UniProtKB - Q86UB9 (TM135_HUMAN)
Protein
Transmembrane protein 135
Gene
TMEM135
Organism
Homo sapiens (Human)
Status
Functioni
Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization.By similarity
GO - Biological processi
- peroxisome organization Source: UniProtKB
- regulation of mitochondrial fission Source: Ensembl
- response to cold Source: Ensembl
- response to food Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | Q86UB9 |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 135Alternative name(s): Peroxisomal membrane protein 52By similarity Short name: PMP52By similarity |
Gene namesi | Name:TMEM135Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26167, TMEM135 |
MIMi | 616360, gene |
neXtProti | NX_Q86UB9 |
VEuPathDBi | HostDB:ENSG00000166575.16 |
Subcellular locationi
Mitochondrion
- Mitochondrion membrane By similarity; Multi-pass membrane protein By similarity
Peroxisome
- Peroxisome membrane By similarity; Multi-pass membrane protein Sequence analysis
Mitochondrion
- mitochondrial membrane Source: UniProtKB-SubCell
Peroxisome
- peroxisomal membrane Source: UniProtKB-SubCell
- peroxisome Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
- lipid droplet Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 68 – 88 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 96 – 116 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 149 – 169 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 298 – 318 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 331 – 351 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 380 – 400 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, Mitochondrion, PeroxisomePathology & Biotechi
Organism-specific databases
DisGeNETi | 65084 |
OpenTargetsi | ENSG00000166575 |
PharmGKBi | PA143485658 |
Miscellaneous databases
Pharosi | Q86UB9, Tdark |
Genetic variation databases
BioMutai | TMEM135 |
DMDMi | 215273901 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000284622 | 1 – 458 | Transmembrane protein 135Add BLAST | 458 |
Proteomic databases
EPDi | Q86UB9 |
jPOSTi | Q86UB9 |
MassIVEi | Q86UB9 |
MaxQBi | Q86UB9 |
PaxDbi | Q86UB9 |
PeptideAtlasi | Q86UB9 |
PRIDEi | Q86UB9 |
ProteomicsDBi | 69795 [Q86UB9-1] 69796 [Q86UB9-2] |
PTM databases
iPTMneti | Q86UB9 |
PhosphoSitePlusi | Q86UB9 |
Expressioni
Developmental stagei
Up-regulated in bone marrow-derived mesenchymal stem cells during differentiation into adipocytes compared to osteoblasts.1 Publication
Gene expression databases
Bgeei | ENSG00000166575, Expressed in adipose tissue and 231 other tissues |
ExpressionAtlasi | Q86UB9, baseline and differential |
Genevisiblei | Q86UB9, HS |
Organism-specific databases
HPAi | ENSG00000166575, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 122392, 5 interactors |
IntActi | Q86UB9, 4 interactors |
STRINGi | 9606.ENSP00000306344 |
Miscellaneous databases
RNActi | Q86UB9, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the TMEM135 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1398, Eukaryota |
GeneTreei | ENSGT00390000000303 |
HOGENOMi | CLU_046474_0_0_1 |
InParanoidi | Q86UB9 |
OMAi | VSTAICF |
OrthoDBi | 706534at2759 |
PhylomeDBi | Q86UB9 |
TreeFami | TF314580 |
Family and domain databases
InterProi | View protein in InterPro IPR026749, Tmem135 IPR031926, TMEM135_N |
PANTHERi | PTHR12459, PTHR12459, 1 hit |
Pfami | View protein in Pfam PF15982, TMEM135_C_rich, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q86UB9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAALSKSIPH NCYEIGHTWH PSCRVSFLQI TGGALEESLK IYAPLYLIAA
60 70 80 90 100
ILRKRKLDYY LHKLLPEILQ SASFLTANGA LYMAFFCILR KILGKFYSWT
110 120 130 140 150
PGFGAALPAS YVAILIERKS RRGLLTIYMA NLATETLFRM GVARGTITTL
160 170 180 190 200
RNGEVLLFCI TAAMYMFFFR CKDGLKGFTF SALRFIVGKE EIPTHSFSPE
210 220 230 240 250
AAYAKVEQKR EQHEEKPGRM NMIGLVRKFV DSICKHGPRH RCCKHYEDNC
260 270 280 290 300
ISYCIKGFIR MFSVGYLIQC CLRIPSAFRH LFTQPSRLLS LFYNKENFQL
310 320 330 340 350
GAFLGSFVSI YKGTSCFLRW IRNLDDELHA IIAGFLAGIS MMFYKSTTIS
360 370 380 390 400
MYLASKLVET MYFKGIEAGK VPYFPHADTI IYSISTAICF QAAVMEVQTL
410 420 430 440 450
RPSYWKFLLR LTKGKFAVMN RKVLDVFGTG ASKHFQDFIP RLDPRYTTVT
PELPTEFS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PIS2 | E9PIS2_HUMAN | Transmembrane protein 135 | TMEM135 | 230 | Annotation score: | ||
E9PJX0 | E9PJX0_HUMAN | Transmembrane protein 135 | TMEM135 | 123 | Annotation score: | ||
E9PQL0 | E9PQL0_HUMAN | Transmembrane protein 135 | TMEM135 | 329 | Annotation score: |
Sequence cautioni
The sequence BAB15233 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 339 | I → T in BAB15233 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_031787 | 193 | P → H1 PublicationCorresponds to variant dbSNP:rs17854687Ensembl. | 1 | |
Natural variantiVAR_031788 | 218 | G → R3 PublicationsCorresponds to variant dbSNP:rs2276102Ensembl. | 1 | |
Natural variantiVAR_031789 | 430 | G → A. Corresponds to variant dbSNP:rs11235097Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_024579 | 133 – 154 | Missing in isoform 2. 2 PublicationsAdd BLAST | 22 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL834493 mRNA Translation: CAD39151.1 BX648678 mRNA Translation: CAH10546.1 AP000811 Genomic DNA No translation available. AP001102 Genomic DNA No translation available. AP002967 Genomic DNA No translation available. BC051462 mRNA Translation: AAH51462.2 AK025757 mRNA Translation: BAB15233.1 Different initiation. |
CCDSi | CCDS53692.1 [Q86UB9-2] CCDS8280.1 [Q86UB9-1] |
RefSeqi | NP_001162195.1, NM_001168724.1 [Q86UB9-2] NP_075069.3, NM_022918.3 [Q86UB9-1] |
Genome annotation databases
Ensembli | ENST00000305494; ENSP00000306344; ENSG00000166575 [Q86UB9-1] ENST00000340353; ENSP00000345513; ENSG00000166575 [Q86UB9-2] |
GeneIDi | 65084 |
KEGGi | hsa:65084 |
UCSCi | uc001pch.4, human [Q86UB9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL834493 mRNA Translation: CAD39151.1 BX648678 mRNA Translation: CAH10546.1 AP000811 Genomic DNA No translation available. AP001102 Genomic DNA No translation available. AP002967 Genomic DNA No translation available. BC051462 mRNA Translation: AAH51462.2 AK025757 mRNA Translation: BAB15233.1 Different initiation. |
CCDSi | CCDS53692.1 [Q86UB9-2] CCDS8280.1 [Q86UB9-1] |
RefSeqi | NP_001162195.1, NM_001168724.1 [Q86UB9-2] NP_075069.3, NM_022918.3 [Q86UB9-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 122392, 5 interactors |
IntActi | Q86UB9, 4 interactors |
STRINGi | 9606.ENSP00000306344 |
PTM databases
iPTMneti | Q86UB9 |
PhosphoSitePlusi | Q86UB9 |
Genetic variation databases
BioMutai | TMEM135 |
DMDMi | 215273901 |
Proteomic databases
EPDi | Q86UB9 |
jPOSTi | Q86UB9 |
MassIVEi | Q86UB9 |
MaxQBi | Q86UB9 |
PaxDbi | Q86UB9 |
PeptideAtlasi | Q86UB9 |
PRIDEi | Q86UB9 |
ProteomicsDBi | 69795 [Q86UB9-1] 69796 [Q86UB9-2] |
Protocols and materials databases
Antibodypediai | 31460, 49 antibodies |
Genome annotation databases
Ensembli | ENST00000305494; ENSP00000306344; ENSG00000166575 [Q86UB9-1] ENST00000340353; ENSP00000345513; ENSG00000166575 [Q86UB9-2] |
GeneIDi | 65084 |
KEGGi | hsa:65084 |
UCSCi | uc001pch.4, human [Q86UB9-1] |
Organism-specific databases
CTDi | 65084 |
DisGeNETi | 65084 |
GeneCardsi | TMEM135 |
HGNCi | HGNC:26167, TMEM135 |
HPAi | ENSG00000166575, Low tissue specificity |
MIMi | 616360, gene |
neXtProti | NX_Q86UB9 |
OpenTargetsi | ENSG00000166575 |
PharmGKBi | PA143485658 |
VEuPathDBi | HostDB:ENSG00000166575.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1398, Eukaryota |
GeneTreei | ENSGT00390000000303 |
HOGENOMi | CLU_046474_0_0_1 |
InParanoidi | Q86UB9 |
OMAi | VSTAICF |
OrthoDBi | 706534at2759 |
PhylomeDBi | Q86UB9 |
TreeFami | TF314580 |
Enzyme and pathway databases
PathwayCommonsi | Q86UB9 |
Miscellaneous databases
BioGRID-ORCSi | 65084, 6 hits in 998 CRISPR screens |
ChiTaRSi | TMEM135, human |
GenomeRNAii | 65084 |
Pharosi | Q86UB9, Tdark |
PROi | PR:Q86UB9 |
RNActi | Q86UB9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000166575, Expressed in adipose tissue and 231 other tissues |
ExpressionAtlasi | Q86UB9, baseline and differential |
Genevisiblei | Q86UB9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026749, Tmem135 IPR031926, TMEM135_N |
PANTHERi | PTHR12459, PTHR12459, 1 hit |
Pfami | View protein in Pfam PF15982, TMEM135_C_rich, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TM135_HUMAN | |
Accessioni | Q86UB9Primary (citable) accession number: Q86UB9 Secondary accession number(s): Q6AW91, Q8ND01, Q9H6M3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 17, 2007 |
Last sequence update: | November 25, 2008 | |
Last modified: | April 7, 2021 | |
This is version 120 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families