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Entry version 118 (25 May 2022)
Sequence version 1 (01 Jun 2003)
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Protein

Out at first protein homolog

Gene

OAF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q86UD1

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q86UD1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Out at first protein homolog
Alternative name(s):
HCV NS5A-transactivated protein 13 target protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OAF
Synonyms:NS5ATP13TP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28752, OAF

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86UD1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000184232

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
220323

Open Targets

More...
OpenTargetsi
ENSG00000184232

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671234

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86UD1, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
OAF

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74727479

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000029242728 – 273Out at first protein homologAdd BLAST246

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86UD1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86UD1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q86UD1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86UD1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86UD1

PeptideAtlas

More...
PeptideAtlasi
Q86UD1

PRoteomics IDEntifications database

More...
PRIDEi
Q86UD1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
69800

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86UD1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86UD1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000184232, Expressed in liver and 211 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86UD1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86UD1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000184232, Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
128640, 137 interactors

Protein interaction database and analysis system

More...
IntActi
Q86UD1, 18 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000332613

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q86UD1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
Q86UD1

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the OAF family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QWDA, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012008

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_043995_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86UD1

Identification of Orthologs from Complete Genome Data

More...
OMAi
CFITRLH

Database of Orthologous Groups

More...
OrthoDBi
1311469at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86UD1

TreeFam database of animal gene trees

More...
TreeFami
TF323953

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026315, Oaf

The PANTHER Classification System

More...
PANTHERi
PTHR13423, PTHR13423, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14941, OAF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q86UD1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLPGVPLAR PALLLLLPLL APLLGTGAPA ELRVRVRLPD GQVTEESLQA
60 70 80 90 100
DSDADSISLE LRKPDGTLVS FTADFKKDVK VFRALILGEL EKGQSQFQAL
110 120 130 140 150
CFVTQLQHNE IIPSEAMAKL RQKNPRAVRQ AEEVRGLEHL HMDVAVNFSQ
160 170 180 190 200
GALLSPHLHN VCAEAVDAIY TRQEDVRFWL EQGVDSSVFE ALPKASEQAE
210 220 230 240 250
LPRCRQVGDH GKPCVCRYGL SLAWYPCMLK YCHSRDRPTP YKCGIRSCQK
260 270
SYSFDFYVPQ RQLCLWDEDP YPG
Length:273
Mass (Da):30,688
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEC752B522917F496
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PJ29E9PJ29_HUMAN
Out at first protein homolog
OAF
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032993210H → R. Corresponds to variant dbSNP:rs2508489Ensembl.1
Natural variantiVAR_032994217R → H. Corresponds to variant dbSNP:rs2508490Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY459296 mRNA Translation: AAR23238.1
BC047726 mRNA Translation: AAH47726.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8430.1

NCBI Reference Sequences

More...
RefSeqi
NP_848602.1, NM_178507.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000328965.9; ENSP00000332613.3; ENSG00000184232.9

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
220323

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:220323

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...
MANE-Selecti
ENST00000328965.9; ENSP00000332613.3; NM_178507.4; NP_848602.1

UCSC genome browser

More...
UCSCi
uc001pxb.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY459296 mRNA Translation: AAR23238.1
BC047726 mRNA Translation: AAH47726.1
CCDSiCCDS8430.1
RefSeqiNP_848602.1, NM_178507.2

3D structure databases

AlphaFoldDBiQ86UD1
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

BioGRIDi128640, 137 interactors
IntActiQ86UD1, 18 interactors
STRINGi9606.ENSP00000332613

PTM databases

iPTMnetiQ86UD1
PhosphoSitePlusiQ86UD1

Genetic variation databases

BioMutaiOAF
DMDMi74727479

Proteomic databases

EPDiQ86UD1
jPOSTiQ86UD1
MassIVEiQ86UD1
MaxQBiQ86UD1
PaxDbiQ86UD1
PeptideAtlasiQ86UD1
PRIDEiQ86UD1
ProteomicsDBi69800

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
49399, 81 antibodies from 20 providers

The DNASU plasmid repository

More...
DNASUi
220323

Genome annotation databases

EnsembliENST00000328965.9; ENSP00000332613.3; ENSG00000184232.9
GeneIDi220323
KEGGihsa:220323
MANE-SelectiENST00000328965.9; ENSP00000332613.3; NM_178507.4; NP_848602.1
UCSCiuc001pxb.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
220323
DisGeNETi220323

GeneCards: human genes, protein and diseases

More...
GeneCardsi
OAF
HGNCiHGNC:28752, OAF
HPAiENSG00000184232, Tissue enriched (liver)
neXtProtiNX_Q86UD1
OpenTargetsiENSG00000184232
PharmGKBiPA142671234
VEuPathDBiHostDB:ENSG00000184232

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QWDA, Eukaryota
GeneTreeiENSGT00390000012008
HOGENOMiCLU_043995_1_0_1
InParanoidiQ86UD1
OMAiCFITRLH
OrthoDBi1311469at2759
PhylomeDBiQ86UD1
TreeFamiTF323953

Enzyme and pathway databases

PathwayCommonsiQ86UD1
SignaLinkiQ86UD1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
220323, 9 hits in 1074 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
OAF, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
220323
PharosiQ86UD1, Tbio

Protein Ontology

More...
PROi
PR:Q86UD1
RNActiQ86UD1, protein

Gene expression databases

BgeeiENSG00000184232, Expressed in liver and 211 other tissues
ExpressionAtlasiQ86UD1, baseline and differential
GenevisibleiQ86UD1, HS

Family and domain databases

InterProiView protein in InterPro
IPR026315, Oaf
PANTHERiPTHR13423, PTHR13423, 1 hit
PfamiView protein in Pfam
PF14941, OAF, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOAF_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86UD1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 1, 2003
Last modified: May 25, 2022
This is version 118 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
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