UniProtKB - Q86U90 (YRDC_HUMAN)
Protein
YrdC domain-containing protein, mitochondrial
Gene
YRDC
Organism
Homo sapiens (Human)
Status
Functioni
May regulate the activity of some transporters.By similarity
GO - Molecular functioni
- double-stranded RNA binding Source: InterPro
- nucleotidyltransferase activity Source: GO_Central
- tRNA binding Source: GO_Central
GO - Biological processi
- negative regulation of transport Source: MGI
- regulation of translational fidelity Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q86U90 |
Names & Taxonomyi
Protein namesi | Recommended name: YrdC domain-containing protein, mitochondrialAlternative name(s): Dopamine receptor-interacting protein 3 Ischemia/reperfusion-inducible protein homolog Short name: hIRIP |
Gene namesi | Name:YRDC Synonyms:DRIP3, IRIP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28905, YRDC |
MIMi | 612276, gene |
neXtProti | NX_Q86U90 |
VEuPathDBi | HostDB:ENSG00000196449.3 |
Subcellular locationi
Mitochondrion
- Mitochondrion Curated
Other locations
Note: Predominantly localized in the plasma membrane.By similarity
Mitochondrion
- mitochondrion Source: UniProtKB-SubCell
Other locations
Keywords - Cellular componenti
Membrane, MitochondrionPathology & Biotechi
Organism-specific databases
DisGeNETi | 79693 |
OpenTargetsi | ENSG00000196449 |
PharmGKBi | PA142670553 |
Miscellaneous databases
Pharosi | Q86U90, Tdark |
Genetic variation databases
BioMutai | YRDC |
DMDMi | 74750410 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 55 | MitochondrionSequence analysisAdd BLAST | 55 | |
ChainiPRO_0000341402 | 56 – 279 | YrdC domain-containing protein, mitochondrialAdd BLAST | 224 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 60 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q86U90 |
jPOSTi | Q86U90 |
MassIVEi | Q86U90 |
MaxQBi | Q86U90 |
PaxDbi | Q86U90 |
PeptideAtlasi | Q86U90 |
PRIDEi | Q86U90 |
ProteomicsDBi | 69783 |
PTM databases
GlyGeni | Q86U90, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q86U90 |
PhosphoSitePlusi | Q86U90 |
Expressioni
Tissue specificityi
Ubiquitously expressed.1 Publication
Gene expression databases
Bgeei | ENSG00000196449, Expressed in bone marrow and 214 other tissues |
Genevisiblei | Q86U90, HS |
Organism-specific databases
HPAi | ENSG00000196449, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with RSC1A1.
By similarityBinary interactionsi
Hide detailsQ86U90
With | #Exp. | IntAct |
---|---|---|
BAG6 - isoform 2 [P46379-2] | 3 | EBI-21659356,EBI-10988864 |
DNALI1 [O14645] | 3 | EBI-21659356,EBI-395638 |
KLF11 [O14901] | 3 | EBI-21659356,EBI-948266 |
NUP58 [Q9BVL2] | 3 | EBI-21659356,EBI-2811583 |
Protein-protein interaction databases
BioGRIDi | 122814, 12 interactors |
IntActi | Q86U90, 7 interactors |
STRINGi | 9606.ENSP00000362135 |
Miscellaneous databases
RNActi | Q86U90, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 67 – 257 | YrdC-likePROSITE-ProRule annotationAdd BLAST | 191 |
Sequence similaritiesi
Belongs to the SUA5 family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG3051, Eukaryota |
GeneTreei | ENSGT00390000015364 |
HOGENOMi | CLU_031397_5_0_1 |
InParanoidi | Q86U90 |
OMAi | WHEQPLA |
OrthoDBi | 1027994at2759 |
PhylomeDBi | Q86U90 |
TreeFami | TF314358 |
Family and domain databases
InterProi | View protein in InterPro IPR017945, DHBP_synth_RibB-like_a/b_dom IPR006070, YrdC-like_dom |
Pfami | View protein in Pfam PF01300, Sua5_yciO_yrdC, 1 hit |
SUPFAMi | SSF55821, SSF55821, 1 hit |
TIGRFAMsi | TIGR00057, TIGR00057, 1 hit |
PROSITEi | View protein in PROSITE PS51163, YRDC, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q86U90-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSPARRCRGM RAAVAASVGL SEGPAGSRSG RLFRPPSPAP AAPGARLLRL
60 70 80 90 100
PGSGAVQAAS PERAGWTEAL RAAVAELRAG AVVAVPTDTL YGLACAASCS
110 120 130 140 150
AALRAVYRLK GRSEAKPLAV CLGRVADVYR YCRVRVPEGL LKDLLPGPVT
160 170 180 190 200
LVMERSEELN KDLNPFTPLV GIRIPDHAFM QDLAQMFEGP LALTSANLSS
210 220 230 240 250
QASSLNVEEF QDLWPQLSLV IDGGQIGDGQ SPECRLGSTV VDLSVPGKFG
260 270
IIRPGCALES TTAILQQKYG LLPSHASYL
Sequence cautioni
The sequence AAH08984 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAP37053 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAP37054 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15668 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY172561 mRNA Translation: AAO41711.1 AL929472 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07317.1 BC008984 mRNA Translation: AAH08984.3 Different initiation. BC067857 mRNA Translation: AAH67857.2 BC068057 mRNA Translation: AAH68057.1 BC080186 mRNA Translation: AAH80186.2 AY286019 mRNA Translation: AAP37053.1 Different initiation. AY286020 mRNA Translation: AAP37054.1 Different initiation. AF250397 mRNA Translation: AAQ14263.1 AK027129 mRNA Translation: BAB15668.1 Different initiation. |
CCDSi | CCDS30675.1 |
RefSeqi | NP_078916.3, NM_024640.3 |
Genome annotation databases
Ensembli | ENST00000373044; ENSP00000362135; ENSG00000196449 |
GeneIDi | 79693 |
KEGGi | hsa:79693 |
UCSCi | uc001cca.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY172561 mRNA Translation: AAO41711.1 AL929472 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07317.1 BC008984 mRNA Translation: AAH08984.3 Different initiation. BC067857 mRNA Translation: AAH67857.2 BC068057 mRNA Translation: AAH68057.1 BC080186 mRNA Translation: AAH80186.2 AY286019 mRNA Translation: AAP37053.1 Different initiation. AY286020 mRNA Translation: AAP37054.1 Different initiation. AF250397 mRNA Translation: AAQ14263.1 AK027129 mRNA Translation: BAB15668.1 Different initiation. |
CCDSi | CCDS30675.1 |
RefSeqi | NP_078916.3, NM_024640.3 |
3D structure databases
SMRi | Q86U90 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122814, 12 interactors |
IntActi | Q86U90, 7 interactors |
STRINGi | 9606.ENSP00000362135 |
PTM databases
GlyGeni | Q86U90, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q86U90 |
PhosphoSitePlusi | Q86U90 |
Genetic variation databases
BioMutai | YRDC |
DMDMi | 74750410 |
Proteomic databases
EPDi | Q86U90 |
jPOSTi | Q86U90 |
MassIVEi | Q86U90 |
MaxQBi | Q86U90 |
PaxDbi | Q86U90 |
PeptideAtlasi | Q86U90 |
PRIDEi | Q86U90 |
ProteomicsDBi | 69783 |
Protocols and materials databases
Antibodypediai | 31792, 26 antibodies |
Genome annotation databases
Ensembli | ENST00000373044; ENSP00000362135; ENSG00000196449 |
GeneIDi | 79693 |
KEGGi | hsa:79693 |
UCSCi | uc001cca.2, human |
Organism-specific databases
CTDi | 79693 |
DisGeNETi | 79693 |
GeneCardsi | YRDC |
HGNCi | HGNC:28905, YRDC |
HPAi | ENSG00000196449, Low tissue specificity |
MIMi | 612276, gene |
neXtProti | NX_Q86U90 |
OpenTargetsi | ENSG00000196449 |
PharmGKBi | PA142670553 |
VEuPathDBi | HostDB:ENSG00000196449.3 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3051, Eukaryota |
GeneTreei | ENSGT00390000015364 |
HOGENOMi | CLU_031397_5_0_1 |
InParanoidi | Q86U90 |
OMAi | WHEQPLA |
OrthoDBi | 1027994at2759 |
PhylomeDBi | Q86U90 |
TreeFami | TF314358 |
Enzyme and pathway databases
PathwayCommonsi | Q86U90 |
Miscellaneous databases
BioGRID-ORCSi | 79693, 658 hits in 872 CRISPR screens |
ChiTaRSi | YRDC, human |
GenomeRNAii | 79693 |
Pharosi | Q86U90, Tdark |
PROi | PR:Q86U90 |
RNActi | Q86U90, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000196449, Expressed in bone marrow and 214 other tissues |
Genevisiblei | Q86U90, HS |
Family and domain databases
InterProi | View protein in InterPro IPR017945, DHBP_synth_RibB-like_a/b_dom IPR006070, YrdC-like_dom |
Pfami | View protein in Pfam PF01300, Sua5_yciO_yrdC, 1 hit |
SUPFAMi | SSF55821, SSF55821, 1 hit |
TIGRFAMsi | TIGR00057, TIGR00057, 1 hit |
PROSITEi | View protein in PROSITE PS51163, YRDC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | YRDC_HUMAN | |
Accessioni | Q86U90Primary (citable) accession number: Q86U90 Secondary accession number(s): Q4W4X8 Q9H5F8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 10, 2008 |
Last sequence update: | June 1, 2003 | |
Last modified: | February 10, 2021 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families