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Entry version 164 (16 Oct 2019)
Sequence version 1 (01 Jun 2003)
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Protein

Protein polybromo-1

Gene

PBRM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation.2 Publications1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi1379 – 1447HMG boxPROSITE-ProRule annotationAdd BLAST69

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-3214858 RMTs methylate histone arginines
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

SIGNOR Signaling Network Open Resource

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SIGNORi
Q86U86

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein polybromo-1
Short name:
hPB1
Alternative name(s):
BRG1-associated factor 180
Short name:
BAF180
Polybromo-1D
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PBRM1
Synonyms:BAF180, PB1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30064 PBRM1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
606083 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86U86

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Renal cell carcinoma (RCC)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionRenal cell carcinoma is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. Clear cell renal cell carcinoma is the most common subtype.
Related information in OMIM

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNET

More...
DisGeNETi
55193

MalaCards human disease database

More...
MalaCardsi
PBRM1
MIMi144700 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000163939

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
404511 Clear cell papillary renal cell carcinoma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA162398846

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q86U86

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1795184

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
2738

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PBRM1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
73921624

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002112071 – 1689Protein polybromo-1Add BLAST1689

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei10PhosphoserineCombined sources1
Modified residuei39PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki96Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei131PhosphoserineCombined sources1
Modified residuei134PhosphotyrosineCombined sources1
Cross-linki154Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei178PhosphoserineCombined sources1
Cross-linki210Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei316PhosphoserineCombined sources1
Modified residuei319PhosphoserineCombined sources1
Modified residuei353PhosphoserineCombined sources1
Modified residuei355PhosphoserineCombined sources1
Modified residuei371PhosphoserineCombined sources1
Modified residuei375PhosphoserineCombined sources1
Modified residuei414N6-acetyllysineBy similarity1
Cross-linki425Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki471Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei498PhosphoserineCombined sources1
Modified residuei509PhosphoserineCombined sources1
Cross-linki511Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki591Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei636PhosphoserineCombined sources1
Cross-linki638Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei648PhosphoserineCombined sources1
Cross-linki653Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei689PhosphoserineCombined sources1
Modified residuei948PhosphoserineCombined sources1
Modified residuei987PhosphoserineCombined sources1
Cross-linki1106Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1111Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1119PhosphoserineCombined sources1
Cross-linki1167Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1289PhosphotyrosineBy similarity1
Cross-linki1293Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki1293Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki1308Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1398Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1405PhosphoserineCombined sources1
Modified residuei1453PhosphoserineCombined sources1
Cross-linki1642Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1654Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1656Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

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CPTACi
CPTAC-1362

Encyclopedia of Proteome Dynamics

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EPDi
Q86U86

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q86U86

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q86U86

MaxQB - The MaxQuant DataBase

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MaxQBi
Q86U86

PeptideAtlas

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PeptideAtlasi
Q86U86

PRoteomics IDEntifications database

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PRIDEi
Q86U86

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
69774 [Q86U86-1]
69775 [Q86U86-2]
69776 [Q86U86-3]
69777 [Q86U86-4]
69778 [Q86U86-5]
69779 [Q86U86-6]
69780 [Q86U86-7]
69781 [Q86U86-8]
69782 [Q86U86-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86U86

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q86U86

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q86U86

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000163939 Expressed in 238 organ(s), highest expression level in forebrain

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q86U86 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q86U86 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA015629
HPA059373

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the SWI/SNF-B (PBAF) chromatin remodeling complex, at least composed of SMARCA4/BRG1, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PBRM1/BAF180, ARID2/BAF200 and actin.

Interacts with PHF10/BAF45A (By similarity).

Interacts with acetylated 'Lys-14' of histone H3 (H3K14ac), and may also interact with other acetylated or methylated Lys residues on histone H3.

2 PublicationsBy similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
120490, 72 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1196 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B variant
CPX-1199 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A variant

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q86U86

Database of interacting proteins

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DIPi
DIP-33045N

Protein interaction database and analysis system

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IntActi
Q86U86, 33 interactors

Molecular INTeraction database

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MINTi
Q86U86

STRING: functional protein association networks

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STRINGi
9606.ENSP00000378307

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q86U86

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11689
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q86U86

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q86U86

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini64 – 134Bromo 1PROSITE-ProRule annotationAdd BLAST71
Domaini200 – 270Bromo 2PROSITE-ProRule annotationAdd BLAST71
Domaini400 – 470Bromo 3PROSITE-ProRule annotationAdd BLAST71
Domaini538 – 608Bromo 4PROSITE-ProRule annotationAdd BLAST71
Domaini676 – 746Bromo 5PROSITE-ProRule annotationAdd BLAST71
Domaini792 – 862Bromo 6PROSITE-ProRule annotationAdd BLAST71
Domaini956 – 1074BAH 1PROSITE-ProRule annotationAdd BLAST119
Domaini1156 – 1272BAH 2PROSITE-ProRule annotationAdd BLAST117

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi630 – 633Poly-Asp4
Compositional biasi1468 – 1599Pro-richAdd BLAST132

Keywords - Domaini

Bromodomain, Repeat

Phylogenomic databases

Ensembl GeneTree

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GeneTreei
ENSGT00390000003017

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q86U86

KEGG Orthology (KO)

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KOi
K11757

Identification of Orthologs from Complete Genome Data

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OMAi
WRNCPRI

Database of Orthologous Groups

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OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q86U86

TreeFam database of animal gene trees

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TreeFami
TF106120

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05515 Bromo_polybromo_V, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.920.10, 6 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001025 BAH_dom
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR037968 PBRM1_BD5
IPR037382 Rsc/polybromo

The PANTHER Classification System

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PANTHERi
PTHR16062 PTHR16062, 5 hits

Pfam protein domain database

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Pfami
View protein in Pfam
PF01426 BAH, 2 hits
PF00439 Bromodomain, 6 hits
PF00505 HMG_box, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00503 BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00439 BAH, 2 hits
SM00297 BROMO, 6 hits
SM00398 HMG, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47095 SSF47095, 1 hit
SSF47370 SSF47370, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51038 BAH, 2 hits
PS00633 BROMODOMAIN_1, 5 hits
PS50014 BROMODOMAIN_2, 6 hits
PS50118 HMG_BOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (9+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 9 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 9 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86U86-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSKRRRATS PSSSVSGDFD DGHHSVSTPG PSRKRRRLSN LPTVDPIAVC
60 70 80 90 100
HELYNTIRDY KDEQGRLLCE LFIRAPKRRN QPDYYEVVSQ PIDLMKIQQK
110 120 130 140 150
LKMEEYDDVN LLTADFQLLF NNAKSYYKPD SPEYKAACKL WDLYLRTRNE
160 170 180 190 200
FVQKGEADDE DDDEDGQDNQ GTVTEGSSPA YLKEILEQLL EAIVVATNPS
210 220 230 240 250
GRLISELFQK LPSKVQYPDY YAIIKEPIDL KTIAQRIQNG SYKSIHAMAK
260 270 280 290 300
DIDLLAKNAK TYNEPGSQVF KDANSIKKIF YMKKAEIEHH EMAKSSLRMR
310 320 330 340 350
TPSNLAAARL TGPSHSKGSL GEERNPTSKY YRNKRAVQGG RLSAITMALQ
360 370 380 390 400
YGSESEEDAA LAAARYEEGE SEAESITSFM DVSNPFYQLY DTVRSCRNNQ
410 420 430 440 450
GQLIAEPFYH LPSKKKYPDY YQQIKMPISL QQIRTKLKNQ EYETLDHLEC
460 470 480 490 500
DLNLMFENAK RYNVPNSAIY KRVLKLQQVM QAKKKELARR DDIEDGDSMI
510 520 530 540 550
SSATSDTGSA KRKSKKNIRK QRMKILFNVV LEAREPGSGR RLCDLFMVKP
560 570 580 590 600
SKKDYPDYYK IILEPMDLKI IEHNIRNDKY AGEEGMIEDM KLMFRNARHY
610 620 630 640 650
NEEGSQVYND AHILEKLLKE KRKELGPLPD DDDMASPKLK LSRKSGISPK
660 670 680 690 700
KSKYMTPMQQ KLNEVYEAVK NYTDKRGRRL SAIFLRLPSR SELPDYYLTI
710 720 730 740 750
KKPMDMEKIR SHMMANKYQD IDSMVEDFVM MFNNACTYNE PESLIYKDAL
760 770 780 790 800
VLHKVLLETR RDLEGDEDSH VPNVTLLIQE LIHNLFVSVM SHQDDEGRCY
810 820 830 840 850
SDSLAEIPAV DPNFPNKPPL TFDIIRKNVE NNRYRRLDLF QEHMFEVLER
860 870 880 890 900
ARRMNRTDSE IYEDAVELQQ FFIKIRDELC KNGEILLSPA LSYTTKHLHN
910 920 930 940 950
DVEKERKEKL PKEIEEDKLK REEEKREAEK SEDSSGAAGL SGLHRTYSQD
960 970 980 990 1000
CSFKNSMYHV GDYVYVEPAE ANLQPHIVCI ERLWEDSAGE KWLYGCWFYR
1010 1020 1030 1040 1050
PNETFHLATR KFLEKEVFKS DYYNKVPVSK ILGKCVVMFV KEYFKLCPEN
1060 1070 1080 1090 1100
FRDEDVFVCE SRYSAKTKSF KKIKLWTMPI SSVRFVPRDV PLPVVRVASV
1110 1120 1130 1140 1150
FANADKGDDE KNTDNSEDSR AEDNFNLEKE KEDVPVEMSN GEPGCHYFEQ
1160 1170 1180 1190 1200
LHYNDMWLKV GDCVFIKSHG LVRPRVGRIE KVWVRDGAAY FYGPIFIHPE
1210 1220 1230 1240 1250
ETEHEPTKMF YKKEVFLSNL EETCPMTCIL GKCAVLSFKD FLSCRPTEIP
1260 1270 1280 1290 1300
ENDILLCESR YNESDKQMKK FKGLKRFSLS AKVVDDEIYY FRKPIVPQKE
1310 1320 1330 1340 1350
PSPLLEKKIQ LLEAKFAELE GGDDDIEEMG EEDSEVIEPP SLPQLQTPLA
1360 1370 1380 1390 1400
SELDLMPYTP PQSTPKSAKG SAKKEGSKRK INMSGYILFS SEMRAVIKAQ
1410 1420 1430 1440 1450
HPDYSFGELS RLVGTEWRNL ETAKKAEYEE RAAKVAEQQE RERAAQQQQP
1460 1470 1480 1490 1500
SASPRAGTPV GALMGVVPPP TPMGMLNQQL TPVAGMMGGY PPGLPPLQGP
1510 1520 1530 1540 1550
VDGLVSMGSM QPLHPGGPPP HHLPPGVPGL PGIPPPGVMN QGVAPMVGTP
1560 1570 1580 1590 1600
APGGSPYGQQ VGVLGPPGQQ APPPYPGPHP AGPPVIQQPT TPMFVAPPPK
1610 1620 1630 1640 1650
TQRLLHSEAY LKYIEGLSAE SNSISKWDQT LAARRRDVHL SKEQESRLPS
1660 1670 1680
HWLKSKGAHT TMADALWRLR DLMLRDTLNI RQAYNLENV
Length:1,689
Mass (Da):192,948
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0A656E319C4FC748
GO
Isoform 2 (identifier: Q86U86-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1430-1484: Missing.

Show »
Length:1,634
Mass (Da):187,188
Checksum:iFAB1C935A9B8B4DD
GO
Isoform 3 (identifier: Q86U86-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     300-332: RTPSNLAAARLTGPSHSKGSLGEERNPTSKYYR → S
     1430-1484: Missing.

Show »
Length:1,602
Mass (Da):183,690
Checksum:iB8BA103E359A48DA
GO
Isoform 4 (identifier: Q86U86-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     989-1013: Missing.
     1336-1362: Missing.
     1430-1484: Missing.

Show »
Length:1,582
Mass (Da):181,085
Checksum:iA2B8A14FAB928A3C
GO
Isoform 5 (identifier: Q86U86-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1430-1484: Missing.
     1485-1536: Missing.

Show »
Length:1,582
Mass (Da):182,118
Checksum:iBCBD5D8E42BAB076
GO
Isoform 6 (identifier: Q86U86-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     857-1689: Missing.

Show »
Length:856
Mass (Da):99,142
Checksum:iAE378B417E0493B3
GO
Isoform 7 (identifier: Q86U86-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     513-513: K → KRNTHDSEMLGLRRLS
     1430-1484: Missing.
     1485-1536: Missing.

Show »
Length:1,597
Mass (Da):183,885
Checksum:i710520F65FF9E981
GO
Isoform 8 (identifier: Q86U86-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     513-513: K → KRNTHDSEMLGLRRLS
     1485-1536: Missing.

Show »
Length:1,652
Mass (Da):189,645
Checksum:iE5BA80E11EE7E6C0
GO
Isoform 9 (identifier: Q86U86-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     989-1013: Missing.
     1430-1484: Missing.

Show »
Length:1,609
Mass (Da):184,043
Checksum:i38BB16B06929BFFC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EVG2E7EVG2_HUMAN
Protein polybromo-1
PBRM1
1,460Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5B5H0Y5B5_HUMAN
Protein polybromo-1
PBRM1
1,085Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J053C9J053_HUMAN
Protein polybromo-1
PBRM1
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JPI5C9JPI5_HUMAN
Protein polybromo-1
PBRM1
230Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JQF1C9JQF1_HUMAN
Protein polybromo-1
PBRM1
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JCJ2C9JCJ2_HUMAN
Protein polybromo-1
PBRM1
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J409C9J409_HUMAN
Protein polybromo-1
PBRM1
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J9L6C9J9L6_HUMAN
Protein polybromo-1
PBRM1
26Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI15010 differs from that shown. Contaminating sequence.Curated
The sequence AAI15011 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAI15012 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
The sequence BAB71210 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1M → T in AAI15011 (PubMed:15489334).Curated1
Sequence conflicti65G → S in AAI15011 (PubMed:15489334).Curated1
Sequence conflicti242Y → C in AAI15012 (PubMed:15489334).Curated1
Sequence conflicti251D → V in AAI15011 (PubMed:15489334).Curated1
Sequence conflicti430L → P in AAI15012 (PubMed:15489334).Curated1
Sequence conflicti553K → R in AAG34760 (PubMed:11078522).Curated1
Sequence conflicti567D → Y in AAI15012 (PubMed:15489334).Curated1
Sequence conflicti750L → P in AAI15012 (PubMed:15489334).Curated1
Sequence conflicti792H → R in AAI15012 (PubMed:15489334).Curated1
Sequence conflicti927Missing in AAI15010 (PubMed:15489334).Curated1
Sequence conflicti927Missing in BAB71210 (PubMed:14702039).Curated1
Sequence conflicti963Y → H in BAB71210 (PubMed:14702039).Curated1
Sequence conflicti1144G → V in AAG34760 (PubMed:11078522).Curated1
Sequence conflicti1245R → K in AAG34760 (PubMed:11078522).Curated1
Sequence conflicti1306E → G in AAG34760 (PubMed:11078522).Curated1
Sequence conflicti1349L → P in AAI15010 (PubMed:15489334).Curated1
Sequence conflicti1488G → D in AAI15012 (PubMed:15489334).Curated1
Sequence conflicti1568G → R in AAG34760 (PubMed:11078522).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06465349V → L Found in a lung cancer cell line. 1 Publication1
Natural variantiVAR_06465456T → A Found in a brain cancer cell line. 1 PublicationCorresponds to variant dbSNP:rs923060956Ensembl.1
Natural variantiVAR_06465557Missing Found in a case of clear cell renal carcinoma; somatic mutation. 1 Publication1
Natural variantiVAR_06465666R → G Found in a colon cancer cell line. 1 PublicationCorresponds to variant dbSNP:rs368888772Ensembl.1
Natural variantiVAR_06465790Q → E Found in a bladder cancer cell line. 1 Publication1
Natural variantiVAR_064658144Y → F Found in a malignant melanoma cell line. 1 Publication1
Natural variantiVAR_064659160E → A Found in a malignant melanoma cell line. 1 Publication1
Natural variantiVAR_064660202R → C Found in a endometrial cancer cell line. 1 PublicationCorresponds to variant dbSNP:rs765525545Ensembl.1
Natural variantiVAR_064661206E → K Found in hematopoietic and lymphoid cancer cell lines. 1 PublicationCorresponds to variant dbSNP:rs1359676390Ensembl.1
Natural variantiVAR_064662226E → G Found in hematopoietic and lymphoid cancer cell lines. 1 Publication1
Natural variantiVAR_064663228I → V Found in a breast cancer cell line. 1 PublicationCorresponds to variant dbSNP:rs201022657Ensembl.1
Natural variantiVAR_064664232T → P Found in a case of clear cell renal carcinoma; somatic mutation. 1 Publication1
Natural variantiVAR_064665233I → T Found in a renal carcinoma cell line. 1 Publication1
Natural variantiVAR_064666256A → T Found in an ovary carcinoma cell line. 1 PublicationCorresponds to variant dbSNP:rs776146971Ensembl.1
Natural variantiVAR_064667340G → A Found in a malignant melanoma cell line. 1 PublicationCorresponds to variant dbSNP:rs200106731Ensembl.1
Natural variantiVAR_064668523M → I Found in a case of clear cell renal carcinoma; somatic mutation. 1 Publication1
Natural variantiVAR_064669540R → S Found in a case of clear cell renal carcinoma; somatic mutation. 1 Publication1
Natural variantiVAR_064670597A → D Found in a case of clear cell renal carcinoma; somatic mutation. 1 Publication1
Natural variantiVAR_064671621K → E Found in a case of clear cell renal carcinoma; somatic mutation. 1 Publication1
Natural variantiVAR_064672661K → N Found in a case of clear cell renal carcinoma; somatic mutation. 1 Publication1
Natural variantiVAR_064673674D → E Found in a case of clear cell renal carcinoma; somatic mutation. 1 Publication1
Natural variantiVAR_064674678R → C1 PublicationCorresponds to variant dbSNP:rs1422119249Ensembl.1
Natural variantiVAR_064675893Y → C Found in hematopoietic, lymphoid, lung and liver cancer cell lines. 1 PublicationCorresponds to variant dbSNP:rs753344888Ensembl.1
Natural variantiVAR_064676895T → S Found in a lung cancer cell line. 1 Publication1
Natural variantiVAR_064677922E → Q Found in a breast cancer cell line. 1 Publication1
Natural variantiVAR_064678925K → Q Found in a colon cancer cell line. 1 Publication1
Natural variantiVAR_0646791079P → Y Requires 2 nucleotide substitutions; found in a colon cancer cell line. 1 Publication1
Natural variantiVAR_0646801098A → S Found in hematopoietic and lymphoid cancer cell lines. 1 PublicationCorresponds to variant dbSNP:rs201156614Ensembl.1
Natural variantiVAR_0646811120R → Q Found in hematopoietic and lymphoid cancer cell lines. 1 PublicationCorresponds to variant dbSNP:rs35102895Ensembl.1
Natural variantiVAR_0646821177G → S Found in a kidney cancer cell line. 1 Publication1
Natural variantiVAR_0646831204H → P Found in a case of clear cell renal carcinoma; somatic mutation. 1 Publication1
Natural variantiVAR_0646841209 – 1214Missing Found in a case of clear cell renal carcinoma; somatic mutation. 1 Publication6
Natural variantiVAR_0646851287E → Q Found in a breast cancer cell line. 1 Publication1
Natural variantiVAR_0646861414G → E Found in a lung cancer cell line. 1 Publication1
Natural variantiVAR_0646871503G → C Found in a stomach cancer cell line. 1 Publication1
Natural variantiVAR_0646881560Q → H Found in an endometrial cancer cell line. 1 Publication1
Natural variantiVAR_0646891614I → N Found in a case of clear cell renal carcinoma; somatic mutation. 1 Publication1
Natural variantiVAR_0646901647R → C Found in a breast cancer cell line. 1 PublicationCorresponds to variant dbSNP:rs200020801Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_015231300 – 332RTPSN…SKYYR → S in isoform 3. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_035499513K → KRNTHDSEMLGLRRLS in isoform 7 and isoform 8. 2 Publications1
Alternative sequenceiVSP_015232857 – 1689Missing in isoform 6. 1 PublicationAdd BLAST833
Alternative sequenceiVSP_015233989 – 1013Missing in isoform 4 and isoform 9. 2 PublicationsAdd BLAST25
Alternative sequenceiVSP_0152341336 – 1362Missing in isoform 4. 2 PublicationsAdd BLAST27
Alternative sequenceiVSP_0152351430 – 1484Missing in isoform 2, isoform 3, isoform 4, isoform 5, isoform 7 and isoform 9. 4 PublicationsAdd BLAST55
Alternative sequenceiVSP_0152361485 – 1536Missing in isoform 5, isoform 7 and isoform 8. 3 PublicationsAdd BLAST52

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF197569 mRNA Translation: AAG34760.1
AF225870 mRNA Translation: AAG48939.1
AF225871 mRNA Translation: AAG48940.1
AF225872 mRNA Translation: AAG48941.1
AF177387 mRNA Translation: AAG48933.1
AY281068 mRNA Translation: AAP34197.1
BC115009 mRNA Translation: AAI15010.1 Different termination.
BC115010 mRNA Translation: AAI15011.1 Different initiation.
BC115011 mRNA Translation: AAI15012.1 Sequence problems.
BC129934 mRNA Translation: AAI29935.1
BC129935 mRNA Translation: AAI29936.1
AK056541 mRNA Translation: BAB71210.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2860.1 [Q86U86-5]
CCDS43099.1 [Q86U86-4]
CCDS87087.1 [Q86U86-2]

NCBI Reference Sequences

More...
RefSeqi
NP_060783.3, NM_018313.4 [Q86U86-4]
NP_851385.1, NM_181042.4 [Q86U86-5]
XP_016862237.1, XM_017006748.1 [Q86U86-1]
XP_016862238.1, XM_017006749.1 [Q86U86-1]
XP_016862239.1, XM_017006750.1 [Q86U86-1]
XP_016862246.1, XM_017006757.1
XP_016862247.1, XM_017006758.1 [Q86U86-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000296302; ENSP00000296302; ENSG00000163939 [Q86U86-1]
ENST00000337303; ENSP00000338302; ENSG00000163939 [Q86U86-5]
ENST00000356770; ENSP00000349213; ENSG00000163939 [Q86U86-3]
ENST00000394830; ENSP00000378307; ENSG00000163939 [Q86U86-4]
ENST00000409057; ENSP00000386593; ENSG00000163939 [Q86U86-2]
ENST00000409114; ENSP00000386643; ENSG00000163939 [Q86U86-8]
ENST00000409767; ENSP00000386601; ENSG00000163939 [Q86U86-7]
ENST00000410007; ENSP00000386529; ENSG00000163939 [Q86U86-9]
ENST00000412587; ENSP00000404579; ENSG00000163939 [Q86U86-6]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55193

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55193

UCSC genome browser

More...
UCSCi
uc003deq.3 human [Q86U86-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF197569 mRNA Translation: AAG34760.1
AF225870 mRNA Translation: AAG48939.1
AF225871 mRNA Translation: AAG48940.1
AF225872 mRNA Translation: AAG48941.1
AF177387 mRNA Translation: AAG48933.1
AY281068 mRNA Translation: AAP34197.1
BC115009 mRNA Translation: AAI15010.1 Different termination.
BC115010 mRNA Translation: AAI15011.1 Different initiation.
BC115011 mRNA Translation: AAI15012.1 Sequence problems.
BC129934 mRNA Translation: AAI29935.1
BC129935 mRNA Translation: AAI29936.1
AK056541 mRNA Translation: BAB71210.1 Different initiation.
CCDSiCCDS2860.1 [Q86U86-5]
CCDS43099.1 [Q86U86-4]
CCDS87087.1 [Q86U86-2]
RefSeqiNP_060783.3, NM_018313.4 [Q86U86-4]
NP_851385.1, NM_181042.4 [Q86U86-5]
XP_016862237.1, XM_017006748.1 [Q86U86-1]
XP_016862238.1, XM_017006749.1 [Q86U86-1]
XP_016862239.1, XM_017006750.1 [Q86U86-1]
XP_016862246.1, XM_017006757.1
XP_016862247.1, XM_017006758.1 [Q86U86-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KTBNMR-B174-293[»]
3G0JX-ray1.78A/B645-766[»]
3HMFX-ray1.63A178-291[»]
3IU5X-ray1.63A43-154[»]
3IU6X-ray1.79A773-914[»]
3K2JX-ray2.20A/B388-494[»]
3LJWX-ray1.50A/B174-293[»]
3MB4X-ray1.66A/B645-766[»]
3TLPX-ray2.13A/B496-637[»]
4Q0NX-ray1.78A/B/C/D/E/F/G/H645-766[»]
4Q0OX-ray1.83A645-766[»]
4Y03X-ray1.94A/B645-766[»]
5E7DX-ray1.87A/B/C/D645-766[»]
5FH6X-ray2.30A/B/C/D645-766[»]
5FH7X-ray1.47A/B645-766[»]
5FH8X-ray1.55A/B/C/D645-766[»]
5HRVX-ray1.70A645-766[»]
5HRWX-ray1.80A/B645-766[»]
5HRXX-ray1.73A/B645-766[»]
5II1X-ray2.02A/B645-766[»]
5II2X-ray2.10A/B645-766[»]
5IIDX-ray2.40A/B645-766[»]
SMRiQ86U86
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi120490, 72 interactors
ComplexPortaliCPX-1196 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B variant
CPX-1199 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A variant
CORUMiQ86U86
DIPiDIP-33045N
IntActiQ86U86, 33 interactors
MINTiQ86U86
STRINGi9606.ENSP00000378307

Chemistry databases

BindingDBiQ86U86
ChEMBLiCHEMBL1795184
GuidetoPHARMACOLOGYi2738

PTM databases

iPTMnetiQ86U86
PhosphoSitePlusiQ86U86
SwissPalmiQ86U86

Polymorphism and mutation databases

BioMutaiPBRM1
DMDMi73921624

Proteomic databases

CPTACiCPTAC-1362
EPDiQ86U86
jPOSTiQ86U86
MassIVEiQ86U86
MaxQBiQ86U86
PeptideAtlasiQ86U86
PRIDEiQ86U86
ProteomicsDBi69774 [Q86U86-1]
69775 [Q86U86-2]
69776 [Q86U86-3]
69777 [Q86U86-4]
69778 [Q86U86-5]
69779 [Q86U86-6]
69780 [Q86U86-7]
69781 [Q86U86-8]
69782 [Q86U86-9]

Genome annotation databases

EnsembliENST00000296302; ENSP00000296302; ENSG00000163939 [Q86U86-1]
ENST00000337303; ENSP00000338302; ENSG00000163939 [Q86U86-5]
ENST00000356770; ENSP00000349213; ENSG00000163939 [Q86U86-3]
ENST00000394830; ENSP00000378307; ENSG00000163939 [Q86U86-4]
ENST00000409057; ENSP00000386593; ENSG00000163939 [Q86U86-2]
ENST00000409114; ENSP00000386643; ENSG00000163939 [Q86U86-8]
ENST00000409767; ENSP00000386601; ENSG00000163939 [Q86U86-7]
ENST00000410007; ENSP00000386529; ENSG00000163939 [Q86U86-9]
ENST00000412587; ENSP00000404579; ENSG00000163939 [Q86U86-6]
GeneIDi55193
KEGGihsa:55193
UCSCiuc003deq.3 human [Q86U86-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55193
DisGeNETi55193

GeneCards: human genes, protein and diseases

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GeneCardsi
PBRM1
HGNCiHGNC:30064 PBRM1
HPAiHPA015629
HPA059373
MalaCardsiPBRM1
MIMi144700 phenotype
606083 gene
neXtProtiNX_Q86U86
OpenTargetsiENSG00000163939
Orphaneti404511 Clear cell papillary renal cell carcinoma
PharmGKBiPA162398846

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

GeneTreeiENSGT00390000003017
InParanoidiQ86U86
KOiK11757
OMAiWRNCPRI
OrthoDBi1318335at2759
PhylomeDBiQ86U86
TreeFamiTF106120

Enzyme and pathway databases

ReactomeiR-HSA-3214858 RMTs methylate histone arginines
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
SIGNORiQ86U86

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PBRM1 human
EvolutionaryTraceiQ86U86

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PBRM1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55193
PharosiQ86U86

Protein Ontology

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PROi
PR:Q86U86

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000163939 Expressed in 238 organ(s), highest expression level in forebrain
ExpressionAtlasiQ86U86 baseline and differential
GenevisibleiQ86U86 HS

Family and domain databases

CDDicd05515 Bromo_polybromo_V, 1 hit
Gene3Di1.20.920.10, 6 hits
InterProiView protein in InterPro
IPR001025 BAH_dom
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR037968 PBRM1_BD5
IPR037382 Rsc/polybromo
PANTHERiPTHR16062 PTHR16062, 5 hits
PfamiView protein in Pfam
PF01426 BAH, 2 hits
PF00439 Bromodomain, 6 hits
PF00505 HMG_box, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00439 BAH, 2 hits
SM00297 BROMO, 6 hits
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
SSF47370 SSF47370, 6 hits
PROSITEiView protein in PROSITE
PS51038 BAH, 2 hits
PS00633 BROMODOMAIN_1, 5 hits
PS50014 BROMODOMAIN_2, 6 hits
PS50118 HMG_BOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPB1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86U86
Secondary accession number(s): A1L381
, A1L382, A4FUJ7, Q1RMD1, Q1RMD2, Q96MS2, Q9H2T3, Q9H2T4, Q9H2T5, Q9H301, Q9H314
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 1, 2003
Last modified: October 16, 2019
This is version 164 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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