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Protein

Serpin A11

Gene

SERPINA11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin A11
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000186910.3
HGNCiHGNC:19193 SERPINA11
neXtProtiNX_Q86U17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi256394
OpenTargetsiENSG00000186910
PharmGKBiPA134988362

Polymorphism and mutation databases

BioMutaiSERPINA11
DMDMi76363411

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000004197320 – 422Serpin A11Add BLAST403

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi350N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ86U17
PeptideAtlasiQ86U17
PRIDEiQ86U17
ProteomicsDBi69759

Expressioni

Gene expression databases

BgeeiENSG00000186910
CleanExiHS_SERPINA11

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000335024

Structurei

3D structure databases

ProteinModelPortaliQ86U17
SMRiQ86U17
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118839
HOGENOMiHOG000238521
HOVERGENiHBG005957
InParanoidiQ86U17
KOiK04525
OMAiHQKEMHR
OrthoDBiEOG091G0ION
PhylomeDBiQ86U17
TreeFamiTF343201

Family and domain databases

InterProiView protein in InterPro
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86U17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPAWLWLLG TGILASVHCQ PLLAHGDKSL QGPQPPRHQL SEPAPAYHRI
60 70 80 90 100
TPTITNFALR LYKELAADAP GNIFFSPVSI STTLALLSLG AQANTSALIL
110 120 130 140 150
EGLGFNLTET PEADIHQGFR SLLHTLALPS PKLELKVGNS LFLDKRLKPR
160 170 180 190 200
QHYLDSIKEL YGAFAFSANF TDSVTTGRQI NDYLRRQTYG QVVDCLPEFS
210 220 230 240 250
QDTFMVLANY IFFKAKWKHP FSRYQTQKQE SFFVDERTSL QVPMMHQKEM
260 270 280 290 300
HRFLYDQDLA CTVLQIEYRG NALALLVLPD PGKMKQVEAA LQPQTLRKWG
310 320 330 340 350
QLLLPSLLDL HLPRFSISGT YNLEDILPQI GLTNILNLEA DFSGVTGQLN
360 370 380 390 400
KTISKVSHKA MVDMSEKGTE AGAASGLLSQ PPSLNTMSDP HAHFNRPFLL
410 420
LLWEVTTQSL LFLGKVVNPV AG
Length:422
Mass (Da):46,989
Last modified:September 27, 2005 - v2
Checksum:i58536B32C91DC2F8
GO

Sequence cautioni

The sequence CAD62587 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061791230E → A. Corresponds to variant dbSNP:rs1885137Ensembl.1
Natural variantiVAR_034511406T → S. Corresponds to variant dbSNP:rs17752285Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248259 mRNA Translation: CAD62587.1 Different initiation.
BC146962 mRNA Translation: AAI46963.1
CCDSiCCDS32149.1
RefSeqiNP_001073920.1, NM_001080451.1
UniGeneiHs.145890

Genome annotation databases

EnsembliENST00000334708; ENSP00000335024; ENSG00000186910
GeneIDi256394
KEGGihsa:256394
UCSCiuc001ydd.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSPA11_HUMAN
AccessioniPrimary (citable) accession number: Q86U17
Secondary accession number(s): B2RV07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: September 27, 2005
Last modified: June 20, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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