NHA2
    Na(+)/H(+) exchanger-like domain-containing protein 2
    Short name:
    NHE domain-containing protein 2
    Sodium/hydrogen exchanger-like domain-containing protein 2
    Solute carrier family 9 subfamily B member 2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:SLC9B2
    Synonyms:NHA2, NHEDC2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:25143, SLC9B2

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    611789, gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q86UD5

    Eukaryotic Pathogen, Vector and Host Database Resources

    More...
    VEuPathDBi
    HostDB:ENSG00000164038.14

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
    Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
    Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
    Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
    Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
    Transmembranei266 – 286HelicalSequence analysisAdd BLAST21
    Transmembranei307 – 327HelicalSequence analysisAdd BLAST21
    Transmembranei341 – 361HelicalSequence analysisAdd BLAST21
    Transmembranei363 – 383HelicalSequence analysisAdd BLAST21
    Transmembranei388 – 408HelicalSequence analysisAdd BLAST21
    Transmembranei425 – 445HelicalSequence analysisAdd BLAST21
    Transmembranei493 – 513HelicalSequence analysisAdd BLAST21

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cell projection, Cilium, Cytoplasmic vesicle, Endosome, Flagellum, Membrane, Mitochondrion, Synapse

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi278 – 279DD → CC: Loss of ion transport activity; Does not rescue insulin secretion defect induced by knockdown of SLC9B2 in Min6 cells. 2 Publications2
    Mutagenesisi432R → K or H: Loss of ion transport activity;. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    133308

    Open Targets

    More...
    OpenTargetsi
    ENSG00000164038

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA162397515

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q86UD5, Tbio

    Genetic variation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    SLC9B2

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    121944426

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003312701 – 537Sodium/hydrogen exchanger 9B2Add BLAST537

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei49PhosphoserineCombined sources1

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q86UD5

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q86UD5

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q86UD5

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q86UD5

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q86UD5

    PeptideAtlas

    More...
    PeptideAtlasi
    Q86UD5

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q86UD5

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    69803 [Q86UD5-1]
    69804 [Q86UD5-2]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q86UD5

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q86UD5

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Widely expressed (PubMed:18508966). High levels detected in the distal tubules of the kidney nephron (PubMed:18508966). Detected in red blood cells (at protein level) (PubMed:18000046, PubMed:18508966).2 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000164038, Expressed in tibia and 165 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q86UD5, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q86UD5, HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000164038, Tissue enhanced (liver)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer (PubMed:28071645).

    1 Publication

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    126354, 5 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q86UD5, 4 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000378265

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q86UD5, protein

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG3826, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000013285

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_018415_4_1_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q86UD5

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    PAILMCF

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q86UD5

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF319087

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.20.1530.20, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR006153, Cation/H_exchanger
    IPR038770, Na+/solute_symporter_sf
    IPR037072, SLC9B2

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR31102:SF14, PTHR31102:SF14, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00999, Na_H_Exchanger, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q86UD5-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MGDEDKRITY EDSEPSTGMN YTPSMHQEAQ EETVMKLKGI DANEPTEGSI
    60 70 80 90 100
    LLKSSEKKLQ ETPTEANHVQ RLRQMLACPP HGLLDRVITN VTIIVLLWAV
    110 120 130 140 150
    VWSITGSECL PGGNLFGIII LFYCAIIGGK LLGLIKLPTL PPLPSLLGML
    160 170 180 190 200
    LAGFLIRNIP VINDNVQIKH KWSSSLRSIA LSIILVRAGL GLDSKALKKL
    210 220 230 240 250
    KGVCVRLSMG PCIVEACTSA LLAHYLLGLP WQWGFILGFV LGAVSPAVVV
    260 270 280 290 300
    PSMLLLQGGG YGVEKGVPTL LMAAGSFDDI LAITGFNTCL GIAFSTGSTV
    310 320 330 340 350
    FNVLRGVLEV VIGVATGSVL GFFIQYFPSR DQDKLVCKRT FLVLGLSVLA
    360 370 380 390 400
    VFSSVHFGFP GSGGLCTLVM AFLAGMGWTS EKAEVEKIIA VAWDIFQPLL
    410 420 430 440 450
    FGLIGAEVSI ASLRPETVGL CVATVGIAVL IRILTTFLMV CFAGFNLKEK
    460 470 480 490 500
    IFISFAWLPK ATVQAAIGSV ALDTARSHGE KQLEDYGMDV LTVAFLSILI
    510 520 530
    TAPIGSLLIG LLGPRLLQKV EHQNKDEEVQ GETSVQV
    Length:537
    Mass (Da):57,564
    Last modified:August 30, 2005 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i85A8BDA60ABE2587
    GO
    Isoform 2 (identifier: Q86UD5-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         420-502: LCVATVGIAV...VAFLSILITA → SADSITGNFGTERPKLLGPPSTQLRFHFFHIQLST
         503-537: Missing.

    Show »
    Length:454
    Mass (Da):48,710
    Checksum:i75C1A26C290D3908
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    B7Z676B7Z676_HUMAN
    Sodium/hydrogen exchanger 9B2
    SLC9B2
    417Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PE63E9PE63_HUMAN
    Sodium/hydrogen exchanger 9B2
    SLC9B2
    480Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    D6RGJ7D6RGJ7_HUMAN
    Sodium/hydrogen exchanger 9B2
    SLC9B2
    143Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A0C4DGB3A0A0C4DGB3_HUMAN
    Sodium/hydrogen exchanger 9B2
    SLC9B2
    354Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    D6R9P2D6R9P2_HUMAN
    Sodium/hydrogen exchanger 9B2
    SLC9B2
    112Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_042751159I → T. Corresponds to variant dbSNP:rs7672710Ensembl.1
    Natural variantiVAR_042752161V → A. Corresponds to variant dbSNP:rs7672707Ensembl.1
    Natural variantiVAR_042753357F → C. Corresponds to variant dbSNP:rs2276976Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_033152420 – 502LCVAT…ILITA → SADSITGNFGTERPKLLGPP STQLRFHFFHIQLST in isoform 2. 1 PublicationAdd BLAST83
    Alternative sequenceiVSP_033153503 – 537Missing in isoform 2. 1 PublicationAdd BLAST35

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AK172823 mRNA Translation: BAD18790.1
    AC097485 Genomic DNA No translation available.
    CH471057 Genomic DNA Translation: EAX06159.1
    BC009732 mRNA Translation: AAH09732.1
    BC047447 mRNA Translation: AAH47447.2

    The Consensus CDS (CCDS) project

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    CCDSi
    CCDS3662.1 [Q86UD5-1]

    NCBI Reference Sequences

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    RefSeqi
    NP_001287685.1, NM_001300756.1
    NP_849155.2, NM_178833.5 [Q86UD5-1]
    XP_006714148.1, XM_006714085.2

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

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    Ensembli
    ENST00000362026; ENSP00000354574; ENSG00000164038 [Q86UD5-1]
    ENST00000394785; ENSP00000378265; ENSG00000164038 [Q86UD5-1]

    Database of genes from NCBI RefSeq genomes

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    GeneIDi
    133308

    KEGG: Kyoto Encyclopedia of Genes and Genomes

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    KEGGi
    hsa:133308

    UCSC genome browser

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    UCSCi
    uc003hwx.5, human [Q86UD5-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AK172823 mRNA Translation: BAD18790.1
    AC097485 Genomic DNA No translation available.
    CH471057 Genomic DNA Translation: EAX06159.1
    BC009732 mRNA Translation: AAH09732.1
    BC047447 mRNA Translation: AAH47447.2
    CCDSiCCDS3662.1 [Q86UD5-1]
    RefSeqiNP_001287685.1, NM_001300756.1
    NP_849155.2, NM_178833.5 [Q86UD5-1]
    XP_006714148.1, XM_006714085.2

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    BioGRIDi126354, 5 interactors
    IntActiQ86UD5, 4 interactors
    STRINGi9606.ENSP00000378265

    Protein family/group databases

    TCDBi2.A.36.2.2, the monovalent cation:proton antiporter-1 (cpa1) family

    PTM databases

    iPTMnetiQ86UD5
    PhosphoSitePlusiQ86UD5

    Genetic variation databases

    BioMutaiSLC9B2
    DMDMi121944426

    Proteomic databases

    EPDiQ86UD5
    jPOSTiQ86UD5
    MassIVEiQ86UD5
    MaxQBiQ86UD5
    PaxDbiQ86UD5
    PeptideAtlasiQ86UD5
    PRIDEiQ86UD5
    ProteomicsDBi69803 [Q86UD5-1]
    69804 [Q86UD5-2]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    26081, 158 antibodies

    Genome annotation databases

    EnsembliENST00000362026; ENSP00000354574; ENSG00000164038 [Q86UD5-1]
    ENST00000394785; ENSP00000378265; ENSG00000164038 [Q86UD5-1]
    GeneIDi133308
    KEGGihsa:133308
    UCSCiuc003hwx.5, human [Q86UD5-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    133308
    DisGeNETi133308

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    SLC9B2
    HGNCiHGNC:25143, SLC9B2
    HPAiENSG00000164038, Tissue enhanced (liver)
    MIMi611789, gene
    neXtProtiNX_Q86UD5
    OpenTargetsiENSG00000164038
    PharmGKBiPA162397515
    VEuPathDBiHostDB:ENSG00000164038.14

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG3826, Eukaryota
    GeneTreeiENSGT00390000013285
    HOGENOMiCLU_018415_4_1_1
    InParanoidiQ86UD5
    OMAiPAILMCF
    PhylomeDBiQ86UD5
    TreeFamiTF319087

    Enzyme and pathway databases

    PathwayCommonsiQ86UD5
    ReactomeiR-HSA-2672351, Stimuli-sensing channels

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    133308, 4 hits in 874 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    SLC9B2, human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    133308
    PharosiQ86UD5, Tbio

    Protein Ontology

    More...
    PROi
    PR:Q86UD5
    RNActiQ86UD5, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000164038, Expressed in tibia and 165 other tissues
    ExpressionAtlasiQ86UD5, baseline and differential
    GenevisibleiQ86UD5, HS

    Family and domain databases

    Gene3Di1.20.1530.20, 1 hit
    InterProiView protein in InterPro
    IPR006153, Cation/H_exchanger
    IPR038770, Na+/solute_symporter_sf
    IPR037072, SLC9B2
    PANTHERiPTHR31102:SF14, PTHR31102:SF14, 1 hit
    PfamiView protein in Pfam
    PF00999, Na_H_Exchanger, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSL9B2_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86UD5
    Secondary accession number(s): B5ME52, Q6ZMD8, Q96D95
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: August 30, 2005
    Last modified: February 10, 2021
    This is version 141 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. Human variants curated from literature reports
      Index of human variants curated from literature reports
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families
    4. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    5. Human entries with genetic variants
      List of human entries with genetic variants
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