UniProtKB - Q86U17 (SPA11_HUMAN)
Protein
Serpin A11
Gene
SERPINA11
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- serine-type endopeptidase inhibitor activity Source: GO_Central
GO - Biological processi
- negative regulation of endopeptidase activity Source: GO_Central
Keywordsi
Molecular function | Protease inhibitor, Serine protease inhibitor |
Enzyme and pathway databases
PathwayCommonsi | Q86U17 |
Names & Taxonomyi
Protein namesi | Recommended name: Serpin A11 |
Gene namesi | Name:SERPINA11 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19193, SERPINA11 |
neXtProti | NX_Q86U17 |
VEuPathDBi | HostDB:ENSG00000186910.3 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 256394 |
OpenTargetsi | ENSG00000186910 |
PharmGKBi | PA134988362 |
Miscellaneous databases
Pharosi | Q86U17, Tdark |
Genetic variation databases
BioMutai | SERPINA11 |
DMDMi | 76363411 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000041973 | 20 – 422 | Serpin A11Add BLAST | 403 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 94 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 106 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 169 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 350 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | Q86U17 |
MassIVEi | Q86U17 |
PaxDbi | Q86U17 |
PeptideAtlasi | Q86U17 |
PRIDEi | Q86U17 |
ProteomicsDBi | 69759 |
PTM databases
GlyGeni | Q86U17, 4 sites |
Expressioni
Gene expression databases
Bgeei | ENSG00000186910, Expressed in liver and 40 other tissues |
Organism-specific databases
HPAi | ENSG00000186910, Tissue enriched (liver) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 129165, 1 interactor |
IntActi | Q86U17, 1 interactor |
STRINGi | 9606.ENSP00000335024 |
Miscellaneous databases
RNActi | Q86U17, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the serpin family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG2392, Eukaryota |
GeneTreei | ENSGT00940000162010 |
HOGENOMi | CLU_023330_2_1_1 |
InParanoidi | Q86U17 |
OMAi | IPMMHQK |
OrthoDBi | 1124079at2759 |
PhylomeDBi | Q86U17 |
TreeFami | TF343201 |
Family and domain databases
Gene3Di | 2.30.39.10, 1 hit 3.30.497.10, 1 hit |
InterProi | View protein in InterPro IPR023796, Serpin_dom IPR000215, Serpin_fam IPR036186, Serpin_sf IPR042178, Serpin_sf_1 IPR042185, Serpin_sf_2 |
PANTHERi | PTHR11461, PTHR11461, 1 hit |
Pfami | View protein in Pfam PF00079, Serpin, 1 hit |
SMARTi | View protein in SMART SM00093, SERPIN, 1 hit |
SUPFAMi | SSF56574, SSF56574, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q86U17-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGPAWLWLLG TGILASVHCQ PLLAHGDKSL QGPQPPRHQL SEPAPAYHRI
60 70 80 90 100
TPTITNFALR LYKELAADAP GNIFFSPVSI STTLALLSLG AQANTSALIL
110 120 130 140 150
EGLGFNLTET PEADIHQGFR SLLHTLALPS PKLELKVGNS LFLDKRLKPR
160 170 180 190 200
QHYLDSIKEL YGAFAFSANF TDSVTTGRQI NDYLRRQTYG QVVDCLPEFS
210 220 230 240 250
QDTFMVLANY IFFKAKWKHP FSRYQTQKQE SFFVDERTSL QVPMMHQKEM
260 270 280 290 300
HRFLYDQDLA CTVLQIEYRG NALALLVLPD PGKMKQVEAA LQPQTLRKWG
310 320 330 340 350
QLLLPSLLDL HLPRFSISGT YNLEDILPQI GLTNILNLEA DFSGVTGQLN
360 370 380 390 400
KTISKVSHKA MVDMSEKGTE AGAASGLLSQ PPSLNTMSDP HAHFNRPFLL
410 420
LLWEVTTQSL LFLGKVVNPV AG
Sequence cautioni
The sequence CAD62587 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_061791 | 230 | E → A. Corresponds to variant dbSNP:rs1885137Ensembl. | 1 | |
Natural variantiVAR_034511 | 406 | T → S. Corresponds to variant dbSNP:rs17752285Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX248259 mRNA Translation: CAD62587.1 Different initiation. BC146962 mRNA Translation: AAI46963.1 |
CCDSi | CCDS32149.1 |
RefSeqi | NP_001073920.1, NM_001080451.1 |
Genome annotation databases
Ensembli | ENST00000334708; ENSP00000335024; ENSG00000186910 |
GeneIDi | 256394 |
KEGGi | hsa:256394 |
UCSCi | uc001ydd.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX248259 mRNA Translation: CAD62587.1 Different initiation. BC146962 mRNA Translation: AAI46963.1 |
CCDSi | CCDS32149.1 |
RefSeqi | NP_001073920.1, NM_001080451.1 |
3D structure databases
SMRi | Q86U17 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 129165, 1 interactor |
IntActi | Q86U17, 1 interactor |
STRINGi | 9606.ENSP00000335024 |
PTM databases
GlyGeni | Q86U17, 4 sites |
Genetic variation databases
BioMutai | SERPINA11 |
DMDMi | 76363411 |
Proteomic databases
jPOSTi | Q86U17 |
MassIVEi | Q86U17 |
PaxDbi | Q86U17 |
PeptideAtlasi | Q86U17 |
PRIDEi | Q86U17 |
ProteomicsDBi | 69759 |
Protocols and materials databases
Antibodypediai | 56616, 126 antibodies |
DNASUi | 256394 |
Genome annotation databases
Ensembli | ENST00000334708; ENSP00000335024; ENSG00000186910 |
GeneIDi | 256394 |
KEGGi | hsa:256394 |
UCSCi | uc001ydd.2, human |
Organism-specific databases
CTDi | 256394 |
DisGeNETi | 256394 |
GeneCardsi | SERPINA11 |
HGNCi | HGNC:19193, SERPINA11 |
HPAi | ENSG00000186910, Tissue enriched (liver) |
neXtProti | NX_Q86U17 |
OpenTargetsi | ENSG00000186910 |
PharmGKBi | PA134988362 |
VEuPathDBi | HostDB:ENSG00000186910.3 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2392, Eukaryota |
GeneTreei | ENSGT00940000162010 |
HOGENOMi | CLU_023330_2_1_1 |
InParanoidi | Q86U17 |
OMAi | IPMMHQK |
OrthoDBi | 1124079at2759 |
PhylomeDBi | Q86U17 |
TreeFami | TF343201 |
Enzyme and pathway databases
PathwayCommonsi | Q86U17 |
Miscellaneous databases
BioGRID-ORCSi | 256394, 3 hits in 867 CRISPR screens |
GenomeRNAii | 256394 |
Pharosi | Q86U17, Tdark |
PROi | PR:Q86U17 |
RNActi | Q86U17, protein |
Gene expression databases
Bgeei | ENSG00000186910, Expressed in liver and 40 other tissues |
Family and domain databases
Gene3Di | 2.30.39.10, 1 hit 3.30.497.10, 1 hit |
InterProi | View protein in InterPro IPR023796, Serpin_dom IPR000215, Serpin_fam IPR036186, Serpin_sf IPR042178, Serpin_sf_1 IPR042185, Serpin_sf_2 |
PANTHERi | PTHR11461, PTHR11461, 1 hit |
Pfami | View protein in Pfam PF00079, Serpin, 1 hit |
SMARTi | View protein in SMART SM00093, SERPIN, 1 hit |
SUPFAMi | SSF56574, SSF56574, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SPA11_HUMAN | |
Accessioni | Q86U17Primary (citable) accession number: Q86U17 Secondary accession number(s): B2RV07 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 27, 2005 |
Last sequence update: | September 27, 2005 | |
Last modified: | February 10, 2021 | |
This is version 124 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families - Human entries with genetic variants
List of human entries with genetic variants