SERPINA11

Functionⁱ

GO - Molecular functionⁱ

serine-type endopeptidase inhibitor activity Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Protease inhibitor, Serine protease inhibitor

Molecular function

Protease inhibitor, Serine protease inhibitor

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serpin A11
Gene namesⁱ	Name:SERPINA11
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000186910.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19193 SERPINA11
neXtProtⁱ	NX_Q86U17

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	256394
Open Targets More...OpenTargetsⁱ	ENSG00000186910
PharmGKBⁱ	PA134988362

Polymorphism and mutation databases

BioMutaⁱ	SERPINA11
DMDMⁱ	76363411

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	Sequence analysisAdd BLAST		19
ChainⁱPRO_0000041973	20 – 422	Serpin A11Add BLAST		403

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	94	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	106	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	169	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	350	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	Q86U17
PeptideAtlas More...PeptideAtlasⁱ	Q86U17
PRIDEⁱ	Q86U17
ProteomicsDBⁱ	69759

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000186910
CleanExⁱ	HS_SERPINA11

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000335024

STRINGⁱ

9606.ENSP00000335024

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q86U17
SMRⁱ	Q86U17
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the serpin family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG2392 Eukaryota COG4826 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118839
HOGENOMⁱ	HOG000238521
HOVERGENⁱ	HBG005957
InParanoidⁱ	Q86U17
KEGG Orthology (KO) More...KOⁱ	K04525
OMAⁱ	HQKEMHR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ION
PhylomeDBⁱ	Q86U17
TreeFamⁱ	TF343201

Family and domain databases

InterProⁱ	View protein in InterPro IPR023796 Serpin_dom IPR000215 Serpin_fam IPR036186 Serpin_sf
PANTHERⁱ	PTHR11461 PTHR11461, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00079 Serpin, 1 hit
SMARTⁱ	View protein in SMART SM00093 SERPIN, 1 hit
SUPFAMⁱ	SSF56574 SSF56574, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q86U17-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGPAWLWLLG TGILASVHCQ PLLAHGDKSL QGPQPPRHQL SEPAPAYHRI 
        60         70         80         90        100
TPTITNFALR LYKELAADAP GNIFFSPVSI STTLALLSLG AQANTSALIL 
       110        120        130        140        150
EGLGFNLTET PEADIHQGFR SLLHTLALPS PKLELKVGNS LFLDKRLKPR 
       160        170        180        190        200
QHYLDSIKEL YGAFAFSANF TDSVTTGRQI NDYLRRQTYG QVVDCLPEFS 
       210        220        230        240        250
QDTFMVLANY IFFKAKWKHP FSRYQTQKQE SFFVDERTSL QVPMMHQKEM 
       260        270        280        290        300
HRFLYDQDLA CTVLQIEYRG NALALLVLPD PGKMKQVEAA LQPQTLRKWG 
       310        320        330        340        350
QLLLPSLLDL HLPRFSISGT YNLEDILPQI GLTNILNLEA DFSGVTGQLN 
       360        370        380        390        400
KTISKVSHKA MVDMSEKGTE AGAASGLLSQ PPSLNTMSDP HAHFNRPFLL 
       410        420 
LLWEVTTQSL LFLGKVVNPV AG

Length:422

Mass (Da):46,989

Last modified:September 27, 2005 - v2

Checksum:ⁱ58536B32C91DC2F8

GO

Sequence cautionⁱ

The sequence CAD62587 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_061791	230	E → A. Corresponds to variant dbSNP:rs1885137Ensembl.		1
Natural variantⁱVAR_034511	406	T → S. Corresponds to variant dbSNP:rs17752285Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BX248259 mRNA Translation: CAD62587.1 Different initiation. BC146962 mRNA Translation: AAI46963.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32149.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001073920.1, NM_001080451.1
UniGeneⁱ	Hs.145890

Genome annotation databases

Ensemblⁱ	ENST00000334708; ENSP00000335024; ENSG00000186910
GeneIDⁱ	256394
KEGGⁱ	hsa:256394
UCSC genome browser More...UCSCⁱ	uc001ydd.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q86U17	UPI0003EB0509		HUMAN		218
Serpin family A member 11		CHLSB		459
SERPINA11 isoform 1		PONAB		422
UPI000C2B2B76		Ugandan red Colobus		422
Serpin family A member 11		Cebus capucinus imitator		422
+16

Protein	Similar proteins		Species	Score	Length
Q86U17	UPI0003EB0509		HUMAN		218
Serpin family A member 11		CHLSB		459
SERPINA11 isoform 1		PANTR		422
Serpin family A member 11		MACFA		422
Uncharacterized protein		MACMU		422
+80

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BX248259 mRNA Translation: CAD62587.1 Different initiation. BC146962 mRNA Translation: AAI46963.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32149.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001073920.1, NM_001080451.1
UniGeneⁱ	Hs.145890

3D structure databases

ProteinModelPortalⁱ	Q86U17
SMRⁱ	Q86U17
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000335024

STRINGⁱ

9606.ENSP00000335024

Polymorphism and mutation databases

BioMutaⁱ	SERPINA11
DMDMⁱ	76363411

Proteomic databases

PaxDbⁱ	Q86U17
PeptideAtlas More...PeptideAtlasⁱ	Q86U17
PRIDEⁱ	Q86U17
ProteomicsDBⁱ	69759

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	256394
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000334708; ENSP00000335024; ENSG00000186910
GeneIDⁱ	256394
KEGGⁱ	hsa:256394
UCSC genome browser More...UCSCⁱ	uc001ydd.2 human

Organism-specific databases

CTDⁱ	256394
DisGeNET More...DisGeNETⁱ	256394
EuPathDBⁱ	HostDB:ENSG00000186910.3
GeneCardsⁱ	SERPINA11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19193 SERPINA11
neXtProtⁱ	NX_Q86U17
Open Targets More...OpenTargetsⁱ	ENSG00000186910
PharmGKBⁱ	PA134988362
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2392 Eukaryota COG4826 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118839
HOGENOMⁱ	HOG000238521
HOVERGENⁱ	HBG005957
InParanoidⁱ	Q86U17
KEGG Orthology (KO) More...KOⁱ	K04525
OMAⁱ	HQKEMHR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ION
PhylomeDBⁱ	Q86U17
TreeFamⁱ	TF343201

Miscellaneous databases

GenomeRNAiⁱ	256394
Protein Ontology More...PROⁱ	PR:Q86U17

Gene expression databases

Bgeeⁱ	ENSG00000186910
CleanExⁱ	HS_SERPINA11

Family and domain databases

InterProⁱ	View protein in InterPro IPR023796 Serpin_dom IPR000215 Serpin_fam IPR036186 Serpin_sf
PANTHERⁱ	PTHR11461 PTHR11461, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00079 Serpin, 1 hit
SMARTⁱ	View protein in SMART SM00093 SERPIN, 1 hit
SUPFAMⁱ	SSF56574 SSF56574, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SPA11_HUMAN
Accessionⁱ	Q86U17Primary (citable) accession number: Q86U17 Secondary accession number(s): B2RV07
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
	Last sequence update:	September 27, 2005
	Last modified:	June 20, 2018
	This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
SIMILARITY comments
Index of protein domains and families

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Supporting data

UniProtKB - Q86U17 (SPA11_HUMAN)

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Serpin A11

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ