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Entry version 124 (10 Feb 2021)
Sequence version 2 (27 Sep 2005)
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Protein

Serpin A11

Gene

SERPINA11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q86U17

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serpin A11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19193, SERPINA11

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86U17

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000186910.3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
256394

Open Targets

More...
OpenTargetsi
ENSG00000186910

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134988362

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86U17, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SERPINA11

Domain mapping of disease mutations (DMDM)

More...
DMDMi
76363411

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004197320 – 422Serpin A11Add BLAST403

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi350N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86U17

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q86U17

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86U17

PeptideAtlas

More...
PeptideAtlasi
Q86U17

PRoteomics IDEntifications database

More...
PRIDEi
Q86U17

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
69759

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q86U17, 4 sites

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000186910, Expressed in liver and 40 other tissues

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000186910, Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
129165, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q86U17, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000335024

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q86U17, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86U17

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2392, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162010

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_023330_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86U17

Identification of Orthologs from Complete Genome Data

More...
OMAi
IPMMHQK

Database of Orthologous Groups

More...
OrthoDBi
1124079at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86U17

TreeFam database of animal gene trees

More...
TreeFami
TF343201

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.39.10, 1 hit
3.30.497.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023796, Serpin_dom
IPR000215, Serpin_fam
IPR036186, Serpin_sf
IPR042178, Serpin_sf_1
IPR042185, Serpin_sf_2

The PANTHER Classification System

More...
PANTHERi
PTHR11461, PTHR11461, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00079, Serpin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00093, SERPIN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56574, SSF56574, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q86U17-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGPAWLWLLG TGILASVHCQ PLLAHGDKSL QGPQPPRHQL SEPAPAYHRI
60 70 80 90 100
TPTITNFALR LYKELAADAP GNIFFSPVSI STTLALLSLG AQANTSALIL
110 120 130 140 150
EGLGFNLTET PEADIHQGFR SLLHTLALPS PKLELKVGNS LFLDKRLKPR
160 170 180 190 200
QHYLDSIKEL YGAFAFSANF TDSVTTGRQI NDYLRRQTYG QVVDCLPEFS
210 220 230 240 250
QDTFMVLANY IFFKAKWKHP FSRYQTQKQE SFFVDERTSL QVPMMHQKEM
260 270 280 290 300
HRFLYDQDLA CTVLQIEYRG NALALLVLPD PGKMKQVEAA LQPQTLRKWG
310 320 330 340 350
QLLLPSLLDL HLPRFSISGT YNLEDILPQI GLTNILNLEA DFSGVTGQLN
360 370 380 390 400
KTISKVSHKA MVDMSEKGTE AGAASGLLSQ PPSLNTMSDP HAHFNRPFLL
410 420
LLWEVTTQSL LFLGKVVNPV AG
Length:422
Mass (Da):46,989
Last modified:September 27, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i58536B32C91DC2F8
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAD62587 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061791230E → A. Corresponds to variant dbSNP:rs1885137Ensembl.1
Natural variantiVAR_034511406T → S. Corresponds to variant dbSNP:rs17752285Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX248259 mRNA Translation: CAD62587.1 Different initiation.
BC146962 mRNA Translation: AAI46963.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32149.1

NCBI Reference Sequences

More...
RefSeqi
NP_001073920.1, NM_001080451.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000334708; ENSP00000335024; ENSG00000186910

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
256394

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:256394

UCSC genome browser

More...
UCSCi
uc001ydd.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248259 mRNA Translation: CAD62587.1 Different initiation.
BC146962 mRNA Translation: AAI46963.1
CCDSiCCDS32149.1
RefSeqiNP_001073920.1, NM_001080451.1

3D structure databases

SMRiQ86U17
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi129165, 1 interactor
IntActiQ86U17, 1 interactor
STRINGi9606.ENSP00000335024

PTM databases

GlyGeniQ86U17, 4 sites

Genetic variation databases

BioMutaiSERPINA11
DMDMi76363411

Proteomic databases

jPOSTiQ86U17
MassIVEiQ86U17
PaxDbiQ86U17
PeptideAtlasiQ86U17
PRIDEiQ86U17
ProteomicsDBi69759

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
56616, 126 antibodies

The DNASU plasmid repository

More...
DNASUi
256394

Genome annotation databases

EnsembliENST00000334708; ENSP00000335024; ENSG00000186910
GeneIDi256394
KEGGihsa:256394
UCSCiuc001ydd.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
256394
DisGeNETi256394

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SERPINA11
HGNCiHGNC:19193, SERPINA11
HPAiENSG00000186910, Tissue enriched (liver)
neXtProtiNX_Q86U17
OpenTargetsiENSG00000186910
PharmGKBiPA134988362
VEuPathDBiHostDB:ENSG00000186910.3

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2392, Eukaryota
GeneTreeiENSGT00940000162010
HOGENOMiCLU_023330_2_1_1
InParanoidiQ86U17
OMAiIPMMHQK
OrthoDBi1124079at2759
PhylomeDBiQ86U17
TreeFamiTF343201

Enzyme and pathway databases

PathwayCommonsiQ86U17

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
256394, 3 hits in 867 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
256394
PharosiQ86U17, Tdark

Protein Ontology

More...
PROi
PR:Q86U17
RNActiQ86U17, protein

Gene expression databases

BgeeiENSG00000186910, Expressed in liver and 40 other tissues

Family and domain databases

Gene3Di2.30.39.10, 1 hit
3.30.497.10, 1 hit
InterProiView protein in InterPro
IPR023796, Serpin_dom
IPR000215, Serpin_fam
IPR036186, Serpin_sf
IPR042178, Serpin_sf_1
IPR042185, Serpin_sf_2
PANTHERiPTHR11461, PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079, Serpin, 1 hit
SMARTiView protein in SMART
SM00093, SERPIN, 1 hit
SUPFAMiSSF56574, SSF56574, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPA11_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86U17
Secondary accession number(s): B2RV07
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: September 27, 2005
Last modified: February 10, 2021
This is version 124 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human variants curated from literature reports
    Index of human variants curated from literature reports
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with genetic variants
    List of human entries with genetic variants
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