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Entry version 130 (16 Oct 2019)
Sequence version 2 (28 Mar 2018)
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Protein

RPA-interacting protein

Gene

RPAIN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri137 – 212RIP-typeAdd BLAST76

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein-containing complex binding Source: MGI

GO - Biological processi

  • DNA-dependent DNA replication Source: MGI
  • DNA recombination Source: MGI
  • DNA repair Source: MGI
  • protein import into nucleus Source: MGI
  • response to UV Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RPA-interacting protein
Short name:
hRIP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPAIN
Synonyms:RIP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28641 RPAIN

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617299 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86UA6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi114K → R: Abolishes sumoylation; when associated with R-121 and R-142. 1 Publication1
Mutagenesisi121K → R: Induces a strong decrease in sumoylation; when associated with N-103. Abolishes sumoylation; when associated with R-114 and R-142. 1 Publication1
Mutagenesisi142K → R: Abolishes sumoylation; when associated with R-114 and R-121. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
84268

Open Targets

More...
OpenTargetsi
ENSG00000129197

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA145007849

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86UA6

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RPAIN

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74727468

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000762991 – 219RPA-interacting proteinAdd BLAST219

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei18PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki121Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); in isoform 21 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Isoform 2: sumoylated. Sumoylation is required for localization in the nuclear PML body and transport of RPA complex in PML body. Upon UV irradiation and during S phase, it is desumoylated, releasing RPA complex that is translocated to sites of DNA damage. Sumoylation takes place at different Lys residues. Variant 'Lys-103' adds a sumoylation site and increases total sumoylation levels.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q86UA6

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q86UA6

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q86UA6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86UA6

PeptideAtlas

More...
PeptideAtlasi
Q86UA6

PRoteomics IDEntifications database

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PRIDEi
Q86UA6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
19663
19952
69786 [Q86UA6-1]
69787 [Q86UA6-2]
69788 [Q86UA6-3]
69789 [Q86UA6-4]
69790 [Q86UA6-5]
69791 [Q86UA6-6]
69792 [Q86UA6-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86UA6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86UA6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed in pancreas, kidney, muscle, liver, lung, placenta, brain, heart, leukocytes, colon, intestine, ovary, testis, prostate, thymus and spleen.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000129197 Expressed in 197 organ(s), highest expression level in quadriceps femoris

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q86UA6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86UA6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA023924
HPA031526

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the RPA1 subunit of RPA complex.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
123995, 10 interactors

Protein interaction database and analysis system

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IntActi
Q86UA6, 9 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000385814

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q86UA6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni164 – 180Mediates nuclear exportAdd BLAST17

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri137 – 212RIP-typeAdd BLAST76

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IX54 Eukaryota
ENOG4111K6G LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006416

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000251596

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86UA6

Identification of Orthologs from Complete Genome Data

More...
OMAi
EHSTHCP

Database of Orthologous Groups

More...
OrthoDBi
1518754at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86UA6

TreeFam database of animal gene trees

More...
TreeFami
TF326215

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR028156 RIP
IPR028159 RPA_interact_C_dom
IPR028155 RPA_interact_central
IPR028158 RPA_interact_N_dom

The PANTHER Classification System

More...
PANTHERi
PTHR31742 PTHR31742, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14768 RPA_interact_C, 1 hit
PF14767 RPA_interact_M, 1 hit
PF14766 RPA_interact_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (9)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 9 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q86UA6-1) [UniParc]FASTAAdd to basket
Also known as: Alpha, hRIPalpha

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAESLRSPRR SLYKLVGSPP WKEAFRQRCL ERMRNSRDRL LNRYRQAGSS
60 70 80 90 100
GPGNSQNSFL VQEVMEEEWN ALQSVENCPE DLAQLEELID MAVLEEIQQE
110 120 130 140 150
LINQEQSIIS EYEKSLQFDE KCLSIMLAEW EANPLICPVC TKYNLRITSG
160 170 180 190 200
VVVCQCGLSI PSHSSELTEQ KLRACLEGSI NEHSAHCPHT PEFSVTGGTE
210
EKSSLLMSCL ACDTWAVIL
Note: Major isoform with isoform 2.
Length:219
Mass (Da):24,770
Last modified:March 28, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBAF576893B8B1B23
GO
Isoform 2 (identifier: Q86UA6-2) [UniParc]FASTAAdd to basket
Also known as: Beta, hRIPbeta

The sequence of this isoform differs from the canonical sequence as follows:
     164-210: Missing.

Note: Major isoform with isoform 1.
Show »
Length:172
Mass (Da):19,712
Checksum:i0F3FF24C142EA4F4
GO
Isoform 3 (identifier: Q86UA6-3) [UniParc]FASTAAdd to basket
Also known as: Gamma2

The sequence of this isoform differs from the canonical sequence as follows:
     143-219: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. May be due to an intron retention.
Show »
Length:142
Mass (Da):16,511
Checksum:iB4DD41B3708D8E5F
GO
Isoform 4 (identifier: Q86UA6-4) [UniParc]FASTAAdd to basket
Also known as: Gamma1

The sequence of this isoform differs from the canonical sequence as follows:
     142-145: KYNL → NLLS
     146-219: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:145
Mass (Da):16,810
Checksum:iA7977963AD41B370
GO
Isoform 5 (identifier: Q86UA6-5) [UniParc]FASTAAdd to basket
Also known as: Delta2

The sequence of this isoform differs from the canonical sequence as follows:
     105-106: EQ → VF
     107-219: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:106
Mass (Da):12,385
Checksum:i184280616713B68C
GO
Isoform 6 (identifier: Q86UA6-6) [UniParc]FASTAAdd to basket
Also known as: Delta3

The sequence of this isoform differs from the canonical sequence as follows:
     105-106: EQ → GL
     107-219: Missing.

Show »
Length:106
Mass (Da):12,309
Checksum:i16B830616713B68C
GO
Isoform 7 (identifier: Q86UA6-7) [UniParc]FASTAAdd to basket
Also known as: Delta1, Delta 4

The sequence of this isoform differs from the canonical sequence as follows:
     105-107: EQS → GTT
     108-219: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:107
Mass (Da):12,398
Checksum:iA2803830616713B6
GO
Isoform 8 (identifier: Q86UA6-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     211-219: ACDTWAVIL → VSVSWDPLCGKRDLWLVLFPP

Note: No experimental confirmation available.
Show »
Length:231
Mass (Da):26,207
Checksum:i216DCFE77EF90199
GO
Isoform 9 (identifier: Q86UA6-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-219: YNLRITSGVV...LACDTWAVIL → PVILGL

Note: No experimental confirmation available.
Show »
Length:148
Mass (Da):17,103
Checksum:i0A6FE6F2628924DD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_023947103N → K Common polymorphism; sumoylated and increases total protein sumoylation levels. 4 PublicationsCorresponds to variant dbSNP:rs12761Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_016402105 – 107EQS → GTT in isoform 7. 2 Publications3
Alternative sequenceiVSP_016403105 – 106EQ → VF in isoform 5. 2 Publications2
Alternative sequenceiVSP_016404105 – 106EQ → GL in isoform 6. 3 Publications2
Alternative sequenceiVSP_016405107 – 219Missing in isoform 5 and isoform 6. 3 PublicationsAdd BLAST113
Alternative sequenceiVSP_016406108 – 219Missing in isoform 7. 2 PublicationsAdd BLAST112
Alternative sequenceiVSP_016407142 – 145KYNL → NLLS in isoform 4. 3 Publications4
Alternative sequenceiVSP_016408143 – 219Missing in isoform 3. 2 PublicationsAdd BLAST77
Alternative sequenceiVSP_046795143 – 219YNLRI…WAVIL → PVILGL in isoform 9. CuratedAdd BLAST77
Alternative sequenceiVSP_016409146 – 219Missing in isoform 4. 3 PublicationsAdd BLAST74
Alternative sequenceiVSP_016410164 – 210Missing in isoform 2. 2 PublicationsAdd BLAST47
Alternative sequenceiVSP_045356211 – 219ACDTWAVIL → VSVSWDPLCGKRDLWLVLFP P in isoform 8. 1 Publication9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY775314 mRNA Translation: AAX14368.1
AY775315 mRNA Translation: AAX14369.1
AY775316 mRNA Translation: AAX14370.1
AY775317 mRNA Translation: AAX14371.1
AY775318 mRNA Translation: AAX14372.1
AY775319 mRNA Translation: AAX14373.1
AY775320 mRNA Translation: AAX14374.1
AY775321 mRNA Translation: AAX14375.1
AY775323 mRNA Translation: AAX14377.1
AY680654 mRNA Translation: AAT80872.1
AY680655 mRNA Translation: AAT80873.1
AY680656 mRNA Translation: AAT80874.1
AY680657 mRNA Translation: AAT80875.1
AY680658 mRNA Translation: AAT80876.1
AY680659 mRNA Translation: AAT80877.1
AY680660 mRNA Translation: AAT80878.1
AK295394 mRNA Translation: BAG58348.1
AK300409 mRNA Translation: BAG62139.1
CH471108 Genomic DNA Translation: EAW90338.1
AC004148 Genomic DNA No translation available.
BC004451 mRNA Translation: AAH04451.1
BC046349 mRNA Translation: AAH46349.1
BC051849 mRNA Translation: AAH51849.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32536.1 [Q86UA6-1]
CCDS54075.1 [Q86UA6-8]
CCDS54076.1 [Q86UA6-2]
CCDS54077.1 [Q86UA6-9]
CCDS54079.1 [Q86UA6-6]

NCBI Reference Sequences

More...
RefSeqi
NP_001028174.2, NM_001033002.3 [Q86UA6-1]
NP_001153715.1, NM_001160243.1 [Q86UA6-8]
NP_001153716.1, NM_001160244.1 [Q86UA6-2]
NP_001153718.1, NM_001160246.1 [Q86UA6-6]
NP_001153738.1, NM_001160266.1 [Q86UA6-9]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000327154; ENSP00000315069; ENSG00000129197 [Q86UA6-9]
ENST00000381208; ENSP00000370605; ENSG00000129197 [Q86UA6-2]
ENST00000381209; ENSP00000370606; ENSG00000129197 [Q86UA6-1]
ENST00000405578; ENSP00000385814; ENSG00000129197 [Q86UA6-8]
ENST00000536255; ENSP00000439939; ENSG00000129197 [Q86UA6-6]
ENST00000539417; ENSP00000446453; ENSG00000129197 [Q86UA6-4]
ENST00000571558; ENSP00000458699; ENSG00000129197 [Q86UA6-7]
ENST00000573577; ENSP00000460162; ENSG00000129197 [Q86UA6-7]
ENST00000574003; ENSP00000467178; ENSG00000129197 [Q86UA6-5]
ENST00000575112; ENSP00000460354; ENSG00000129197 [Q86UA6-7]
ENST00000575599; ENSP00000458218; ENSG00000129197 [Q86UA6-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84268

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84268

UCSC genome browser

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UCSCi
uc002gbw.3 human [Q86UA6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY775314 mRNA Translation: AAX14368.1
AY775315 mRNA Translation: AAX14369.1
AY775316 mRNA Translation: AAX14370.1
AY775317 mRNA Translation: AAX14371.1
AY775318 mRNA Translation: AAX14372.1
AY775319 mRNA Translation: AAX14373.1
AY775320 mRNA Translation: AAX14374.1
AY775321 mRNA Translation: AAX14375.1
AY775323 mRNA Translation: AAX14377.1
AY680654 mRNA Translation: AAT80872.1
AY680655 mRNA Translation: AAT80873.1
AY680656 mRNA Translation: AAT80874.1
AY680657 mRNA Translation: AAT80875.1
AY680658 mRNA Translation: AAT80876.1
AY680659 mRNA Translation: AAT80877.1
AY680660 mRNA Translation: AAT80878.1
AK295394 mRNA Translation: BAG58348.1
AK300409 mRNA Translation: BAG62139.1
CH471108 Genomic DNA Translation: EAW90338.1
AC004148 Genomic DNA No translation available.
BC004451 mRNA Translation: AAH04451.1
BC046349 mRNA Translation: AAH46349.1
BC051849 mRNA Translation: AAH51849.1
CCDSiCCDS32536.1 [Q86UA6-1]
CCDS54075.1 [Q86UA6-8]
CCDS54076.1 [Q86UA6-2]
CCDS54077.1 [Q86UA6-9]
CCDS54079.1 [Q86UA6-6]
RefSeqiNP_001028174.2, NM_001033002.3 [Q86UA6-1]
NP_001153715.1, NM_001160243.1 [Q86UA6-8]
NP_001153716.1, NM_001160244.1 [Q86UA6-2]
NP_001153718.1, NM_001160246.1 [Q86UA6-6]
NP_001153738.1, NM_001160266.1 [Q86UA6-9]

3D structure databases

SMRiQ86UA6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi123995, 10 interactors
IntActiQ86UA6, 9 interactors
STRINGi9606.ENSP00000385814

PTM databases

iPTMnetiQ86UA6
PhosphoSitePlusiQ86UA6

Polymorphism and mutation databases

BioMutaiRPAIN
DMDMi74727468

Proteomic databases

EPDiQ86UA6
jPOSTiQ86UA6
MassIVEiQ86UA6
PaxDbiQ86UA6
PeptideAtlasiQ86UA6
PRIDEiQ86UA6
ProteomicsDBi19663
19952
69786 [Q86UA6-1]
69787 [Q86UA6-2]
69788 [Q86UA6-3]
69789 [Q86UA6-4]
69790 [Q86UA6-5]
69791 [Q86UA6-6]
69792 [Q86UA6-7]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
84268

Genome annotation databases

EnsembliENST00000327154; ENSP00000315069; ENSG00000129197 [Q86UA6-9]
ENST00000381208; ENSP00000370605; ENSG00000129197 [Q86UA6-2]
ENST00000381209; ENSP00000370606; ENSG00000129197 [Q86UA6-1]
ENST00000405578; ENSP00000385814; ENSG00000129197 [Q86UA6-8]
ENST00000536255; ENSP00000439939; ENSG00000129197 [Q86UA6-6]
ENST00000539417; ENSP00000446453; ENSG00000129197 [Q86UA6-4]
ENST00000571558; ENSP00000458699; ENSG00000129197 [Q86UA6-7]
ENST00000573577; ENSP00000460162; ENSG00000129197 [Q86UA6-7]
ENST00000574003; ENSP00000467178; ENSG00000129197 [Q86UA6-5]
ENST00000575112; ENSP00000460354; ENSG00000129197 [Q86UA6-7]
ENST00000575599; ENSP00000458218; ENSG00000129197 [Q86UA6-5]
GeneIDi84268
KEGGihsa:84268
UCSCiuc002gbw.3 human [Q86UA6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84268
DisGeNETi84268

GeneCards: human genes, protein and diseases

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GeneCardsi
RPAIN
HGNCiHGNC:28641 RPAIN
HPAiHPA023924
HPA031526
MIMi617299 gene
neXtProtiNX_Q86UA6
OpenTargetsiENSG00000129197
PharmGKBiPA145007849

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IX54 Eukaryota
ENOG4111K6G LUCA
GeneTreeiENSGT00390000006416
HOGENOMiHOG000251596
InParanoidiQ86UA6
OMAiEHSTHCP
OrthoDBi1518754at2759
PhylomeDBiQ86UA6
TreeFamiTF326215

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RPAIN human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RPAIN

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84268
PharosiQ86UA6

Protein Ontology

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PROi
PR:Q86UA6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000129197 Expressed in 197 organ(s), highest expression level in quadriceps femoris
ExpressionAtlasiQ86UA6 baseline and differential
GenevisibleiQ86UA6 HS

Family and domain databases

InterProiView protein in InterPro
IPR028156 RIP
IPR028159 RPA_interact_C_dom
IPR028155 RPA_interact_central
IPR028158 RPA_interact_N_dom
PANTHERiPTHR31742 PTHR31742, 1 hit
PfamiView protein in Pfam
PF14768 RPA_interact_C, 1 hit
PF14767 RPA_interact_M, 1 hit
PF14766 RPA_interact_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRIP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86UA6
Secondary accession number(s): A0A0B4J1T3
, B4DI36, B4DTX7, E9PDG9, E9PES3, J3KNH8, Q4G2Y0, Q4G2Y5, Q4G2Y8, Q6B4V9, Q6B4W0, Q6B4W1, Q6B4W4, Q86X49, Q9BT00
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 28, 2018
Last modified: October 16, 2019
This is version 130 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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