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UniProtKB - Q86UB9 (TM135_HUMAN)

Entry version 119 (10 Feb 2021)
Sequence version 2 (25 Nov 2008)
Previous versions | rss
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Protein

Transmembrane protein 135

Gene

TMEM135

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q86UB9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 135
Alternative name(s):
Peroxisomal membrane protein 52By similarity
Short name:
PMP52By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM135Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:26167, TMEM135

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		616360, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q86UB9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000166575.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Transmembranei298 – 318HelicalSequence analysisAdd BLAST21
Transmembranei331 – 351HelicalSequence analysisAdd BLAST21
Transmembranei380 – 400HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane, Mitochondrion, Peroxisome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		65084

Open Targets

More...OpenTargetsi		ENSG00000166575

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA143485658

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q86UB9, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TMEM135

Domain mapping of disease mutations (DMDM)

More...DMDMi		215273901

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002846221 – 458Transmembrane protein 135Add BLAST458

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q86UB9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q86UB9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q86UB9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q86UB9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q86UB9

PeptideAtlas

More...PeptideAtlasi		Q86UB9

PRoteomics IDEntifications database

More...PRIDEi		Q86UB9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		69795 [Q86UB9-1]
69796 [Q86UB9-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q86UB9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q86UB9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Up-regulated in bone marrow-derived mesenchymal stem cells during differentiation into adipocytes compared to osteoblasts.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000166575, Expressed in adipose tissue and 231 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q86UB9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q86UB9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000166575, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122392, 4 interactors

Protein interaction database and analysis system

More...IntActi		Q86UB9, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000306344

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q86UB9, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM135 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1398, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000000303

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_046474_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q86UB9

Identification of Orthologs from Complete Genome Data

More...OMAi		VSTAICF

Database of Orthologous Groups

More...OrthoDBi		706534at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q86UB9

TreeFam database of animal gene trees

More...TreeFami		TF314580

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026749, Tmem135
IPR031926, TMEM135_N

The PANTHER Classification System

More...PANTHERi		PTHR12459, PTHR12459, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15982, TMEM135_C_rich, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86UB9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAALSKSIPH NCYEIGHTWH PSCRVSFLQI TGGALEESLK IYAPLYLIAA 
        60         70         80         90        100
ILRKRKLDYY LHKLLPEILQ SASFLTANGA LYMAFFCILR KILGKFYSWT 
       110        120        130        140        150
PGFGAALPAS YVAILIERKS RRGLLTIYMA NLATETLFRM GVARGTITTL 
       160        170        180        190        200
RNGEVLLFCI TAAMYMFFFR CKDGLKGFTF SALRFIVGKE EIPTHSFSPE 
       210        220        230        240        250
AAYAKVEQKR EQHEEKPGRM NMIGLVRKFV DSICKHGPRH RCCKHYEDNC 
       260        270        280        290        300
ISYCIKGFIR MFSVGYLIQC CLRIPSAFRH LFTQPSRLLS LFYNKENFQL 
       310        320        330        340        350
GAFLGSFVSI YKGTSCFLRW IRNLDDELHA IIAGFLAGIS MMFYKSTTIS 
       360        370        380        390        400
MYLASKLVET MYFKGIEAGK VPYFPHADTI IYSISTAICF QAAVMEVQTL 
       410        420        430        440        450
RPSYWKFLLR LTKGKFAVMN RKVLDVFGTG ASKHFQDFIP RLDPRYTTVT 

PELPTEFS
Length:458
Mass (Da):52,291
Last modified:November 25, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB6BDEC84237D5FE2
GO
Isoform 2 (identifier: Q86UB9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-154: Missing.

Show »
Length:436
Mass (Da):49,914
Checksum:i20F8E048A3421016
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PIS2E9PIS2_HUMAN
Transmembrane protein 135
TMEM135
230Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJX0E9PJX0_HUMAN
Transmembrane protein 135
TMEM135
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQL0E9PQL0_HUMAN
Transmembrane protein 135
TMEM135
329Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15233 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti339I → T in BAB15233 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031787193P → H1 PublicationCorresponds to variant dbSNP:rs17854687Ensembl.1
Natural variantiVAR_031788218G → R3 PublicationsCorresponds to variant dbSNP:rs2276102Ensembl.1
Natural variantiVAR_031789430G → A. Corresponds to variant dbSNP:rs11235097Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_024579133 – 154Missing in isoform 2. 2 PublicationsAdd BLAST22

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL834493 mRNA Translation: CAD39151.1
BX648678 mRNA Translation: CAH10546.1
AP000811 Genomic DNA No translation available.
AP001102 Genomic DNA No translation available.
AP002967 Genomic DNA No translation available.
BC051462 mRNA Translation: AAH51462.2
AK025757 mRNA Translation: BAB15233.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS53692.1 [Q86UB9-2]
CCDS8280.1 [Q86UB9-1]

NCBI Reference Sequences

More...RefSeqi		NP_001162195.1, NM_001168724.1 [Q86UB9-2]
NP_075069.3, NM_022918.3 [Q86UB9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000305494; ENSP00000306344; ENSG00000166575 [Q86UB9-1]
ENST00000340353; ENSP00000345513; ENSG00000166575 [Q86UB9-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		65084

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:65084

UCSC genome browser

More...UCSCi		uc001pch.4, human [Q86UB9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834493 mRNA Translation: CAD39151.1
BX648678 mRNA Translation: CAH10546.1
AP000811 Genomic DNA No translation available.
AP001102 Genomic DNA No translation available.
AP002967 Genomic DNA No translation available.
BC051462 mRNA Translation: AAH51462.2
AK025757 mRNA Translation: BAB15233.1 Different initiation.
CCDSiCCDS53692.1 [Q86UB9-2]
CCDS8280.1 [Q86UB9-1]
RefSeqiNP_001162195.1, NM_001168724.1 [Q86UB9-2]
NP_075069.3, NM_022918.3 [Q86UB9-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi122392, 4 interactors
IntActiQ86UB9, 4 interactors
STRINGi9606.ENSP00000306344

PTM databases

iPTMnetiQ86UB9
PhosphoSitePlusiQ86UB9

Genetic variation databases

BioMutaiTMEM135
DMDMi215273901

Proteomic databases

EPDiQ86UB9
jPOSTiQ86UB9
MassIVEiQ86UB9
MaxQBiQ86UB9
PaxDbiQ86UB9
PeptideAtlasiQ86UB9
PRIDEiQ86UB9
ProteomicsDBi69795 [Q86UB9-1]
69796 [Q86UB9-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31460, 49 antibodies

Genome annotation databases

EnsembliENST00000305494; ENSP00000306344; ENSG00000166575 [Q86UB9-1]
ENST00000340353; ENSP00000345513; ENSG00000166575 [Q86UB9-2]
GeneIDi65084
KEGGihsa:65084
UCSCiuc001pch.4, human [Q86UB9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		65084
DisGeNETi65084

GeneCards: human genes, protein and diseases

More...GeneCardsi		TMEM135
HGNCiHGNC:26167, TMEM135
HPAiENSG00000166575, Low tissue specificity
MIMi616360, gene
neXtProtiNX_Q86UB9
OpenTargetsiENSG00000166575
PharmGKBiPA143485658
VEuPathDBiHostDB:ENSG00000166575.16

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1398, Eukaryota
GeneTreeiENSGT00390000000303
HOGENOMiCLU_046474_0_0_1
InParanoidiQ86UB9
OMAiVSTAICF
OrthoDBi706534at2759
PhylomeDBiQ86UB9
TreeFamiTF314580

Enzyme and pathway databases

PathwayCommonsiQ86UB9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		65084, 4 hits in 878 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TMEM135, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		65084
PharosiQ86UB9, Tdark

Protein Ontology

More...PROi		PR:Q86UB9
RNActiQ86UB9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000166575, Expressed in adipose tissue and 231 other tissues
ExpressionAtlasiQ86UB9, baseline and differential
GenevisibleiQ86UB9, HS

Family and domain databases

InterProiView protein in InterPro
IPR026749, Tmem135
IPR031926, TMEM135_N
PANTHERiPTHR12459, PTHR12459, 1 hit
PfamiView protein in Pfam
PF15982, TMEM135_C_rich, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM135_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86UB9
Secondary accession number(s): Q6AW91, Q8ND01, Q9H6M3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 25, 2008
Last modified: February 10, 2021
This is version 119 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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