UniProtKB - Q86UD4 (ZN329_HUMAN)
Protein
Zinc finger protein 329
Gene
ZNF329
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 203 – 225 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 231 – 253 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 259 – 281 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 287 – 309 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 315 – 337 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 343 – 365 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 371 – 393 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 399 – 421 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 427 – 449 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 455 – 477 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 483 – 505 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 511 – 533 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q86UD4 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 329 |
Gene namesi | Name:ZNF329 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000181894.14 |
HGNCi | HGNC:14209, ZNF329 |
neXtProti | NX_Q86UD4 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nuclear chromatin Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 79673 |
OpenTargetsi | ENSG00000181894 |
PharmGKBi | PA37858 |
Miscellaneous databases
Pharosi | Q86UD4, Tdark |
Polymorphism and mutation databases
BioMutai | ZNF329 |
DMDMi | 296453050 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000307288 | 1 – 541 | Zinc finger protein 329Add BLAST | 541 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 50 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q86UD4 |
MassIVEi | Q86UD4 |
MaxQBi | Q86UD4 |
PaxDbi | Q86UD4 |
PeptideAtlasi | Q86UD4 |
PRIDEi | Q86UD4 |
ProteomicsDBi | 69802 |
PTM databases
iPTMneti | Q86UD4 |
PhosphoSitePlusi | Q86UD4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000181894, Expressed in amniotic fluid and 224 other tissues |
ExpressionAtlasi | Q86UD4, baseline and differential |
Genevisiblei | Q86UD4, HS |
Organism-specific databases
HPAi | ENSG00000181894, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ86UD4
Protein-protein interaction databases
BioGRIDi | 122798, 28 interactors |
IntActi | Q86UD4, 24 interactors |
MINTi | Q86UD4 |
STRINGi | 9606.ENSP00000470323 |
Miscellaneous databases
RNActi | Q86UD4, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 203 – 225 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 231 – 253 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 259 – 281 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 287 – 309 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 315 – 337 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 343 – 365 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 371 – 393 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 399 – 421 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 427 – 449 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 455 – 477 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 483 – 505 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 511 – 533 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162872 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | Q86UD4 |
OMAi | QEAICEY |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q86UD4 |
TreeFami | TF341817 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 11 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 12 hits |
SUPFAMi | SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 12 hits PS50157, ZINC_FINGER_C2H2_2, 12 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q86UD4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLKMTTRNF PEREVPCDVE VERFTREVPC LSSLGDGWDC ENQEGHLRQS
60 70 80 90 100
ALTLEKPGTQ EAICEYPGFG EHLIASSDLP PSQRVLATNG FHAPDSNVSG
110 120 130 140 150
LDCDPALPSY PKSYADKRTG DSDACGKGFN HSMEVIHGRN PVREKPYKYP
160 170 180 190 200
ESVKSFNHFT SLGHQKIMKR GKKSYEGKNF ENIFTLSSSL NENQRNLPGE
210 220 230 240 250
KQYRCTECGK CFKRNSSLVL HHRTHTGEKP YTCNECGKSF SKNYNLIVHQ
260 270 280 290 300
RIHTGEKPYE CSKCGKAFSD GSALTQHQRI HTGEKPYECL ECGKTFNRNS
310 320 330 340 350
SLILHQRTHT GEKPYRCNEC GKPFTDISHL TVHLRIHTGE KPYECSKCGK
360 370 380 390 400
AFRDGSYLTQ HERTHTGEKP FECAECGKSF NRNSHLIVHQ KIHSGEKPYE
410 420 430 440 450
CKECGKTFIE SAYLIRHQRI HTGEKPYGCN QCQKLFRNIA GLIRHQRTHT
460 470 480 490 500
GEKPYECNQC GKAFRDSSCL TKHQRIHTKE TPYQCPECGK SFKQNSHLAV
510 520 530 540
HQRLHSREGP SRCPQCGKMF QKSSSLVRHQ RAHLGEQPME T
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketM0R136 | M0R136_HUMAN | Zinc finger protein 329 | ZNF329 | 42 | Annotation score: |
Sequence cautioni
The sequence BAB14154 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 122 | S → N in AAH47501 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_060428 | 99 | S → N. Corresponds to variant dbSNP:rs2279333Ensembl. | 1 | |
Natural variantiVAR_035403 | 182 | N → D. Corresponds to variant dbSNP:rs34255209Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK022648 mRNA Translation: BAB14154.1 Different initiation. AK090893 mRNA Translation: BAG52244.1 AK096542 mRNA Translation: BAG53319.1 AC008751 Genomic DNA No translation available. CH471135 Genomic DNA Translation: EAW72560.1 BC047501 mRNA Translation: AAH47501.1 |
CCDSi | CCDS12972.1 |
RefSeqi | NP_078896.3, NM_024620.3 XP_006723444.1, XM_006723381.2 XP_006723445.1, XM_006723382.3 XP_006723446.1, XM_006723383.3 XP_006723447.1, XM_006723384.3 XP_011525617.1, XM_011527315.1 XP_011525618.1, XM_011527316.2 XP_016882796.1, XM_017027307.1 XP_016882797.1, XM_017027308.1 XP_016882798.1, XM_017027309.1 XP_016882799.1, XM_017027310.1 XP_016882800.1, XM_017027311.1 |
Genome annotation databases
Ensembli | ENST00000358067; ENSP00000350773; ENSG00000181894 ENST00000500161; ENSP00000439527; ENSG00000181894 ENST00000597186; ENSP00000470323; ENSG00000181894 ENST00000598312; ENSP00000470008; ENSG00000181894 |
GeneIDi | 79673 |
KEGGi | hsa:79673 |
UCSCi | uc002qrn.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK022648 mRNA Translation: BAB14154.1 Different initiation. AK090893 mRNA Translation: BAG52244.1 AK096542 mRNA Translation: BAG53319.1 AC008751 Genomic DNA No translation available. CH471135 Genomic DNA Translation: EAW72560.1 BC047501 mRNA Translation: AAH47501.1 |
CCDSi | CCDS12972.1 |
RefSeqi | NP_078896.3, NM_024620.3 XP_006723444.1, XM_006723381.2 XP_006723445.1, XM_006723382.3 XP_006723446.1, XM_006723383.3 XP_006723447.1, XM_006723384.3 XP_011525617.1, XM_011527315.1 XP_011525618.1, XM_011527316.2 XP_016882796.1, XM_017027307.1 XP_016882797.1, XM_017027308.1 XP_016882798.1, XM_017027309.1 XP_016882799.1, XM_017027310.1 XP_016882800.1, XM_017027311.1 |
3D structure databases
SMRi | Q86UD4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122798, 28 interactors |
IntActi | Q86UD4, 24 interactors |
MINTi | Q86UD4 |
STRINGi | 9606.ENSP00000470323 |
PTM databases
iPTMneti | Q86UD4 |
PhosphoSitePlusi | Q86UD4 |
Polymorphism and mutation databases
BioMutai | ZNF329 |
DMDMi | 296453050 |
Proteomic databases
EPDi | Q86UD4 |
MassIVEi | Q86UD4 |
MaxQBi | Q86UD4 |
PaxDbi | Q86UD4 |
PeptideAtlasi | Q86UD4 |
PRIDEi | Q86UD4 |
ProteomicsDBi | 69802 |
Protocols and materials databases
Antibodypediai | 19680, 179 antibodies |
DNASUi | 79673 |
Genome annotation databases
Ensembli | ENST00000358067; ENSP00000350773; ENSG00000181894 ENST00000500161; ENSP00000439527; ENSG00000181894 ENST00000597186; ENSP00000470323; ENSG00000181894 ENST00000598312; ENSP00000470008; ENSG00000181894 |
GeneIDi | 79673 |
KEGGi | hsa:79673 |
UCSCi | uc002qrn.4, human |
Organism-specific databases
CTDi | 79673 |
DisGeNETi | 79673 |
EuPathDBi | HostDB:ENSG00000181894.14 |
GeneCardsi | ZNF329 |
HGNCi | HGNC:14209, ZNF329 |
HPAi | ENSG00000181894, Low tissue specificity |
neXtProti | NX_Q86UD4 |
OpenTargetsi | ENSG00000181894 |
PharmGKBi | PA37858 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162872 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | Q86UD4 |
OMAi | QEAICEY |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q86UD4 |
TreeFami | TF341817 |
Enzyme and pathway databases
PathwayCommonsi | Q86UD4 |
Miscellaneous databases
BioGRID-ORCSi | 79673, 2 hits in 865 CRISPR screens |
ChiTaRSi | ZNF329, human |
GenomeRNAii | 79673 |
Pharosi | Q86UD4, Tdark |
PROi | PR:Q86UD4 |
RNActi | Q86UD4, protein |
Gene expression databases
Bgeei | ENSG00000181894, Expressed in amniotic fluid and 224 other tissues |
ExpressionAtlasi | Q86UD4, baseline and differential |
Genevisiblei | Q86UD4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 11 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 12 hits |
SUPFAMi | SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 12 hits PS50157, ZINC_FINGER_C2H2_2, 12 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN329_HUMAN | |
Accessioni | Q86UD4Primary (citable) accession number: Q86UD4 Secondary accession number(s): B3KR32, Q9H9R7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 23, 2007 |
Last sequence update: | May 18, 2010 | |
Last modified: | December 2, 2020 | |
This is version 152 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations